한방안이비인후피부과학회지에 게재된 여드름과 관련된 논문에 관한 고찰

김지수,박수연,최정화,김종한,이두희,Kim, Ji-Soo,Park, Soo-Yeon,Choi, Jeong-Hwa,Kim, Jong-Han,Rhee, Doo-Hee 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3

Objective : This study was carried out to analyze the trends of Acne related articles that have been published in the Journal of Korean Medicine Ophthalmology, Otolaryngology & Dermatology(JKOOD). Method : We studied 29 research papers relevant to Acne that published in JKOOD from 1998 to 2013. All the paper were classified into three categories; original article, review article and case report. We sub-classified the original articles into three categories; descriptive study, analytic study and experimental study. We analyzed the case report according to various types of treatment. Results : 1. The number of searched journals is 29 papers; 17 original ordicles, 4 review articles, 8 case reports. 2. Classification of 17 original articles into three categories; 10 experimental studies, 7 descriptive studies, 0 analytic study. 3. Method of Evaluation; Korean Acne Grading System(KAGS) is used frequently in descriptive studies and experimental studies. 4. Treatment in Case reports; 7 Case reports used External medical treatments. Conclusions : It is needed to develop the methods of grading system in acne related to Oriental medicine to obtain objectivity of studies. The number of analytic study, clinical trial and experimental study is need to increase.

희첨 추출물이 B16F10 세포에서 Melanin 생성과 Tyrosinase 활성에 미치는 억제효과

김지수,정민영,김종한,최정화,박수연,Kim, Ji-Soo,Jeong, Min-Young,Kim, Jong-Han,Choi, Jeong-Hwa,Park, Soo-Yeon 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.1

Objective : Siegesbeckia Herba can treat various skin disease by expelling wind and removing dampness and clearing away heat and toxic material effects. This study was designed to investigate effects of Siegesbeckia Herba Extracts(SHE) on skin elasticity and whitening using B16F10 cell lines. Method : In this experiment, We observed effect of SHE on cell viability, inhibition of melanin synthesis and inhibitory effect on tyrosinase and elastase. Results : 1. SHE treated group showed decreased cell viability rates significantly compared with non-treated group. More than SHE $250{\mu}g/ml$, $500{\mu}g/ml$ and $1,000{\mu}g/ml$ of treated groups were lower levels of melanin synthesis respectively. 2. SHE significantly showed tyrosinase inhibitory activity in vitro, SHE increased tyrosinase inhibitory activity and elastase inhibitory activity in B16F10 cells, and tyrosinase inhibitory activity in vitro. 3. Tyrosinase inhibitory activity and elastase inhibitory activity in B16F10 cells, tyrosinase inhibitory activity in vitro were not accepted statistical significance compared with non-treated group. 4. SHE treated group showed increased SOD-like activity rates significantly compared with non-treated group. More than SHE $250{\mu}g/ml$, $500{\mu}g/ml$ and $1,000{\mu}g/ml$ of treated groups were lower levels of melanin synthesis respectively. Conclusion : These results suggest that SHE can inhibit melanin synthesis and tyrosinase inhibtory activity. So, We suggest that SHE can be maintained skin whitening.

생료사물탕(生料四物湯)이 DNCB로 유발된 생쥐의 아토피 피부염에 미치는 영향

김지수,최정화,김종한,정민영,박수연,Kim, Ji-Soo,Choi, Jung-Hwa,Kim, Jong-Han,Jeong, Min-Yeong,Park, Soo-Yeon 대한한방안이비인후피부과학회 2017 한방안이비인후피부과학회지 Vol.30 No.1

Objectives : Atopic Dermatitis (AD) is chronic skin disease characterized by allergic hypersensitivity reactions. Saeng-ryo-Samul-tang (SRSM) can treat skin disease by cooling down blood heat, cealering away congenital fever and detoxicating. This study was conducted to investigate the effects of SRSM on AD induced by 2,4-dinitrochlorobenzene (DNCB) in mice Methods : In this study, the effects of SRSM on changes in body weights, thicknesses of dorsum skin, thicknesses and weights of ear, changes of symptoms on the dorsum skin, histopathological degree of ear and dorsum skin, IL-10 and $TNF-{\alpha}$ in serum were observed. And the effects on the proliferation rates of splenocytes were also investigated in vivo and in vitro study. Results : In SRSM topical application (Topical) group, SRSM oral application (Oral) group and SRSM Combination (Combi) group thickness of dorsum skin decreased significantly. But in TPC, ORL and CBN group, weight of ear didn't show any changes, but thickness of ear decreased significantly. And TPC, ORL and CBN group showed meaningful effectiveness symptoms like desquamation and erythema on AD's clinical espect. In histopathological observation, spongiosis, edema and inflammatory cell infiltration of epidermal were remarkably diminished in TPC, ORL and CBN group. And SRSM diminished the proliferation rates of splenocytes in vivo and vitro study. Conclusions : The present study suggests that SRSM can significantly reduced symptoms of AD, therefore SRSM is effective to treatment of AD.

최고 속력 동적 휴리스틱을 이용한 경로탐색

김지수,이지완,조대수,Kim, Ji-Soo,Lee, Ji-Wan,Cho, Dae-Soo 한국정보통신학회 2009 한국정보통신학회논문지 Vol.13 No.8

Generally, the Terminal Based Navigation System(TBNS) used embedded road data searches a path that has less qualitative than The Center Based Navigation System(CBNS). TBNS has not used real time road data but it is recently able to use it with technique such as TPEG. However, it causes to increase a cost of exploring by using real time road data for improvement quality of a path, because of limited performance. In this paper, we propose a Dynamic Heuristic to improve quality of path in the TBNS. Dynamic Heuristic(DH) is not fixed data and is dynamically modified using transferred real time road data from server. In this paper, we propose path-lading algorithm with Maximum Speed Dynamic Heuristic (DH-MAX) and do an experiment. The DH-MAX is to be used the highest speed as DH, in real map divided by same size. And proposed algorithm searches path using the priority searching only of the fixed data, but also the highest speed with real time information. In the performance test, the quality of path is enhanced but the cost of searching is increased than A* algorithm. 일반적으로 단말기 기반의 경로탐색 시스템은 자체적으로 내장된 정보만을 사용하기 때문에 센터 기반의 탐색보다 경로의 질이 떨어진다. 최근 TPEG와 같은 기술을 이용하여 단말기 기반의 경로탐색 시스템에서도 실시간 교통 정보를 전송 받을 수 있다. 그러나 단말기의 제한된 성능으로 인해 실시간 교통정보를 모두 활용하여 경로의 질을 높이면 탐색 비용이 급격히 증가하는 문제가 있다. 이 논문에서 단말기 기반 시스템에서 경로탐색의 질을 높이기 위해 동적 휴리스틱을 제안한다. 동적 휴리스틱이란 고정된 정보가 아닌 서버로부터 실시간 도로정보를 전송받아 동적으로 변경되는 휴리스틱이다. 이 논문에서는 최고속력 동적휴리스틱을 이용하는 경로탐색 기법을 제안하고, 성능 실험을 하였다. 최고속력 동적 휴리스틱이란 지도를 일정크기로 나눈 그리드내의 도로 중 최고속력을 동적 휴리스틱으로 활용하며, 최고속력이 높은 곳을 우선 탐색함으로 인해 거리에 따른 정보뿐만 아니라 실시간 정보를 활용하여 경로를 탐색한다. 성능 실험 결과 A* 알고리즘에 비해 경로의 질은 향상되었으나 탐색비용이 조금 늘었다.

공공도서관의 VR 기반 교육문화프로그램 개발에 관한 연구

김지수,김성주,박신이,신지원,권선영,Kim, Ji Soo,Kim, Seong Ju,Park, Si Ni,Shin, Ji Won,Kwon, Sun Young 한국정보관리학회 2021 정보관리학회지 Vol.38 No.2

최근 들어 다양한 분야에서 VR 기술을 활용한 콘텐츠가 점차 증가하고 있으며 기술 또한 급속도로 보급되는 추세이다. 이러한 배경에서 공공도서관 또한 시대의 흐름에 따라 VR 기술을 활용한 서비스를 제공할 필요가 있다. 이에 본 연구는 공공도서관의 교육적, 문화적 기능을 고려한 VR 기반 교육문화프로그램을 제안하는 것을 목적으로 한다. 이를 위해 VR 프로그램이 진행되고 있는 국내·외 공공도서관 및 산업군 사례 조사 그리고 선행연구, 이론분석을 통해 적용점 및 시사점을 도출하였으며 이를 종합, 검토하여 공공도서관에서의 VR 기반 교육문화프로그램을 제안하였다. 본 연구에서 제시한 VR 기반 교육문화프로그램은 향후 공공도서관에서 VR 기반 교육문화프로그램 기획을 위한 기초 자료로 활용될 수 있을 것이다. Recently, content using VR technology in various fields is gradually increasing, and the technology is also rapidly spreading. Against this background, public libraries also need to provide services using VR technology according to the flow of the times. Therefore, this study drew application points through the investigation and analysis of domestic and foreign public libraries where VR programs are underway. And based on this, a final proposal is prepared after planning and reviewing VR-based educational and cultural programs in public libraries. VR-based educational and cultural programs introduced can be used as basic data for planning VR-based cultural programs in public library.

초음파 플립칩 접합 모듈의 위상최적화 설계 및 성능 실험

김지수,김종민,이수일,Kim, Ji Soo,Kim, Jong Min,Lee, Soo Il 대한용접접합학회 2012 대한용접·접합학회지 Vol.30 No.6

Ultrasonic bonding is the novel packaging method for flip-chip with high yield and low-temperature bonding. The bonding module is a core part of the bonding machine, which can transfer the ultrasonic energy into the bonding spot. In this paper, we propose topology optimization technique which can make new design of boding modules due to the constraints on resonance frequency and mode shapes. The designed bonding module using topology optimization was fabricated in order to evaluate the bonding performance and reliable operation during the continuous bonding process. The actual production models based on the proposed design satisfied the target frequency range and ultrasonic power. The bonding test was performed using flip-chip with lead-free Sn-based bumps, the results confirmed that the bonding strength was sufficient with the designed bonding modules. Also the performance degradation of the bonding module was not observed after the 300-hour continuous process with bonding conditions.

구안와사에 대한 훈증요법 복합치료 효과

김지수,박수연,최창원,김경수,김경옥,위통순,양승정,Kim, Ji-Soo,Park, Soo-Yeon,Choi, Chang-Won,Kim, Kyeong-Soo,Kim, Kyeong-Ok,Wei, Tung-Shuen,Yang, Seung-Joung 대한한의학방제학회 2015 大韓韓醫學方劑學會誌 Vol.23 No.1

Objectives : This study was performed to investigate the effect of herbal steam therapy on peripheral facial paralysis. Methods : 55 patients with peripheral facial paralysis were treated with Korean Medicine therapy including herbal steam therapy. We evaluated the effect of Korean Medicine therapy including herbal steam therapy by Yanagihara grading system. Results : 1. 55 patients were treated with Korean Medicine therapy and 23.27±14.11 times of herbal steam therapy. 2. After treatment, Y-system score was significantly increased(p-value＜0.001) from 18.00±6.5514 to 35.00±6.3404. Conclusions : Herbal stream therapy seem to be effective to improve symptoms of peripheral facial paralysis. Further studies will be needed to identify the beneficial of herbal steam therapy on peripheral facial paralysis.

만성육아종질환 환자에서 합병된 식도 폐쇄 사례 -만성육아종질환의 육아종성 식도 폐쇄

김지수,황진솔,최영훈,김우선,김중곤,Kim, Ji Soo,Hwang, Jinsol,Choi, Young Hun,Kim, Woo Sun,Kim, Joong Gon 대한소아감염학회 2014 Pediatric Infection and Vaccine Vol.21 No.1

CGD 환자에서는 면역 체계의 결함으로 인한 반복적인 감염과 육아종 형성이 특징적이다. CGD 환자에서 육아종의 형성에 의한 식도 폐쇄는 매우 드문 합병증 중 하나로 CGD 환자의 육아종 형성에 의한 식도 폐쇄의 치료에 대해서는 불현성 감염이 동반될 가능성이 있어 스테로이드 치료와 항생제 치료에 대한 논란이 있어왔다. 저자들은 항생제 치료에 반응하지 않는 육아종 형성에 의한 식도 폐쇄 증상을 보인 8세 만성육아종질환 환자를 보고하는 바이다. 환자는 스테로이드 치료 이후에 임상적 증상과 영상 검사 상의 급격한 호전을 보였으나 스테로이드 치료를 중단한 지 한 달 뒤 환자의 식도 폐쇄 증상은 재발하였고, 이는 스테로이드를 재 투약 후 호전되었다. 스테로이드 중단 이후 한 차례 다시 재발하였으나, 항생제 치료 후 호전되었고 이후 추가적 재발 없이 경과 관찰 중이다. Chronic granulomatous disease (CGD) is an inherited immunodeficient disease characterized by recurrent infections and granuloma formation. Granulomatous obstruction of esophagus is one of the rare complications of CGD. The use of steroids and antimicrobials for esophageal obstruction by granuloma in CGD patients has been controversial due to the possibility of concomitant inapparent infection. We report a case of esophageal obstruction in an 8-year-old CGD patient showing the poor response to antibiotics therapy. However, dramatic improvement of symptoms and radiologic findings of esophageal obstruction were achieved after steroid therapy. One month after discontinuation of steroid, esophageal obstruction recurred and the patient was re-treated with steroid. After that time, he experienced one more recurrence of esophageal obstruction. This symptom subsided after antibiotics therapy without steroid and he has been followed up to the present without further relapse.

알레르기성 자반증 한방 치험 2례

김지수,최정화,김종한,정민영,박수연,Kim, Ji-Soo,Choi, Jeong-Hwa,Kim, Jong-Han,Jeong, Min-Young,Park, Soo-Yeon 대한한의학방제학회 2016 大韓韓醫學方劑學會誌 Vol.24 No.1

Objective This study is designed to investigate the effect of Korean medical therapy on Allergic purpura patients.Method This is a case report on a male and a female patients who has been suffering from allergic purpura. To reduce her symptoms, we provided with internal herbal medicine 2-3 times a day, acupuncture therapy 1-2 times a day.Results After series of treatments, the symptoms of allergic purpura were remarkably improved.Conclusions This study shows us that Korean medical treatments has remedial values for purpura patients. Hence, more studies should be demanded in Korean medicine for elevation of treatment rate.

체내에서 성숙이 재개된 생쥐난자의 투명대 경화

김지수,김해권,박종민,이승재,이준영,김문규,Kim, Ji-Soo,Kim, Hae-Kwon,Park, Jong-Min,Lee, Seung-Jae,Lee, Joon-Young,Kim, Moon-Kyoo 대한생식의학회 1997 Clinical and Experimental Reproductive Medicine Vol.24 No.1

It is well known that the zona pellucidae of mouse oocytes become "hardened" when they are allowed to mature in vitro in the absence of serum components. To see if oocytes already undergone meiotic resumption in vivo exhibit similar zona hardening, hardening of ZP of cumulus-enclosed oocytes(CEOs) was examined after culture in vitro since their release from follicles various hours after hCG injection. When CEOs matured in vivo for 3h or longer were subjected to culture in vitro for 14h with BSA alone, zona hardening was significantly reduced compared to those cultured in vitro from the begining of maturation. However, when CEOs matured in vivo for 5h were freed from cumulus cells and then cultured in vitro with BSA alone, little reduction of zona hardening was observed. Preincubation of CEOs for 5h with fetuin, one of the well known inhibitor of in vitro zone hardening, did not prevent zona hardening during its subsequent culture of CEOs for 14h without fetuin. However, when CEOs precultured with both fetuin and PMSG for 5h and then further cultured with BSA alone for 14h, zona hardening was dramatically reduced. Under these conditions, the expansion of cumulus cell was observed. In addition, CEOs cultured with both BSA and dbcAMP to prevent their meiotic resumption showed a significant increase of zona hardening. Whether the observed zona hardening was correlated with the conversion of ZP2 to $ZP2_{f}$ was examined. Zona pellucida, isolated from CEOs matured for 5h in vivo and then further cultured with BSA alone was subjected to SDS-PAGE. Most of ZP2 molecules from these CEOs did not undergo conversion from ZP2 to $ZP2_{f}$. From these results, it is concluded that CEOs undergone meiotic resumption in vivo do not exhibit zona hardening when they were subsequently cultured in vitro without serum components. It appears that cumulus cells play an important role in this phenomenon.