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Vaclav Vetvicka,Aruna Vashishta,Marta Fuentes,Roberto Baigorri,Jose M. Garcia-Mina,Jean-Claude Yvin 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.7
Despite the rather common presence of humic acid (HA), our full knowledge of its biological effect is still lacking. In this article, we first performed a physicochemical characterization of several HAs, and next, we evaluated their ability to affect interleukin-2 secretion, antibody secretion, wound healing (an in vitro model using HaCaT cells), cancer growth (the Lewis lung carcinoma model), and protection against hepatotoxicity. In all tested reactions, HA showed significant stimulation on immune reactions, including suppression of cancer growth and inhibition of lipopolysaccharideinduced hepatotoxicity. These effects were dependent on its chemical properties. The pleiotropic effects of HA observed in this article suggest the possible role of these compounds in human nutrition.
( Judith Alvarez Otero ),( Lucia Gonzalez Gonzalez ),( Jose Luis Lamas Ferreiro ),( Alexandra Arca Blanco ),( Jose Ramon Bermudez Sanjurjo ),( Maria Rodriguez Conde ),( Javier De La Fuente Aguado ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The aim of this study was to analyze the prevalence of carbapenem resistant Pseudomonas aeruginosa (CRPA) in urine cultures in our hospital. Moreover, we determined the mortality and risk factors associated to CRPA infection. Methods: Positive urine cultures to Pseudomonas aeruginosa between september 2012 and september 2013 were identified. We excluded repititive cultures from the same patient and episode. We created a database with demographic, clinical and laboratory items, including previous antibiotic therapy and antimicrobial resistance. Results: Forty-three cases with positive urine cultures to Pseudomonas aeruginosa were included. CRPA was observed in 12cases, with a prevalence of 27.9%. Sixty per cent were male with a median age of 73 years (range: 17-102). Sixty-seven per cent of patients were hospitalized when the culture was collected, but only 30% met criteria to nosocomial infection. Twenty-one percent of urine cultures corresponded to asymptomatic bacteriuria and 25% presented with sepsis. Mortality at 30 days was 20.7% in CRPA patients and 13.8% in the other group, without estatistical significance. Obesity (p =0.003), previous treatment with ciprofloxacin (p = 0.004) and quinolones in general (p = 0.001) and previous treatment with more than one antibiotic (p = 0.03) or with more than one family of antibiotics (p = 0.01) were risk factors to CRPA infection in the univariate analysis. Only obesity (p = 0.04) and previous treatment with ciprofloxacin (p = 0.02) showed statistically significant differences in the multivariate analysis, Conclusions: There is a high prevalence of CRPA in urine cultures in our population, wich is a potencial threat. We should assess the presence of risk factors for development of infections by such pathogen, as previous treatment with quinolones or obesity, in order to start appropiate empirical treatment in patients with severe urinary tract infections.
( Cecilia Perez-cruz ),( Carlos N. Cano-gonzalez ),( Jose Fuentes ),( Nagamani Balagurusamy ),( Carolina E. Vita ),( Roque A. Hours ),( Cristobal N. Aguilar ),( Sebastian F. Cavalitto ),( Juan C. Cont 한국키틴키토산학회 2018 한국키틴키토산학회지 Vol.23 No.3
Aspergillus niger biomass, an industrial by-product of citric acid fermentation is an emergent source of glycoderivatives with applications in biofuel, cosmetics, feed, energy, food, medicine, and nanotechnology. In this study, the effect of purified neutral protease for deprotenization of fungal biomass studied at various levels (0, 5, 10, 20 and 40 U/100 mg of biomass) and the saccharification of fungal biomass was evaluated with amylolytic enzymes and chitosanases. The efficiency of deproteinization of fungal biomass was based on the enzyme concentration and contact time. Protease at a concentration of 20 U/100 mg of dry biomass and with a contact time of 8 h achieved 30% final deproteinization. No effect on saccharification of A. niger biomass was observed by treatment with purified amylolytic enzymes. Meanwhile, the endo- and exo-chitosanases treatment yielded 54 g of g reducing sugars (equivalent to amino sugars)/ kg of fungal biomass, which can be employed for tailor-made carbohydrate production.
Factors Affecting the Vineyard Populational Diversity of Plasmopara viticola
Boso, Susana,Gago, Pilar,Santiago, Jose-Luis,de la Fuente, Maria,Martinez, Maria-Carmen The Korean Society of Plant Pathology 2019 Plant Pathology Journal Vol.35 No.2
Vitis vinifera is very susceptible to downy mildew (Plasmopara viticola). A number of authors have suggested different genetic populations of this fungus exist in Europe, each showing a different degree of virulence. Work performed to date indicates this diversity to be the result of different factors. In areas where gene flow is greater and recombination more frequent, the diversity of P. viticola appears to be wider. In vineyards isolated by geographic barriers, a race may become dominant and produce clonal epidemics driven by asexual reproduction. The aim of the present work was to identify the conditions that influence the genetic diversity of P. viticola populations in the vineyards of northwestern Spain, where the climatic conditions for the growth of this fungus are very good. Vineyards situated in a closed, narrow valley of the interior, in more open valleys, and on the coast were sampled and the populations of P. viticola detected were differentiated at the molecular level through the examination of microsatellite markers. The populations of P. viticola represented in primary and secondary infections were investigated in the same way. The concentration of airborne sporangia in the vegetative cycle was also examined, as was the virulence of the different P. viticola populations detected. The epidemiological characteristics of the fungus differed depending on the degree of isolation of the vineyard, the airborne spore concentration, and on whether the attack was primary or secondary. Strong isolation was associated with the appearance of dominant fungal races and, therefore, reduced populational diversity.
Oxidative stress is associated with the number of components of metabolic syndrome: LIPGENE study
Elena Maria Yubero-Serrano,Javier Delgado-Lista,Patricia Pena-Orihuela,Pablo Perez-Martine,Francisco Fuentes,Carmen Marin,Isaac Tunez,Francisco Jose Tinahones,Francisco Perez-Jimenez,Helen M Roche,Jos 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.6
Previous evidence supports the important role that oxidative stress (OxS) plays in metabolic syndrome (MetS)-related manifestations. We determined the relationship between the number of MetS components and the degree of OxS in MetS patients. In this comparative cross-sectional study from the LIPGENE cohort, a total of 91 MetS patients (43 men and 48women; aged between 45 and 68 years) were divided into four groups based on the number of MetS components: subjects with 2, 3, 4 and 5 MetS components (n¼20, 31, 28 and 12, respectively). We measured ischemic reactive hyperemia (IRH),plasma levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), total nitrite, lipid peroxidation products (LPO), hydrogen peroxide (H2O2), superoxide dismutase (SOD) and glutathione peroxidase (GPx) plasma activities. sVCAM-1, H2O2 and LPO levels were lower in subjects with 2 or 3 MetS components than subjects with 4 or 5 MetS components. IRH and total nitrite levels were higher in subjects with 2 or 3 MetS components than subjects with 4 or 5 MetS components. SOD and GPx activities were lower in subjects with 2 MetS components than subjects with 4 or 5 MetS components. Waist circumference,weight, age, homeostatic model assessment-b, triglycerides (TGs), high-density lipoprotein and sVCAM-1 levels were significantly correlated with SOD activity. MetS subjects with more MetS components may have a higher OxS level. Furthermore, association between SOD activity and MetS components may indicate that this variable could be the most relevant OxS biomarker in patients suffering from MetS and could be used as a predictive tool to determine the degree of the underlying OxS in MetS.