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강연심,고정군,진국림,오순자,고석찬 제주대학교 생명과학연구소 1999 제주생명과학연구 Vol.2 No.-
The characteristics of chlorophyll fluorescence were studied in the leaves of Sargent juniper (Juniperus chinensis var. sargentii) and crowberry (Empetrum nigrum var. japonicum) under natural field conditions. The photochemical efficiency of photosystemⅡ(PSⅡ), Fv/Fm, was slightly lower in the leaves of Sargent juniper than in those of crowberry, and the non-photochemical fluorescence quenching (NPQ) was higher in the leaves of Sargent juniper. In both species, the Fv/Fm values decreased temporarily at midday. This midday photoinhibition was more severe in Sargent juniper than in crowberry. Between Fv/Fm and environmental factors, there was no significant relationship with any factor in Sargent juniper leaves, while there were significant relationships with all factors in crowberry leaves. These results suggest that Sargent juniper has the mechanism for protecting or avoiding the photodamage although it is more sensitive to environmental changes than crowberry.
양파(Allium cepa L.) 추출물이 Tyrosinase 유전자 발현에 미치는 효과
조남철,윤연희,이혜진,손현정,김양경,최근희,나명석,조영권,이황희,진종언 한국식품영양학회 2001 韓國食品營養學會誌 Vol.14 No.3
Melanin 생성에 관여하는 tyrosinase 유전자의 발현을 억제하는 물질을 탐색하고자 tyrosinase promoter를 지닌 Bl6 mouse melanoma cell해 앙파 methanol 추출물을 처리한 바 양파 methanol 추풀물은 10.0㎍/ml, 100.0 ㎍/ml, 1.0 ㎎/ml의 농도에서 대조군에 비해서 약 15%, 23% 57%의 억제효과를 나타냈으며 세포생존율은 1.0 ㎍/ml, 10.0 ㎍/ml, I00.0 ㎍/ml, 1.0㎎/ml의 농도에서 약 126 %, 92%. 85%, 64%로서 세포독성이 낮게 나타났다. Ethyl acetate, butyl alcohol, 그리고 물 용매 분획물은 tyrosinase 유전자의 발현물 억제하는 효과가 없었지만 methylene chloride 용해 분획물은 10.0 ㎍/ml과 100.0 ㎍/ml의 농도에서 약 37%와 35%의 발현율을 나타냄으로서 대조군에 비해 크게 억제하였다. Onion(Allium cepa L,) extract by methanol repressed the expression of tyrosinase gene of B16 mouse melanoma cell containing tyrosinase promoter. 10.0 ㎍/ml, 100.0 ㎍/ml, 1.0 ㎎/ml of the extract repressed expression of tyrosinase gene about 15%, 23%, and 57%, respectively, compared with control. In the MTT assay, the same extract exhibited low cytotoxicity at 1.0 ㎍/ml, 10.0 ㎍/ml, 100.0 ㎍/ml, and 1.0 ㎎/ml, respectively. The fractions of ethyl acetate, butyl alcohol, and water did not showed the repressive effect on the expression of tyrosinase gene, but the fraction of methylene chloride repressed highly at 10.0 ㎍/ml and 100.0 ㎍/ml.
Strategies for Management of the Early Chronic Obstructive Lung Disease
( Jung Yeon Lee ),( Chin Kook Rhee ),( Ki Suck Jung ),( Kwang Ha Yoo ) 대한결핵 및 호흡기학회 2016 Tuberculosis and Respiratory Diseases Vol.79 No.3
Lung function reportedly declines with age and that this decline is accelerated during disease progression. However, a recent study showed that the decline might peak in the mild and moderate stage. The prognosis of chronic obstructive pulmonary disease (COPD) can be improved if the disease is diagnosed in its early stages, prior to the peak of decline in lung function. This article reviews recent studies on early COPD and the possibility of applying the U.S. Preventive Services Task Force recommendation 2008 and 2015 for early detection of COPD in Korea.
Extensive primary cardiac lymphoma diagnosed by percutaneous endomyocardial biopsy.
Chin, Jung Yeon,Chung, Mi Hyang,Kim, Jin Jin,Lee, Jae Hak,Kim, Ji Hyun,Maeng, Il Ho,Jung, Soo-Yeon,Hwang, Hui Jeong,Lee, Jea Beom,Youn, Ho-Joong Korean Society of Echocardiography 2009 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.17 No.4
<P>Primary cardiac lymphoma (PCL) is an extranodal non-Hodgkin's lymphoma exclusively located in the heart and/or pericardium. It is rare in immunocompetent patients and represents 1.3% of primary cardiac tumors and 0.5% of extranodal lymphomas. The clinical behavior is aggressive and the early symptoms are cardiac failure, syncope, arrhythmia, or pericardial effusion. Although echocardiography, computed tomography (CT) scan, magnetic resonance image (MRI) are the mainly used imaging techniques to detect cardiac tumors, pathologic examination is always required to confirm the diagnosis. Diagnosis of PCL is difficult due to non-specific clinical manifestations and requires invasive approach to get histopathologic evidence. While surgery with systemic chemotherapy or in combination with irradiation has been attempted, the only effective treatment is chemotherapy. However, the prognosis remains poor. We report on a 42-year-old woman who is diagnosed histopathologically as PCL by cardiac catheterization assisted percutaneous endomyocardial biopsy and treated successfully by anthracycline based chemotherapy.</P>
( Jung Yeon Chin ),( Ki-woon Kang ),( Kyung Min Moon ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.2
Background/Aims: Scrub typhus is known as a self-limited infectious disease. Cardiac complication is uncommon and usually not life-threatening. Until now, few cases of fulminant myocarditis by scrub typhus have been reported. So, we investigated incidence and predictors of acute myocarditis in severe scrub typhus. Methods: We retrospectively reviewed 89 patients among 91 scrub typhus confirmed patients who examined an echocardiogram and cardiac biomarkers from 2005 to 2015 in the intensive care unit at our hospital. We excluded two patients who didn’t have electrocardiography. Patients were divided into two groups and compared between scrub typhus with (n = 13) and without (n = 76) acute myocarditis. Results: Age, sex, and underlying diseases were similar between the groups. The existence of eschar and duration of general ache and fever were similar between the groups. However, patients with acute myocarditis had more elevated total bilirubin, high incidence of ST elevations and paroxysmal atrial fibrillation (PAF) than those without acute myocarditis. Receiver operating characteristic analysis showed that the PAF was a predictor of myocarditis with a sensitivity of 70% and specificity of 84%. Predictive power of combination of ST-segment elevation and PAF was significantly associated with myocarditis in the multivariate analysis (odds ratio, 1.57; 95% confidence interval [CI], 1.21 to 11.7; p = 0.041) and area under the curve was 0.947 (95% CI, 0.878 to 0.983; p < 0.001). Conclusions: Acute myocarditis with scrub typhus may be more common than previously reported. Patients with high bilirubin and PAF are at increased risk of acute myocarditis with scrub typhus. These patients warrant closer follow-up and echocardiogram would be needed.
Strategies for Management of the Early Chronic Obstructive Lung Disease
Lee, Jung Yeon,Rhee, Chin Kook,Jung, Ki Suck,Yoo, Kwang Ha The Korean Academy of Tuberculosis and Respiratory 2016 Tuberculosis and Respiratory Diseases Vol.79 No.3
Lung function reportedly declines with age and that this decline is accelerated during disease progression. However, a recent study showed that the decline might peak in the mild and moderate stage. The prognosis of chronic obstructive pulmonary disease (COPD) can be improved if the disease is diagnosed in its early stages, prior to the peak of decline in lung function. This article reviews recent studies on early COPD and the possibility of applying the U.S. Preventive Services Task Force recommendation 2008 and 2015 for early detection of COPD in Korea.
Case Reports : A Case of Pulmonary Capillary Hemangiomatosis-Like Lesion Followed for Seven Years
( Chin Kook Rhee ),( Nam Yeol Yim ),( So Yeon Shim ),( Hui Jung Kim ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.3
Pulmonary capillary hemangiomatosis (PCH) is a rare disease of unknown etiology that is characterized by nodules composed of infiltrating capillary blood vessels. Herein, we describe a case of a PCH-like lesion that was detected by chest computed tomography. Transthoracic needle aspiration resulted in life-threatening hemorrhage. The patient was followed for seven years. He remained in good health and a follow up image showed little interval change.
Jung, Ki-Young,Cho, Jae-Wook,Joo, Eun Yeon,Kim, Sun Hwa,Choi, Kyung Mook,Chin, Juhee,Park, Kun-Woo,Hong, Seung Bong Elsevier 2010 CLINICAL NEUROPHYSIOLOGY - Vol.121 No.9
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy.</P> <P><B>Methods</B></P> <P>Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA).</P> <P><B>Results</B></P> <P>Neuropsychological tests (<I>n= </I>18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (<I>n= </I>13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions.</P> <P><B>Conclusions</B></P> <P>Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects.</P> <P><B>Significance</B></P> <P>Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.</P>
증례 : 내분비-대사 ; 카테콜아민치가 정상인 발작성 갈색세포종 1예
유정래 ( Jung Re Yu ),진현정 ( Hyoun Jung Chin ),김미연 ( Mi Yeon Kim ),정우성 ( Woo Seong Jeong ),이상아 ( Sang Ah Lee ),이대호 ( Dae Ho Lee ),고관표 ( Gwan Pyo Koh ) 대한내과학회 2012 대한내과학회지 Vol.83 No.4
A 53-year-old woman had a 1.7 cm left adrenal mass on an abdominal computed tomography (CT) scan. She presented with paroxysmal headache, palpitation, sweating, and hypertension. The patient was highly suspected of having a pheochromocytoma, but measurements of 24-hour urinary metanephrine, catecholamines, and vanillylmandelic acid were normal. Plasma and urine catecholamine levels were within the normal range even during paroxysmal episodes. A scintigraphic study with 131I-metaiodobenzylguanidine (MIBG) revealed selective concentration of the radiotracer, corresponding to the CT mass. The patient underwent a left adrenalectomy and the pathological examination confirmed the diagnosis of pheochromocytoma. In this report, we describe a rare case of a symptomatic pheochromocytoma with normal catecholamine levels. Our case illustrates that routine nuclear scintigraphy, such as 131I-MIBG, should be performed even in cases with normal hormonal testing for all patients with high clinical suspicion of pheochromocytoma. (Korean J Med 2012;83:503-509)
( Hyo Jung Son ),( Hwa Mi Lee ),( Ji Hyun Chin ),( Dae Kee Choi ),( Eun Ho Lee ),( Ji Yeon Sim ),( In Cheol Choi ) 대한마취과학회 2011 Korean Journal of Anesthesiology Vol.60 No.2
Conventional aortic valve replacement for severe aortic stenosis is associated with a high operative mortality in the elderly patients with significant comorbidities, including severe respiratory dysfunction, renal insufficiency, and compromised cardiac function. Human transcatheter aortic valve implantation was first reported in 2002 and has become a valid alternative in selected high-risk patients in Europe and North America. This article describes the first attempt of transfemoral transcatheter aortic valve implantation in Korea. The procedure was applied in two consecutive patients with severe aortic stenosis. Despite several intra-operative complications during procedure, the post-operative outcomes were good for both patients. At post-operative 30 days there was satisfactory prosthetic valve function and hemodynamic stability. (Korean J Anesthesiol 2011; 60: 128-133)