Free-flap reconstruction in recurrent head and neck cancer: A retrospective review of 124 cases

Kim, Hyeong Seop,Chung, Chul Hoon,Chang, Yong Joon Korean Cleft Palate-Craniofacial Association 2020 Archives of Craniofacial Surgery Vol.21 No.1

Background: Free-flap reconstruction for recurrent head and neck cancer may be challenging depending on the previous treatments, those are, chemotherapy, radiotherapy, and surgery, including neck dissection or free tissue transfer. Specifically, the previous treatment could compromise the neck vessels, thereby making free-flap reconstruction more difficult. This study aimed to investigate the correlation between previous treatments and vascular compromise of the free flap. Methods: In this retrospective study, 124 free-flap reconstructions in 116 patients for recurrent head and neck cancer between 1993 and 2017 were investigated. The demographic characteristics, previous treatments, flap choices, infections, recipient vessels, and vascular crises were evaluated. Results: Of the 124 reconstruction cases, 10 had vascular crises. There were six revisions, totaling six flap failures. The success rate of free-flap reconstruction for recurrent cancer was 95.2%, which significantly differed from that for primary cancer (98.8%, p= 0.006). Moreover, in the recurrent cancer group, no correlation was found between previous treatments and vascular crises (p> 0.05). Increased rates of contralateral or uncommon anastomoses were found following neck dissection (p< 0.05). Conclusion: Previous neck dissection or radiotherapy could lead to scarring and tissue damage, which could in turn make microvascular reconstruction more challenging; however, the effect was not definite in this study. Approximately 60% of patients with previous neck dissection had compromised ipsilateral recipient vessels, which resulted in contralateral or uncommon anastomoses. In this study, free-flap reconstruction seems to be quite safe and preferable in patients with recurrent head and neck cancer based on the overall survival rate.

Lowering the concentration affects the migration and viability of intracerebroventricular-delivered human mesenchymal stem cells

Kim, Hyeong Seop,Lee, Na Kyung,Yoo, Dongkyeom,Lee, Jeongmin,Choi, Soo Jin,Oh, Wonil,Chang, Jong Wook,Na, Duk L. Elsevier 2017 Biochemical and biophysical research communication Vol. No.

<P><B>Abstract</B></P> <P>Due to their widely known therapeutic benefits, mesenchymal stem cells have been proposed as a novel treatment option for a wide range of diseases including Alzheimer's disease. To maximize these benefits, critical factors such as delivery route, cell viability, and cell migration must be accounted for. Out of the various delivery routes to the brain, the intracerebroventricular (ICV) route stands out due to the widespread distribution that can occur via cerebrospinal fluid flow. The major objective of this present study was to observe how altering cell concentration influences the migration and viability of human umbilical cord blood derived-mesenchymal stem cells (hUCB-MSCs), delivered via ICV injection, in the brains of wild-type (WT) mice. C3H/C57 WT mice were divided into three groups and were injected with 1 × 10<SUP>5</SUP> hUCB-MSCs suspended in varying volumes: high (3 μl), middle (5 μl), and low (7 μl) concentrations, respectively. Lowering the concentration increased the migratory capabilities and elevated the viability of hUCB-MSCs. These results suggest that cell concentration can affect the physiological state of hUCB-MSCs, and thus the extent of therapeutic efficacy that can be achieved.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Cell concentration must be considered for stem cell therapy. </LI> <LI> More widespread distribution in the brain is achieved with ICV injections of lower cell concentrations. </LI> <LI> A higher number of engrafted cells was observed with ICV injections of higher cell concentrations. </LI> <LI> Lowering concentration increased viability and enhanced migration. </LI> </UL> </P>

Klebsiella pneumoniae necrotizing fasciitis on the upper lip in a patient with uncontrolled diabetes

Kim, Hyeong Seop,Chang, Yong Joon,Chung, Chul Hoon Korean Cleft Palate-Craniofacial Association 2020 Archives of Craniofacial Surgery Vol.21 No.2

A 60-year-old woman with a history of diabetes mellitus and chronic renal failure was admitted to the hospital with severe pain in the upper lip, which began 4 days prior to admission, accompanied by a bullous lesion and suspected cellulitis in the upper lip. Immediately after admission, as the patient's general condition worsened, tests revealed a non-ST elevated myocardial infarction, septic embolism of the lung, as well as septic shock. Her upper lip suddenly presented a gangrenous and necrotic change, which the tissue and blood culture confirmed to be a Klebsiella pneumoniae infection. After a quick response, the patient's general condition improved. Subsequently, serial debridement was performed to effectively clear away the purulent discharge. While under general anesthesia, the process confirmed full-layer necrosis of the upper lip including the orbicularis oris muscle. Almost half of the entire upper lip sustained a full-layer skin and soft tissue defect, with scar contracture. Six months later, to correct the drooling and lip sealing following the defects, a scar release and an Abbe flap coverage were performed considering both functional and aesthetic aspects. The follow-up revealed a favorable corrective result of the upper lip drooling, and the patient was satisfied from a functional perspective.

Correction: The Clinical Features of Preschool Children With Speech and Language Disorder and the Role of Maternal Language

Hyeong Seop Kim,Heesuk Shin,Chul Ho Yoon,Eun Shin Lee,Min-Kyun Oh,Se-Woong Chun,Seung-Kyu Lim,Hoi Sik Min,Hayoung Byun 대한재활의학회 2021 Annals of Rehabilitation Medicine Vol.45 No.3

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The Clinical Features of Preschool Children With Speech and Language Disorder and the Role of Maternal Language

Hyeong Seop Kim,Heesuk Shin,Chul Ho Yoon,Eun Shin Lee,Min-Kyun Oh,Se-Woong Chun,Seung-Kyu Lim,Hoi Sik Min,Hayoung Byun 대한재활의학회 2021 Annals of Rehabilitation Medicine Vol.45 No.1

Objective To retrospectively review the characteristics of preschool children with speech and language disorders to determine their clinical features and compares the average degrees of language delay based on hospital visit purposes, language developmental delay causes, and maternal language. Methods One thousand one hundred two children (832 males, 270 females) with the chief complaint of language or speech problems who underwent language assessment for the first time were included. Their medical records, including demographic data, language environments, and family history of language problems and other developmental problems, were collected. Furthermore, the results of language and developmental assessments and hearing tests were collected. Results Among the children enrolled in this study, 24% had parental problems and 9% were nurtured by their grandparents. The average degree of language delay did not differ regarding purposes of hospital visits. The average degree of language delay was greatest in children with autism spectrum disorders and least in children with mixed receptive–expressive language disorders. In children with mothers who do not speak Korean as their native language, social quotients in the social maturity scale were less than 70. Conclusion Language environment is an essential factor that may cause speech and language disorders. Moreover, maternal language seems to affect the social quotient of the social maturity scale.

Lactobacillus and Pediococcus Attenuates the Progression of Alcoholic Liver Disease by Improving Inflammation

( Hyeong Seop Kim ),( Mi Ran Choi ),( Ye Rin Choi ),( Ji Ye Hyun ),( Min Kyo Jeong ),( Hee Jin Park ),( Jung A Eom ),( Byeong Hyun Min ),( Sang Jun Yoon ),( Haripriya Gupta ),( Yoseph Asmelash ),( Raj 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1

Anti-Fibrotic Effect of Urushiol (Rhus Verniciflua Stokes) on Thioacetamide-Induced Liver Fibrosis of Mice Model

( Hyeong Seop Kim ),( Ye Rin Choi ),( Mi Gun Hong ),( Min Jea Shin ),( Sang Jun Yoon ),( Na Young Lee ),( Hyun Ji Ye ),( Sang Hak Han ),( Dong Joon Kim ),( Gi Soo Youn ),( Ki Tae Suk ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Liver fibrosis constitutes a serious problem worldwide due to its rapidly leads to cirrhosis, and even cancer. However, there is no clear medical treatment other than treating the cause. Urushiol has been known to have anti-inflammatory and anti-oxidative effects on various disease. We investigated the effect of urushiol on liver fibrosis induced by thioacetamide (TAA). Methods: Thirty C57BL/6 mice were randomly divided into 3 groups and urushiol was dissolved in vehicle (DMSO) for in vivo experiments: (1) control group; (2) TAA (normal saline as solvent, 300 mg/kg/day, 3 times/week, i.p.) + vehicle (gavage). (3) TAA (300 mg/kg/day, 3 times/week, i.p.) + urushiol (0.128 mg/ mL/day, 28 times, gavage). These groups were analyzed by immunohistochemical staining, reverse transcription polymerase chain reaction, and microarray. Results: The TAA + Urushiol group improved the deposition of fibrillar collagen (Sirius Red (%) 1.55 ± 0.25 vs. TAA, P<0.0001), Fibrosis stage reduced (1.64 ± 0.20 vs. TAA, P<0.0001) and Inflammation activity decreased concurrently (1.17 ± 0.16 vs. TAA, P<0.0001). The analysis of mRNA expression showed that Col1a1 (2.30-fold change vs. TAA, P<0.0001) and TIMP-1 (1.48-fold change vs. TAA, P<0.05), IL-6 (3.03- fold change vs. TAA, P<0.0001), JAK2 (0.89-fold change vs. TAA, P<0.05), STAT3 (3.26-fold change vs. TAA, P<0.0001) downregulated significantly. As shown microarray analysis, downregulation of Col1a1 (1.12-fold change vs. TAA, P<0.05), Chka, lipid metabolic process gene (2.21-fold change vs. TAA, P<0.001), Pnpla3, patatin-like phospholipase domain containing 3 (1.57-fold change, P<0.001) Contrast, Orm2, regulation of immune system process gene (2.28-fold change vs. TAA, P<0.001) Saa1, serum amyloid A (2.25-fold changes vs. TAA, P<0.05), Saa2 (3.09-fold change, P<0.001) Conclusions: Our results indicated that urushiol has therapeutic effect on liver fibrosis. Although it is needed more clinical research, urushiol can be a potential agent for the treatment of liver fibrosis.

『상한론(傷寒論)』과 『황제내경(黃帝內經)』의 의사 집단의 정체 - 무(巫), 의(醫), 공(工)의 어원 분석을 바탕으로 -

김형섭 ( Hyeong-seop Kim ),서희애 ( Hee-ae Seo ),이숭인 ( Soong-in Lee ) 대한상한금궤의학회 2020 대한상한금궤의학회지 Vol.12 No.1

Objectives: To define the difference in the identity of the authors of 『傷寒論』and 『黄帝內經』by analyzing the etymology of 巫, 毉, 醫, and 工. Methods: We analyzed the meaning of three Chinese characters based on oracle bones and bronze inscriptions, and considered examples of their utilization in two books. Results:In『Gangpyeong-Shanghanlun』, 巫appears once, 醫appears 28 times, and 工 appears once. In 『Huangdi Neijing』, 巫appears twice, 醫appears 24 times, and 工appears 64 times. Conclusions: The authors of 『傷寒論』recognized themselves as ‘醫’, and they were doctors who mainly treated prescriptions in the liquid form represented by 湯(tang). The authors of 『黃帝內經』recognized themselves as '工', and they were doctors who treated them with a tool represented by “acupuncture.”

노인 맞춤형 소방안전교육 활성화 방안

김형섭 ( Kim¸ Hyeong-seop ),주성빈 ( Joo¸ Seong-bhin ) 한국융합과학회 2021 한국융합과학회지 Vol.10 No.5

연구목적: 급속한 고령화 현상은 노인들의 일자리 증가 등 사회활동이 빈번해지는 가운데 노인의 신체적·인지적 기능이 저하됨으로써 나타나는 위기 대처능력의 부족이 안전사고의 위험성을 높일 것으로 예상되고, 안전에 대한 경각심이 필요한 시기이다. 특히, 1960∼70년대 빠른 경제성장 과정에서 소방안전교육을 받을 기회조차 적었던 노인들에게 파생될 수 있는 사회적 문제를 준비해야 하는 시점이라 여겨진다. 연구방법: 주요 연구방법은 문헌연구, 통계자료 검토 및 분석, 설문조사이고, 구체적인 내용은 다음과 같다. 첫째, 문헌연구를 통해 안전취약계층의 노인 복지시설의 현황을 살펴보았다. 그 중 노인 안전사고사례를 통하여 소방안전교육의 화재대피의 중요성이 부각된 2018년 밀양 세종요양병원의 대형화재와 스위스 치즈 모델의 안전사고 이론을 접목하여 실제 재난발생사례를 활용하여 노인시설의 화재대피에 대한 소방안전교육의 중요성을 검토하였으며, 국외 선진국의 노인관련 안전교육 프로그램을 파악하고, 안전에 대한 개념과 정의, 안전취약계층인 소방안전교육의 필요성을 살펴보았다. 둘째, 유아와 청소년 그리고 성인과 비교한 노인에 대한 소방안전교육 프로그램의 현 실태를 파악하기 위해 부산소방 119구급대의 65세이상 노인 이송현황 및 유형별 사고부상 등의 통계자료를 검토하였다. 마지막으로 노인시설을 방문하여 노인시설 종사자에게 소방안전교육 프로그램의 적정성과 추가로 필요한 소방안전교육 프로그램을 설문조사하였다. 결론: 분석결과와 논의를 통해 안전취약계층인 노인에 대한 표준화된 맞춤형 소방안전교육 프로그램 구축하여 우리 사회에서 노인들을 보호하고 안전의식 문화를 확산해 나가는 등의 노인의 소방안전교육 활성화를 위한 정책적 시사점을 도출하였다. Purpose: Rapidly aging phenomenon is expected to increase the risk of safety accidents and the lack of crisis response ability caused by the deterioration of the elderly's physical and cognitive functions amid frequent social activities such as job growth. In particular, it is believed that it is time to prepare social problems that can be derived from the elderly, who had fewer opportunities to receive fire safety education in the process of rapid economic growth in the 1960s and 1970s. Methods: The main research methods are literature research, statistical data review and analysis, surveys, and details are as follows: First, through literature research, we examined the current status of welfare facilities for senior citizens of the safety vulnerable class. Among them, the importance of fire safety education for senior citizens was reviewed by combining the safety accident theory of the Swiss cheese model with the large fire evacuation in Miryang Sejong Nursing Hospital in 2018. Second, statistical data such as the status of transportation of senior citizens aged 65 or older and accident injuries by type of Busan Fire Department were reviewed to identify the current status of fire safety education programs for senior citizens compared to infants, adolescents and adults. Finally, a survey was conducted on the appropriateness of fire safety education programs and additional necessary fire safety education programs for senior citizens.s. Conclusion: Through these analysis results and discussions, we established a standardized customized fire safety education program for the elderly, who are vulnerable to safety, to protect the elderly in our society and spread a safety awareness culture.

『상한론(傷寒論)』 '明'에 대한 고찰 : 변병진단체계(辨病診斷體系)에 입각해 치료한 양명병(陽明病) 증례 2례에 근거하여

김형섭 ( Hyeong-seop Kim ),조성환 ( Seong-hwan Cho ),이성준 ( Sung-jun Lee ) 대한상한금궤의학회 2018 대한상한금궤의학회지 Vol.10 No.1

Objectives : This study is to propose a new hypothesis about the interpretation of 'Ming (明)' in Shanghanlun and the direction of future research about Yangmingbing(陽明病). Methods : We analyzed the original form of the chinese characters 'Ming(明)' and tried to understand their contexts in Shanghanlun. At the same time, we analyzed 2 clinical cases diagnosed and treated as Yangmingbing according to newly hypothesized definition. Results : From etymology, ‘Ming(明)' means becoming distinct. Patients in 2 cases suffered from cold hypersensitivity of hands and feet, overactive bladder syndrome and dizziness, all of which became distinct and problematic. For this reason, we diagnosed patients with Yangmingbing(陽明病) and administered herbal medicine then they improved. Conclusions : The disease names in Shanghanlun have clinical message by the name itself. From etymology, at least in 15 characters provision of Shanghanlun, Yanmingbing means the disease made by becoming conscious about symptoms. Future research about Yangmingbing (陽明病) should start from here.