『經世訓民正音圖說』 坤冊 「群書折衷」 연구

심소희(Shim, So-hee) 한국고전번역원 2014 民族文化 Vol.43 No.-

『經世訓民正音圖說』는 조선후기 최석정(1646-1715)의 저작으로서 출판을 전제로 필사된 사본이다. 1968년 김지용이 일본 京都대학의 河合文庫에서 발견하였는데 오랫동안 방치된 탓에 훼손된 부분도 많고 식별하기 어려운 자구가 적지 않다. 최석정은 영의정을 8번이나 역임한 명문관료로서 『切韻』『唐韻』『廣韻』등 ‘切韻系韻書’의 맥을 잇는 문언음 음운체계를 지향하고 있었고, 邵雍의 易理적인 운도의 틀에 이러한 음운체계를 담아내었다. 그러므로 『經世訓民正音圖說』에는 최석정의 한자 성운에 대한 그의 사변뿐만 아니라, 명이 멸망하고 청이 건국되는 ‘천하대란’의 시대적 상황에서 ‘조선중화주의’를 실현하고자 하는 그의 포부와 소명의식이 고스란히 실려 있다. 지금까지 『경세훈민정음도설』의 연구범위는 乾冊에 국한되어 『경세훈민정음도설』 坤冊에 대해선 소개조차 전혀 되어있지 않아 『경세훈민정음도설』에 대한 전면적인 연구가 이루어지지 않고 있다. 본고에서는 『경세훈민정음도설』 坤冊의 69%분량을 차지하는 「群書折衷」의 주석을 통하여 최석정의 성음인식과 세계관, 그리고 학문배경에 대해 입체적인 조망을 실현하고자 한다. 『Ky?ngsehunminch?ng?mtos?l(經世訓民正音圖說)』was a book which was written by Ch’oe, S?kch?ng(崔錫鼎, 1646-1715) in the late Joseon dynasty. This book was transcribed by hand, whose original copy was written for a publication. Kim, Chiyong(金智l勇) found 『Ky?ngsehunminch?ng?mtos?l』in Hahapmunko(河合文庫) at Tokyo University in Japan. Since it was in a state of total neglect, it has many parts damaged and many characters unre cognized. However, Ch’oe, S?kch?ng, who served eight times as the prime minister of the Joseon dynasty, was a legitimist following the phonemic system of so-called ‘Ch?lunkyeuns?(切韻系韻書)’such as『Ch?lun(切韻)』,『Tangun(唐韻)』, and 『Kwangun(廣韻)』. In addition, he provided specific sound values of the Chinese characters with Hunminjeongeum in the frame of divining art, which was under the influence of 『Hwangk?kky?ngses?ng?mch’anghwato(皇極經世聲音唱和圖)』by Soong(邵雍). Therefore, 『Ky?ngsehunminch?ng?mtos?l(經世訓民正音圖說)』clearly shows not only Ch’oe, S?kch?ng‘s view for the traditional Chinese phonology, but also his strong sense of vocation and ambition for ‘Chos?nchunghwachu?i(조선중화주의)’in an age of turmoil when Ming dynasty had fallen and Qing dynasty was established. The studies of『Ky?ngsehunminch?ng?mtos?l』have been usually focused only on K?nch’aek(乾冊) while Konch’aek(坤冊) has never been introduced. Hence, a full scale of study on『Ky?ngsehunminch?ng?mtos?l』is needed. Through interpreting annotates of ?Kuns?ch?lch’ung(群書折衷)?which are 69% of Kon ch’aek(坤冊), this study will illuminate Ch’oe, S?kch?ng‘s perspective for phonology, his view of the world, and his academic backgrounds from all angles.

한열변증에 따른 중풍 환자의 제반특성 비교

김민경,이인환,신애숙,김나희,김혜미,심소라,나병조,조승연,박성욱,정우상,문상관,박정미,고창남,조기호,김영석,배형섭,Kim, Min-kyung,Lee, ln-whan,Shin, Ae-sook,Kim, Na-hee,Kim, Hye-mi,Shim, So-ra,Na, Byung-Jo,Cho, Seung-yeon,Park, Seong-uk,Jung, Woo Sang 대한중풍순환신경학회 2010 대한중풍.순환신경학회지 Vol.11 No.1

Object : This study was conducted as part of the national project to standardize stroke diagnosis in Korean medicine. In this study, we aimed to evaluate the characteristics of acute stroke between heat pattern group and cold pattern group. Methods : We recruited stroke patients from 5 universities(Kyung-Hee University oriental medical center, Kyung-Hee University East-West Neo medical center, Kyungwon university lncheon oriental medical center, Kyungwon university Songpa oriental medical center and DongGuk university llsan oriental medical center) from April, 2007 until February, 2010. We diagnosed them and selected 463 heat pattern patients and 182 cold pattern patients. Results : We find that the risk factor of smoking, alcohol, diet(prefer to meat) are more associated with the heat pattern group. On the other hand, inflammation history in recent 3 months and diet(prefer to sea food) are more associated with the cold pattern group. RBC, Hg, Hct, TG, CK and Cl are more related to the heat pattern group. CPT, total cholesterol and HDL are more related to the cold pattern group. Tae-eum type takes high distribution of the heat pattern group, and So-eum type takes high distribution of the cold pattern group. Conclusions : This study provides evidence that the heat pattern group have more risk factor than the cold pattern group.

간호사를 위한 재활간호 교육의 효과

소희영,김봉옥,송재금,심희숙 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

To explore the effects of the rehabilitation nursing education on registered nurses, this study was designed quasi-experimentally for one group pre-test and post-test respectively. The study employed the Client Satisfaction Questionnaire, Positive Feeling Questionnaire, Self-Attitude (Confidence) Inventory, and Nurses Attitude Scale. The study found that only the positive feeling of professional nurses toward their rehabilitation clientele increased after rehabilitation nursing education, which means both that nurses showed inadequate awareness of the disabled and that a change of nursing awareness was critical if a change in popular awareness was to be realized. One influence on positive feeling was the current job position of the nurse subjects, with the position of head nurse especially affecting positive feeling. Considering experiences and career of head nurse, the positive feeling could be the influence of professional life. Another influence on the self-confidence of the nurse subjects was the working ward, specifically the rehabilitation ward. Because the level of self-confidence in rehabilitation nurses should increase the level of rehabilitation nursing received by the clients, rehabilitation nursing education must continue in future. Since a significant positive correlation was found between rehabilitation nursing education and positive feeling, the higher satisfaction about rehabilitation nursing education could result more positive feeling of nurses toward the disabled. Therefore there should be further educational programming to increase client satisfaction. The opinions of educational participants should be considered in instituting improved educational programs for rehabilitation nurses.

자궁경부종양에서 HPVDNAChip^(�) 및 Hybrid Capture Ⅱ^(TM)검사를 이용한 인유두종 바이러스의 검출

여소진,김달수,남계현,심일구,김태희,이해혁,이권해 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.2

목적 : 인유두종 바이러스는 자궁경부암의 의의있는 원인 인자이다. 이 연구의 목적은 HPVDNAChip??검사를 이용하여 정상, 전암병변, 침윤성 경부암의 인유두종 바이러스의 분포를 알아보고 그 결과를 Hybrid CaptureⅡ^(^(TM)) 검사와 비교하였다. 연구 방법 : 149명의 대상환자 중 57명은 병변이 없었고, 59명은 전암 병변이었으며, 33명은 침윤성 경부암이었다. HPVDNAChip??검사와 이 검사처럼 아형 66, 69를 제외한 고위험군(HPV-16/18/31/33/35/45/51/52/56/58/59/68) 인유두종 바이러스를 검사할 수 있는 Hybrid CaptureⅡ^(^(TM))검사를 이용하여 연구하였다. 결과 : 두 검사 모두 인유두종 바이러스를 검사하는 데 유용하였고, 결과가 의의있게 일치하였다(kappa value 0.721, p<0.01). Hybrid CaptureⅡ^(^(TM))검사에서 양성이나 HPVDNAChip??검사에서 음성인 경우는 18명(12.1%)으로 평균 Hybrid CaptureⅡ^(^(TM))값이 120.7±233.0 (mean±SD)이였고, 두 검사 모두 양성인 경우의 Hybrid CaptureⅡ^(^(TM))값은 448.1±732.8 (mean±SD)이였다. Hybrid CaptureⅡ^(^(TM))검사의 민감도는 94.6%이고, 특이도는 78.9%였고 HPVDNAChip??검사의 민감도는 83.7%이고, 특이도는 89.5%였다. HPVDNAChip??검사는 모두 15가지의 고위험군의 인유두종 바이러스 아형을 알아낼 수 있으며 아형 16이 전암병변(28.8%, 15/59)과 침윤성 경부암(48.5%, 19/33)에서 가장 흔한 아형이었으며 그 다음으로 흔한 아형은 58이었다. 결론 : HPVDNAChip??검사는 Hybrid CaptureⅡ^(^(TM))검사처럼 인유두종 바이러스 검사에 매우 민감하고 유용한 검사이다. HPVDNAChip??검사는 Hybrid CaptureⅡ^(^(TM))검사와 비교할 때, 인유두종 바이러스의 아형과 중복감염에 대한 정보를 준다. 앞으로 HPVDNAChip??검사의 자궁경부암의 선별검사로서의 가치에 대한 연구가 더 필요하다. Objective : Human Papillomavirus (HPV) is well known as one of the major risk HPVDNAChip?? factors for cervical cancer. The purpose of this study is to know HPV genotype distribution in women with normal cervix, precancerous lesion, and invasive cervical cancer by HPVDNAChip?? test. In addition, the result of HPVDNAChip?? test was compared with Hybrid CaptureⅡ^(TM) system for HPV detection. Methods : One hundred forty nine patients were included in this study. 57 women had normal cervix, 59 women had precancerous lesion, and 33 women had invasive cervical cancer. We tested them with two method for detection of Human Papillomavirus (HPV) by HPVDNAChip?? test and Hybrid CaptureⅡ^(TM) system. Hybrid CaptureⅡ^(TM) test can detect same high-risk HPVs (16/18/31/33/35/39/45/51/52/56/58/59/68) with HPVDNAChip?? test which can detect additional 66 & 69 high risk types of HPV. Results : Both methods for the detection of HPV were useful tests. The correlation between the results of two methods was very significant (kappa value 0.721 [p<0.01]). Positive Hybrid CaptureⅡ^(TM) test and negative HPVDNAChip?? test group were 18 women (12.1%) and average Hybrid CaptureⅡ^(TM) titer value of this group was 120.7±233.0 (mean±SD), positive Hybrid CaptureⅡ^(TM) test and positive HPVDNAChip?? test group were 84 women (54.4%) and average titer was 448.1±732.8. The Hybrid CaptureⅡ^(TM) test showed a sensitivity of 94.6% and a specificity of 78.9% and the HPVDNAChip?? test showed a sensitivity of 83.7% and a specificity of 89.5%. HPVDNAChip?? test detected total 14 genotype of HPV. HPV-16 was 28.8% (15/59) in precancerous lesion and 48.5% (19/33) in invasive cancer, most common in both groups. Next common type HPV-58 was 25.4% (12/59) in precancerous lesion and 9.1% (3/33) in invasive cancer. Conclusion : HPVDNAChip?? test is very sensitive and effective method for detection of Human Papillomavirus (HPV) infection as Hybrid CaptureⅡTMtest. In comparison with Hybrid CaptureⅡ^(TM) test, HPV genotype and multiple HPV infection information can be given by HPVDNAChip?? test. Further study will be needed to know the value of screening of cervical cancer by HPVDNAChip?? test in future.

Pseudomonas sp. G314가 생산하는 생물 계면활성제의 특성

So Hee Shim(심소희),Kyeong Ryang Park(박경량) 한국생명과학회 2012 생명과학회지 Vol.22 No.2

대전일원의 유류오염 지역의 토양에서 분리된, 생물 계면활성제 생성능이 우수한 Pseudomonas sp. G314균주 [23]가 생산하는 생물 계면활성제의 특성을 조사하고 그 성분을 확인하였다. Pseudomonas sp. G314가 생산하는 생물 계면활성제는 상온에서 10일 보관 후에도 26.2 dyne/㎝ 정도의 표면장력을 유지해 냉장 보관한 계면활성제와 비슷하게 안정하였고, 5 l 발효조를 이용한 배양에서 회분배양의 25 dyne/㎝ 보다는 약간 높은 27 dyne/㎝ 정도의 계면활성제를 생산해 대량 배양 할 수 있음을 확인하였다. 또 이 계면활성제는 acetone과 methanol에 잘용해 되고 benzene과 toluene에 약하게 용해되어 glycolipid 계열의 생물계면활성제임이 추정되었고[23], 이를 silica gel column을 통해 용출하고, TLC로 전개하여 확인된 Rf 0.58인 spot이 bial’s reagent와 rhodamine 6G에서 양성반응을 나타내 Pseudomonas sp. G314가 생산하는 생물 계면활성제는 탄수화물과 지질이 함유된 glycolipid 계열의 생물 계면활성제임을 확인하였다. The purpose of this paper is to analyze the characteristics and chemical components of biosurfactant produced by Pseudomonas sp. G314. Pseudomonas sp. G314 was isolated from soil samples which were contaminated with oil in Daejon area. As such, it produced quality biosurfactant [23]. One type of biosurfactant was kept in a refrigerator, whereas another type of biosurfactant was kept in room temperature. The surface tension activities were then compared. As a result, the biosurfactant from Pseudomonas sp. G314 that was kept at room temperature was stable for 10 days, showing 26.2 dyne/㎝ of surface tension activity. This result was found to be similar to that of the refrigerator storage. The surface tension of batch culture was 25 dyne/㎝, but the culture in the 5 l fermentor was 27 dyne/㎝. Therefore, it can be suggested that the large-scale culture is feasible via the fermentor. Biosurfactant from Pseudomonas sp. G314 was estimated to be a kind of glycolipid because it dissolved in acetone and methanol much better than in benzene and toluene [23]. A spot was detected through the elution of silica gel column and the spread of TLC, and the Rf value was 0.58. This spot has a positive reaction with Bail’s reagent and rhodamine 6G. Hence, we can conclude that biosurfactant from Pseudomons sp. G314 was a glycolipid containing carbohydrate and lipid.

Risk Factors of Postpartum Depression Among Korean Women: An Analysis Based on the Korean Pregnancy Outcome Study (KPOS)

Shim So Hyun,Lee Su Young,Jung Inkyung,Heo Seok-Jae,Han You Jung,Kwak Dong Wook,Kim Min Hyoung,Park Hee Jin,Chung Jin Hoon,Lim Ji Hyae,Kim Moon Young,Cha Dong Hyun,Shim Sung Shin,Cho Hee Young,Ryu Hyu 대한의학회 2024 Journal of Korean medical science Vol.39 No.3

Background: Postpartum depression (PPD) can negatively affect infant well-being and child development. Although the frequency and risk factors of PPD symptoms might vary depending on the country and culture, there is limited research on these risk factors among Korean women. This study aimed to elucidate the potential risk factors of PPD throughout pregnancy to help improve PPD screening and prevention in Korean women. Methods: The pregnant women at 12 gestational weeks (GW) were enrolled from two obstetric specialized hospitals from March 2013 to November 2017. A questionnaire survey was administered at 12 GW, 24 GW, 36 GW, and 4 weeks postpartum. Depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale, and PPD was defined as a score of ≥ 10. Results: PPD was prevalent in 16.3% (410/2,512) of the participants. Depressive feeling at 12 GW and postpartum factors of stress, relationship with children, depressive feeling, fear, sadness, and neonatal intensive care unit admission of baby were significantly associated with a higher risk of PPD. Meanwhile, high postpartum quality of life and marital satisfaction at postpartum period were significantly associated with a lower risk of PPD. We developed a model for predicting PPD using factors as mentioned above and it had an area under the curve of 0.871. Conclusion: Depressive feeling at 12 GW and postpartum stress, fear, sadness, relationship with children, low quality of life, and low marital satisfaction increased the risk of PPD. A risk model that comprises significant factors can effectively predict PPD and can be helpful for its prevention and appropriate treatment.

Experiences and efficacy of noninvasive prenatal test using maternal plasma in single center: 1,591 cases

So Yeon Hong,So Hyun Shim,Hee Jin Park,Sung Shin Shim,Ji Youn Kim,Yeon Kyung Cho,Soo Hyun Kim,Dong Hyun Cha 대한의학유전학회 2020 대한의학유전학회지 Vol.17 No.1

Purpose: The objective of this study was to analyze the results of several noninvasive prenatal tests (NIPTs) from a single cen-ter and conἀrm their efἀcacy and reliability. In addition, we aimed to conἀrm the changes in the number of invasive tests per-formed after introducing NIPT. Materials and Methods: NIPT data from a large single center from March 2014 to November 2018 were analyzed. Karyotyping was confirmed based on chorionic villus sampling, amniocentesis, or postnatal cord/peripheral blood sampling. Data on maternal age, gestational age, fetal fraction, and ultrasonographic results were analyzed. As the secondary outcome, the number of amniocentesis cases before and after the introduction of NIPT was compared. Results: Overall, 1,591 single pregnancy cases that underwent NIPT were enrolled. The mean maternal age was 36.05 (22-45) years. The average gestational age and fetal fraction were 12+1 (9+3 to 27+1) weeks and 10.95% (3.6% to 31.3%), respectively. A total of 1,544 cases (97.0%) were reported to have negative NIPT re-sults and 40 (2.5%) had positive NIPT results. The sensitivity and specificity of the overall abnormalities in NIPT were 96.29% and 99.36%, respectively. The positive predictive value (PPV) and negative predictive value were 72.22% and 99.93% respectively. The mean number of amniocentesis cases were 21.7 per month (21.7±3.9), which significantly decreased from 31.5 per month (31.5±4.8) before conducting NIPT as a screening test. Conclusion: NIPT is currently a useful, powerful, and safe screening test. In particular, trisomy 21 is highly speciἀc due to its high PPV. NIPT can reduce the potential risks of procedure-related miscarriages during invasive testing.

Experiences and Efficacy of non-invasive prenatal test (NIPT) using maternal plasma in single center: 1591 cases

( So Yeon Hong ),( So Hyun Shim ),( Soo Hyun Kim ),( Hee Jin Park ),( Sung Shin Shim ),( Ji Youn Kim ),( Yeon Kyung Cho ),( Kyung Jin Lee ),( Dong Hyun Cha ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: To analyze the result of a large number of NIPT in single center and confirm the efficacy and reliability. Methods: The data of NIPT in single center from Mar.2014 to Nov.2018 were analyzed. The patients who referred from other hospital due to abnormal result were also included. All of the patient have completed the delivery. Karyotyping confirmation was done by CVS or amniocentesis or postnatal cord blood sampling. We consider normal karyotype if there were no special abnormalities during pregnancy, no abnormal phenotype in neonate after birth. Details on age, gestational age, platform, fetal fraction, sonographic results were analyzed. Results: Total 1591 single pregnancy cases who performed NIPT were enrolled.640cases were individual SNP method, and 951cases were whole genome MPS method. Mean age was 36.1(22-45) years and gestational age, fetal fraction were 12+1(9+3-27+1)wks and 10.9(3.6-31.3)%.1544cases(97.1%) reported as negative NIPT results,40cases(2.5%) reported as positive NIPT results,7 cases(0.4%) were uninformed. In positive group, only 36cases cytogenetic confirmation tests were done whereas 4cases were F/U loss. Confirmed 36cases were following; Among the 19karyotype tests in NIPT trisomy21 positive group, all 19cases revealed as trisomy 21(100%).In 2cases of trisomy18 high risk group, 1case(50%) was confirmed as trisomy18.Trisomy13(n=1) was also confirmed as trisomy13.Among Sex chromosome abnormality group(n=8), 4cases showed discordancy result. Since we used MPS method, other uncommon trisomy;trisomy15(n=2),7(n=1) and 14(n=1) were incidentally detected. In this study, sensitivity and specificity were 96.3% and 99.4%, PPV and NPV were 72.2% and 99.9%,respectively. Conclusion: Clinical review of general cases are introduced based on single center’s results. NIPT is currently a useful, powerful and safe screening test, as the result we can reduce invasive test. In particular, trisomy 21 is highly effective due to its high PPV. In case of trisomy13,18 and SCA, confirmed test is necessarily required.

Maternal antimullerian hormone as a predictor of fetal aneuploidy occurring in an early pregnancy loss

( So Hyun Shim ),( Hyeong In Ha ),( Yong Wook Jung ),( Sung Shin Shim ),( Yeon Kyung Cho ),( Ji Youn Kim ),( Kyoung Jin Lee ),( Dong Hyun Cha ),( Soo Hyun Kim ),( Hee Jin Park ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.6

Objective The purpose of the study was to examine the relationship between the parameter representing ovarian reserve and the fetal aneuploidy in early spontaneous miscarriage. Methods A multicenter retrospective cohort study was performed in patients who were diagnosed with early pregnancy loss (≤13 gestational weeks) and examined for fetal karyotype at the CHA Gangnam Medical Center, CHA Bundang Medical Center, and CHA Gumi Medical Center between January 2011 and December 2012. Karyotyping was performed by the Genetic Laboratory of the Fertility Center of CHA Gangnam Medical Center. Medical records were reviewed for demographics, karyotype analysis and hormonal assay of ovarian reserve including antimullerian hormone (AMH) and follicle stimulating hormone. Statistical analysis was performed using SPSS software. Results A total 462 patients were included in this study. The mean age of the patients was 35.31±4.12 years and the mean AMH level was 3.88±3.50 ng/mL (n=195). Two hundred eleven conceptuses (45.7%) of patients showed the euploid and 251 (54.3%) showed the aneuploid. There are significant differences in maternal age, AMH and gestational age between fetal euploid and aneuploid groups (34.46±4.35 vs. 36.04±3.78 years, P<0.001; 4.60±3.86 vs. 3.43±3.18 ng/mL, P=0.022; 7.67±1.54 vs. 8.27±1.46 weeks, P<0.001, respectively). Multivariate analysis revealed that low AMH level and early gestational age were maternal age-independent markers for fetal aneuploid (P<0.001 and P=0.045, respectively). Conclusion Low maternal AMH level might be a predicting marker for fetal aneuploid in early pregnancy loss.

황윤석의 정음관 연구 2

沈小喜(Shim So-hee) 중국어문학연구회 2010 중국어문학논집 Vol.0 No.64