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( Yune Young Shin ),( Ho Il Yoon ),( Choon-taek Lee ),( Jae Ho Lee ),( Young-jae Cho ),( Jong Sun Park ),( Yeon Joo Lee ),( Eun Sun Kim ),( Sung Yoon Lim ),( Byung Soo Kwon ),( Yong Hee Lee ),( Sun Yo 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Introduction: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder and patients respond differently to treatment. Blood eosinophil count can serve as a predictive biomarker for the efficacy of inhaled corticosteroid treatment. Analysis of exhaled breath for volatile organic compounds (VOCs) also offers the possibility of noninvasive diagnosis and biomarker for underlying inflammation in various diseases. The aim of this study was to evaluate the association between exhaled VOCs and blood eosinophil count in patients with COPD. Methods: We conducted a prospective study on 108 patients with stable COPD recruited from the tertiary-care academic hospital. End-tidal exhalation breath of every enrolled patients was collected and analyzed by using gas chromatography- mass spectrometry to identify specific VOCs. All patients checked VOCs more than one time in different days to minimize bias and the difference of VOCs between room air and the exhaled gas was calculated. Results: In this prospective study, the average age was 71.7 ± 8.2 years and 97.2% (105) were male. Patients were divided into two groups based on the eosinophil count: those involving eosinophil counts of less than 300 (n=22) and those involving counts of 300 or more (n=86). Three VOCs were significantly lower in the group with high eosinophil count: Undecane (108800.7 ± 109230.2, p=0.017), Phthalicanhydride (69315.2 ± 57919.6, p=0.038) and Ethylbenzene (60378.3 ± 57227.3, p=0.032). Among these VOCs, ROC analysis for Udecane showed high sensitivity (57.1%) and specificity (88.0%) for high eosinophil count in patients with COPD. Conclusion: In this prospective cohort study, Udecane among VOCs can be used as the predictive marker for high serum eosinophil level.
성인의 전완부 양골 골절의 치료에서 금속판 내고정술과 골수강내 고정술의 임상적 결과비교
신현대,윤승호,이광진,양준영,이문종 대한골절학회 1999 대한골절학회지 Vol.12 No.1
The fractures of the forearm bone are common and the forearm has the specific movement of supination and pronation, So, the goal of the treatment of forearm fractures is the recovery of rotatory function of the forearm as well as the function of the elbow and wrist. Surgical treatment usually is not necessory in children under 10 years of age because of remodelling potential and spontaneous correction ability. But, anatomical reduction and rigid fixation is essential in fractures of adult forearm above 15 years of age because of rotational deformity and angulation after forearm fractures may result in serious functional problems of the forearm. The purpose of the our retrospective study is to compare the clinical result between the plate fixation and intramedullary nailing of the diaphyseal both forearm bone fractures in adult. We reviewed 64 patients above 15 ages who had diaphyseal both forearm bone fractures, and were treated with fixation using compression plate or Rush pin. Forty patients were treated with both plates, 7 patients with both Rush pins, and 17 patients with plate and rush pin,Galeazzi or Monteggia fractures were excluded in this study. On final follow up, we performed the radiological analysis and compared the operation interval, immobilization period after operation, bone union time, functional result and complications in these groups. Functional results was more higher in both plate fixation, and complications were high in both intramedullary nailing. In conclusion, both plate fixation is the best treatment method in the diaphyseal both forearm bone fractures in adult. Thus in both forearm bone fractures, both plate fixation is recommended, but if it is not available, at least one bone with plate fixation is necessary.
Shin, Dong Wook,Cho, Juhee,Roter, Debra L.,Kim, So Young,Park, Jong Hyock,Yang, Hyung Kook,Lee, Hyun Woo,Kweon, Sun-Seog,Kang, Yune Sik,Park, Keeho Korean Cancer Association 2018 Cancer Research and Treatment Vol.50 No.3
<P><B>Purpose</B></P><P>Older patient populations commonly have cognitive impairment, which might impact decisional capacity. We examined patients and family caregivers preferences for family involvement in treatment decision making assuming different level of cognitive impairment, and sought to explore the factors associated with the preferences and the degree to which patients and family members agree on preferences.</P><P><B>Materials and Methods</B></P><P>A total of 358 elderly cancer patient and caregiver dyads were recruited from the 11 cancer centers in Korea andwere asked to express their preferences forfamily involvement in treatment decision making using hypothetical scenarios with three different levels of cognitive status (intact, mild impairment, and severe impairment).</P><P><B>Results</B></P><P>Both patients and family caregivers preferred greater family dominance in treatment decision makingwith the increasing the level of cognitive impairment (39.7%, 60.9%, and 86.6% for patients and 45.0%, 66.2%, and 89.7% for caregivers in each scenarios). Patient and family caregiver concordance in decisional control preference was small for all three scenarios (weighted κ=0.32, κ=0.26, and κ=0.36, respectively). Higher patient education was associated with preference for patient dominance in treatment decision in conditions of both mild and severe cognitive impairment. The association of higher patient education and patient-caregiver preference concordance was positive with intact cognition, while it was negative with severe cognitive impairment.</P><P><B>Conclusion</B></P><P>Decision control preferences were affected by hypothesized cognitive status of the patients. Findings from our study would be helpful to develop effective strategy for optimizing family involvement in cancer treatment decision in the context of deteriorating cognitive function of the patients.</P>
Yoon, Yune-Jung,Kim, Kwon-Bok,Kim, Hyunmi,Seo, Kyung-Ah,Kim, Ho-Sook,Cha, In-June,Kim, Eun-Young,Liu, Kwang-Hyeon,Shin, Jae-Gook American Society for Pharmacology and Experimental 2007 Drug metabolism and disposition: the biological fa Vol.35 No.9
<P>Benidipine is a dihydropyridine calcium antagonist that has been used clinically as an antihypertensive and antianginal agent. It is used clinically as a racemate, containing the (-)-alpha and (+)-alpha isomers of benidipine. This study was performed to elucidate the metabolism of benidipine and its enantiomers in human liver microsomes (HLMs) and to characterize the cytochrome P450 (P450) enzymes that are involved in the metabolism of benidipine. Human liver microsomal incubation of benidipine in the presence of NADPH resulted in the formation of two metabolites, N-desbenzylbenidipine and dehydrobenidipine. The intrinsic clearance (CL(int)) of the formation of N-desbenzylbenidipine and dehydrobenidipine metabolites from (-)-alpha isomer was similar to those from the (+)-alpha isomer (1.9 +/- 0.1 versus 2.3 +/- 2.3 microl/min/pmol P450 and 0.5 +/- 0.2 versus 0.6 +/- 0.6 microl/min/pmol P450, respectively). Correlation analysis between the known P450 enzyme activities and the rate of the formation of benidipine metabolites in the 15 HLMs showed that benidipine metabolism is correlated with CYP3A activity. The P450 isoform-selective inhibition study in liver microsomes and the incubation study of cDNA-expressed enzymes also showed that theN-debenzylation and dehydrogenation of benidipine are mainly mediated by CYP3A4 and CYP3A5. The total CL(int) values of CYP3A4-mediated metabolite formation from (-)-alpha isomer were similar to those from (+)-alpha isomer (17.7 versus 14.4 microl/min/pmol P450, respectively). The total CL(int) values of CYP3A5-mediated metabolite formation from (-)-alpha isomer were also similar to those from (+)-alpha isomer (8.3 versus 11.0 microl/min/pmol P450, respectively). These findings suggest that CYP3A4 and CYP3A5 isoforms are major enzymes contributing to the disposition of benidipine, but stereoselective disposition of benidipine in vivo may be influenced not by stereoselective metabolism but by other factors.</P>
박철신(Cheol Shin Park),윤오주(Oh Joo Yune),이헌영(Heon Young Lee),김영건(Young Kun Kim),노흥규(Heung Kyu Ro),이복희(Bok Hee Lee) 대한내과학회 1989 대한내과학회지 Vol.36 No.2
Actinomycosis is a chronic, progressive, Suppurative, granulomatous disease. Definite diagnosis will generally be based upon histologic identification of actinomycotic granules or culture of the Actinomyces, or both. The diagnosis of abdomino-pelvic actinomycosis is often difficult to make. Since abdominal actinomycosis is indeed an uncommonly encountered clinical entity today, many clinicians fail to consider actinomycosis as a possibility. Actinomyces is anaerobic. It is not usually isolated from routine cultures and anaerobic cultures are difficult to obtain. It may be impossible to clinically distinguish abdominal actinomycosis from other diseases because of the variable forms of presentation which may be recognized in patients, including fever, anorexia, nausea and vomiting. Especially in Korea, the clinical presentation of actinomycosis often resembles intestinal tuberculosis, which should not usually be treated surgically. We experienced a case of Abdomino-pelvic Actinomycosis in which it was difficult to make a early diagnosis.
Choi Myeong Geun,Joo Young Woong,Kim Min-Ho,Park Sojung,Shin Yune-Young,Chun Eun Mi 대한의학회 2024 Journal of Korean medical science Vol.39 No.2
Background: Although data on post-coronavirus disease 2019 (COVID-19) conditions are extensive, the prognostic factors affecting symptom duration in non-hospitalized patients with COVID-19 are currently not well known. We aimed to investigate the various prognostic factors affecting symptom duration among outpatients with COVID-19. Methods: Data were analyzed from 257 patients who were diagnosed with mild COVID-19 and visited the ‘post-COVID-19 outpatient clinic’ between April and December 2022 after a mandatory isolation period. The symptom duration was measured from diagnosis to symptom resolution. Laboratory and pulmonary function test results from their first visit were collected. Results: The mean age of patients was 55.7 years, and the median symptom duration was 57 days. The development of post-COVID-19 conditions (> 12 weeks) were significantly correlated with not using antiviral drugs, leukocytosis (white blood cell > 10,000/µL), lower 25(OH)D3 levels, forced vital capacity (FVC) < 90% predicted, and presence of dyspnea and anxiety/depression. Additionally, in multivariable Cox regression analysis, not using antiviral drugs, lower 25(OH)D3 levels, and having dyspnea were poor prognostic factors for longer symptom duration. Particularly, vitamin D deficiency (< 20 ng/mL) and not using antivirals during the acute phase were independent poor prognostic factors for both post-COVID-19 condition and longer symptom duration. Conclusion: The non-use of antivirals, lower 25(OH)D3 levels, leukocytosis, FVC < 90% predicted, and the presence of dyspnea and anxiety/depression symptoms could be useful prognostic factors for predicting post-COVID-19 condition in outpatients with COVID-19. We suggest that the use of antiviral agents during the acute phase and vitamin D supplements might help reduce COVID-19 symptom duration.