http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김굉배,김정경,박설,정재진,윤형식,고상훈,고재이,박수진,남선우,이재환,현민수 대한심장학회 2011 Korean Circulation Journal Vol.41 No.1
Background and Objectives: It was reported that atorvastatin co-administered with clopidogrel for 8 months did not affect the anti-platelet potency of clopidogrel in Korean patients with acute coronary syndrome, but not in patients with stable angina. We investigated whether co-administration of statins with clopidogrel affected the anti-platelet efficacy of clopidogrel in Korean patients with stable angina. Subjects and Methods: This was a randomized, open-label and two-period crossover design study conducted at two centers. Two hundreds thirty three patients with stable angina scheduled for coronary stenting were randomized into two groups. In Group A, 119 patients first received atorvastatin (10 mg) followed by fluvastatin (80 mg) for 12 weeks per treatment. In Group B, 114 patients received the same treatments in reverse order. Results: Baseline adenosine diphosphate (ADP, 10 μmol/L)-induced platelet aggregation was 54.4±9.1% in Group A and 53.8±9.0% in Group B (p=0.44), and significant differences were noted after each treatment period (p<0.001). Inhibition of platelet aggregation was similar between Group A and Group B at 24 hours following clopidogrel loading (29.2±11.0% vs. 30.4±12.7%; p=0.42). The two treatment least square means of 12-week ADP (10 mol/L)-induced platelet aggregation [29.50±0.79 {standard error (SE)}% on the atorvastatin treatment group vs. 28.16±0.70 (SE)% in the fluvastatin treatment group] in a 2×2 cross-over study were not significantly different (p=0.204). Conclusion: Statin and clopidogrel co-administration for 12 weeks is not associated with attenuated anti-platelet activity of clopidogrel in Korean patients with stable angina after coronary stenting, in support of the findings of similar studies conducted in Caucasian populations.
증례 : 소화기 ; 송편에 의해 유발된 크고 넓은 대칭적 식도궤양 1예
김굉배 ( Goeng Bae Kim ),정재진 ( Jae Jin Jeong ),박설 ( Sul Park ),고재이 ( Jae Ee Ko ),고상훈 ( Sang Hoon Ko ),강현모 ( Hyoun Mo Kang ),이계성 ( Gye Sung Lee ) 대한내과학회 2012 대한내과학회지 Vol.82 No.5
There are many possible causes of esophageal ulcer, such as reflux esophagitis, pill-induced esophagitis, infectious esophagitis, tuberculosis, syphilis, Behcet`s disease, radiation injury, caustic injury, foreign body-induced injury, esophageal cancer, and so on. However, there are only a few cases of esophageal ulcer by thermal injury from food, and most of these were caused by liquids; few are related to ingestion of solid food. We experienced a case of a large symmetrical esophageal ulcer caused by thermal and compressive injury from a hot solid foodstuff known as ``Song-pyen``, a traditional Korean food, and report the natural course of healing by conservative treatment, with a review of the few available reports regarding such injuries. (Korean J Med 2012;82:589-593)
증례 : 소화기 ; 급성 A형 간염에서 우연히 발견된 만성 B형 간염과 연관된 신조직 소견
정재진 ( Jae Jin Jeong ),김굉배 ( Goeng Bae Kim ),박설 ( Seol Park ),윤형식 ( Hyung Sik Yoon ),서광선 ( Kwang Sun Seo ),이계성 ( Gye Sung Lee ),강현모 ( Hyoun Mo Kang ) 대한내과학회 2011 대한내과학회지 Vol.80 No.1
저자들은 비전격성 형태로 발현된 급성 A형 간염으로 인한 급성 신부전을 경험하였다. 환자의 임상 경과와 병리 소견을 알기 위해 실시한 신조직 검사에서 급성 신부전의 특징적인 조직 소견인 급성 신세뇨관 괴사를 확인하였고, 광학 현미경 소견에서 IgA신병증 그리고 면역 형광 염색에서 과막증식 사구체 신염을 확인하여 역으로 만성 B형 간염으로 인한 신병증도 함께 진단할 수 있었다. 이후 실시한 혈액 투석으로 신기능이 회복된 예를 경험하였기에 이를 보고하는 바이며 이런 환자에서 특별한 금기가 없는 한 신조직 검사를 실시하는 것이 환자의 임상경과를 알고 치료하는데에 도움이 된다 하겠다. Hepatitis A is usually a self-limited liver disease that is treated conservatively. Acute renal injury complicating acute hepatitis A in the absence of fulminant hepatic failure is rare. We experienced a 33-year-old man who was healthy, and did not know that he was a hepatitis B virus (HBV)carrier with non-fulminant hepatitis A. He developed an acute kidney injury that necessitated dialysis therapy and a renal biopsy. He recovered within about 1 month. Pathologically, the renal biopsy showed acute tubular necrosis. It also showed IgA nephropathy and mesangium proliferation with glomerular nephritis, which are seen in chronic viral hepatitis B. We describe the association of acute hepatitis A with acute kidney injury and report the pathological findings of a renal biopsy related to chronic hepatitis B in an acute hepatitis A patient discovered by chance. (Korean J Med 2011;80:87-91)
Oxaliplatin, 5-Fluorouracil, Leucovorin 복합항암화학요법 중에 발생한 간질성 폐질환 1예
박설 ( Sul Park ),정재진 ( Jae Jin Jung ),김굉배 ( Goeng Bae Kim ),윤형식 ( Hyung Sik Yoon ),고상훈 ( Sang Hun Ko ),고재이 ( Jae Ee Ko ),이연선 ( Yeun Seun Lee ) 대한소화기학회 2010 대한소화기학회지 Vol.55 No.5
Oxaliplatin with 5-fluorouracil plus leucovorin (FOLFOX) has become the standard treatment in patients with colorectal cancer. Among known toxicities induced by oxaliplatin, hematological, gastrointestinal and neurological toxicities are common. However, acute pulmonary toxicity associated with oxaliplatin is unusual. One case of interstitial lung disease associated with the FOLFOX protocol is reported here. (Korean J Gastroenterol 2010;55: 340-343)
증례 : 호흡기 ; 쯔쯔가무시병에 의한 급성 무결석 담낭염과 동시 감염된 기관지 결핵 1예
강유진 ( Yu Jin Kang ),김수민 ( Su Min Kim ),박미희 ( Mi Hyi Park ),박설 ( Sul Park ),정재진 ( Jae Jin Jeong ),김굉배 ( Goeng Bae Kim ),이연선 ( Youn Sun Lee ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5S
쯔쯔가무시병에 의한 합병증인 무결석 담남염은 고령이거나 만성 질환을 앓고 있는 고위험군의 환자에게서 뿐만 아니라 면역 억제제를 사용하고 있었던 환자에게도 치명적인 결과를 가져올 수 있으며, 또한 면역 억제제 복용을 하는 환자는 다른 감염이 동시 감염될 수 있음을 잘 염두에 두어야겠다. 조기 진단과 적절한 치료가 중요하며, 이는 외과적 치료도 피할 수 있다. 저자들은 우상복부 압통을 호소하는 쯔쯔가무시병 환자에서 드물게 나타나는 합병증으로 급성 무결석성 담낭염을 진단하였고, 또한 동시 감염된 기관지 결핵을 진단 후 적절한 내과적 치료 후 호전된 증례들을 경험하였기에 이를 국내에서 처음으로 보고하는 바이다. Acute acalculous cholecystitis, induced by Tsutsugamushi disease, is rare. A 69-year-old woman was admitted with eschar, fever, and right upper quadrant (RUQ) abdominal pain. The patient`s blood chemistry showed a high titer of anti-Rickettsia (R)-Tsutsugamushi antibodies. Abdominal ultrasonography showed gall bladder distension with wall thickening and ultrasonographic Murphy`s sign. Thus, we first diagnosed acalculous cholecystitis and pneumonitis in scrub typhus, which was treated with macrolide antibiotics, but the patient`s right lung collapsed. By bronchoscopic examination, endobronchial tuberculosis was determined. The patient had rheumatoid arthritis, which was treated by leflunomide and steroids. We suggest that leflunomide may have aggravated the scrub typhus infection and induced tuberculosis co-infection. The patient was successfully treated with appropriate antibiotic therapy following an early diagnosis by physical examination, radiologic, and bronchoscopic studies. (Korean J Med 77:S1193-S1197, 2009)