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만삼(Codonopis pilosula (Franch.) Nannfeldt)의 Alkaloid 成分의 검색
김인봉,홍정애 이화여자대학교 약학회 1978 梨花藥學會誌 Vol.- No.18
Compound H that appeared positive reaction on Meyer and Dragendorff reagent was isolated from root of Codonopsis pilosula (Franch.) Nannfeldt by chromatographic purification. Compound H was identified as alkaloid had -OH, >C=O, C≡C or C≡N functional group by chemical and spectral analysis
만삼(Codonopis pilosula (Franch.) Nannfeldt)의 Alkaloid 成分의 검색
김인봉,홍정애 梨花女子大學校 藥學硏究所 1978 梨花藥學硏究 Vol.- No.18
Compound H that appeared positive reaction on Meyer and Dragendorff reagent was isolated from root of Codonopsis pilosula (Franch.) Nannfeldt by chromatographic purification. Compound H was identified as alkaloid had -OH, >C=O, C≡C or C≡N functional group by chemical and spectral analysis.
카드뮴 정맥주사시 랏트의 치사율과 간, 신에서의 양-반응관계
김인봉,박정덕,홍연표,장임원 중앙대학교 의과대학 의과학연구소 1992 中央醫大誌 Vol.17 No.4
To investigate the lethality and dose-response relationship in liver and kidney of rats at 48 hours after cadmium exposure, single doses of cadmium chloride were given to Sprague-Dawley male rats by tail-intravenous injection with several groups of doses ranging from 2 to 8 mg CdCl_2/kg for lethality and from 0.2 to 3.2 mg CdCl_2/kg for dose-response relationship. In addition, control was treated with distilled water by same method. Hepatic and renal cadmium concentrations were analyzed with I.C.P.(Inductively Coupled Plasm) Emission Spectrometry (Jobin Yvon, Model JY 24, France). Dosages over 4 mg/kg were relevant to LD_100 and LD_50 was calculated as 3.3 mg/kg at 48 hours after cadmium chloride exposure in rat. The concentration in liver and kidney were increased according to given doses, and dose-response relationship was expressed as log Cd in liver= 0.8799+0.913×log Dose (F=1116.1, r=0.9877) and log Cd in kidney= 0.2542+0.0653×log Dose (F=884.8, r=0.9845), respectively. Also, the correlation between hepatic and renal cadmium concentration was highly significant(p<0.01), and dose-response relationship was expressed as long Cd in kidney = -0.6649+1.0259×log Cd in liver (F=411.1, r=0.9676). I consider that this data will be useful for the further studying of low-dose cadmium toxicity.
김인봉,김무강,조성환,김덕환,유명조,이성호,이성옥,권건오,김명철 한국임상수의학회 1999 한국임상수의학회지 Vol.16 No.2
To establish feline electroacupuncture anesthesia, 5 cats (mixed, 1 month old, 0.4~0.5 kg, female) were examined in the present study. The acupoints used for feline electroacupuncture anesthesia were Tian-ping and Bai-hui. After perpendicular insertion of needle to Tian-ping and Bai-hui, respectively, positive electrode was connected at Tian-ping and negative electrode was connected at Bai-hui, respectively, Electric condition was 3 V and 30 Hz. To examine the effect of electroacupuncture anesthesia, laparotomy (5 heads)was applied. The pain of the body surface and the extremities excluding the tail was not found, and the induction time of electroacupuncture anesthesia was approximately 1 minute. As for the reactions with electroacupuncture anesthesia, the head part was directed to backward, blepharoreaction was mild and the consciousness was vivid. The class of anesthesia effect was excellent in 4 heads and was poor in 1 head. The pain was not observed and bleeding was comparatively small volume during surgery in excellent group.
사람 피부 섬유아세포와 치은 섬유아세포에서 아라키돈산 처리에 따른 세포외기질 발현의 차이
임원봉,장미선,김지선,고영종,김인애,권혁일,김상우,최홍란,김옥준 대한구강악안면병리학회 2010 대한구강악안면병리학회지 Vol.34 No.2
The pattern of wound healing process differs markedly according to the cell types. Gingival wounds heal more rapidly without scar, however dermal wounds show collagen laid down in thick disorganized patterns and keloid formation. This h as b een s uggested t o be d ue t o the presence of d ifferent E C M components a nd c ytokines a s well a s growth factors. The purpose of this study was to examine the differential expression of genes in connection with keloid formation in gingival fibroblasts (hGFs) and dermal fibroblasts (hDFs) in response to inflammation. In this study, we investigated the differences between hGFs and hDFs in the expression and production of cyclooxygenase (COX-2), prostaglandins E2 (PGE2), transforming growth factor (TGF)-β, collagens, matrix metalloproteinases (MMPs), and tissue inhibitors of matrix metalloproteinases (TIMPs) which play important roles in collagen deposition in wound healing. The hGFs and hDFs were primary cultured and allocated to arachidonic acid (AA) treatment group and control group. Protein and mRNA were extracted right after (0 hr) and 24 hr after AA treatment. At a defined concentration of AA in hGFs and hDFs, MTT assay was performed. The mRNA and protein expression levels of COX-2, TGF-β, collagen 1 and 3, MMP 1 and TIMP 1 were examined by Real-time PCR and Western blots. The amounts of PGE2 were measured by enzyme-linked immunosorbent assay (ELISA).The expression of COX-2 and TGF-β exhibited reduced levels in hGFs , but were increased in hDFs at 24 hr after AA treatment. Production of PGE2 was increased in hGFs and hDFs at right after AA treatment but, not changed at 24 hr after AA treatment. The protein and mRNA expression of collagen 1 and 3 were decreased in hGFs , whereas increased in hDFs at 24 hr AA treatment. Expression of MMP-1 protein was increased in hGFs at 24 hr but, was decreased in hDFs at 24 hr compared with that of control. The protein expression of TIMP-1 was decreased in hGFs but, was increased in hDFs at 24 hr compared with that of control. These observations demonstrate differential expression between gingival and dermal fibroblasts in regulation of collagenolytic capacity by extracellular matrix-associated genes in keloid formation associated with wound repair.