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인터넷 중독 청소년의 자존감, 우울, 충동성과 사회관계
윤혜미(Hye Mee Yoon),남영옥(Young Ok Nam) 충북대학교 생활과학연구소 2009 생활과학연구논총 Vol.13 No.1
Over the last decade, there has been increased interest in the addictive potential of the Internet, and past studies have indicated that the addictive pattern of Internet use are associated with some psycho-social traits of the users and adolescents and young adults are especially vulnerable population. This study investigated the extent to which psycho-social factors were related to the extent of Internet usage among adolescents and to examine the potential influences of self-esteem, depression and impulsiveness on social relations of the adolescents with Internet addiction. A total of 2,495 adolescents ages between 15-17 responded to the questionnaire, which included Young's IAT, Rosenberg's Self-esteem instrument, Beck's BDI, BISII, Hudson's IFR and IPR. Results showed that 61.0% of the sample were considered Internet addicted(4.0% seriously pathological, 57.0% moderate), who suffer from higher level of depression, impulsiveness, and problems of social relations and low self-esteem than their peers. Regression analysis indicated that problems in social relations among adolescents with Internet addiction were predicted by low self-esteem and depression. No link was found between impulsiveness and social relations. Results suggest that preventive efforts for Internet addiction of adolescents are in imminent needs. Implications to help professionals are addressed.
Yoon, Seung Hwan,Shim, Yu Shik,Park, Yong Hoon,Chung, Jong Kwon,Nam, Jung Hyun,Kim, Myung Ok,Park, Hyung Chun,Park, So Ra,Min, Byoung-Hyun,Kim, Eun Young,Choi, Byung Hyune,Park, Hyeonseon,Ha, Yoon Wiley (John WileySons) 2007 Stem Cells Vol.25 No.8
<P>To assess the safety and therapeutic efficacy of autologous human bone marrow cell (BMC) transplantation and the administration of granulocyte macrophage-colony stimulating factor (GM-CSF), a phase I/II open-label and nonrandomized study was conducted on 35 complete spinal cord injury patients. The BMCs were transplanted by injection into the surrounding area of the spinal cord injury site within 14 injury days (n = 17), between 14 days and 8 weeks (n = 6), and at more than 8 weeks (n = 12) after injury. In the control group, all patients (n = 13) were treated only with conventional decompression and fusion surgery without BMC transplantation. The patients underwent preoperative and follow-up neurological assessment using the American Spinal Injury Association Impairment Scale (AIS), electrophysiological monitoring, and magnetic resonance imaging (MRI). The mean follow-up period was 10.4 months after injury. At 4 months, the MRI analysis showed the enlargement of spinal cords and the small enhancement of the cell implantation sites, which were not any adverse lesions such as malignant transformation, hemorrhage, new cysts, or infections. Furthermore, the BMC transplantation and GM-CSF administration were not associated with any serious adverse clinical events increasing morbidities. The AIS grade increased in 30.4% of the acute and subacute treated patients (AIS A to B or C), whereas no significant improvement was observed in the chronic treatment group. Increasing neuropathic pain during the treatment and tumor formation at the site of transplantation are still remaining to be investigated. Long-term and large scale multicenter clinical study is required to determine its precise therapeutic effect. Disclosure of potential conflicts of interest is found at the end of this article.</P>
( Young Soo Kim ),( Su Jin Choi ),( Young Ok Kim ),( Sun Ae Yoon ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
A 45-year-old alcoholic male presented with sudden visual loss at our hospital. He had been taking medications including NSAIDs (mefenamic acid) for the treatment of a common cold. His visual acuity determined by an ophthalmological examination was at the level of hand motion detection. The patient was oliguric, and his laboratory tests revealed an extremely high serum level of blood urea nitrogen and creatinine along with significantly increased anion gap metabolic acidosis. An ultrasound scan revealed moderately echogenic but normal-sized kidneys. Magnetic resonance imaging (MRI) revealed a vasogenic edema in the parietal-occipital regions of the brain. After two rounds of dialysis, his vision improved, and completely recovered after 10 days. A follow up brain MRI also revealed improvement. A kidney biopsy indicated severe acute tubular necrosis (ATN). Ten weeks after his hospital admission, his renal function was normal. Here, we report a patient with severe ATN that presented as sudden vision loss due to uremic posterior leukoencephalopathy syndrome (PLS).
Ok Jeong Lee,Su-Jin Kim,박형두,이수연,Chi-Hwa Kim,Ah-Ra Ko,Yeon-Joo Yook,Su-Jin Lee,박성원,Se-Hwa Kim,Sung-Yoon Cho,Eun-Kyung Kwon,Sun Ju Han,진동규,Young Bae Sohn 대한소아청소년과학회 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.3
Purpose: Mucopolysaccharidosis type II (MPS II or Hunter syndrome)is a rare lysosomal storage disorder caused by iduronate-2-sulfatase (IDS) deficiency. MPS II causes a wide phenotypic spectrum of symptoms ranging from mild to severe. IDS activity, which is measured in leukocyte pellets or fibroblasts, was reported to be related to clinical phenotype by Sukegawa-Hayasaka et al. Measurement of residual plasma IDS activity using a fluorometric assay is simpler than conventional measurements using skin fibroblasts or peripheral blood mononuclear cells. This is the first study to describe the relationship between plasma IDS activity and clinical phenotype of MPS II. Methods: We hypothesized that residual plasma IDS activity is related to clinical phenotype. We classified 43 Hunter syndrome patients as having attenuated or severe disease types based on clinical characteristics,especially intellectual and cognitive status. There were 27 patients with the severe type and 16 with the attenuated type. Plasma IDS activity was measured by a fluorometric enzyme assay using 4-methylumbelliferyl-α-iduronate 2-sulphate. Results: Plasma IDS activity in patients with the severe type was significantly lower than that in patients with the attenuated type (P=0.006). The optimal cut-off value of plasma IDS activity for distinguishing the severe type from the attenuated type was 0.63 nmol·4 hr-1·mL-1. This value had 88.2% sensitivity, 65.4% specificity, and an area under receiver-operator characteristics (ROC) curve of 0.768 (ROC curve analysis; P=0.003). Conclusion: These results show that the mild phenotype may be related to residual lysosomal enzyme activity.
Yoon, Il,Seo, Joobeom,Lee, Ji-Eun,Song, Mi Ryoung,Lee, So Young,Choi, Kyu Seong,Jung, Ok-Sang,Park, Ki-Min,Lee, Shim Sung Royal Society of Chemistry 2005 Dalton Transactions Vol.2005 No.14
<P>By virtue of simple one donor variations of O<SUB>2</SUB>S<SUB>2</SUB>X-donor macrocycles (L<SUP>1</SUP>: X&z.dbd;S, L<SUP>2</SUP>: X&z.dbd;O and L<SUP>3</SUP>: X&z.dbd;NH) towards silver(<SMALL>I</SMALL>) perchlorates, four supramolecular complexes (1–3) with different topologies have been isolated; L<SUP>1</SUP> afforded solvent- and anion-free sandwich complex (1), otherwise L<SUP>2</SUP> and L<SUP>3</SUP> gave the dimeric (2a), 1-D polymeric (2b), and tetrameric bowl-type (3) complexes with solvent or anion coordination.</P> <P>Graphic Abstract</P><P>By virtue of simple one donor variations of O<SUB>2</SUB>S<SUB>2</SUB>X-donor macrocycles (L<SUP>1</SUP>: X&z.dbd;S, L<SUP>2</SUP>: X&z.dbd;O and L<SUP>3</SUP>: X&z.dbd;NH) towards silver(<SMALL>I</SMALL>) perchlorates, four supramolecular complexes (1–3) with different topologies have been isolated. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b506438d'> </P>
( Yoon Ok Jang ),( Baek Gyu Jun ),( Soon Koo Baik ),( Moon Young Kim ),( Sang Ok Kwon ) 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.2
Background/Aims: Therapies involving bone-marrow-derived mesenchymal stem cells (BM-MSCs) have considerable potential in the management of hepatic disease. BM-MSCs have been investigated in regenerative medicine due to their ability to secrete various growth factors and cytokines that regress hepatic fibrosis and enhance hepatocyte functionality. The aim of this study was to determine the antifibrosis effect of BM-MSCs on activated hepatic stellate cells (HSCs) and the mechanism underlying how BM-MSCs modulate the function of activated HSCs. Methods: We used HSCs in both direct and indirect co-culture systems with BM-MSCs to evaluate the antifibrosis effect of BM-MSCs. The cell viability and apoptosis were evaluated by a direct co-culture system of activated HSCs with BM-MSCs. The activations of both HSCs alone and HSCs with BM-MSCs in the direct co-culture system were observed by immunocytochemistry for alpha-smooth muscle actin (α-SMA). The levels of growth factors and cytokines were evaluated by an indirect co-culture system of activated HSCs with BM-MSCs. Results: The BM-MSCs in the direct co-culture system significantly decreased the production of α-SMA and the viability of activated HSCs, whereas they induced the apoptosis of activated HSCs. The BM-MSCs in the indirect co-culture system decreased the production of transforming growth factor-β1 and interleukin (IL)-6, whereas they increased the production of hepatocyte growth factor and IL-10. These results confirmed that the juxtacrine and paracrine effects of BM-MSCs can inhibit the proliferative, fibrogenic function of activated HSCs and have the potential to reverse the fibrotic process by inhibiting the production of α-SMA and inducing the apoptosis of HSCs. Conclusions: These results have demonstrated that BM-MSCs may exert an antifibrosis effect by modulating the function of activated HSCs. (Clin Mol Hepatol 2015;21:141-149)
Yoon Yoonsun,Lee Hye Sun,Yang Juyeon,Gwack Jin,Kim Bryan Inho,Cha Jeong-ok,Min Kyung Hoon,Kim Yun-Kyung,Shim Jae Jeong,Lee Young Seok 대한의학회 2023 Journal of Korean medical science Vol.38 No.40
Background: Nonpharmacological interventions (NPIs) reduce the incidence of respiratory infections. After NPIs imposed during the coronavirus disease 2019 pandemic ceased, respiratory infections gradually increased worldwide. However, few studies have been conducted on severe respiratory infections requiring hospitalization in pediatric patients. This study compares epidemiological changes in severe respiratory infections during pre-NPI, NPI, and post-NPI periods in order to evaluate the effect of that NPI on severe respiratory infections in children. Methods: We retrospectively studied data collected at 13 Korean sentinel sites from January 2018 to October 2022 that were lodged in the national Severe Acute Respiratory Infections (SARIs) surveillance database. Results: A total of 9,631 pediatric patients were admitted with SARIs during the pre-NPI period, 579 during the NPI period, and 1,580 during the post-NPI period. During the NPI period, the number of pediatric patients hospitalized with severe respiratory infections decreased dramatically, thus from 72.1 per 1,000 to 6.6 per 1,000. However, after NPIs ceased, the number increased to 22.8 per 1,000. During the post-NPI period, the positive test rate increased to the level noted before the pandemic. Conclusion: Strict NPIs including school and daycare center closures effectively reduced severe respiratory infections requiring hospitalization of children. However, childcare was severely compromised. To prepare for future respiratory infections, there is a need to develop a social consensus on NPIs that are appropriate for children.