일반화된 Active Contour Model을 이용한 변형 물체의 움직임 추적과 분석에 관한 연구

이웅기,허영남,양환석 조선대학교 기초과학연구소 1997 自然科學硏究 Vol.20 No.1

본 논문은 일반화된 Active Contour Model을 이용하여 연속적으로 입력되는 영상에서 변화하는 물체의 움직임 추적과 분석 방법을 제안한다. 그리고 연속적인 영상 프레임에서 물체 경계의 추적은 외곽선 모델의 에너지 함수를 최소화하므로써 이루어진다. 물체의 추적, 적응적인 움직임 예측의 효율을 증가시키기 위하여 입력되는 영상에 존재하는 일시적인 움직임 정보를 이용하였고 물체의 움직임과 변형 처리를 위하여 움직임 추적 알고리즘으로부터 변형 행렬을 유도했다. 본 논문에서 제안한 일반화된 Active Contour Model을 입술추적 실험의 행동 분석에 적용하였다. 그리고 그 응용에서 전위 벡터와 변형 행렬의 일시적인 변화는 인간 얼굴 특징의 국부적 변형을 설명하는데 이용된다.

고속 HMC 이송계의 운동특성 평가 및 운동오차 예측

최헌종,허남환,강은구,이석우,홍원표 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

Recently, the evolution in production techniques (e.g. high-speed milling) and the complex shapes involved in modern production design has been increasingly popular. The key to the achievement is a drastic improvement of the dynamic behavior of the machine tool axes used in production machinery. The more complex these tool paths the higher the speed and acceleration requirements. But it is very difficult to reach the target for high speed machine tool because of the limitations of servo system and motion control system. However the direct drive design of machine tool axes, which is based on linear motors and which recently appeared on the market, is a viable candidate to meet the ever increasing demands, because of these advantages such as no backlash, less friction, more mechanical simplicity and very higher acceleration and velocity comparing to the traditional system. This paper focused on the performance tests of the high speed horizontal machine tool based on linear motor. Especially, dynamic characteristics were investigated through circular test and circular form machining test is carried out considering many important parameter. Therefore these several experiments is used to be evaluated the model for prediction of circular motion error and circular machined error.

유전 및 육종 : 한우 L4번 염색체 QTL 영역내 Fatty acid binding protein 5 유전자의 다형성과 도체 및 육질 형질과의 관련성 분석

허강녕 ( Kang Nyeong Heo ),김남국 ( Nam Kuk Kim ),이승환 ( Seung Hwan Lee ),김남영 ( Nam Young Kim ),전진태 ( Jin Tae Jeon ),박응우 ( Eung Woo Park ),오성종 ( Sung Jong Oh ),김태헌 ( Tae Hun Kim ),성환후 ( Hwan Hoo Seong ),윤두학 한국동물자원과학회(구 한국축산학회) 2011 한국축산학회지 Vol.53 No.4

본 연구는 한우에서 소 염색체 14번(BTA14)에서 근내지방도 및 도체중과 관련성이 보고된 QTL영역(48-58cM) 내의 FABP5 유전자를 대상으로 SNP를 발굴하고 도체형질과의 관련성 분석을 위하여 수행하였다. PCR 및 염기서열결정법을 통해 FABP5 유전자내 4개의 SNP(-1141A>G, 949A>G, 969A>G, 1085C>G)를 발굴하였고, 이중 promoter 영역에 위치하는 SNP의 경우 미 보고된 신규 SNP로 확인되었다. 발굴된 4개의 SNP를 대상으로 표현형 기록치를 보유한 후대검정후 583두에 대하여 유전자형 분석 및 관련성 분석을 수행하였다. 분석 결과 4개의 SNP중 SNP1 (-1141A>G)은 근내지방도에 있어서 G유전자형이 A유전자형에 비해서 근내지방도가 2.2 정도 높았고, SNP2(949A>G)는 배최장근 단면적에 있어서 G유전자형이 A유전자형보다 배장근단면적에 있어서 3cm2 만큼 높은 효과를 보였다. 본 결과에 대해 추후 지속적인 연구가 요구되어지며, FABP5의 SNPs은 한우의 도체 및 육질 관련 형질을 위한 유전자 마커로서 활용 가능할 수 있을 것으로 사료된다 The aim of this study was to evaluate the association between economic traits of Korean cattle (Hanwoo) and genetic variation in fatty acid binding protein 5 (FABP5) gene within QTL region of carcass weight and marbling score traits on BTA 14. We sequenced for detection of single nucleotide polymorphism (SNP) with 24 unrelated Hanwoo samples and identified four SNPs (-1141A>G, 949A>G, 969A>G and 1085C>G). Relationship between the genotypes of 583 Hanwoo individuals by PCR-RFLP and economic traits were analyzed by the mixed regression model implemented in the ASReml program. As the result of statistical analysis, SNP1 (-1141A>G) showed significant effect (p<0.003) on marbling score (MS) and SNP2 (949A>G) showed significant effect (p<0.034) on eye muscle area (EMA). Further studies are required to validate the significant SNPs in a bigger population, but the SNPs (-1141A>G and 949A>G) of FABP5 could be a genetic marker to estimate molecular breeding value (MEBV) for carcass traits in Hanwoo.

양성 및 악성 담관폐쇄로 인한 급성 담관염의 담즙과 혈액에서의 세균 동정

허재형,이재현,이만용,신기철,장효식,송승호,남승우,노임환 대한소화기학회 2002 대한소화기학회지 Vol.40 No.1

목적: 담관염은 대부분 세균성 감염에 의하여 발생되며 담관담석증같은 양성 담관염은 물론 악성 담관폐쇄 질환에서도 담관염이 유발될 수 있다. 본 연구에서는 양성 및 악성 담관 질환으로 인한 급성 담관염 환자에서 담즙과 혈액에서 세균 배양을 하여 담관세균의 동정 및 분포 빈도를 조사하였다. 대상 및 방법: 1996년 1월부터 1999년 12월까지 4년간 급성 담관염으로 진단된 환자들에서 응급 내시경적 역행성 담췌관조영술에 의해 삽입된 비담도배액관을 통해 배액술 당일에 담즙 배양과 혈액 배양을 시행하였다. 대상 환자들은 58예의 양성 담관염(간내담관담석증 19예, 간외 담관담석증 25예, 간내 및 간외담관담석증 14예)와 25예의 악성 담관염(Klatskin 종양 4예, 간외담관암 10예, 췌장암 9예, 간암의 담관 전이 2예)등 모두 83예였으며 혈액 세균 배양은 양성 담관염 환자 51예, 악성 담관염 환자 24예에서 시행되었다. 결과: 담관염에서 담즙 세균 배양상 96.3% (80/83예)에서, 혈액 세균 배양은 80.0% (60/75예)에서 양성 이었다. 58예의 양성 담관염의 담즙에서 가장 많이 배양된 균주는 Escherichia coli로 37.9% (22/58예)였고 다음이 Klebsiella spp. 29.3% (17/58예)였으며 그 뒤로 Enterobacter spp., Enterococcus spp.가 각각 13.8% (8/58예)의 순이었다. 양성 담관염의 혈액 배양에서는 담즙 배양의 결과와 유사하게 Escherichia coli가 39.2% (20/51예), Klebsiella spp. 21.6% (11/51예)가 가장 많이 차지하였다. 악성 담관폐쇄 질환으로 인한 담관염(n=25)에서는 담즙 배양상 Pseudomonas가 48.0% (12/25예)로 가장 많았고 다음으로 Escherichia coli 32.0% (8/25예), Klebsiella spp. 20.0% (5/25예)의 순이었으며 혈액배양(n=25)에서는 Pseudomonas와 Escherichia coli가 각각 33.3% (8/24예)로 가장 많았으며 Klebsiella spp. 16.7% (4/24예)의 순이었다. 혐기성 배양에서는 양성 담관 염에서 담즙과 혈액 배양에서 Bacteroides가 각기 1예로 1.7%, 2.0%의 적은 빈도를 보였다. 양성 담관염에서 담즙 배양상 2종 이상의 세균이 분리된 경우는 32.8% (19/58예)였고 혈액 배양에서도 2종 이상 다균주는 19.6% (10/51예)였다. 악성 담관염에서 2종 이상의 다균주가 분리된 경우는 담즙 배양에서 52.0% (13/25예), 혈액 배양에서는 54.2% (13/24예)였다. 결론: 양성 및 악성 담관염은 모두 대부분 세균이 관여하고 있으며 E.coli, Klebsiella spp., Pseudomonas aeruginosa 등이 주종을 차지하였다. Background/Aims: The purpose of the present study was to identify the major bacterial organisms in the patients with cholangitis due to benign and malinant bile duct obstruction. Methods: Bacterial culture was undertaken in the bile and blood specimens from eighty-three patients with acute cholangitis due to benign (n=58) or malignant (n=25) bile duct obstruction. Results: Bacteria were detected in 96.3% of bile and 80.0% of blood samples. We isolated 78 strains from 58 bile specimens and 54 strains from 51 blood samples of the patients with benign cholangitis. The major isolates were Escherichia coli and Klebsiella spp.. In the patients with malignant cholangitis, 35 strains and 26 strains were isolated from 25 bile specimens and 24 blood samples, respectively, and Pseudomonas aeruginosa and E. coli were prevalent. Two or more bacterial strains were isolated simultaneously in 19 (32.8%) of 58 benign bile duct obstruction and in 11 (44.0%) of 25 malignanct bile duct obstruction. Conclusions: Bacteria play a major role in the pathogenesis of acute cholangitis of malignancy as well as benign bile duct obstruction.

Establish for Manufacturing Process of Craft Beer using Indigenous Yeast

Nam jun Kim,Jeong Hwan Je,Bong-Hwan Chung,Heo Seong Il 한국식품영양과학회 2019 한국식품영양과학회 학술대회발표집 Vol.2019 No.10

Improved Time Intervals by Implementation of Computerized Physician Order Entry-Based Stroke Team Approach

Nam, Hyo Suk,Han, Sang Won,Ahn, Seong Hwan,Lee, Jong Yun,Choi, Hye-Yeon,Park, In Cheol,Heo, Ji Hoe S. Karger AG 2007 Cerebrovascular diseases Vol.23 No.4

<P><I>Background:</I> The need for rapid evaluation and treatment of acute stroke patients has been well documented. A computerized physician order entry (CPOE) system can improve communication and provide immediate access to information, which may be useful for an effective team approach program targeted to reduce in-hospital time delays. <I>Methods:</I> To reduce the time from a patient’s arrival at the emergency department to thrombolysis, a team approach program using CPOE was developed, and its efficacy was investigated by comparing time intervals from arrival to evaluation and intravenous tissue-type plasminogen activator (tPA) treatment before and after the implementation of the program. <I>Results:</I> Among 379 consecutive patients who were screened as potential candidates for thrombolysis, 25 patients (6.6%) received tPA during a 1-year period after initiation of the program. Fourteen patients were treated with tPA in the previous year. After program implementation, time from arrival to computed tomography scan was reduced from 34 to 19 min (p = 0.01). Time to report of complete blood count was also shortened from 52 to 33 min (p < 0.01). Finally, time from arrival to tPA treatment was reduced by 23 min (from 79 to 56 min; p < 0.01). Onset-to-door time tended to be longer after the program implementation (from 41 to 60 min; p = 0.14). <I>Conclusions:</I> Implementation of the CPOE-based team approach program significantly reduced time from emergency department arrival to evaluations and treatment.</P><P>Copyright © 2007 S. Karger AG, Basel</P>

만성 알코올성 췌장염이 의심되는 환자에서 내시경초음파의 진단적 가치

남승우,신기철,이재현,노임환,이만용,허재형,신현덕,장효식 대한소화기학회 2002 대한소화기학회지 Vol.39 No.2

Background/Aims: This study was to evaluate the usefulness of endoscopic ultrasonography (EUS) in diagnosing suspected chronic alcoholic pancreatitis. Methods: EUS was performed on 48 patients who underwent endoscopic retrograde pancreatography (ERP) for recurrent episodes of alcohol induced pancreatitis. According to the ERP findings, the patients were divided into two groups: the group I showing normal pancreatogram (n=18) and the group II showing abnormal dilatated pancreatogram of Cambridge classification II or higher (n=30). EUS evaluated parenchymal changes (inhomogeneity, interlobular septae, echogenic foci, pseudocyst) and ductal changes (dilatation, tortuosity, thickened wall, stone or calcification, and side branch ectasia). Results: Group I showed one or more abnormal parenchymal features were found in 17 patients (94.4%), two or more in 11 patients (61.1%), and three or more in 6 patients (33.3%). However, no abnormal ductal features were found in the Group I. In the group II, all patients had three or more abnormal EUS features. Conclusions: EUS shows definite parenchymal changes in patients suspected of having chronic alcoholic pancreatitis. Therefore, EUS can be an useful diagnostic tool in the early stage of chronic alcoholic pancreatitis.

A Computerized In-Hospital Alert System for Thrombolysis in Acute Stroke

Heo, Ji Hoe,Kim, Young Dae,Nam, Hyo Suk,Hong, Keun-sik,Ahn, Seong Hwan,Cho, Hyun Ji,Choi, Hye-Yeon,Han, Sang Won,Cha, Myoung-Jin,Hong, Ji Man,Kim, Gyeong-Moon,Kim, Gyu Sik,Kim, Hye Jin,Kim, Seo Hyun,K Ovid Technologies Wolters Kluwer -American Heart A 2010 Stroke Vol.41 No.9

<P>Background and Purpose-An effective stroke code system that can expedite rapid thrombolytic treatment requires effective notification/communication and an organized team approach. We developed a stroke code program based on the computerized physician order entry (CPOE) system and investigated whether implementation of this CPOE-based program is useful for reducing the time from arrival at emergency departments (ED) to evaluation steps and the initiation of thrombolytic treatment in various hospital settings. Methods-The CPOE-based program was implemented by 10 hospitals. Time intervals from arrival at the ED to blood tests, computed tomography scanning, and thrombolytic treatment during the 1-year period before and the 1-year period after the program implementation were compared. Results-Time intervals from ED arrival to evaluation steps were significantly reduced after implementation of the CPOE-based program. Times from ED arrival to CT scan, complete blood counts, and prothrombin time testing were reduced by 7.7 minutes, 5.6 minutes, and 26.8 minutes, respectively (P<0.001). The time from ED arrival to intravenous thrombolysis was reduced from 71.7 +/- 33.6 minutes to 56.6 +/- 26.9 minutes (P<0.001). The number of patients who were treated with thrombolysis increased from 3.4% (199/5798 patients) before the CPOE-based program to 5.8% (312/5405 patients) afterward (P<0.001). The CPOE implementation also improved the inverse relationship between onset-to-door time and door-to-needle time. Conclusions-The CPOE-based stroke code could be successfully implemented to reduce in-hospital time delay in thrombolytic therapy in various hospital settings. CPOE may be used as an efficient tool to facilitate in-hospital notification/communication and an organized team approach. (Stroke. 2010; 41:1978-1983.)</P>

Localized Surface Plasmon Resonance Chip for the detection of HbA1c

Nam Su HEO,Cheol Hwan KWAK,Gi-bum KIM,Yun Suk HUH 한국생물공학회 2015 한국생물공학회 학술대회 Vol.2015 No.4

CRISPR/Cas9 Nuclease-Mediated Gene Knock-In in Bovine-Induced Pluripotent Cells

Heo, Young Tae,Quan, Xiaoyuan,Xu, Yong Nan,Baek, Soonbong,Choi, Hwan,Kim, Nam-Hyung,Kim, Jongpil Mary Ann Liebert 2015 STEM CELLS AND DEVELOPMENT Vol.24 No.3