Reduction of allergenicity of irradiated ovalbumin in ovalbumin-allergic mice

Seo, Ji-Hyun,Lee, Ju-Woon,Kim, Jae-Hun,Byun, Eui-Baek,Lee, Soo-Young,Kang, Il-Jun,Byun, Myung-Woo Elsevier 2007 Radiation physics and chemistry Vol.76 No.11

<P><B>Abstract</B></P><P>Egg allergy is one of the most serious of the immediate hypersensitivity reactions to foods. Such an allergic disorder is mediated by IgE antibodies stimulated by T-helper type 2 (Th2) lymphocytes. This study was undertaken to evaluate changes of allergenicity and cytokine profiles by exposure of irradiated ovalbumin (OVA), a major allergen of egg white, in the OVA-allergic mice model. OVA solutions (2mg/ml in 0.01M phosphate buffered saline (PBS) were gamma-irradiated to 50 and 100kGy. The allergenicity in the OVA-allergy-induced mice model was remarkably reduced when challenged with irradiated OVA. Cultures of spleen cells harvested from OVA-sensitized mice showed a significant decrease in Th2 cytokine levels of ILs-4 and -5 with a concomitant increase in Th1 cytokine levels of IL-12 when co-cultured with irradiated OVA. However, IFN-<I>γ</I> level decreased dependant on the radiation dose of co-cultured OVA. The levels of IgEs and Th2-cytokine were reduced dependant on the radiation dose. These data show that the irradiated OVA could downregulate the activity of Th2 lymphocytes in OVA-sensitized mice.</P>

갑상선결절의 임상 및 초음차소견의 진단적 가치

박거운,박철진,박일구,신지혜,정중화,배학연,김상용 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Backgrounds: Thyroid nodule have been relatively common disease and it's prevalence estimated about 4-7%. Recently, high resolution ultrasonography has made the detection of small thyroid nodule possible, Increases in the detection of thyroid nodule have created a clinical dilemma on how to properly manage such thyroid nodules. We investigated the prevalence, clinical and ultrasonographic characterristics, and optimal diagnostic approach toward detected benign and malignant thyroid nodules. Methods: A retrosepctive review was undertaken on the 372 patients who was done Ultrasonograpy guided fine needle aspiration biopsy in Chosun University Hospital, Gwang-Ju, Korea between July 2003 and Spring 2005. Devided into four group such as benign and malignant thyroid nodule on the basis of size 1.5Cm. The review consisted of thyroid function test, antithyroid antibodies, thyroid autoantibodies, thyroid ultrasonography, fine needle aspiration biopsy in each group. Results: The prevalence of thyroid nodule malignancy rate was 18.0%. The prevalence of thyroid incidentaloma malignanct rate was 17.5%. There were no significant differences in age, sex, thyroid function test and size between the benign, malignant incidentalomas and nodule. Ultrasonographic characteristics, include ultrasonography index point showed meaningful diagnostic value for the detection of malignancy in thyroid nodule, Conclusion: Thyroid cancers are fairly common finding. There are no clinical difference between benign and malignant thyroid nodule; however, ultrasonographic findings can be used to decision of optimal management strategies 배경: 최근갑상선 초음파의 빈번한 시행으로 갑상선 결절의 발견이 증가하고 있다. 이러한 갑상선 결절중 특히 갑상션우연종을 임상적으로 어떻게 접근하고 치료를해야하는지는 적지 않는 문제가 되고 있다. 본 연구에서는 갑상선 우연종 및 직경 1.5 cm 이상의 갑상션결절의 유병률, 임상적 특징, 초음파특정 및 초음파의 진단적 유용성에 대해 알아 보았다. 방법: 2003년 7윌부터 2005년 3월까지 조선 대학교병원 내과 및 일반외과및 건강검진 센터를 통해 갑상선 초음파, 경동맥 초음파 및 경부 CT등을 통해 우연히 발견된 갑상션결절을 가진 372명을 대상으로 후향적 연구를 시행하였다. 크기 1.5 cm 미만의 양성및 악성 갑상선 결절군과 크기 1.5 cm 이상의 양성 및 악성결절로 그룹을 나누고 각 군에서 나이, 성별, 갑상선 기능검사, 항갑상선 항체, 갑상선 초음파 및 미세침흡인세포검사등을 검토하였고, 모든 갑상선 결절에 Koike (6)가 제한한 초음파지표 점수(Ultrasonographie index point)를 부여하여 각 군을 비교하였다. 결과: 분석한 갑상선 결절 372예 중 악성결절의 유병율은 18.0% (67예)였다. 갑상선 우연 종의 유병율은 81.5% (303예)였다. 갑상선 우연 종에서의 악성률은 17.5% (53예)로 나왔다. 크기 1.5 cm 이상의 양성 및 악성 갑상선 결절과 양성 및 악성 갑상선 우연종에서 나이, 성별, 갑상선 기능검사, 항갑상선항체에는 의미있는 차이가 없었다. 또한 양성 및 악성우연종에서 의 갑상선 결절크기에도 의미있는 차이는 보이지 않았다. 갑상선 결절의 초음파 지표점수만이 양성 및 악성우연종과 양성 및 악성갑상선 결절의 감별에 의미있는 차이를 보였다. 갑상 선우연종과 크기 1.5 cm 이상의 갑상선 결절에 서 양성을 나타내는 초음파지표점수는 각각 3 점과 4점으로 다르게 나타났다. 양성 및 악성 갑상선우연종의 감별에서 초음파 지표점수의 민감도는 93.6%, 특이도는 52.8%, 양성예측율은 92.4%로 나왔고, 진단적 효율은 86.4% 였으며 크기 1.5 cm 이상의 양성 및 악성 갑상선 결정의 감별에서 초음파지수 민감도는 92.7%, 특이도가 42.9%, 양성 예측도 86%, 효율 82.6%를 보였다. 결론: 갑상선결절에서의 양성 및 악성의 유무는 임상적으로 판단하기 힘들지만 갑상선 결절에서의 초음파 소견 및 초음파 지표 점수를 도입하면 이에 대한 감별에 도움을 줄 수 있다. 따라서 갑상선 초음파검사시 초음파지표점수의 사용은 향후 갑상선 결절의 진단 방향을 제시하는 중요한 길잡이가 될 수 있으리라 사료된다.

제 2형 당뇨병 환자에서 대사증후군의 유병률 및 관련요인의 특징

박철진,박거운,박일구,신지혜,김진화,배학연,김상용 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.3

Background: People with insulin resistance has a higher risk of developing cardiovascular disease. This leads to the importance in diagnosing metabolic syndrome. The incidence of metabolic syndrome has increased significantly in korea because of an increased population of obese people and also the incidence of DM. There have been many studies done on the incidence of metabolic syndrome in the general population. Therefore, the authors have designed this study to identify the incidence of metabolic syndrome in patients with type 2 DM and also the associated characteristics in that population. Methods: The study included 169 adults over the age of 20 (84 males and 85 females) admitted to the endocrinology department of Chosun University between Jan, 1st 2005 and May, 31st 2006. Out of the people diagnosed with type 2 DM people were excluded when any of the physical measurements (height, weight, blood pressure, abdominal circumference) and blood measurements (TG, HDL-cholesterol, fasting blood sugar) were insufficient and when the patient was taking any drugs other than anti-hy-pertensive agents and oral anti-diabetic agents. Obesity and the other risk factors were defined by the Asian-Pacific guideline and 2001 ATP III of NCEP, respectively. Result: The each prevalence according to the metabolic syndrome criteria of the type 2 DM patients showed low HDL cholesterolemia with the highest incidence of 57.4% followed by hypertng1yceridemia(52.0%), obesity(40.9%) and hypertension(33.0%). The each incidence of diagnostic criteria in metabolic syndrome according to sex was different, In males, hypertriglyceridemia was the highest with the incidence of 57.7% followed by low HDL-cho1estero1emia(49.5%), obesity(40.9%) and hypertension (30.0%). In women, the incidence were low HDL-cho1estero1emia(64.8%), hyperthg1yceridemia(47.6%), obesity(45.0%) and hypertension(36.0%), in a descending order. The analysis between the diagnosis of metabolic syndrome in type 2 DM patients and the criteria showed that hyperthglyceridemia (correlative value 0.575) had the highest correlation followed by low HDL-cholesterolemia (correlative value 0.446), obesity (correlative value 0.350) and hypertension (correlative value 0.410). All the correlations were statistically significant with a p-value less than 0.01. Conclusions: Type 2 DM is a important factor of metabolic syndrome based on insulin resistance. The control of blood glucose with prevention and early diagnosis of the other factors related to metabolic syndrome in type 2 DM is important for preventing cardiovascular complications.

단일융모막 쌍태아 임신의 관리

( Il Woon Ji ) 대한산부인과학회 2011 교육강연 Vol.2011 No.-

Case Reports : Spontaneously resolved fetal echogenic Lung: A case of congenital Lobar emphysema

( Il Woon Ji ),( Seung Hwa Hong ),( Yeon Jin Park ),( Eun Hwan Jeong ),( Hak Soon Kim ) 대한산부인과학회 2008 Journal of Womens Medicine Vol.1 No.1

We are reporting a case of congenital lobar emphysema (CLE) that was treated by lobectomy during the neonatal period. The abnormality was initially detected antenatally by ultrasound. We suggest that the differential diagnosis of cystic adenomatoid malformation (CAM) should include CLE in cases with lesions that improve especially when the amniotic fluid volume is normal and considered during prenatal counseling.

종설 : 태반 형성

지일운 ( Il Woon Ji ) 대한주산의학회 2006 大韓周産醫學會雜誌 Vol.17 No.4

최신임상강좌 : 제왕절개 후 자연분만

지일운 ( Il Woon Ji ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.3

The American College of Obstetricians and Gynecologists (ACOG) has recommended that the most women with one previous cesarean delivery with a low-transverse incision are candidates for vaginal birth after cesarean and should be counseled about VBAC and offered a trial of labor in the hospital which has physicians immediately available to provide emergency care including cesarean section and personnel familiar with the potential complications of a trial of labor who should be vigilant for nonreassuring fetal heart rate patterns and inadequate progress of labor. The safer VBAC will be provided when the physicians and patients are alert about the risk, benefit and disadvantage of VBAC, and when the reasonable management of the labor is performed. The success of VBAC will contribute to prevent unnecessary primary cesarean and reduce the overall cesarean delivery rate.

Development and validation of an analysis method for the compounds such as lidocaine and prilocaine in illegal products

Ji Hyun Lee,Hye Min Bae,Min Kyeong Seo,So woon Seo,Hyung Il Kim,Sooyeul Cho 한국분석과학회 2023 학술대회논문집 Vol.2023 No.5

Short-Term Repeated Treadmill Exercise More Potently Increases Cell Proliferation and Brain-Derived Neurotrophic Factor Expression in the Hippocampus of Rats

Ji-Heon Jung,Hyung-Hwan Baik,Tae-Woon Kim,Il-Gyu Ko,Eun-Sang Ji,Mal-Soon Shin,Bo-Kyun Kim,Jin-Hee Seo,Dong-Hee Kim,Seung-Soo Baek,Young-Ho Jin 대한스트레스학회 2010 스트레스硏究 Vol.18 No.4

운동은 해마 치상회에서 신경세포의 생성을 증가시킨다. 뇌 유래 신경영양 인자(brain-derived neurotrophic factor, BDNF)는 신경전달 물질의 분비, 신경 성장, 그리고 신경의 생존 등에 관여하며, tyrosine kinas B (TrK)에 결합하게 된다. 본 연구에서, 일회의 긴 시간 운동과 여러 번의 짧은 시간의 운동이 해마에서 신경세포 생성과 뇌 유래 신경영양 인자와 TrKB의 발현에 미치는 영향을 비교하였다. 무게 200±5 g의 Sprague-Dawley계 흰쥐를 대조군, 하루 1시간 1회 운동군, 하루 10분씩 6회 운동군의 세 군으로 분류하였다(각 군=8마리). 하루 1시간 1회 운동군은 16시에 매일 한 시간씩 트레드밀 운동을 시행하였다. 하루 10분씩 6회 운동군은 10시, 11시, 14시, 15시, 19시, 20시에 각 10분씩 하루 6번 트레드밀 운동을 시행하였다. 이러한 운동은 7일간 지속하였다. 실험결과, 두 가지 형태의 트레드밀 운동 모두 해마에서 신경세포 생성과 뇌 유래 신경영양 인자, 그리고 TrkB의 발현을 증가시켰다 신경세포 생성과 뇌 유래 신경영양 인자는 하루 10분씩 6회 운동군에서 더욱 증가되었다. 본 실험을 통하여 긴 시간의 일회 운동보다 짧은 시간 여러 번 운동이 뇌기능의 향상에 좋은 결과를 미침을 알 수 있었다. Physical exercise enhances cell proliferation and/or neurogenesis in the hippocampal dentate gyrus. Brain-derived neurotrophic factor (BDNF) is implicated in the modulation of neurotransmitters turnover, neurite genesis, and neuronal survival. BDNF binds to the tyrosine kinas B (TrK). In this study, we compared the effects of the one bout of long-duration treadmill exercise and the repeated short-duration treadmill exercise on cell proliferation and expressions of BDNF and TrKB in the hippocampus. Adult male Sprague-Dawley rats, weighing 200±5 g, were randomly divided into three groups (n=8 in each group): control group, one hour-one bout-treadmill exercise group, and ten minutes-six bouts-treadmill exercise group. The rats in the one hour-one bout-treadmill exercise group were forced to run on a motorized treadmill for 60 min once a day (at 16:00). The rats in the ten minutes-six bouts-treadmill exercise group were forced to run on a treadmill once 10 minutes per six times for a day (at 10:00, 11:00, 14:00, 15:00, 19:00, 20:00). Treadmill exercise was continued for 7 consecutive days. The rats in the control group were left without running. Both types of treadmill exercise increased cell proliferation and enhanced expressions of BDNF and TrkB in the hippocampus. Cell proliferation and BDNF expression was more potently increased by the ten minutes-six bouts treadmill exercise than the one hour-one bout treadmill exercise. These results showed that repeated bouts of short-duration treadmill exercise may achieve more useful results for the brain functions than one-bout long-duration treadmill exercise. (Korean J Str Res 2010;18:295∼303)

자연 소실된 태아 심방 조동 증례 보고

지일운, 연현경, 최진영, 경규상, 홍승화, 정은환, 김학순 충북대학교 의학연구소 2018 忠北醫大學術誌 Vol.28 No.1

본문 참고