盛明巴蜀文人楊慎對孔明的批評

楊釗(Yang Zhao) 동아인문학회 2017 동아인문학 Vol.39 No.-

Yang Shen had made many comments on Kong Ming, which can be seen in his works, poems, poetic criticisms and “the Whole Shu Yiwenzhi”. Yang Shen mainly focused on the analysis of hot issues such as the moral and utilitarian achievements, the academic and governance abilities of Kong Ming. Yang Shen’s purpose in comments on Kong Ming aimed was to admire for former worthies and educate the future generation, not pedantically to look for quotes in order to embellish his writings.

楊愼 《全蜀藝文志》 編輯的文化背景考論

楊釗(Yang Zhao) 중국어문학연구회 2016 중국어문학논집 Vol.0 No.98

Yang Shen, in the introduction to “Arts and Literatures History of the Whole Shu nation”, provided that the cultural background of editting this book was to “carry forward the fragrance of the Si Zi, and write the Su nation’s history”. Thus the selected works in this book were not only the literatural ones but also those that reflected the Bashu’s history and academic thoughts. Meanwhile, he had self-consciously assumed the responsibilities of the inheritance of the rural culture and encouraging the backwards through editting the book. Yang Shen and his son had carried forward the local culture through the following three aspects, that is, to devote much attention to the nation’ history, to praise the local loyal bachelors and to place emphasize on the moral education.Besides, Yang Shen and his son had taken great pains to discuss these issues and carry out the social pracitice.

MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis

Yang Yang,Rongfang Qiu,Qiaoyou Weng,Ziwei Xu,Jingjing Song,Siyu Zhao,Miaomiao Meng,Dengke Zhang,Chunli Kong,Hailin Wang,Min Xu,Zhongwei Zhao,Jiansong Ji 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3

Purpose Mixed-lineage leukemia protein 4 (MLL4/KMT2D) is a histone methyltransferase, and its mutation has been reported to be associated with a poor prognosis in many cancers, including lung cancer. We investigated the function of MLL4 in lung carcinogenesis. Materials and Methods RNA sequencing (RNA-seq) in A549 cells transfected with control siRNA or MLL4 siRNA was performed. Also, we used EdU incorporation assay, colony formation assays, growth curve analysis, transwell invasion assays, immunohistochemical staining, and in vivo bioluminescence assay to investigate the function of MLL4 in lung carcinogenesis. Results We found that MLL4 expression was downregulated in non–small cell lung cancer (NSCLC) tissues compared to adjacent normal tissues and tended to decrease with disease stage progression. We analyzed the transcriptomes in control and MLL4- deficient cells using high-throughput RNA deep sequencing (RNA-seq) and identified a cohort of target genes, such as SOX2, ATF1, FOXP4, PIK3IP1, SIRT4, TENT5B, and LFNG, some of which are related to proliferation and metastasis. Our results showed that low expression of MLL4 promotes NSCLC cell proliferation and metastasis and is required for the maintenance of NSCLC stem cell properties. Conclusion Our findings identify an important role of MLL4 in lung carcinogenesis through transcriptional regulation of PIK3IP1, affecting the PI3K/AKT/SOX2 axis, and suggest that MLL4 could be a potential prognostic indicator and target for NSCLC therapy.

論錢穆對漢代『春秋』學的硏究

楊兆貴 ( Yang¸ Zhao Gui ),趙殷尙 ( Cho¸ Eun Sang ) 한국중국학회 2021 중국학보 Vol.97 No.-

錢穆對秦漢史、漢代經學研究飮譽學林, 影響很大。他這兩方面的論著大多已逾半世紀, 在出土文獻日益增多、研究方法多元化等學風下, 他的論著有哪些價值?對當代相關研究有什麼影響?筆者結合他這兩方面的研究, 聚焦他的漢代『春秋』學, 以見他治學、見解之一斑。 要探討他對漢代『春秋』學的看法, 則先簡介他對『春秋』及三傳的看法。他與傳統主張孔子作『春秋』的看法相同, 並從史學肯定『春秋』、『左傳』的史學價值。他認為漢代經學今古文之別是王官學與百家言之殊, 而非文字古今之異。這是他論漢代經今古文最具特色的部分。他撰『孔子與春秋』一文, 著重闡釋『公羊』學的精神, 強調孔子『春秋』以百家言而成為新的王官學。他在不同時期對『公羊』學與董仲舒的評價不同。他認為漢儒多通古今, 因此治『春秋』者多能兼採三傳或兩傳之義、說。他又指出, 『春秋』學與漢代思想尤其是災異說、禪讓說、禮制說有密切的關係。 Prof. Qian Mu has a great influence on the honorary scholars of Qin and Han history and Han dynasty studies. Most of his works in these two areas have been over half a century. With the increasing number of unearthed documents and diversified research methods, what is the value of his works? And what is the impact on contemporary related research? This essay combines his research in these two areas and focuses on his study of Chun Qiu in the Han Dynasty, so as to see his academic research methods and insights. To explore his views on the study of Chun Qiu in the Han Dynasty, the first part of the essay introduces his views on Chun Qiu and the three ‘Zhuan’. He is the same as the traditional view that Confucius wrote Chun Qiu, and affirmed the historical value of Chun Qiu and Zuo Zhuan from his historiography. He believes that the difference between modern and ancient literatures in Han dynasty is the difference between Ancient Official Document and Philosophers, rather than the difference between ancient and modern writing. He wrote the article Confucius and Chun Qiu, focusing on explaining the spirit of school of Gong Yang, emphasizing that Confucius' Chun Qiu became a new official ideology with the philosophical thought in Han China. He had different evaluations of Gong Yang and Dong Zhongshu in different periods. He believes that the Han scholars are mostly integrated with the ancient and modern literatures, so most of them who studied Chun Qiu can adopt the meaning and theories of the three or two ‘Zhuan’ at the same time. He also pointed out that the study of Chun Qiu has a close relationship with the thoughts of the Han Dynasty, especially the theory of catastrophe, concession, and etiquette.

Hypothalamic Norepinephrine Mediates Acupunctural Effects on Hypothalamic-Pituitary-Adrenal Axis During Ethanol Withdrawal

Zhao, Z.L.,Kim, S.C.,Zhang, J.,Liu, H.F.,Lee, B.H.,Jang, E.Y.,Lee, C.W.,Cho, I.J.,An, W.G.,Yang, C.H.,Kim, Y.W.,Zhao, R.J.,Wu, Y.Y. Elsevier Science B.V., Amsterdam 2016 JOURNAL OF ACUPUNCTURE AND MERIDIAN STUDIES Vol.9 No.1

A previous study demonstrated that acupuncture at ST36 (Zu-San-Li) attenuates ethanol withdrawal (EW)-induced hyperactivation of the hypothalamic-pituitary-adrenal axis in rats. The current study investigated the involvement of hypothalamic norepinephrine (NE) in that process. Rats were intraperitoneally treated with 3 g/kg/d of ethanol or saline for 28 days. After 24 hours of EW, acupuncture was applied to rats at bilateral ST36 points or at nonacupoints (tail) for 1 minute. A high-performance liquid chromatography analysis showed that EW significantly increased both the NE and the 3-methoxy-4-hydroxy-phenylglycol (MHPG) levels in the hypothalamic paraventricular nucleus (PVN). Western blot analysis also revealed that EW markedly elevated the phosphorylation rates of tyrosine hydroxylase (TH), but spared TH protein expression in the PVN. However, acupuncture at ST36, but not at nonacupoints, greatly inhibited the increase in the hypothalamic NE, MHPG, and phosphorylation rates of TH. Additionally, postacupuncture infusion of NE into the PVN significantly attenuated the inhibitory effects of acupuncture at ST36 on the oversecretion of plasma corticosterone during EW. These results suggest that acupuncture at ST36 inhibits EW-induced hyperactivation of the hypothalamic NEergic system to produce therapeutic effects on the hypothalamic-pituitary-adrenal axis.

Current covariance analysis-based open-circuit fault diagnosis for voltage-source-inverter-fed vector-controlled induction motor drives

Yang, Huanwen,Zhou, Yang,Zhao, Jin The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.2

In recent years, a faulty leg is mostly replaced by a healthy leg for current fault-tolerant control of power converters, and its fault diagnosis only needs to confirm the fault leg. For fault-tolerant control, this paper proposed a real-time, robust and accurate diagnosis method for the legs of insulated gate bipolar transistor open-circuit faults in the pulse-width-modulated voltage source inverters for vector-controlled induction motors based on three-phase current. The covariance of three-phase current is used to diagnose and locate faults by analyzing the correlation between them, and its performance is explained specifically under both health condition and fault conditions. The proposed method is simple and no additional current or voltage sensors are required. The fault diagnosis time is about half a current cycle. Experiments are conducted and the obtained results demonstrate the effectiveness and merit of the proposed method.

Comparison of Fecal Microbiota of Mongolian and Thoroughbred Horses by High-throughput Sequencing of the V4 Region of the 16S rRNA Gene

Zhao, Yiping,Li, Bei,Bai, Dongyi,Huang, Jinlong,Shiraigo, Wunierfu,Yang, Lihua,Zhao, Qinan,Ren, Xiujuan,Wu, Jing,Bao, Wuyundalai,Dugarjaviin, Manglai Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.9

The hindgut of horses is an anaerobic fermentative chamber for a complex and dynamic microbial population, which plays a critical role in health and energy requirements. Research on the gut microbiota of Mongolian horses has not been reported until now as far as we know. Mongolian horse is a major local breed in China. We performed high-throughput sequencing of the 16S rRNA genes V4 hypervariable regions from gut fecal material to characterize the gut microbiota of Mongolian horses and compare them to the microbiota in Thoroughbred horses. Fourteen Mongolian and 19 Thoroughbred horses were used in the study. A total of 593,678 sequence reads were obtained from 33 samples analyzed, which were found to belong to 16 phyla and 75 genera. The bacterial community compositions were similar for the two breeds. Firmicutes (56% in Mongolian horses and 53% in Thoroughbred horses) and Bacteroidetes (33% and 32% respectively) were the most abundant and predominant phyla followed by Spirochaete, Verrucomicrobia, Proteobacteria, and Fibrobacteres. Of these 16 phyla, five (Synergistetes, Planctomycetes, Proteobacteria, TM7, and Chloroflexi) were significantly different (p<0.05) between the two breeds. At the genus level, Treponema was the most abundant genus (43% in Mongolian horses vs 29% in Thoroughbred horses), followed by Ruminococcus, Roseburia, Pseudobutyrivibrio, and Anaeroplasma, which were detected in higher distribution proportion in Mongolian horses than in Thoroughbred horses. In contrast, Oscillibacter, Fibrobacter, Methanocorpusculum, and Succinivibrio levels were lower in Mongolian horses. Among 75 genera, 30 genera were significantly different (p<0.05) between the two breeds. We found that the environment was one of very important factors that influenced horse gut microbiota. These findings provide novel information about the gut microbiota of Mongolian horses and a foundation for future investigations of gut bacterial factors that may influence the development and progression of gastrointestinal disease in horses.

Gaseous signal molecule SO2 regulates autophagy through PI3K/ AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes

Zhao Junxiong,Wu Qian,Yang Ting,Nie Liangui,Liu Shengquan,Zhou Jia,Chen Jian,Jiang Zhentao,Xiao Ting,Yang Jun,Chu Chun 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6

Myocardial fibrosis is a key link in the occurrence and development of diabetic cardiomyopathy. Its etiology is complex, and the effect of drugs is not good. Cardiomyocyte apoptosis is an important cause of myocardial fibrosis. The purpose of this study was to investigate the effect of gaseous signal molecule sulfur dioxide (SO2) on diabetic myocardial fibrosis and its internal regulatory mechanism. Masson and TUNEL staining, Western-blot, transmission electron microscopy, RT-qPCR, immunofluorescence staining, and flow cytometry were used in the study, and the interstitial collagen deposition, autophagy, apoptosis, and changes in phosphatidylinositol 3-kinase (PI3K)/AKT pathways were evaluated from in vivo and in vitro experiments. The results showed that diabetic myocardial fibrosis was accompanied by cardiomyocyte apoptosis and down-regulation of endogenous SO2-producing enzyme aspartate aminotransferase (AAT)1/2. However, exogenous SO2 donors could up-regulate AAT1/2, reduce apoptosis of cardiomyocytes induced by diabetic rats or high glucose, inhibit phosphorylation of PI3K/AKT protein, up-regulate autophagy, and reduce interstitial collagen deposition. In conclusion, the results of this study suggest that the gaseous signal molecule SO2 can inhibit the PI3K/AKT pathway to promote cytoprotective autophagy and inhibit cardiomyocyte apoptosis to improve myocardial fibrosis in diabetic rats. The results of this study are expected to provide new targets and intervention strategies for the prevention and treatment of diabetic cardiomyopathy.

QTL Analysis for Low-Temperature Requirement Vernalization in Brassica campestris

Yang Xu,Yu Yang Jun,Zhang Feng Lan,Zhao Xiu Yun,Zhang De Shuang,Xu Jia Bing 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

The physics and chemistry of graphene-on-surfaces

Zhao, G.,Li, X.,Huang, M.,Zhen, Z.,Zhong, Y.,Chen, Q.,Zhao, X.,He, Y.,Hu, R.,Yang, T. Royal Society of Chemistry 2017 Chemical Society reviews Vol.46 No.15