Nocardia SP . 에 의한 Δ4 - 3 - Ketosteroid 류의 산화

김옥희,이상섭 ( Ok Hee Kim,Sang Sup Lee ) 생화학분자생물학회 1974 BMB Reports Vol.7 No.1

Rationalizing of conformational or structural modification effect on 9α-hydroxylation of 17-ketosteroids which have Δ⁴-3-keto-system was attempted. When 6-methylandrost-4-ene-3,17-dione was incubated with Nocardia opaca, the rate of 9 a-hydroxylation was much slower than that of androst-4-ene-3,17-dione. In contrast, 9 a-hydroxylation of 6α-methylandrost-4-ene-3, 17-dione was faster than that of 6 ~-isomer. In addition to these two compounds, 19-norandrost-4-ene3,17-dione and 6,19-oxidoandrost-4-ene-3,17-dione were also compared with androst-4-ene-3,17-dione, and it was found that the rate of 9α-hydroxylation and B-ring rupturing of androst-4-ene-3,17-dione was fastest among tested steroids.

Nocardia Sp.에 의한 ${\Delta}^4$-3-Ketosteroid 류의 산화

김옥희,이상섭,Kim, Ok-Hee,Lee, Sang-Sup 생화학분자생물학회 1974 한국생화학회지 Vol.7 No.1

Steroid의 핵구조(ring structure)가 $9{\alpha}$-hydroxylation에 미치는 영향을 검토하기 위하여 $6{\beta}$-methylandrost-4-ene-3, 17-dione, $6{\alpha}$-methylandrost-4-ene-3, 17-dione, 19-norandrost-4-ene-3, 17-dione, androst-4-ene-3, 17-dione과 6, 19-oxidoandrost-4-ene-3, 17-dione 등 ${\Delta}^4$-keto-system을 갖고 있는 steroid를 Nocardia opaca 배양액중에 첨가하여 주고 $9{\alpha}$-hydroxylation 되는 과정을 살폈다. ${\Delta}^4$-keto-system에 $6{\beta}$-methyl group이 존재하면 현저히 hydroxylation의 속도가 느린 것을 발견하였다. Rationalizing of conformational or structural modification effect on $9{\alpha}$-hydroxylation of 17-ketosteroids which have ${\Delta}^4$-3-keto-system was attempted. When $6{\beta}$-methylandrost-4-ene-3, 17-dione was incubated with Nocardia opaca. the rate of $9{\alpha}$-hydroxylation was much slower than that of androst-4-ene-3, 17-dione. In contrast, $9{\alpha}$-hydroxylation of $6{\alpha}$-methylandrost-4-ene-3, 17-dione was faster than that of $6{\beta}$-isomer. In addition to these two compounds, 19-norandrost-4-ene-3, 17-dione and 6.19-oxidoandrost-4-ene-3, 17-dione were also compared with androst-4-ene-3, 17-dione, and it was found that the rate of $9{\alpha}$-hydroxylation and B-ring rupturing of androst-4-ene-3, 17-dione was fastest among tested steroids.

쑥뜸치료가 암환자의 심박변이도에 미치는 영향

김옥희,최정은,윤정원,유화승,Kim, Ok-Hee,Choi, Jung-Eun,Yoon, Jeung-Won,Yoo, Hwa-Seung 대한암한의학회 2011 大韓癌韓醫學會誌 Vol.16 No.1

Objective : The study aims to investigate the effect of moxibustion treatments on autonomic nervous system function of cancer patients through the evaluation of heart rate variability (HRV) biofeedback testing. Materials and Methods : Six cancer patients from inpatient care unit of Dunsan Oriental Hospital, Daejeon University were given three moxibustion treatment sessions every other day over one week period on five Oriental Medicine meridian points CV4, CV6, CV12, KD1, and PC8. HRV biofeedback was conducted before and after each treatment sessions. Three areas of analyses were done from the test conducted; Time Domain Analysis, Frequency Domain Analysis and Autonomic Nervous System (ANS) balance analysis. Results : Time Domain Analysis has shown increased Standard Deviation of all Normal R-R Intervals (SDNN), and decreased Mean Heart Rate and Physical Stress Index (PSI) levels, with statistical significance (P<0.05). In Frequency Domain Analysis, series of moxa treatments have increased Total Power (TP), Very Low Frequency Oscillation Power (VLF), High Frequency Oscillation Power (HF), normalized HF values while decreasing Low Frequency Oscillation Power (LF), normalized LF and LF/HF ratio with statistical significance (P<0.05). The values of ANS activity, ANS balance, Stress resistance, Stress index, have also shown significant changes. For cardiac stability stroke volume power (SP) and Blood Vessel Tension (BVT) were followed, which were both increased after treatment. All changes were statistically significant (P<0.05). Conclusion : The results have shown a positive correlation between the moxibustion treatments and autonomic nervous system responses on cancer patients through the HRV biofeedback testing. This study suggests possible application of moxibustion treatments for managing ANS functions of cancer patients, although additional studies with larger population are necessary to confirm the data.

교합 유도 형태에 따른 저작근 활성도에 관한 연구

김옥희,계기성,Kim, Ok-Hee,Kay, Kee-Sung 대한치과보철학회 1989 대한치과보철학회지 Vol.27 No.2

The purpose of this study was to investigate the muscle activity of the group function occlusion and the changed canine guided occlusion using EM2. In this study, 13 subjects with group function occlusion and without temporomandibular disorders were selected, each subject was changed to the canine guided occlusion by forming the lingual ramps in the upper canines with light curing composite resin. The muscle activities of the anterior temporal and masseter muscle were recorded in the group function occlusion and immediately, one week, and two weeks after changing to the canine guided occlusion under the condition of maximum voluntary clenching in centric occlusion, lateral excursion, and during gum chewing. The results were as follows: 1. In case of maximum voluntary clenching in centric occlusion, the muscle activities of the anterior temporal and masseter muscle of working and balancing side didn't show any difference immediately after changing to the canine guided occlusion, one week after changing to the canine guided occlusion, one week after changing to it the muscle activities of the anterior temporal masseter muscle of working and balancing side were increased significantly, and two weeks after changing to it the muscle activities of the masseter muscle were increased significantly in comparison with the group function occlusion. 2. In case of maximum voluntary clenching in lateral excursion, the muscle activities of the anterior temporal and masseter muscle of working and balancing side were reduced significantly immediately after changing to the canine guided occlusion, one week after changing to it the muscle activities of the anterior temporal muscle of balancing side and of the anterior temporal and masseter muscle of working side were reduced significantly, and 2 weeks after changing to it the muscle activities of the anterior temporal and masseter muscle of working side were reduced significantly in comparison with the .group function occlusion. 3. During gum chewing, the muscle activities of the anterior temporal and masseter muscle of working and balancing side didn't show any difference immediately after changing to the canine guided occlusion, one week after changing to it the muscle activities of the masseter muscle of working and balancing side were increased significantly, and two weeks after changing to it only the muscle activities of masseter muscle of working side were increased significantly.

생강성분 6-Paradol의 세포 독성 및 병리학적 연구

김옥희,유은숙,정인경,이상섭,Kim, Ok-Hee,Yoo, Eun-Sook,Jung, In-Kyung,Lee, Sang-Sup 한국환경성돌연변이발암원학회 1998 한국환경성돌연변이·발암원학회지 Vol.18 No.1

It is previously reported that 6-paradol can induce prolonged analgesia in experimental animals. In order to investigate the mutagenicity of 6-paradol, Ames Samonella/microsome plate assay was carried out with Salmonella typhimurium strains, TA 98, TA 100, TA 1535 and TA 1538, 6-Paradol was nonmutagenic in Salmonella typhimurium with and without rat liver microsomal activation. The rec assay with Bacillus substilis strains H 17 $rec^+$ and M 45 $rec^+$ was carried out ot test 6-paradol and other compounds (1-3 mg/disc) for DNA damaging activity, 6-Paradol was also nonmutagenic in DNA damaging activity. The relative size of the inhibition zone for 6-paradol was smaller than that of capsaicin. We have also determined the pathological effects of this compound on the various tissues of rats after administrating(i.p.) with increasing doses of 4, 8, 12, 16 mg/kg at 2 hour intervals and found no significant changes in terms of histology.

전기 베이비부머의 노화 인식과 성공적 노화 준비에 관한 연구 -저소득 무배우자 남성을 중심으로-

김옥희 ( Ok Hee Kim ),서연희 ( Yeon Hee Seo ) 한국가족복지학회 2015 한국가족복지학 Vol.20 No.1

This study conducted qualitative research using Colaizzi``s analytical method with a phenomenological approach to understand deeply and concretely non-mate males in low-income groups’ awareness of their aging and their preparation for successful aging. After the data from in-depth interviews with eight non-mate males in low-income groups among former baby boomers was analyzed, the results of this study were deducted with 16 constituted meanings and 6 categorized themes as the essential structure of the experiences. The results of this study are as follows. First, the participants recognized aging as “black hole like poverty”, “adaptation/avoidance about aging”, “realizing the importance of their family” and “becoming a new person in the workplace.” Second, the participants recognized unprepared old age as “Miserable old age without having money”, “Feeling desolate of the unemployment in old age” , and they prepared for their successful aging by health care and Settling their single life, working continually and having a religion like a crutch of life.

논문 6 : 복잡계 이론으로 본 생태무용의 내적 경험체계

김옥희 ( Ok Hee Kim ) 한국무용교육학회 2015 韓國舞踊敎育學會誌 Vol.26 No.1

This research intends to discover the meaning of internal creation of individuals through the life preservation experience of eco-dance that connects the value and meaning of ecology with life based on complex systems and find the internal experience system of eco-dance in which mental reasoning as the combination of emotion, thought and value system of individuals and not as an pre-existed dance finds out body and soul as a subject that recognizes itself and comes to realization. Concentration and experience in eco-dance is a way of knowledge and internalization of ecological value, which results in enhancing the life quality through aesthetic experience, and sharing and getting along in eco-dance is the process of perceiving the ecological life that knows how to fulfill life. Therefore eco-dance provides the foundation for a communal awareness that respects life characteristics and negates discrimination and alienation. Also in this regard, eco-dance matches the systematic thought process in which experiencing the wholeness of nature through body and living in harmony with the nature comes to completion by contributing to the Commons.

진로만다라 과제학습이 대학생의 진로준비행동에 미치는 영향

김옥희(Kim, Ok- Hee) 한국진로교육학회 2005 진로교육연구 Vol.18 No.1

제주도(濟州島) 천주교(天主敎)의 수용(受容) 전개과정(展開過程)

김옥희 ( Ok Hee Kim ) 제주대학교 탐라문화연구소 1987 탐라문화 Vol.0 No.6

커뮤니티댄스 실행 모델 생태감성 무용 구조 연구

김옥희 ( Ok Hee Kim ) 한국무용교육학회 2012 韓國舞踊敎育學會誌 Vol.23 No.2

Ecological sensitivity based community dance has been an practical attempt to build up an alternative that seeks to recover and yearn human being`s innate naturalness and beauty through emotional education teaching how to feel nature-friendly life. In other word, ecological sensitivity based movement is both the process of changing the perspective about our lives through rediscovering emotion about body and a body movement that can perform the genuine communication with our body. This is an activity that experiences both nature and art, which is also a program that respects emotion that activates a variety of human senses through natural images, thereby making us get to know our unique emotion. Ecological sensitivity based body movement program is divided into body self-realization, sympathy, emotion expression and communication segments. Ecological sensitivity based body movement program is centered around community dance which encourages the handicapped and disabled to overcome their limited life condition through rediscovery of innate emotion by communication with natural life.