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화학적으로 활성화된 GroupⅢ와 GroupⅣ구심성 근신경의 Gamma Motoneuron에 대한 반사효과
방대홍,홍승길,남숙현 고려대학교 의과대학 1983 고려대 의대 잡지 Vol.20 No.3
In decerebrated cats the effects of fine muscle afferents (groups Ⅲ and Ⅳ) upon gamma motoneurons were studied. The efferent activity was exracellularly recorded from small filaments of ventral roots or from filaments of musole nerves. Fine muscle afferents were selectively activated by bradykinin, potassium and serotonin. For comparison, succinylcholine was administrated to activated muscle spindle afferents. Forty gastrocnemius-soleus gamma motoneurons were recorded. Thirty-six (90%) of them had a tonic background discharge in the absence of intentional stimulation. A high susceptibility to an increased activity in fine muscle efferents was found for the gamma motoneurons. Practically all neurons both to homonymous extensor and antagonistic flexor muscles responded with an excitation to at least one of the algesic substances applied. Only two out of fifteen gamma motoneurons responded to succinylcholine. Thus indicationg a weak convergence from muscle spindle afferents. Control experiments demonstrated that the responses to bradykinin and potassium are entirely due to the nervorus outflow from the gastrocnemius-soleus muscle. In contrast, serotonin influencing the gamma motoneurons has unknown additional sites of action. The results indicate that muscular group Ⅲ and/or group Ⅳ units activated by algesic substances evoke excitatory effects upon gamma motoneurons.
健康한 韓國人의 動脈血液 가스 및 酸一鹽基 平衡値에 對한 觀察
崔震守,曺方煥,朴喜淑,金顯承,金瑛,白正敏,徐錫助 순천향의과대학 1979 Journal of Soonchunhyang Medical Science Vol.2 No.3
The purpose of this paper is to make an attempt in this investigation to determine normal adult values of arterial blood gas and acid-base balance in 53 healthy Korean male and female subjects of varying age and then compare with the data obtained by others. Determinations of the acid-base status of the arterial blood were performed at 37℃ by the Astrup method using a radiometer instruments, consisted of BGA2A/3-MK 2 system. The mean and standard errors of each component were as follows: pH 7.42±0.043, oxygen saturation 96.96±0.089%, pO?? 97.66±0.91mmHg, pCO?? 37.08±0.68mmHg, CO?? content 24.29±0.43mM/L, bicarbonate 23.26±0.68mM/L, buffer base 46.56±0.66mEg/L, and base excess -0.024±0.001mEg/S. Compared with normal adult values in literatures, all the components of the data appear to be in the same range without any significant difference.
이희상,이성훈,조현상,남궁기,한승진,방승규 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.1
본 연구에서는 수면무호흡증이 혈압에 미치는 영향을 살펴보고자 하였다. 연구대상은 1995년 1월1일부터 1995년 10월 31일까지 코골기와 수면무호흡 증상으로 인해 연정 뇌기능 수면 연구소에 수면다원검사가 의뢰된 140명의 환자를 대상으로 하였으며 그 중에서 원발성 고혈압을 제외한 심혈관계 질환이 있거나 항고혈압제를 복용하고 있는 환자, 그리고 자료가 불충분하거나 수면무호흡증으로 진단되지 않은 24명을 제외하고 나머지 116명을 최종분석 대상으로 하였다. 이들 대상 환자들로부터 얻은 자료를 수면변수와 호흡변수로 나누어 혈압과의 관계를 Pearson 상관관계와 다중회귀분석을 통해 다음과 같은 결과를 얻었다. 1) 평균 수축기 및 확장기 혈압과 유의한 상관관계가 있는 변수는 수면무호흡의 총시간 및 총횟수, 총수면시간중 평균 혈중산소포화도, 무호흡지수, 중추성 수면무호흡의 총시간 및 횟수, 폐쇄성 수면무호흡의 총시간등 이었다. 2) 다중회귀분석 결과 평균 수축기 및 확장기 혈압에 유의한 영향을 미치는 것으로 나타난 변인은 수면무호흡의 총시간이었으며 이것이 평균 수축기 및 확장기 혈압에 미치는 영향의 도는 각각 7.9%와 6.2%였다. 이상의 결과로 볼 때, 수면무호흡증이 혈압에 미치는 영향은 적은 것으로 나타났으며 무호흡의 유형에 관계없이 수면무호흡의 총시간만이 혈압에 영향을 주는 것으로 나타났다. 그리고 중추성 수면무호흡의 경우 평균 혈중 산소포화도의 감소, 각성에 따른 교감신경계 활성도의 증가이외에도 다른 기전에 의해 혈압 상승이 나타날 가능성이 있을 것으로 생각된다. Objects : This study was conducted to investigate the effects of sleep apnea syndromes on th systemic blood pressure. Methods : The subjects were 140 patients who were consulted to Yon-jung brain function and sleep research center for polysomnography due to snoring and sleep apnea from Jan. 1st 1995 to Oct. 31st 1995. Twenty-four out of 140 were excluded due to cardiovascular diseases other than systemic hypertension, antihypertensive medication, inadequate data or diagnosis other than sleep apnea syndrome. The remaining 116 were accepted as proper subjects. Using Pearson's correlation and multiple regression analysis, we looked for the relationship between sleep and respiratory variables to systemic blood pressure. Results : The results were as follows : 1) According to the correlation analysis, statistically significant variables to mean systolic and diastolic blood pressure were the total time and total number of sleep apnea, degree of oxygen saturation of total sleep time, apnea index, total time and total number of central apnea, and the total time of obstructive apnea. 2) According to the multiple regression analysis, only the total time of sleep apnea significantly affected mean systolic and diastolic blood pressure, and the degrees of affection were 7.9% and 6.2% respectively. Conclusion : these findings showed that sleep apnea syndrome had lower influence over systemic blood pressure than expected and regardless of the type, only the total time of sleep apnea influenced systemic blood pressure. In the case of central apnea, mechanisms other than hypoxemia and the increase of sympathetic activity during arousal may make it possible to increase systemic blood pressure.
( Hye Jung Chang ),( Jae Hoon Lee ),( Young Rok Do ),( Sung Hwa Bae ),( Jung Lim Lee ),( Seung Hyun Nam ),( Sung Soo Yoon ),( Soo Mee Bang1 ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.4
Background/Aims: The clinical efficacy and safety of a three-drug combination of melphalan, prednisone, and thalidomide were assessed in patients with multiple myeloma who were not candidates for high-dose therapy as a firstline treatment. Because the side effects of thalidomide at a dose of ≥ 100 mg daily can be a barrier to effective treatment for these patients, we evaluated the efficacy and safety of a reduced dose of thalidomide, 50 mg, for non-transplant candidates. Methods: Twenty-one patients were treated in 4-week cycles, receiving 4 mg/m2 melphalan and 40 mg/m2 prednisone on days 1-7 and 50 mg thalidomide daily. The primary efficacy outcome was the overall response rate. Aspirin (100 mg daily) was also provided as prophylactic treatment for thromboembolism. Results: The overall response rate was 57.1%; a complete response was seen in 23.8% of patients, a partial response in 33.3%, and stable disease in 9.5%. After a median follow-up time of 16.1 months, the median time to progression was 11.4 months (95% confidence interval, 2.1 to 20.6); the median overall survival was not reached. Grades 3 and 4 adverse events included infection (10%), peripheral neuropathy (5%), diarrhea (5%), thrombosis (10%), and loss of consciousness (10%). Two patients discontinued treatment due to loss of consciousness and neuropathy. Conclusions: Low-dose thalidomide (50 mg) plus melphalan and prednisone is an effective combination drug therapy option for newly diagnosed myeloma patients who are ineligible for high-dose chemotherapy.
( Seung Hyun Bang ),( Seung Mi Lee ),( Chan-wook Park ),( Joong Shin Park ),( Jong Kwan Jun ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: Induction of labor (IOL) is the most common procedures in obstetrics, and twin pregnancy is reported to be the risk factor for failed induction. The patients need to be counselled before induction, but there were not enough data regarding success rate of IOL in twin, especially in nulliparous women. The purpose of this study was to examine the success rate of vaginal delivery after IOL in term nulliparous women with twin pregnancy. Methods: In this retrospective cohort study, 806 nulliparous women with twin pregnancy were delivered at term after IOL between 2005 and 2018. A successful induction was defined as vaginal delivery after IOL, and a failed induction was defined as cesarean delivery. Clinical characteristics were compared according to the success or failure of induction. Results: Among the study population, 78% (628/806) women were successfully delivered vaginally. Women with successful induction had lower maternal age, higher maternal height, earlier gestational age at delivery, and lower summated birthweight of both twin. Logistic regression analysis showed that maternal age, height and summated birthweight of both twin were significant associated factors with successful IOL. Conclusion: In term nulliparous women with twin pregnancy, IOL resulted in 78 % of success rate. This can be used in counselling before induction of labor in twin pregnant women.
Selection and Evaluation of Acaropathogenic fungi to the Bulb mite, Rhizoglyphus echinopus
Seung Hyun Ko,Tae Young Shin,Won Woo Lee,Jae Bang Choi,Sung Min Bae,Soo Dong Woo 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04
The bulb mite (Rhizoglyphus echinopus) damages garlic, shallot and onion in the bulbs, corms and tubers. It has recently become a serious problem because of the continuous use of acaricides resulting in resistance among bulb mite population. Thus, there is need to find alternative control measures to suppress bulb mite population. Here, we report the screening result of pathogenic fungi for the control of R. echinopus. Initial screenings were performed using 352 isolates of entomopathogenic fungi from Korea soils. As results, 15 isolates of acaropathogenic fungi showed the pathogenicity to bulb mite supporting fungal conidiation. These isolates were identified as 3 isolates of Metarhizium flavoviride var. pemphigi and 12 isolates of Metarhizium pingshaense by microscopic examination and genetic sequencing of the ITS region and elongation factor-1 alpha. Selected 15 isolates were tested for their virulence against adult R. echinopus and the thermotolerance and the activity to UV-B irradiation of conidia. Additionally, the activities of chitinases and proteases produced by M. pingshaense were compared according to the medium. These acaropathogenic fungi would be considered promising for biological control of bulb mite.
Bang, Jae Seung,Kwon, O-Ki,Kim, Jeong Eun,Kang, Hyun-Seung,Park, Hyun,Cho, Sung Yun,Oh, Chang Wan Oxford University Press 2012 Neurosurgery Vol.70 No.3
<P>Up-to-date, quantitative angiographic measurement of revascularization extent after bypass surgery has not been reported.</P>