야생차 가공 기술 개발

고영옥,이종옥,신동국 진주산업대학교 농업기술연구소 2002 農業技術硏究所報 Vol.15 No.-

현대인의 기호에 맞는 지리산 반발효차(구황차)를 개발하기 위하여 옛날 제차법이 보존되어 있는 절간의 기술에 새로운 과학기법을 접목하여 개발한 차의 결과는 다음과 같다. 1. 총질소함량은 고온황토방의 녹차에 비하여 황토방의 녹차의 함량이 다소 높았다. 2. 총아미노산, 카페인 및 비타민-C함량은 황토방과 고온황토방의 제차방법에 따른 차이는 그다지 높지 않았다. 3. Geraniol함량은 황토방의 녹차(2회차)가 2.4%이며, 고온황토방의 녹차에 비하여 높은 경향이었다. 4. Pyrrole류의 pyrrole성분은 고온황토방이 다소 높았으나, ethyl pyrrole는 황토방에서 조성비가 현저히 높았다. 5. 꽃향기에 기여하는 Jasmone함량은 고온황토방의 녹차에서 조성비가 다소 높았다. In the order to taste go well with half-ferment green tea(kuhwang green tea) in the products of Mt. jiri garden were made try to development for modern people, according to once upon time there buddhist temple preserve course of green tea processing was approachable to new science of skill . The results were summarized as follows: 1. The amount of total nitrogen in green tea was high for yellow soil room than high temperature of yellow soil room 2. The amounts of total amino acid, caffeine and Vit. C in green tea were not difference according to yellow soil according to making method 3. The amount of geraniol in green tea was high tendency of yellow soil room(2.4%) than high temperature of yellow soil room 4. The component of pyrrole, in green tea was a few high such as high temperature yellow soil room, but the ethyl pyrrole was high ratio with yellow soil room. 5. The aroma component of amount of jasmone in green tea was a few high with high temperature of yellow soil room

급성 전벽 심근경색에서 Q파의 소실과 심실 기능 호전과의 관계

김종윤,박성하,고영국,최동훈,장양수,심원홈,조승연 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.4

당뇨족에서 하지 동맥의 죽상 동맥 경화성 폐쇄와 경피적 중재술의 효과 : Effectiveness of Percutaneous Intervention

이상학,최동훈,고영국,차봉수,이진우,이도연,장양수,심원흠,조승연 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

관동맥우회술 후 발생한 급성 장간막경색 1예

문용화,김지현,강웅철,박병은,고영국,최동훈,유경종 대한내과학회 2004 대한내과학회지 Vol.66 No.3

관동맥우회술을 포함한 심장수술 후에 생기는 급성 장간막경색은 매우 드물지만 치명적인 합병증으로 발생률은 비교적 낮으나 사망률은 매우 높게 보고 되고 있다. 본 증례에서는 55세 여자 환자가 관동맥우회술을 시행받고 수술 후 1일째에 발생한 복부통증에 대해서 장간막경색증을 의심하지 못하고 수술과 연관된 비특이적 증상으로 판단하였으나 그 후 환자의 증상이 악화되면서 상장간막동맥 혈전 색전증에 의한 광범위한 급성 장괴사로 판명되었다. 관독맥우회술 후 상장간막 동맥에 생긴 혈전색전증에 의해 발생한 급성 장간막경색의 증례는 국내에 보고된 바 없고 본 증례를 통해 교육적인 경험을 하였기에 저자들은 문헌고찰과 함께 보고하는 바이다. 심폐우회술을 요하는 심장수술을 받은 환자 중 특히 급성 장간막허혈의 위험인자를 가지고 있는 환자에 대해서는 급성 장간막허혈이 생길 수 있다는 세심한 관찰이 진단이 늦어지지 않게 하는 방법이며 장간막허혈이 의심되면 즉시 적극적인 진단 및 치료적인 접근을 시도해야 하겠다. Acute mesenteric ischemia leading to massive bowel infarction following cardiac surgery particularly coronary artery bypass graft (CABG), is reported to be a very rare but serious life-threatening complication. In this case, a 55-year-old female underwent CABG and complained of abdominal pain on the first postoperative day, which was thought to be nonspecifically related to the operation wound, In the further hospital course, the patient was found to have extensive acute mesenteric infarction due to thromboembolism of superior mesenteric artery. This is a valuable educational case, since only high index of suspicion does not delay making a diagnosis especially in the patients with risk factors of acute mesenteric ischemia after cardiac surgery requiring cardiopulmonary bypass. On suspicion of acute mesenteric ischemia, an aggressive diagnostic and therapeutic approach should be performed immediately.(Korean J Med 66:317-320, 2004)

Elevated Levels of Inflammatory and Vasoactive Factors in the Culprit Coronary Artery of Acute Myocardial Infarction

( Young Guk Ko ),( Jae Hun Jung ),( Sung Ha Park ),( Eui Young Choi ),( Bo Young Joung ),( Ki Chul Hwang ),( Dong Hoon Choi ),( Yang Soo Jang ),( Nam Sik Chung ),( Won Heum Shim ),( Seung Yun Cho ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.3

Distal embolization of the thrombus and plaque debris, as well as the release of inflammatory and vasoactive factors are suggested as important factors that may jeopardize successful myocardial reperfusion during primary coronary intervention. However, there are currently few clinical data on the presence and the role of such factors. We performed in 18 acute myocardial infaction patients primary percutaneous coronary intervention(PCI) with the distal protection device of distal occlusive balloon type, PercuSurge GuideWire system. We collected blood samples from the femoral artery before PCI and from culprit coronary artery using Export aspiration catheter after predilation while inflating the distal protection balloon and after completing PCI with deflation of the distal protection balloon. We determined concentrations of C-reactive protein, soluble CD40 ligand, IL-6, serotonin, tissue factor, and factor VIIa inblood samples. The concentrations of soluble CD40 ligand(2.84±3.74 vs 0.98±0.63 ng/mL, p= 0.004), IL-6(33.67±32.63 vs 17.08±21.41 pg/mL, p<0.001), serotonin(2.05±0.76 vs 0.92±0.60 ng/mL, p<0.001), tissue factor (257.17±84.34 vs 154.60±87.99 pg/mL, p<0.001) and factor VIIa(34.30±27.30 vs 24.19±28.00 ng/mL, p=0.016) were significantly higher in the culprit coronary artery after the first predilation than those in the peripheral blood before PCI. However, the CRP concentrations in the samples from the culprit coronary artery and the femoral artery did not differ significantly(4.15±3.19 vs 4.60±3.68 mg/L, p=0.056). The blood samples from coronary artery after multiple aspirations showed reduced concentrations of soluble CD40 ligand(2.84±3.74 to 1.64±1.96 ng/mL, p=0.030), IL-6(33.67±32.63 to 22.44±21.87 ng/mL, p=0.010), serotonin(2.05±0.76 to 1.29±0.82 ng/mL, p<0.001), tissue factor(257.17±84.34 to 198.45±95.14 ng/mL, p=0.001) and factor VIIa(34.30±27.30 to 27.65±27.24 ng/mL, p=0.001) compared to those in the coronary aspirates obtained after first balloon dilation of the culprit lesions. We found increased levels of soluble inflammatory and vasoactive factors such as soluble CD40 ligand, IL-6, serotonin, tissue factor and factor VII in the aspirate from the culprit coronary artery compared to those in peripheral blood. The aspiration of blood from culprit lesion during PCI resulted in significantly reduced concentrations of inflammatory and vasoactive markers.

Efficacy of stent-supported subintimal angioplasty in the treatment of long iliac artery occlusions

Ko, Young-Guk,Shin, Sanghoon,Kim, Kwang Joon,Kim, Jung-Sun,Hong, Myeong-Ki,Jang, Yangsoo,Shim, Won-Heum,Choi, Donghoon Elsevier 2011 Journal of vascular surgery Vol.54 No.1

<P><B>Background</B></P><P>Subintimal angioplasty (SA) is becoming increasingly accepted as a revascularization technique for chronic arterial occlusive disease. However, its efficacy in iliac artery occlusions has not been established. Therefore, we investigated the procedural and clinical outcomes of subintimal angioplasty in long iliac artery occlusions and compared them with those of intraluminal angioplasty (IA) in nonocclusive stenotic iliac artery lesions.</P><P><B>Methods</B></P><P>We retrospectively analyzed data from 151 consecutive patients with long (>5 cm) iliac artery lesions (204 limbs) who underwent angioplasty with primary stent implantation from October 2004 through July 2008. Among them, 100 lesions in 100 patients were treated with intentional SA, and 104 lesions in 82 patients were treated with IA. We compared the baseline characteristics and immediate and long-term outcomes of iliac artery lesions treated with SA versus IA.</P><P><B>Results</B></P><P>Baseline characteristics showed that longer lesions and critical limb ischemia were found more frequently in the SA group, whereas diabetes and combined femoropopliteal lesions were present more often in the IA group. The technical success rate of SA was lower than that of IA (93.0% vs 99.0%; <I>P</I> = .048). However, there was no significant difference in the procedure-related complications between the SA and IA groups (4.0% vs 4.8%; <I>P</I> = .779). Primary patency rates for SA and IA were 96.8% and 98.0% at 1 year, and 93.9% and 90.6% at 2 years, respectively (log rank <I>P</I> = .656).</P><P><B>Conclusion</B></P><P>Stent-supported SA in occlusive iliac lesions was safe and showed a high long-term patency rate comparable to that of IA performed in nonocclusive iliac lesions despite longer lesion length. Thus, SA with implantation of stents is an effective technique for the treatment of chronic long iliac artery occlusion.</P>

Effects of combination therapy with cilostazol and probucol versus monotherapy with cilostazol on coronary plaque, lipid and biomarkers: SECURE study, a double-blind randomized controlled clinical trial.

Ko, Young-Guk,Choi, Seung-Hyuk,Chol Kang, Woong,Kwon Lee, Byoung,Wook Kim, Sang,Shim, Won-Heum Japan Atherosclerosis Society 2014 Journal of atherosclerosis and thrombosis Vol.21 No.8

<P>The study aim is to investigate synergistic effects of cilostazol and probucol combination therapy on coronary plaque volume and composition.</P>

Correlations between Coronary Plaque Tissue Composition Assessed by Virtual Histology and Blood Levels of Biomarkers for Coronary Artery Disease

Ko, Young-Guk,Le, Van Cuong,Kim, Bo Hyun,Shin, Dong-Ho,Kim, Jung-Sun,Kim, Byeong-Keuk,Choi, Donghoon,Jang, Yangsoo,Hong, Myeong-Ki Yonsei University College of Medicine 2012 Yonsei medical journal Vol.53 No.3

<P><B>Purpose</B></P><P>We investigated correlations of coronary plaque composition determined by virtual histology (VH) intravascular ultrasound (IVUS) and blood levels of biomarkers that represent the vulnerability of coronary plaques.</P><P><B>Materials and Methods</B></P><P>Pre- and postprocedural blood levels of high sensitivity C-reactive protein, soluble CD40 ligand (sCD40L), matrix metalloproteinase-9, and neopterin were measured in 70 patients with stable angina (SA) or unstable angina (UA) who were undergoing percutaneous coronary intervention (PCI) for single lesions. We evaluated the data for correlations between these biomarkers and necrotic core contents in PCI target lesions analyzed by VH.</P><P><B>Results</B></P><P>Clinical characteristics, IVUS, VH, and biomarker blood levels were not different between the SA and the UA group except for more frequent previous statin use (52.3% vs. 23.1%, <I>p</I>=0.017) and lower remodeling index in the SA group (0.98±0.09 vs. 1.10±0.070, <I>p</I><0.001). Among the biomarkers evaluated, only pre-PCI neopterin level showed a weakly significant correlation with the absolute volume of the necrotic core (r=0.320, <I>p</I>=0.008). Pre- and post-PCI blood levels of sCD40L (r=0.220, <I>p</I>=0.072; r=0.231, <I>p</I>=0.062) and post-PCI blood level of neopterin (r=0.238, <I>p</I>=0.051) showed trends toward weakly positive correlations with the absolute volume of necrotic core.</P><P><B>Conclusion</B></P><P>We found a weakly positive correlation between the pre-PCI neopterin level and necrotic core volume in the PCI-target lesion. The clinical implications of our findings need to be investigated in further studies.</P>

Effects of Drug-eluting Stents on Plasma C-reactive Protein Levels after Coronary Stenting: Comparison with Bare Metal Stents

( Young Guk Ko ),( Jong Youn Kim ),( Chi Young Shim ),( Sung Ha Park ),( Ki Chul Hwang ),( Dong Hoon Choi ),( Yang Soo Jang ),( Won Heum Shim ),( Nam Sik Chung ),( Seung Yun Cho ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.3

After coronary stenting, inflammatory mechanisms play a crucial role in the pathogenesis of neointimal proliferation and in-stent restenosis. Drug eluting stents(DES) have been shown to reduce in-stent restenosis in various studies. We investigated plasma C-reactive protein (CRP) levels after DES implantation and compared with those after bare metal stent(BMS) implantation. In a prospective single center study, we performed percutaneous coronary intervention with a single stent in 67 patients(n=21 in BMS group, n=46 in DES group) with clinically stable angina. Plasma CRP levels were determined before intervention and 48 hrs, 72 hrs and 2 weeks after coronary stenting. There were 54 men(80.6%) and the age of patients ranged from 37 to 75 years(mean, 59±9 years). There was no difference in clinical and angiographic baseline characteristics except that more diabetic patients were included in DES group(34.8% vs 9.5%, p=0.04) and that the stent diameter was larger in BMS group(3.4±0.5 mm vs 3.0±0.4 mm, p<0.01). The plasma CRP levels at 48(13.4±14.7 vs 5.9±4.9 mg/L, p<0.01) and 72 hrs(16.7±19.8 vs 5.4±3.9 mg/L, p<0.01) after stent implantation were significantly higher in BMS than DES group. DES showed significantly lower plasma CRP levels after coronary stent implantation compared to BMS. This may reflect potent effects of DES on acute inflammatory reactions induced by coronary intervention.

Five-year outcomes of sirolimus-eluting versus paclitaxel-eluting stents: A propensity matched study: Clinical evidence of late catch-up?

Ko, Young-Guk,Kim, Jung-Sun,Choi, Donghoon,Hong, Myeong-Ki,Min, Pil-Ki,Yoon, Young Won,Hong, Bum-Kee,Lee, Byoung-Kwon,Kwon, Hyuck-Moon,Kim, Byeong-Keuk,Oh, Sung-Jin,Jeon, Dong-Wun,Yang, Joo-Young,Jang Elsevier 2011 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.152 No.3

<P><B>Abstract</B></P><P><B>Background</B></P><P>Siroliums-eluting stents (SES) and paclitaxel-eluting stents (PES) have been widely used for the treatment of coronary artery disease. We investigated 5-year clinical outcomes of patients treated with SES versus PES in a multicenter registry.</P><P><B>Methods</B></P><P>We used a propensity score matching method with 2:1 matching, including 512 patients treated with SES and 256 patients treated with PES from March 2003 to December 2004. The primary endpoint was major adverse cardiac events, which included all-cause death, myocardial infarction (MI), and target vessel revascularization (TVR).</P><P><B>Results</B></P><P>After matching, baseline characteristics were similar between the two groups. At 5years, cumulative survival free of major adverse cardiac events, MI, and stent thrombosis did not differ between the two groups. Survival free of TVR at 5years was higher in the SES group (88.4%) than the PES group (84.3%, Log-rank <I>p</I>=0.016). In contrast to the trend toward more likely target lesion revascularization in the PES group during the first 2years (hazard ratio 0.62, <I>p</I>=0.057), target lesion revascularization tended to occur more frequently in the SES group from 2 to 5years (hazard ratio 2.26, <I>p</I>=0.099).</P><P><B>Conclusions</B></P><P>Long-term risk of TVR was slightly lower with SES, compared with PES, despite no significant difference in major adverse cardiac events. However, the SES group had more frequent target lesion reintervention 2 to 5years after stent implantation, whereas reintervention in the PES group occurred mainly within the first 2years. This may reflect the temporal difference in neointimal growth of the two stent types.</P>