가자의 즉각형 알레르기 반응 억제 효과

엄용대,신민교,이영미,김형민,신태용,정종길,송호준 대한본초학회 2000 大韓本草學會誌 Vol.15 No.1

We investigated the effects of methanol extract of Fructus Chebula (MEFC) on local and systemic anaphylaxis. Passive cutaneous anaphylaxis inhibited to 61.42 12.8 % by oral administration of MEFC(I.0 glkg). MEFC inhibited compound 48/80-induced anaphylactic shock 100% with doses of 0.05-1.0 glkg . Administrations of MEFC (1.0 glkg) 60 min before, 5 min after, and 10 min after the compound 48/80 treatment were shown the mortality rates as 0%. MEFC (0.01-1.0 glkg) inhibited the histamine release significantly from the rat peritoneal mast cells by compound 48/80. These results indicate that MEFC inhibits mast cell mediated anaphylactic reactions by inhibition of mast cell degranulation in vivo and in vitro.

韓國産 가지과 植物에 관한 本草學的 硏究

정대기,변종호,신민교,송호준 대한본초학회 1998 大韓本草學會誌 Vol.13 No.1

For the purpose of developing Korean Herbalogy with the plants of Solanceae which grow wild and is planted in Korea, the these and writings on herbalogy, from literature of successive generations, have been throughly investigative and the results obtained were as follows: 1. There were totaled to 13 genera and 26 species in Korea and among them medicinal plants are 11 genera, 19 species, some 73% in total but, the number of species may be added because of the similiar plants. 2. According to the oriental names which can be used for medical purpose, the medicinal plants belonging to the Solanaceae family were classified as Radix 8, Fructus 8, Herba 6 ,Foilum 5, Semen 3, Lignum and Flos 2. 3. According to sum of 26 species in Solanaceae family, they were classified into Solanum genera 8, Physalis and Capsicum genera 3 each, Datura and Nicotiana genera 2 each. Thus it was noticed that Solanum genera was the main kind, some 30% in total. 4. According to the number of species of the origin plants about each chinese materia medicals, they were calssified into HERBA SOLANI LYRATI 3, FRUCTUS CAPSICI and FLOS DATURAE 2 each. 5. According to nature and flavour of medicinal plants, they were classified into cold, cool; 17 each,warmth,heat; 8 each, balance 5 and unidentified 6. Thus it was noticed that cold and cool is the main in nature and flavour of medicinal plants. 6. According to the Properties and Principal curative action, they were classified into Drugs for treating febrifugal and detoxicant 14, Drugs for relieving pain 7, Antitussives . Diuretics . Drugs for invigorating blood circulation. Tonics 4 each, Anthelmintics 3. 7. Comparing to whole medicinal plants 19 kinds, toxic drugs include minor toxin were 3 kinds, 16% of the whole. From this result, It was revealed that the plants for medical purpose in Solanaceae was 73% of the whole, in which RADIX and FRUCTUS were abundunt. It is considered that many experiments and clinical approaches must be continued to use Solanaceae plants widely.

韓國産 薔薇科 植物에 관한 本草學的 硏究 I

정종길,황상욱,송호준,신민교 한국전통의학연구소 2004 한국전통의학지 Vol.14 No.1

For the purpose of developing Korean Herbalogy with the plants of Rosaceae which grow wild and is planted in Korea, the these and writings on herbalogy, from literature of successive generations, have been thoroughly investigated and the results obtained as follows: 1. There were totaled to 36 genera and 262 in Korea and among them medicinal plants are 27 genera, 117species, some 44% in total, but the number of species may be added because of the similiar plants. 2. According to sum of 262 species in Rosaceae family, they were classified into Agrimonia genera 3, Potentilla genera 26, Prunus genera 48,pyrus genera 17, Rosa genera 24, Rubus genera 28, Sorbaria genera 17, Spiraea genera 20. Thus it was noticed that Prunus genera was the main kind in total. 3. According to the oriental names which can be used for medical purpose, the medicinal plants belonging to the Rosaceae family were classified as Herba 24, Radix 43, Foilum 31, Fructus 48, Semen 11, cortex 14, Lignum, Ramulus;12 each Flos 3, pericarpium 3, resina 2, the others 6. so Fructus is 24% of all and it is the most applied in the clinical treatments. 4. According to nature and flavour of medicinal plants, they were classified into balance 84, warmth, heat; 44 each, cold, cool; 35 each bitter taste 79, sweet taste 74, sour taste 61 thus it was noticed that balance and bitter taste is the main in nature and flavour of medicinal plants 5. According to meridian tropism of herbs they were classified into liver meridian 50 lung meridian 28, stomach meridian 22, spleen meridian 20, heart meridian 19 thus it was noticed that liver meridian is the main kind 6. According to the Properties and Principal curative action, they were classified into drugs for treating detoxicant 72, drugs for treating febrifugal 55, drugs for invigorating blood circulation 53, drugs for removing dampness 46, drugs for expelling wind and drugs to stop bleeding 38 each, drugs to cure tramatic swelling and drugs for relieving pain 36 each. Thus it was noticed that drugs for treating detoxicant and febrifugal was the main kind 7. It was researched that toxic drugs include minor toxin were 10 kinds From this result, it was revealed that Fructus was the main kind in the plants for medical purpose of Rosaceae. and toxic plants was slightly poisonous that it will be used for clinical treatments more easily. It is considered that many experiments and clinical approaches must be continued to use Rosaceae plants widely.

다당류 생산 균주의 분리 및 탐색

김교창,조재민,정준영 충북대학교 농업과학기술연구소 1996 農業科學硏究 Vol.13 No.-

For the screening of new functional and speecific exopolysaccharide, a microoragnisms were isolated from soil. Two microorganisms were finally selected as potential producer of crude polysaccharide which made very viscous and large size of colony on the selected plate. Isolated strains were identified as Bacillus spp. from the results of morphological and biochemical characteristics. The results of determination of produced crude polysaccharide according to the glucose concentration, P-1 and P-2 strains were produced 6.66, 9.85g/L at 4.0% glucose concentration, respectively, From the color reaction of the produced crude polysaccharides, the crude polysaccharides, produced by P-1 strain, was Fehiling reaction positive, Modish reaction positive, Molish rone reaction, Ninhydrin reaction negative and the other crude polysaccharides, produced by P-2 strain, was Fehiling reaction negative and Modish, Ninhydrin, Anthrone reaction positive.

Glucose Oxidase가 척수지각신경절세포에 미치는 영향과 천마의 효과에 관한 연구

송호준,이용석,손영우,이강창,정종길,신민교,홍기연 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : To clarify the cytotoxic effect of glucose oxidase(GO) and protective effect of gastrodiae Rhizoma (GR) on spinal sensory ganglion(DRG) neurons, neurotoxicity mediated by GO was measured by MTT assay and neurofilament enzymeimmuno assay(EIA). Methods : DRG neurons were cultured in the media containing various concentrations of GO for 3 hours. In addition, neuroprotective effects of GR, on GO-induced neurotoxicity in DRG neurons were examined after DRG neurons were preincubated with various concentrations of GR for 2 hours before 15mU/ml GO for 3 hours. Results : GO decreased remarkably cell viability in dependently in these cultures, and also RG increased cell viability and amount of neurofilament in DRG neurons damaged by GO. Conclusion : It is suggested that GO has toxic effect in cultured mouse DRG neurons, and also RG was effective in the protection of GO-induced neurotoxicity in these cultures.

깊은 근이완의 회복을 위한 Anticholinesterases 의 사전예비정주법

김교상,전정우,이명의,한정욱,민용진,전민선,나도준 대한마취과학회 1994 Korean Journal of Anesthesiology Vol.27 No.12

The success of accelerating the onset of neuromvacular blocking drugs by giving them in divided doses encouraged others to attempt the same $quot;priming principle$quot; using reversal agents. Naguib et al and Abdulatif et al demonstrated that the reversal time(time to reach a TOF of 0.75) was reduced when the reversal agent was administered in divided doses at T, 10% of control. But Donati et al and Szalados et al either could not detect any differences in the rate of reversal when anticholinestereses were administered in divided doses. This study hes been conducted to evaluate the reversal effects of neostigmine or pyridostigmine with priming principle in the rabbit after pancuronium injection when pro- found relaxation(PTC=0) was confirmed. Rabbits(n=60) were randomly allocated to 4 groups. After pancuranium 0.2mg/kg IV, the onset and recovery times were evalusted. When the profound relaxation(PTC=0) was confirmed at Smin. after pancuronium injection, neostigmine 50 ㎍/kg and atropine sulfate (atropine) 20 ㎍/kg we injected in group 1. At thst time, neostigmine 10/kg and atropine 4 ㎍/kg were injected and after 3min. neostigmine 40㎍/kg and atropine 16 ㎍/kg were injected in group 2. At that time, pyridostigmine 250 ㎍/kg and atropine 20 ㎍/kg were injected in group 3. At that time, pyridostigmine 50 ㎍/kg and atropine 4 ㎍/kg were injected and after 3min. pyridostigmine 200 ㎍/kg and atropine 16 ㎍/kg were injected in group 4. The results were as follows : 1) The time until 75% recovery of twitch amplitude was 53.1±12.4min. in group 1, 44.9±212.1min. in group 2, 54.9±9.7min. in group 3 and 48.2±7.1min. in group 4. The reversal times were tended to reduce when the reversal agents were administered with $quot;priming principle$quot; at the profound relaxation. 2) At the profound relaxation the reversal effects of neostigmine were greater than that of pyridostigmine.

Cellular prion protein regulates the differentiation and function of adipocytes through autophagy flux

Jeong, Jae-Kyo,Lee, Ju-Hee,Kim, Sung-Wook,Hong, Jeong-Min,Seol, Jae-Won,Park, Sang-Youel Elsevier 2019 Molecular and cellular endocrinology Vol.481 No.-

<P><B>Abstract</B></P> <P>The role of autophagy modulation in adipogenic differentiation and the possible autophagy modulators targeting adipogenesis remain unclear. In this study, we investigated whether normal cellular prion protein (PrP<C>) is involved in the modulation of autophagy and affects adipogenic differentiation in vivo and in vitro. Surprisingly, autophagy flux signals were activated in the adipose tissue of prion protein-deficient mice and PrP<C>-deleted 3T3-L1 adipocytes. The activation of autophagy flux mediated by PrP<C> deletion was confirmed in the adipose tissue via transmission electron microscopy. Adipocyte differentiation factors were highly induced in prion protein-deficient adipose tissue and 3T3-L1 adipocytes. In addition, deletion of prion protein significantly increased visceral fat volume, body fat weight, adipocyte cell size, and body weight gain in <I>Prnp</I>-knockout mice and increased lipid accumulation in PrP<C> siRNA-transfected 3T3-L1 cells. However, the overexpression of prion protein using adenovirus inhibited the autophagic flux signals, lipid accumulation, and the PPAR-γ and C/EBP-α mRNA and protein expression levels in comparison to those in the control cells. Our results demonstrated that deletion of normal prion protein accelerated adipogenic differentiation and lipid accumulation mediated via autophagy flux activation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Autophagy flux was activated in adipose tissue of prion protein-deficient mice. </LI> <LI> Adipogenic factors were highly induced in prion protein-deficient adipose tissue. </LI> <LI> Prion protein overexpression inhibited the autophagy-mediated lipid accumulation. </LI> <LI> Prion protein regulates adipogenic differentiation via autophagy flux signals. </LI> </UL> </P>

Discontinuous PWM Scheme for Switching Losses Reduction in Modular Multilevel Converters

Min-Gyo Jeong,Seok-Min Kim,June-Seok Lee,Kyo-Beum Lee 전력전자학회 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.6

The modular multilevel converter (MMC) is generally considered to be a promising topology for medium-voltage and high-voltage applications. However, in order to apply it to high-power applications, a huge number of switching devices is essential. The numerous switching devices lead to considerable switching losses, high cost and a larger heat sink for each of the switching device. In order to reduce the switching losses of a MMC, this paper analyzes the performance of the conventional discontinuous pulse-width modulation (DPWM) method and its efficiency. In addition, it proposes a modified novel DPWM method for advanced switching losses reduction. The novel DPWM scheme includes an additional rotation method for voltage-balancing and power distribution among sub modules (SMs). Simulation and experimental results verify the effectiveness and performance of the proposed modulation method in terms of its switching losses reduction capability.

High refractive index organic/inorganic hybrid films prepared by carbazole phenoxy based copolymers and titanium alkoxide

Jeong, Min Kyo,Choi, Won Tae,Ahn, Byung-Hyun,Gal, Yeong-Soon,Lim, Kwon Taek Taylor & Francis Inc. 2019 Molecular Crystals and Liquid Crystals Vol.686 No.1

Discontinuous PWM Scheme for Switching Losses Reduction in Modular Multilevel Converters

Jeong, Min-Gyo,Kim, Seok-Min,Lee, June-Seok,Lee, Kyo-Beum The Korean Institute of Power Electronics 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.6

The modular multilevel converter (MMC) is generally considered to be a promising topology for medium-voltage and high-voltage applications. However, in order to apply it to high-power applications, a huge number of switching devices is essential. The numerous switching devices lead to considerable switching losses, high cost and a larger heat sink for each of the switching device. In order to reduce the switching losses of a MMC, this paper analyzes the performance of the conventional discontinuous pulse-width modulation (DPWM) method and its efficiency. In addition, it proposes a modified novel DPWM method for advanced switching losses reduction. The novel DPWM scheme includes an additional rotation method for voltage-balancing and power distribution among sub modules (SMs). Simulation and experimental results verify the effectiveness and performance of the proposed modulation method in terms of its switching losses reduction capability.