구취환자의 구강건조와 기허${\cdot}$기울 변증의 상관성 분석

김소연,김유승,홍인아,허원영,엄국현,이선령,윤상협,류봉하,김진성,Kim, So-Yeon,Kim, Yoo-Seung,Hong, In-A,Hur, Won-Young,Eom, Guk-Hyeon,Lee, Seon-Young,Yoon, Sang-Hyub,Ryu, Bong-Ha,Kim, Jin-Sung 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.1

Objectives : This study investigated the correlation between dry mouth and comprehensive diagnosis of Qi xu and Qi yu in patients with halitosis. Methods : We surveyed 124 halitosis patients by reviewing the questionnaires from the Halitosis Clinic in the Hospital of Oriental Medicine, Kyunghee University from January 2004 to March 2006. The halitosis questionnaires contained self-awareness of halitosis, self-assessed severity of halitosis, dry mouth and taste abnormality. Among comprehensive diagnosis of Qui Xue Shui, Qi xu and Qi yu parts were investigated by questionnaire and physical examination, and each Qi xu and Qi yu part scores were summed. Winkel tongue coating index was estimated by investigator, the level of volatile sulfur compounds were measured by halimeter, and salivary function was assessed by salivary scan test. All patients were divided into two groups based on salivary scan test (salivary function normal and decreased). Results : Qi xu score of halitosis patients with decreased salivary function was higher than normal halitosis patients. There was highly significant correlation between Qi yu score and dry mouth, and another significant correlation between self-assessed halitosis severity and dry mouth was noted. Conclusions : The results of this study suggest that Qi yu condition influences dry mouth in halitosis patients, and halitosis is affected by dry mouth. Therefore. we assume that treating Qi yu condition can be a potentially effective way of treating dry mouth and halitosis.

기능성 소화불량증에서 위운동성 장애 진단을 위한 양도락 지표 연구

김소연,윤상협,김윤범,정승기,Kim, So-Yeon,Yoon, Sang-Hyup,Kim, Yoon-Bum,Jung, Sung-Ki 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.2

Objectives : The aim of this study was to investigate the characteristics of Ryodoraku and association of Ryodoraku with gastric dysmotility in functional dyspepsia(FD). Methods : Subjects were 154 patients with FD and 18 patients with asthma. We calculated the average Ryodoraku score(RS, ${\mu}A$) and each variation from physiologic range of 12 Ryodoraku points, and investigated the incidence when left and right points were simultaneously below(bilateral deficiency) or above(bilateral excess) physiologic range. Postprandial regularity of normal slow waves, power ratio, and postprandial % of bowel sound were obtained by electrogastrography and enterotachography, and were used as gastric dysmotility index. Results : 1. Bilateral excess of H4, H5, F1, and F4 and bilateral deficiency of H4, H5, and H6 were characteristic in FD compared with asthma patients. 2. Incidence of gastric dysmotility in bilateral deficiency of H4, H5, and H6 was 100%, and was higher than in total FD patients(88.3%). 3. There was a positive correlation between the variation of H6 and % postprandial bowel sound. 4. Deficient tendency of H4, H5, and H6 was more evident when RS was above $40{\mu}A$ in FD. Conclusions : These findings suggest that gastric dysmotility in FD can be diagnosed when a pattern of H4, H5, H6 bilateral deficiency and F1, F4 bilateral excess is shown at the same time. We think this phenomenon is related to low activity of the vagus nerve rather than meridian pathway with result based on positive correlation between variation of H6 and postprandial % of bowel sound.

A Selective Effect of Combined Treatment of Electroacupuncture at Zusanli(ST36), Manual Acupuncture, and Pyengwi-san in Function Dyspepsia Patients with Pyloric Valve Disturbance and Hypoactivity of Gastric Vagus Nerve

김소연,윤상협,Kim, So-Yeon,Yoon, Sang-Hyub The Society of Internal Korean Medicine 2009 大韓韓方內科學會誌 Vol.30 No.1

Objectives : The aim of this study was to evaluate the therapeutic effect of acupuncture and herbal medicine in patients who had hvpoactivity of the gastric vagus nerve and pyloric valve disturbance simultaneously with function dyspepsia by bowel sounds analysis. Methods : Bowel sounds of 10 patients (male 1, female 9) were recorded and their % of bowel sound (%BS) and ratio of dominant frequency (DF) were analyzed before and after treatment. Hypoactivity of the gastric vagus nerve was considered if % BS was <6%. and pyloric valve disturbance was accepted if DF ratio (e.g.. postprandial DF/fasting DF) was <1. Electroacupuncture at Zusanli (ST36, 3Hz, 30 minutes) and manual acupuncture at other meridian points were applied daily for 2 weeks. Herbal medicine, Pyengwi-san. was administered to all patients (100cc, 3 times/day). Results : DF ratio significantly increased from $0.93\pm0.06$ to $1.06\pm0.04$ after treatment for 2 weeks (p=0.005). 9 of 10 patients were improved to DF ratio>1. %BS also increased from $2.97\pm1.17%$ to $4.49\pm4.27%$. not significantly. 3 patients showed a remarkable elevation, and their %BS reached >6% of normal value. Conclusions : Combined effect of electroacupuncture at Zusanli (ST36), manual acupuncture. and Pyengwi-san was shown effective in the improvement of pyloric valve disturbance more than hypoactivity of gastric vagus nerve on patients with functional dyspepsia. 목 적 : 위 미주신경 활성 저하와 유문부 기능 장애를 동시에 가지고 있는 기능성 소화불량증 환자에서 전침 및 한약의 복합처치 치료가 이 두가지 면에서 각각 어떤 영향을 미치는지를 살펴보았다. 방 법 : 장음검사상 위 미주신경 활성 저하와 유문부 기능 장애를 동시에 가지고 있는 환자 10명을 대상으로 치료 전후의 장음 지표 변화를 비교하였다. 장음지표는 % of bowel sound (%BS)와 주 주파수(dominant frequency, DF)를 사용하였으며, %BS(6인 경우를 위 미주신경 활성저하 DF ratio(식후/식 전)<1를 유문부 기능장애로 평가하였다. 환자들에게 2주간 족삼리전 침과 체침이 매일 시술되었으며 평위산 전탕액이 하루 3회 투여되었다. 결 과 : 2주간의 치료 후 DF ratio는 $0.93\pm0.06$에서 $1.06\pm0.04$으로 유의성있게 증가했으며, 10명 중 9명의 환자가 DF ratio>1의 정상치로 회복되었다. %BS 역시 $2.97\pm1.17%$에서 4.27%로 증가했지만 통계적 유의성은 없었으며, 3명의 환자에서 %BS가 6이상으로 정상회복되었다. 결 론 : 위 미주신경 활성 저하와 유문부 기능 장애를 동시에 가지고 있는 기능성 소화불량증 환자에 대한 족삼리 전침과 일반 체침, 평위산의 치료는 미주신경 활성 저하보다는 유문부 기능 장애에 더 유의한 효과를 보였다.

기능성 소화불량증에서 위장관 미주신경 활성 평가를 위한 심박변이지표와 장음지표의 상관성 연구

김소연,윤상협,Kim, So-Yeon,Yoon, Sang-Hyub 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.1

Objectives : The aim of this study was to investigate the evaluation of gastrointestinal parasympathetic nerve activity by comparing between HRV and bowel sound parameters in patients with functional dyspepsia. Methods : 62 patients (male 22, female 40) were enrolled. HRV was measured in all patients. and TP (total power), LF (low frequency density: 0.04$\sim$0.15Hz), HF (high frequency density: 0.15$\sim$0.4Hz). and LF/HF ratio were analyzed. HF band is a reflection of parasympathetic activity. and the LF-to-HF ratio is considered a marker of sympathovagal balance. Bowel sounds were recorded at the day after, and postprandial %BS was used to indicate the gastric vagal activity after eating. HRV and bowel sound parameters were compared. and correlation between them was analyzed. Results : There was no difference in LF/HF ratio between patient group and healthy group of other report. According to values of %BS, each patient was classified into a normal (>6 %BS) or hypoactivity (<6 %BS) of gastric vagus nerve group. HF component of the hypoactivity group was not significantly higher than that of the normal group. There was no correlation between HRV and bowel sound parameters. Conclusions : Because no correlation was found between HRV and bowel sound parameters in patients with functional dyspepsia, we concluded that it is not proper to evaluate gastric vagus nerve activity by HRV measurement.

간경변 백서 모델에서 아데노바이러스 벡터를 이용한 Matrix Metalloproteinase-3 유전자 치료

김소연 ( So Yeon Kim ),허원희 ( Won Hee Her ),류종순 ( Jong Soon Ryu ),왕진상 ( Jing Sang Wang ),배시현 ( Si Hyun Bae ),장정원 ( Jeong Won Jang ),김창욱 ( Chang Wook Kim ),동미숙 ( Mi Sook Dong ),윤승규 ( Seung Kew Yoon ) 대한내과학회 2006 대한내과학회지 Vol.71 No.6

목적: 간경변은 활성화된 간성상 세포에 의해 이상 증식된 세포외기질이 축적되는 것을 특징으로 하며 matrix metalloproteinase (MMP)에 의해 분해되는 것으로 보고되고 있다. 본 연구의 목적은 간경변 모델 흰쥐에서 MMP-3를 발현하는 아데노바이러스를 이용한 유전자 치료로 간섬유화가 경감되는지를 알아보고자 하였다. 방법: 몸무게 200~250 g의 6주령된 수컷 백서에 8주 동안 DMN을 복강에 주사하여 간경변 동물 모델을 만들었다, 일주일 후에 AdMMP3.GFP, Ad.GFP, PBS를 문맥에 주사한 후 매주마다 백서를 희생시켜 조직을 채취하였다. 간경변의 개선정도는 활성형의 간성상 세포지표인 a-SMA, Desmin, TGFβRⅡ의 면역화학적 염색, 간세포 성장 표지자인 PCNA 및 dry liver weight 측정을 통해 분석하였다. 결과: MMP-3를 주사한 군에서 Masson`s trichorm 염색 시의 교원질과 hydroxyproline의 양은 현저히 감소하였다. MMP-3올 주사한 군에서 α-SMA, Desmin, TGFβRⅡ 양성 세포수는 감소하며, PCNA 양성 세포수와 dry liver weight은 증가하였다. 결론: 본 연구의 결과를 종합해 볼 때 MMP-3를 이용한 유전자 치료가 비가역적으로 알려진 간경변을 최소한 경감시킬 수 있는 가능성을 보여주어 향후 항섬유화 분자치료적 관점에서 긍정적인 가능성올 제시하고 있다. Background: Liver cirrhosis is characterized by fibrous scarring and hepatocellular regeneration. Matrix metalloproteinases (MMPs) comprise a family of zinc-dependent enzymes that degrade the extracellular matrix (ECM) components. This study examined whether or not gene delivery of human MMP-3 can attenuate established liver cirrhosis in a rat. Methods: Rat liver cirrhosis was induced by an intraperitoneal injection of dimethylnitrosamine (DMN) three times a week for 8 weeks. The rats were infected once with either a recombinant adenovirus. AdMMP3.GFP, or a control adenovirus, Ad.GFP, into a portal vein and followed up for 3 weeks. In the rat liver tissues, the collagen content, histopathology and immunohistochemical staining were measured. Results: Liver fibrosis in the DMN induced cirrhotic rat was attenuated along with a diminished hydroxyproline content and increased dried liver weight after the gene delivery of AdMMP3.GFP. In addition, the number of activated hepatic stellate cells was lower whereas the proliferation of hepatocytes, which was confirmed by immunohistochemical staining using anti-proliferating cell nuclear antigen (PCNA) antibody, was observed in the AdMMP3.GFP infected rats, suggesting that human MMP-3 stimulated hepatocyte proliferation. Conclusions: These results suggest that the gene transfer of human MMP-3 in the liver attenuates established fibrosis and induces hepatocyte proliferation. Therefore, gene therapy using MMP-3 in liver cirrhosis might be a promising therapeutic option in the future. (Korean J Med 71:609-619, 2006)

행동분석 및 군집분석을 통한 전자출판 과정의 상호 관련도에 관한 연구

김소연(So Yoon Kim),이경숙(Kyung Sook Lee),박길철(Gil-Chul Park) 한국산업정보학회 2002 한국산업정보학회논문지 Vol.7 No.5

탄소 동소체-황토 복합재료를 사용한 친환경 발열체 제작과 특성 분석

김소연 ( So Yun Kim ),최예윤 ( Ye Yoon Choi ),윤대현 ( Dae Hyun Yoon ),김효권 ( Hyokwon Kim ),정규관 ( Kyukwan Zong ) 전북대학교 과학교육연구소 2019 과학과 과학교육 논문지 Vol.44 No.1

본 연구는 친환경적 재료인 황토와 탄소 동소체인 탄소 나노튜브와 흑연을 혼합하여 발열체를 제작하고 발열 특성을 분석한 연구이다. 황토는 우리나라 대표적인 전통 건축 재료이다. 최근 황토가 친환경적이고 전자파를 차단하고 원적외선을 방출한다고 해서 전통 가옥의 벽과 실내의 온돌 바닥 재료로서 각광을 받고 있다. 특히 황토는 단열과 통풍성이 좋으며 겨울에는 따뜻하고 여름에는 시원한 특성을 가지고 있어 우리나라와 같은 사계절을 가진 나라에서 매우 적합한 건축 재료이다. 황토의 이런 장점을 살리고 매우 안정하고 인체에 무해한 전도성이 뛰어난 탄소 동소체인 흑연과 탄소 나노튜브의 장점을 살려 이 두 물질의 복합체를 합성하였다. 합성한 복합체를 사용하여 발열체를 제작하고 저항과 발열 효과를 측정하였다. 황토에 흑연을 넣어 만든 혼합체의 저항 값 측정에서 흑연 0.1g이 섞인 시료의 경우 저항 값이 크게 나타났지만 0.2g ~ 0.5g 까지의 시료의 경우 상대적으로 매우 낮은 저항 값을 보였다. 이들 시료는 평균 저항 값이 0.2kΩ ~ 4kΩ 까지의 매우 우수한 전기전도성을 나타내는 것을 알 수 있었다. 이로써 황토에 적정량의 흑연을 섞어 넣은 경우 매우 우수한 발열체로서의 기능을 가질 수 있음을 예측할 수 있었다. 실험을 통하여 탄소나노튜브보다는 흑연이 황토와 잘 혼합되는 성질을 보여 주었다. 그리고 동일 질량인 경우 탄소나노튜브가 흑연보다 더 높은 발열 효율을 보여 주었다. 따라서 황토와의 혼합성, 혼합 질량 비율, 경제성 등을 고려해 볼 때 흑연은 혼합성과 경제성에서 우수하고, 탄소나노튜브는 혼합 질량 비율에서 더 우수한 결과를 보여 주었다. This study centers around the construction of environmental friendly heating devices and characterization using the composites of carbon allotrope and loess. Loess is one of the most popular traditional construction materials. It has been extensively studied that loess is environmentally friendly construction material and very helpful to stop electrical radiation, also known to emit long wave length of infra-red. It also is excellent in permeating air and insulating, therefore the houses made of loess enjoy cool in summer and warm in winter. Meanwhile, carbon allostopes including graphite and carbon nanotube are very stable and highly conductive. From a variety of merits for loess and carbon allostropes, we designed and evaluated a heating device consisted of a composite of loess and carbon allotropes such as carbon nanotubes and graphite. the composites including up to 0.1 g of graphite showed very big electrical resistance but they displayed relatively low resistance in the range of 0.2-0.5g. These samples showed average of 0.2-4kΩ resistance and thus excellent electrical conductivities. Our study demonstrated that graphite showed superior miscibility with loess than carbon nanotube did. The composites including carbon nanotube displayed superior heating efficiencies than those including graphite did if the composites prepared from the same weight ratio between carbon allostrope and loess.

칼로스 쌀의 유변학적 특성과 이로 제조된 냉동 강황밥의 해동방법에 따른 품질특성 변화

김소연(So Yeon Kim),최유라(Yu Ra Choi),김경섭(Kyeong Seop Kim),이상준(Sang Jun Lee),장윤혁(Yoon Hyuk Chang) 한국식품영양과학회 2017 한국식품영양과학회지 Vol.46 No.6

본 연구는 칼로스 품종으로 제조한 쌀가루 분산액(3, 6, 9%, w/w)에 따른 유변학적 특성 및 해동방법에 따른 냉동 강황밥의 품질특성에 대하여 평가하였다. 쌀가루 분산액은 전단담화 거동을 나타내었으며, 쌀가루 농도가 증가함에 따라 쌀가루 분산액의 점조도 지수, 겉보기 점도, Casson 항복응력 값이 증가하는 경향을 나타내었다. 쌀가루 분산액의 동적점탄 특성에 의하면 진동수 범위(0.63~62.8 rad/s)에서 진동수가 증가함에 따라 G′과 G″ 값들이 증가하는 경향을 나타내었다. RVA에 의한 쌀가루의 페이스팅 특성은 농도가 증가할수록 peak viscosity, trough viscosity, final viscosity, breakdown viscosity, setback viscosity 값이 증가하였다. 재가열 조건에 따른 냉동 강황밥의 수분함량은 스팀기, 스마트오븐, 전자레인지로 해동한 순으로 유의적으로 높았다. 색도 측정 결과 L값은 스팀기가 유의적으로 높은 값을 보였다. a값은 음의 값을 보였으며, 스팀기에서 가장 낮았고 전자레인지에서 가장 높은 값을 보였다. b값은 전자레인지가 가장 높은 값을 보였으며, 스팀기와 스마트오븐은 유의적으로 차이가 없었다. 기계적 텍스처 특성 분석 결과 경도, 부착성, 탄력성, 응집성, 깨짐성, 씹힘성 모든 값에서 스팀기가 유의적으로 낮은 값을 보였다. 결과적으로 스팀기를 이용하여 해동한 냉동 강황밥이 가장 부드러운 조직감을 보였다. This study investigated the rheological properties of Calrose rice flour dispersions as well as the effects of different thawing methods (steamer, smart oven, and microwave oven) on quality characteristics of frozen turmeric rice. Apparent viscosity, consistency index, and yield stress significantly increased at higher rice flour concentrations. Magnitudes of storage modulus and loss modulus significantly increased with elevation of rice flour concentration. Frozen turmeric rice thawed using a steamer had the highest moisture content and largest size (length, width, and thickness) among all thawing methods. The L values of turmeric rice after thawing using a steamer was significantly higher than those of other thawing methods. The a value of turmeric rice after thawing using a steamer was significantly lower than those of other thawing methods. Textural properties (hardness, adhesiveness, springiness, cohesiveness, brittleness, and chewiness) of frozen turmeric rice after thawing using a steamer were significantly lower than those of other thawing methods. Therefore, it can be concluded that frozen turmeric rice after thawing using a steamer might be desirable for improvement of texture.

집단 기반의 번개 모임 구축 서비스에 관한 연구

김소연 ( So-yeon Kim ),마예지 ( Ye-ji Ma ),윤하민 ( Ha-min Yoon ),이지원 ( Ji-won Lee ),강승석 ( Seung-seok Kang ) 한국정보처리학회 2022 한국정보처리학회 학술대회논문집 Vol.29 No.1

새로운 사회의 흐름에 발맞춰 소속과 공유에 대한 필요성이 부각되고 있다. 본 서비스는 통일된 양식, 확실한 답변, 부담 없는 만남을 기반으로 사용자 경험을 제공한다. 사용자가 커뮤니티 그룹을 통해 친근감을 경험할 수 있는 UX/UI 를 디자인 했고 신속하고 간편한 인터랙션으로 다른 사용자와 즉석 번개 만남을 제공할 수 있는 서비스를 제안한다. 이를 위해 본 연구는 집단 기반 즉흥적인 만남을 위한 모바일 앱을 구현했다.

혈관내피세포에서 TNF-α로 유도되는 혈관염증에 대한 쏙(Upogebia major) 효소가수분해물의 억제 효과

김소연 ( So-yeon Kim ),양지은 ( Ji-eun Yang ),송재희 ( Jae-hee Song ),맹상현 ( Sang-hyun Maeng ),이지현 ( Ji-hyun Lee ),윤나영 ( Na-young Yoon ) 한국수산과학회(구 한국수산학회) 2018 한국수산과학회지 Vol.51 No.2

Arteriosclerosis is the major cause of coronary artery and cerebrovascular disease, which are leading causes of death. Pro-inflammatory cytokines induce injury to vascular endothelial cells by increasing cell adhesion molecules, leading to vascular inflammation, a major risk factor for the development of arteriosclerosis. In the current study, we investigated the inhibitory effect of enzymatic hydrolysate from Japanese mud shrimp Upogebia major on the inflammation of tumor necrosis factor-α (TNF-α)-stimulated human umbilical vein endothelial cells (HUVECs). We first evaluated the antioxidant and angiotensin I-converting enzyme (ACE) inhibitory activities of eight U. major enzymatic hydrolysates: alcalase, papain, α-chymotrypsin (α-Chy), trypsin, pepsin, neutrase, protamex and flavourzyme. Of these, α-Chy exhibited potent antioxidant and ACE inhibitory activities. The α-Chy hydrolysate was fractionated by two ultrafiltration membranes of 3 and 10 kDa. The α-Chy hydrolysate of U. major and its molecular weight cut-off fractions resulted in a significant reduction in NO production and a decrease in cell adhesion molecules [vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and endothelial-selectin (E-selectin)] and pro-inflammatory cytokines [interleukin-6 (IL-6), interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1)] in TNF-α-stimulated HUVECs. These results suggest that enzymatic hydrolysate from U. major can be used in the control and prevention of vascular inflammation and arteriosclerosis.