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( Na Eun Lee ),( Hong Seon Son ),( Sung Hoon Choi ),( Chang Hun Lee ),( Seung Young Seo ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ),( In Hee Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Tenofovir disoproxil fumarate (TDF) is considered as the preferred treatment option for chronic hepatitis B (CHB) patients with treatment failure or resistance to prior nucleos(t)ide analogues (NAs) treatment. We investigated the efficacy of long-term TDF-based therapy in CHB patients with previous NAs-experience. Methods: This study included total 251 patients who had previous history of NAs therapy and were treated with TDF mono (n=173) or TDF combined with other NA (n=78) from August 2012 to March 2017. Virologic response (VR) was defined as undetectable serum HBV DNA by PCR (<20 IU/mL). Results: Mean age of patients was 49.3 years, median duration of TDF therapy was 27.2 months, 75.7% were HBeAg-positive, and median HBV DNA was 3.7 log10IU/mL. The cumulative rates of VR were 188/244 (77.0%), 180/211 (85.3%), and 146/161 (90.7%) at 12, 24, and 36 months, respectively. Multivariate analysis showed that body mass index (OR 0.77, 95% CI 0.61-0.95, p=0.0189) and duration of TDF therapy (OR 1.09, 95% CI 1.02-1.18, p=0.0221) was significantly associated with VR. TDF monotherapy, HBeAg-positivity, platelet count, serum albumin was associated with VR in the univariate analysis, but not significant in the multivariate analysis. In relation to renal safety, patients showed renal impairment (7, 3.0%), mild hypophosphatemia (15, 7.2%), severe hypophosphatemia (1, 0.4%). Conclusions: Long-term TDF-based therapy demonstrated highly effective in viral suppression and relatively favorable renal safety in CHB patients with previous NA-experience. The body mass index and duration of TDF therapy was independent factors associated with VR.
( Hong Seon Son ),( Sung Hoon Choi ),( Na Eun Lee ),( Chang Hun Lee ),( Seung Young Seo ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ),( In Hee Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Tenofovir (TDF) entecavir (ETV) are considered as the preferred treatment options for treatment-naïve chronic hepatitis B (CHB) patients. We compared the virologic response and renal safety of long-term TDF versus ETV therapy in naïve CHB patients. Methods: This retrospective study included total 432 patients who were treated with TDF (n=205) or ETV (n=227) from August 2012 to March 2017. Virologic response (VR) was defined as undetectable serum HBV DNA by PCR (<20 IU/mL). Results: Mean age of patients, sex, baseline serum levels of AST, ALT, creatinine, and HBV DNA were not significantly different between TDF and ETV groups. The cumulative rates of VR between TDF and ETV groups were 71.6% vs. 61.8% (p=0.477), 88.1% vs. 79.6% (p=0.058), and 84.8% vs. 83.7% (p=0.966) at 1, 2, and 3 years, respectively. The cumulative rates of genotypic resistance between TDF and ETV groups were 0% vs. 0%, 0% vs. 1.5% (p=0.404), and 0% vs. 2.2% (p=0.447) at 1, 2, and 3 years, respectively. Incidences of renal impairment and hypophosphatemia during treatment up to 3 years were not significantly different between two groups. Multivariate analysis showed that HBeAg-positivity (OR 0.27, 95% CI 0.12-0.58, p=0.0012) and serum HBV DNA at 1 year 2000 IU/mL (OR 0.09, 95% CI 0.03-0.25, p<0.0001) were significantly associated with VR. Conclusions: Long-term TDF and ETV treatments appear to have similar virologic response and renal safety in naïve CHB patient. However, long-term ETV therapy might to be associated with genotypic resistance in 2.2% up to 3 years, while none of patients on TDF therapy did.
보육교사의 심리적 소진과 교사-영유아 상호작용의 관계에서 정서노동의 매개효과
이나영(Lee, Na-Young),국지윤(Kook, Ji-Youn),김영옥(Kim, Young-Ok) 한국영유아보육학회 2014 한국영유아보육학 Vol.0 No.89
본 연구는 보육교사의 심리적 소진과 교사-영유아 상호작용의 관계에서 정서노동이 어떠한 영향을 미치는지 살펴보고자 하였다. 연구대상은 전라남도에 소재한 보육교사 321명이며 교사의 심리적 소진, 교사-영유아 상호작용, 정서노동에 관한 설문지 도구를 사용하여 조사하였다. 연구에서 얻어진 결과는 첫째, 교사-영유아 상호작용과 심리적 소진 및 정서노동의 관계를 살펴본 결과 심리적 소진과 교사-영유아 상호작용은 부적인 관계가, 정서노동과 교사-영유아간에는 정적인 관계가 있는 것으로 확인되었다. 둘째, 정서노동은 교사의 심리적 소진에 따른 교사-영유아 상호작용의 부정적인 영향력을 감소시키는 것으로 확인되었다. 이러한 결과는 교사의 심리적 소진이 교사-영유아 상호작용에 미치는 영향을 완화하기 위해 정서노동을 중요하고도 잠재적인 요소로 고려할 필요가 있음을 시사한다. This study was conducted in order to examine how emotional labor affects the relationship between teachers’ burnout and teacher-young children interaction. The subjects of this study were 321 teachers working at child care centers in Jollanam-do. Their burnout, teacher-young children interaction, and emotional labor were surveyed using a questionnaire. In an examination of the correlations among child care teachers’ burnout, teacher-young children interaction and emotional labor, the findings were as follows. Teachers’ burnout was found to have a negative correlation with teacher?young children interaction, and emotional labor was found to have a positive correlation with teacher-young children interaction. Also, emotional labor was found to reduce the negative impact of teachers’ burnout on teacher-young children interaction. These results suggest that emotional labor needs to be considered as an important factor for mitigating the impact of child care teachers’ burnout on teacher-young children interaction.
Inoculation Methods for Sclerotinia Rot-Resistance Screening in Perilla Germplasm
Young Ah Jeon(전영아),Jung Sook Sung(성정숙),Hyung Jin Baek(백형진),On Sook Hur(허온숙),Na Young Ro(노나영),Ju Hee Lee(이주희),Hyun Choong Ok(옥현충),Ho Cheol Ko(고호철),Awraris Derbie Assefa(아와리스 더비 아세파) 한국약용작물학회 2017 한국약용작물학회 학술대회논문집 Vol.2017 No.2
Translocation of Annexin I to the Nucleus by Epidermal Growth Factor in A549 Cells
Na, Doe Sun,Lee, Soo Ok,Kim, Seung Wook,Rhee, Hae Jin,Park, Young Min The Korea Science and Technology Center 1999 BMB Reports Vol.32 No.1
Annexin 1 (also called lipocortin 1), a 37-kDa member of the annexin family of proteins, has been implicated in the mitogenic signal transduction by epidermal growth factor (EGF). Annexin 1 is phosphorylated by the EGF signal, however, the role of annexin 1 in the EGF signal transduction is still unknown. To transduce extracellular signals into the intracellular targets, selective translocation of the signaling molecules to their targets would be necessary. In this study, we examined the subcellular locations of annexin 1 during EGF signal transduction. Treatment of A549 cells with EGF resulted in the translocation of cytoplasmic annexin 1 to the nucleus and perinuclear region as determined by Western blot and immunofluorescent staining. The nuclear translocation of annexin 1 was inhibited by tyrphostin AG 1478 and genistein, the inhibitors of EGF receptor kinase and downstream tyrosine kinases, respectively. Pretreatment of cells with cyclohexamide did not inhibit the nuclear translocation. The results suggest that nuclear translocation of annexin 1 is controlled by a series of kinase dependentevents in the EGF receptor signaling pathway and may be important in tranducing the signals by EGF.
Ok, Byeori,Na, Wonjun,Kwon, Tae-Hoon,Kwon, Young-Wan,Cho, Sangho,Hong, Soon Man,Lee, Albert S.,Lee, Jin Hong,Koo, Chong Min Elsevier 2019 Journal of industrial and engineering chemistry Vol.80 No.-
<P><B>Abstract</B></P> <P>Non-aqueous lithium-ion redox flow batteries (Li-RFBs) have recently garnered much interest because of their high operating voltage and energy density. Albeit these outstanding advantages, challenges, such as poor cyclability and efficiency, still remain in employing the practical application. In an attempt to address these problems, a series of 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) and TEMPO derivatives catholytes were prepared and investigated as redox-active materials. Electrochemical evaluation exhibited that the introduction of polar and electron-withdrawing substituents to TEMPO was able to enhance the rate capability and cycling stability, when compared to those with the neat TEMPO. Extensive analysis of the electrochemical properties revealed that the electrophilic heteroatom stabilized the radical as well as alleviated the catholyte degradation. Overall, a careful selection of redox-active species demonstrates great promise in improving the current redox flow battery technology.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Simultaneous Determination of Plasticizers in Food Simulants Using GC/MS
Na Young Park,Hae Jung Yoon,In Shin Kwak,Dae Hoon Jeon,Hyun Chul Choi,Mi Ok Eum,Hyung Il Kim,Jun Hyun Sung,So Hee Kim,Young Ja Lee 한국포장학회 2009 한국포장학회지 Vol.15 No.3
Migration levels of plasticizers, di-n-butyl phthalate (DBP), benzyl-butyl phthalate (BBP), di-n- octyl phthalate (DNOP), di-iso-decyl phthalate (DIDP) and di-iso-nonyl phthalate (DINP), di-(2-ethylhexyl) adipate (DEHA), from 46 poly(vinyl chloride) (PVC) wrap films and 54 PVC gaskets into food simulants were determined using gas chromatography/ mass spectrometry (GC/MS). The method was validated with limit of detection (LOD) of 0.01 ~ 0.02 μg/mL for DBP, BBP, DNOP and DEHA, and 2 μg/mL for DIDP and DINP. The linearity were found to be > 0.99 for all the compounds in concentration range of 0.1 ~ 81.4 μg/mL, and overall recoveries were ranged from 90.4 ~ 99.6%. DBP, BBP, DNOP, DEHA, DIDP and DINP were not detected in food simulants, except 1 wrap sample from which 0.28 and 0.99 μg/mL of DEHA were detected respectively when tested with 20% ethanol and n-heptane as food simulants. These values were below the regulatory limitation in European Union (EU).
Effect of Environmental Tobacco Smoke (ETS) on Atopic Dermatitis
Ok-hee Yi(이옥희),Ho-Jang Kwon(권호장),Ho Kim(김호),Mi-na Ha(하미나),Soo-Jong Hong(홍수종),Yun-Chul Hong(홍윤철),Jong-Han Leem(임종한),Joon-kong Sa(사공준),Chul-Gab Lee(이철갑),Su-Young Kim(김수영),Dong-mug Kang(강동묵) 한국환경독성학회 2010 한국독성학회 심포지움 및 학술발표회 Vol.2010 No.11