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Shin, Woosung,Yoon, Jeongyeon,Oh, Goo Taeg,Ryoo, Sungwoo The Korean Society of Ginseng 2013 Journal of Ginseng Research Vol.37 No.1
Korean red ginseng water extract (KG-WE) has known beneficial effects on the cardiovascular system via inducting nitric oxide (NO) production in endothelium. Endothelial arginase inhibits the activity of endothelial nitric oxide synthase (eNOS) by substrate depletion, thereby reducing NO bioavailability and contributing to vascular diseases including hypertension, aging, and atherosclerosis. In the present study, we demonstrate that KG-WE inhibits arginase activity and negatively regulates NO production and reactive oxygen species generation in endothelium. This is associated with increased dimerization of eNOS without affecting the protein expression levels of either arginase or eNOS. In a vascular tension assay, when aortas isolated from wild type mice were incubated with KG-WE, NO-dependent enhanced vasorelaxation was observed. Furthermore, KG-WE administered via by drinking water to atherogenic model mice being fed high cholesterol diet improved impaired vascular function. Taken together, these results suggest that KG-WE may exert vasoprotective effects through augmentation of NO signaling by inhibiting arginase. Therefore, KG-WE may be useful in the treatment of vascular diseases derived from endothelial dysfunction, such as atherosclerosis.
Double‑stranded RNA confers resistance to pepper mottle virus in Nicotiana benthamiana
Yoon Jeongyeon,Fang Miao,Lee Dowhan,Park Minsu,Kim Kook-Hyung,Shin Chanseok 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.1
RNA interference (RNAi) is a regulatory mechanism of gene expression mediated by small RNAs. By using the RNAi technique, exogenous double-stranded RNA (dsRNA) designed to target mRNA, suppresses target gene expression levels in plants. In this study, we adopted the RNAi mechanism as a tool to protect plants from viruses. We designed and synthesized several dsRNAs targeting the pepper mottle virus (PepMoV) genes HC-Pro and NIb. When used on Nicotiana benthamiana plants, these dsRNAs protected the plant against viral infection over a specific period. By optimizing dsRNA and virus injection time, the protection efficiency of dsRNA by targeting virus genes could be maximized. It seems that exogenous dsRNA-derived RNA-induced silencing complex was able to defend the host against viral infection instantly. Furthermore, each dsRNA designed to target different regions within a transcript had varying levels of effects on virus survival in the host plants. When targeting the middle part of both the NIb and HC-Pro genes using the dsRNAs, the highest viral growth inhibitory effect was observed. An RLM-5′ RACE was performed using plant leaves infected with PepMoV after dsRNA treatment and it was observed that most of the mRNA cleavages occurred close to the 3′ part within the dsRNA target position on the mRNA. These results suggest that the dsRNA tool can be used as a plant vaccine platform for crop protection.
신체 부위 별 각도 변화 패턴 분석을 통한 걸음걸이 인식 방법
김정연(Jeongyeon Kim),조근호(Geunho Cho),신동민(Dongmin Shin),허선(Sun Hur) 대한산업공학회 2014 대한산업공학회 추계학술대회논문집 Vol.2014 No.11
최근 생체 인식 기술의 하나로, 걸음걸이 인식에 대한 관심이 크게 증가하고 있다. 걸음걸이 인식은 기존의 생체인식 기술이 가진 한계점인 외적 요소에 의한 데이터 변화, 데이터 추출의 어려움을 보완하고, 원거리 영상을 이용한 인식이 가능하다는 장점이 있다. 기존에 제안된 걸음걸이 인식 기법은 각 개인의 모션정보, 걸음걸이 영상의 광류(optical flow), 다리의 각도, 키와 보폭 등을 분석하여 인식에 사용하는 모델 기반 방법과 걸음걸이 실루엣 영상 전체를 사용하여 하나의 패턴으로 사용하는 비모델 기반 방법으로 크게 구분될 수 있다. 본 연구에서는 사람의 신체 부위별 관절의 각도변화 패턴을 통한 걸음걸이 인식 방법을 제안한다. 사람들이 걷는 방향의 측면에서 관절 별 각도변화 데이터를 추출하고, 추출한 데이터를 RNN(recurrent neural network)기법으로 분석하여 개개인을 구별한다. 본 연구에서 제시한 방법은 재난상황, 방범, 의료 등 다양한 분야에 적용될 수 있을 것으로 기대된다.
나정연(JeongYeon Na),권민지(Minji Kwon),김두영(DooYoung Kim),박영화(YoungHwa Park),서정은(JungEun Seo),신민철(MinCheol Shin),김희지(HeeJi Kim),김화일(HwaIl Kim),류향우(Hyangwoo Ryu),조만수(ManSu Cho) 한국환경보건학회 2017 한국환경보건학회지 Vol.43 No.5
Objectives: The rate at which the nationwide highway is outsourcing the duties of toll gate cashiers to the public is increasing. The aim of this study is to conduct research on job stress for the rate at which the fares are collected by national highway toll gate cashiers. Methods: The population selected was a statistically significant group making up 10% of the total number of people surveyed in 2015, with a population of approximately 5,495 persons. The sample size is intended to cover the maximum sample size of 550 samples and the maximum number of samples that should be obtained. After allocating the number of samples by quota allocation, the qualitative function of Quality Function Deployment (QFD) was applied by random sampling. Results: Job stress ranked at 46.6 ± 11.5 points was found to be under the stress of 50% reported in other occupations. Job stress items showed higher for “job instability” compared to other types of tasks. Also, it appeared lower in “conflict in relationships.” This is a result of the work characteristics of highway service operators. Conclusions: Time was found to have the highest influence on the workload (β = 0.80, p. 0.001), which calls for a reduction in time and workload. est influence on the workload (β = 0.80, p. 0.001), which requires a reduction in time and workload.
Woosung Shin,Jeongyeon Yoon,Goo Taeg Oh,Sungwoo Ryoo 고려인삼학회 2013 Journal of Ginseng Research Vol.37 No.1
Korean red ginseng water extract (KG-WE) has known beneficial effects on the cardiovascular system via inducting nitric oxide (NO) production in endothelium. Endothelial arginase inhibits the activity of endothelial nitric oxide synthase (eNOS) by substrate depletion, thereby reducing NO bioavailability and contributing to vascular diseases including hypertension, aging, and atherosclerosis. In the present study, we demonstrate that KG-WE inhibits arginase activity and negatively regulates NO production and reactive oxygen species generation in endothelium. This is associated with increased dimerization of eNOS without affecting the protein expression levels of either arginase or eNOS. In a vascular tension assay, when aortas isolated from wild type mice were incubated with KG-WE, NO-dependent enhanced vasorelaxation was observed. Furthermore, KG-WE administered via by drinking water to atherogenic model mice being fed high cholesterol diet improved impaired vascular function. Taken together, these results suggest that KG-WE may exert vasoprotective effects through augmentation of NO signaling by inhibiting arginase. Therefore, KG-WE may be useful in the treatment of vascular diseases derived from endothelial dysfunction, such as atherosclerosis.