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Effects of ATP on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Small Intestine
박일구,김진호,박찬국,김만우,Shankar Prasad Parajuli,홍찬식,최석,전제열 전남대학교 의과학연구소 2018 전남의대학술지 Vol.54 No.1
Purinergic receptors play an important role in regulating gastrointestinal (GI) motility. Interstitial cells of Cajal (ICCs) are pacemaker cells that regulate GI smooth muscleactivity. We studied the functional roles of external adenosine 5’-triphosphate (ATP)on pacemaker activity in cultured ICCs from mouse small intestines by using thewhole-cell patch clamp technique and intracellular Ca2+ ([Ca2+]i) imaging. ExternalATP dose-dependently depolarized the resting membrane and produced tonic inwardpacemaker currents, and these effects were antagonized by suramin, a purinergic P2receptor antagonist. ATP-induced effects on pacemaker currents were suppressed byan external Na+-free solution and inhibited by the nonselective cation channel blockers,flufenamic acid and niflumic acid. The removal of external Ca2+ or treatment with thapsigargin(inhibitor of Ca2+ uptake into endoplasmic reticulum) inhibited the ATP-inducedeffects on pacemaker currents. Spontaneous [Ca2+]i oscillations were enhancedby external ATP. These results suggest that external ATP modulates pacemaker activityby activating nonselective cation channels via external Ca2+ influx and [Ca2+]i releasefrom the endoplasmic reticulum. Thus, it seems that activating the purinergicP2 receptor may modulate GI motility by acting on ICCs in the small intestine.
박일구,박철진,신지혜,김진화,김상용,배학연 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.1
인슐린 자가면역 증후군은 항체에 결합되어 있던 인슐린이 혈당정도와 관계없이 유리됨으로써 저혈당이 야기되는 질환으로, 인슐린종 등과 감별을 필요로 하는 질환이다. 저자들은 고인슐린혈증과 인슐린 자가항체가 양성이면서 공복검사상에서 저혈당이 유발되며 경구 포도당 부하 검사에서 저혈당이 유발된 자가면역성 저혈당증을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hypoglycemia is one of the rare causes of hypoglycemia, and characterized by hyperinsulinemia. Insulin autoimmune syndrome is characterized by insulin autoantibody, hyperinsulinemia, and fasting hypoglycemia without previous insulin immunization. Insulin autoimmune syndrome is usually related to autoimmune disease such as Graves' disease and to previous exposure to drugs. This syndrome is a self-limited disorder. The hypoglycemia was treated with prednisolone and the patient recovered from this. Recently we experinenced two cases of insulin autoimmune syndrome that developed symptomatic hypoglycemia during both the fasting and oral glucose tolerance test. Here in, We present those cases with a review of the literature.