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경동맥화학색전술 및 방사선 치료에 불충분한 반응을 보인 문맥 침범간세포암 환자에서 성공적인 수술적 구제 치료 1예
나성균 ( Seong Kyun Na ),임형준 ( Hyung Joon Yim ),서상준 ( Sang Jun Suh ),정영걸 ( Young Kul Jung ) 대한간암학회 2016 대한간암학회지 Vol.16 No.2
Hepatocellular carcinoma (HCC) with portal vein invasion has a poor prognosis. Treatments such as transarterial chemoembolization (TACE), radiation therapy (RT), sorafenib are done as a first line treatment. But in case of incomplete response to first line treatment, there’s no established guideline about salvage treatment. We present a 47 year-old male who was diagnosed as HCC with portal vein invasion. He was treated with RT and repeated TACE, but remnant viable tumor was observed. Surgical resection was performed as a salvage treatment, and HCC was completely removed. He has been followed up over 3 years, but there was no recurrence. (J Liver Cancer 2016;16:118-122)
증례 : 감염 ; 낼리딕산 내성 Salmonella enteritidis에 의한 급성 대퇴골 골수염 1예
나성균 ( Seong Kyun Na ),김태준 ( Tae Jun Kim ),이정아 ( Jeong A Lee ),이승순 ( Seung Soon Lee ),고성혜 ( Sung Hye Koh ),김태영 ( Tae Young Kim ),김한성 ( Han Sung Kim ) 대한내과학회 2015 대한내과학회지 Vol.88 No.3
비장티푸스성 살모넬라균은 주로 급성 위장염을 일으키고 자연 호전되는 경우가 많지만 균혈증이나 전이성 국소감염을 일으킨 경우 항생제 치료가 필요하다. 3세대 cephalosporin, fluoroquinolone이 1차 치료제로 사용되나 1990년대부터 낼리딕산 내성 균주에 의한 감염이 보고되었고 이 경우 fluoroquinolone에 감수성임에도 불구하고 임상적으로 치료 반응이 지연되거나 치료에 실패하는 경우가 발생했다. 국내에서도 낼리딕산 내성 균주가 빠르게 증가하고 있으며 비장티푸스성 살모넬라 감염에서 혈청형 또는 낼리딕산 내성을 확인하여 항생제를 선택하는 것이 치료 실패를 줄이기 위한 방법이 될 것으로 생각된다. 저자들은 건강한 환자에서 발생한 낼리딕산 내성 S.enteritidis에 의한 골수염 및 골막 농양을 골조직 투과력 및 경구 흡수율이 좋은 고용량 flu-oroquinolone을 16주간 투여로 부작용 없이 성공적으로 치료한 예를 경험하여 문헌고찰과 함께 보고하는 바이다. Infection with nontyphoidal Salmonella most often results in self-limited acute gastroenteritis. However, occasionally it causes bacteremia and localized infection requiring antibiotic treatment. A third-generation cephalosporin or fluoroquinolone is often the first choice of antibiotic. However, there has been an increase in nalidixic-acid-resistant nontyphoidal Salmonella with decreased fluoroquinolone susceptibility. Although there have been many cases reported of nontyphoidal Salmonella, no cases of nalidixic- acid-resistant nontyphoidal Salmonella have been reported in Korea. Here, we report on the case of a 61-year-old man with a diagnosis of acute osteomyelitis and periosteal abscess of the femur caused by nalidixic-acid-resistant Salmonella enteritidis. He was treated successfully with prolonged administration of a high-dose of ciprofloxacin and drainage of the abscess. (Korean J Med 2015;88:340-345)
빈뇨와 복통, 설사로 발현된 방광과 위장관을 동시 침범한 과호산구증가증후군 1예
김자경 ( Ja Kyung Kim ),김주희 ( Joo Hee Kim ),박한민 ( Han Min Park ),정용설 ( Yong Seol Jeong ),최청조 ( Chung Jo Choi ),나성균 ( Seong Kyun Na ),김종혁 ( Jong Hyeok Kim ),송영림 ( Young Rim Song ),황용일 ( Yong Il Hwang ),장승 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.1
Idiopathic hypereosinophilic syndrome (IHES) is a rare disorder defined by persistent blood eosinophilia, evidence of eosinophil-associated organ dysfunction and absence of secondary causes. Eosinophilic infiltration and its mediator release can cause damage to multiple organs. Although IHES can involve every organ system, bladder involvement is rarely evidenced. We recently reported a case of IHES with both bladder and gastrointestinal tract involvement. A 43-year-old woman visited Hallym University Sacred Heart Hospital complaining of urinary frequency, abdominal pain, and diarrhea for several months. Abdominal pelvic computed tomographic scan showed diffuse wall thickenings in her bladder and colon with small pelvic ascites. Laboratory investigation showed a marked peripheral eosinophilia and tissue biopsies confirmed eosinophilic infiltration in the bladder wall, esophagus, and duodenum. The patient was treated with prednisolone and her eosinophilia and symptoms have gradually improved.
李淳赫,羅性均 충북대학교 농업과학기술연구소 1990 農業科學硏究 Vol.8 No.2
This study was conducted to pursue the normalization of frequency distribution by approaching the coefficient of skewness to zero through power transformation to the annual maximum series of four watersheds along Han, Guem, Nag Dong river basin. Analysis for the comparison of design flows according to the return periods were carried out between the best fitted probability distribution and power transformation. The results were analyzed and summarized as follows. 1. Power transformation has found to be best one in comparison with log and square root transformation for being the coefficient of skewness into closer zero as a means of getting the normalization of frequency distribution in the annual maxium series for the applied watersheds. 2. The best fitted probability was acknowledged as three paramater lognormal destribution for Jeong sun of Han, Im Ha of Nag Dong river basin and type 1 extremal distribution for Seok Hwa, Gyu Am of Geum river, respectively. 3. Empirical formulas for the probable flood flows and design flows according to the return periods were derivated for the applied watersheds. 4. Relative errors of three parameter lognormals and type 1 extermal distribution to power transformation which was acknowledged as a best fitted probable flows were shown to be within 10 percent in common for all watersheds from two to two hundred years of return period. 5. The part of higher nonexceedance probabilities, i.e. probable flood flows for power transformation leas found to be more approached to the observed data in comparison with the results of other fitted distributions in view of relative suitability.