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이창우,송준엽,하태호,정영상 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-
The micro factory of size is so small that consuming power is reduced and also manufacturing line could be easily reconfigurable. The micro factory is required automation to satisfy high productivity. It is one of the big problems to convey goods, In case of automated reconfigurable micro factory. Planar motor that can perform linear motion in XY direction is one of solution that solves this problem. But conventional planar motor using a magnetic force has a disadvantage that planar motor base is permanent magnet. In this paper we consider new type of a planar motor based on principle of ultrasonic waves using PZT.
정태엽 ( Tae Yeob Jeong ),김유선 ( You Sun Kim ),박경준 ( Kyung Jun Park ),이종성 ( Jong Sung Lee ),허진국 ( Jin Gook Huh ),류수형 ( Soo Hyung Ryu ),이정환 ( Jung Hwan Lee ),문정섭 ( Jeong Seop Moon ) 대한소화기학회 2008 대한소화기학회지 Vol.51 No.3
Leiomyosarcoma is a rare tumor of the liver. It usually arises from many other organs including uterus, gastrointestinal tract, retroperitoneum, and soft tissues. Primary hepatic leiomyosarcoma progresses very slowly and is not associated with chronic liver disease. When the tumor is detected early enough to be treated by operation, the prognosis is favorable. While several cases of primary hepatic leiomyosarcoma have been reported in Korea, there was no case associated with acute bleeding. We report a 80-year old male patient with huge primary hepatic leiomyosarcoma, who presented with acute bleeding and IVC obstruction. The patient was treated by embolization and IVC stenting. (Korean J Gastroenterol 2008;51:194-198)
초기 간세포암종을 동반한 간경변증 환자에서 생존 예측에 있어서의 간정맥압력차와 연관인자
김태엽 ( Tae Yeob Kim ),김문영 ( Moon Young Kim ),장재영 ( Jae Young Jang ),석기태 ( Ki Tae Suk ),정승원 ( Soung Won Jeong ),김동준 ( Dong Joon Kim ),손주현 ( Joo Hyun Sohn ),백순구 ( Soon Koo Baik ) 대한간암학회 2014 대한간암학회지 Vol.14 No.1
Background/Aims: To analyze the usefulness of hepatic venous pressure gradient (HVPG) in survival prediction in cirrhotic patients with early and very early hepatocellular carcinoma (HCC). Methods: We consecutively collected data of 45 stable cirrhotic patients (male 41, median age 57.2 years, BCLC A 29) with early-stage HCC undergoing HVPG measurement. Prognostic accuracy of HVPG was analyzed by the area under curve (AUC). Survival curves and the associated factors of HVPG status were obtained using Kaplan-Meier method and logistic regression analysis, respectively. Results: The AUC value for prediction of survival by HVPG were 0.754 (95% CI, 0.603-0.870, P=0.006). The cut-off value of HVPG to predict death was 12 mmHg. Among the 45 patients, 11 patients (24.4%) died: 11 of 28 patients in the high HVPG group and none of 17 patients in the low HVPG group during followup period (P=0.003). The survival rate with high HVPG group was higher than those of low HVPG group (log rank P=0.008). In Child-Turcott-Pugh (CTP) class, the survival rate with CTP A class was higher than that with CTP B class (log rank P<0.001). The only associated factor with HVPG ≥12 mmHg in CTP A class and early-stage HCC was the presence of medium or large sized esophageal varices (odds ratio 66.8, 95% CI, 1.3-3530.4, P=0.038). Conclusions: HVPG ≥12 mmHg may be suggested a predictor of survival in cirrhotic patients with early-stage HCC. In CTP A class, the presence of medium or large sized esophageal varices were associated with high HVPG.
유지혈액투석을 받고있는 당뇨병과 비당뇨병 환자에서 혈중 총 이산화탄소량의 의미
정태엽 ( Tae Yeob Jeong ),박원도 ( Won Do Park ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.1
목적 : 신기능이 감소됨에 따라 다양한 정도의 대사성 산증 동반하게 되며, 대사성 산증은 투석 환자의 장기적 예후 및 합병증의 발생과 관련이 있는 것으로 알려져 있다. 일반적으로 투석 환자에서 심한 산증은 교정하여야 하는 것으로 알려져 있으나, 정도의 산증이 있는 혈액투석환자가 오히려 영향상태가 좋다는 보고도 있었다. 그러나, 투석 환자에서 당뇨병 환자가 차지하는 비율에 비해서 당뇨병 환자를 대상으로 하는 연구 결과는 미미한 실정이다. 이에 장기혈액투석 환자에서 당뇨병 환자의 혈청 총 이산화탄소량과 기타 영양지표를 측정하여 비당뇨병 환자와 비교 분석하여 그 의미를 알아보고자 하였다. 방법 : 1999년 1월 부터 2000년 12월까지 3개월 이상 혈액투석을 받았던 50명의 환자들을 대상으로 당뇨병 환자 21명과 비당뇨병 환자 29명으로 나누어 매월 초 시행한 혈액검사를 바탕으로 TCO_2 및 여러 지표를 측정하여 비교분석 하였다. 결과 : 전체 대상 환자에서 TCO_2는 nPCR, 혈철 알부민, 요소질소, 그리고 크레아티닌과 역상관관계가 있었으며, 다중 희귀분석을 이용한 독립 인자 분석에서는 혈중 요소질소와 연령이 TCO_2에 영향을 주는 독립인자이었다. 전체 대상 환자를 당뇨병 환지에 비당뇨병 환자로 나누어 비교해 보았을 때 각종 영양지표와 투석지표 사이에는 차이가 없었으며, 당뇨병 환자에서 TCO_2가 nPCR과 역상관관게가 있었고 nPCR이 독립인자이었으며, 비당뇨병 환자에서 TCO_2가 혈청크레아티닌과 역상관관계가 있었고 혈청 크레아티닌이 독립인자이었다. 결론 : 단백질 섭취의 증가가 대사성 산증을 일으키는 중요한 원인의 하나이지만, 본 연구에서는 당뇨병 환자에서 충분한 단백질의 섭취로 인해 TCO_2와 개선된 영양상태를 유지하였다. 그러므로, 또한 당뇨병 환자에서 비당뇨병 환자보다 충분한 단백질의 섭취가 산-연기 평형에 중요한 역할을 함으로서, 당뇨병 환자에서 영양상태 및 단백질 섭취에 대한 감시가 더욱 필요할 것으로 사료된다. Objective : Various degrees of metabolic acidosis are accompanied by the decrease in the kidney function. It is known that dialysis patients` long-term convalescences and complications are related to metabolic acidosis. It is generally known that the extreme acidosis of the dialysis patients should be corrected but on the contrary, there are reports on hemodialysis patients with slight acidosis have better nutritional condition. However, the research results are rare compared to the ratio of diabetic patients among dialysis patients. Therefore, in this paper we tried to reach a conclusion by comparing and analyzing the total carbon dioxide of the serum and other nutrition parameters of the diabetic patients among long-term hemodialysis patients with the non-diabetic patients. Methods : We divided 50 patients, who have been hemodialysis for longer than three months, into 21 patients with diabetes and 29 patients with nondiabetes. And compared and analyzed the TCO_2 in addition to measuring other parameters based on the blood tests carried out on the beginning of every month from January of 1999 to December of 2000. Results : TCO_2 showed a inverse correlation with nPCR, serum albumin, blood urea nitrogen, and creatinine on the correlation analysis of the total target patients. And blood urea nitrogen and age were the independent factors in the independent factor analysis using multiple regression analysis. When we divided and compared the total target patients into diabetic patients and no-diabetic patients, there were no signigicant differences between various kinds of nutrition parameters and dialysis parameters. And TCO_2 showed a inverse correlation with nPCR, nPCR being the independent factor in the diabetic patients. In addition, TCO_2 showed a inverse correlation with serum creatinine, serum creatinine being the independent factor in the non-diabetic patients. Conclusion : Increase of ingestion of protein was one of the important factors in inducing metabolic acidosis, but the TCO_2 and improved nutritional condition resulting from ingesting sufficient protein could be preserved in the diabetic patients. Therefore we think that the diabetic patients` nutritional condition and supervision of their ingestion of protein is more needed as sufficient ingestion of protein is a major factor in balancing acid-base for diabetic patients than non-diabetic patients.
Baek, Jeong Yeob,Jeong, Jae Yeong,Kim, Kyoung In,Won, So-Yoon,Chung, Young Cheul,Nam, Jin Han,Cho, Eun Ju,Ahn, Tae-Beom,Bok, Eugene,Shin, Won-Ho,Jin, Byung Kwan MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.11
<P>We demonstrated that capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), inhibits microglia activation and microglia-derived oxidative stress in the substantia nigra (SN) of MPP<SUP>+</SUP>-lesioned rat. However, the detailed mechanisms how microglia-derived oxidative stress is regulated by CAP remain to be determined. Here we report that ciliary neurotrophic factor (CNTF) endogenously produced by CAP-activated astrocytes through TRPV1, but not microglia, inhibits microglial activation and microglia-derived oxidative stress, as assessed by OX-6 and OX-42 immunostaining and hydroethidine staining, respectively, resulting in neuroprotection. The significant increase in levels of CNTF receptor alpha (CNTFRα) expression was evident on microglia in the MPP<SUP>+</SUP>-lesioned rat SN and the observed beneficial effects of CNTF was abolished by treatment with CNTF receptor neutralizing antibody. It is therefore likely that CNTF can exert its effect via CNTFRα on microglia, which rescues dopamine neurons in the SN of MPP<SUP>+</SUP>-lesioned rats and ameliorates amphetamine-induced rotations. Immunohistochemical analysis revealed also a significantly increased expression of CNTFRα on microglia in the SN from human Parkinson’s disease patients compared with age-matched controls, indicating that these findings may have relevance to the disease. These data suggest that CNTF originated from TRPV1 activated astrocytes may be beneficial to treat neurodegenerative disease associated with neuro-inflammation such as Parkinson’s disease.</P>