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Hye-Ran Kim,Choong Won Seo,김종완 질병관리청 2023 Osong Public Health and Research Persptectives Vol.14 No.6
Objectives: The prognostic significance of CDC42 effector protein 2 (CDC42EP2) and its association with tumor-infiltrating immune cells (TIICs) have not been explored in liver hepatocellular carcinoma (LIHC). This study aims to assess the potential prognostic value of CDC42EP2 by conducting a comprehensive analysis of online databases pertaining to LIHC. Methods: We evaluated the potential of CDC42EP2 as a prognostic biomarker by utilizing online databases such as TIMER, GEPIA2, KM, OSlihc, HPA, and LinkedOmics. Results: In LIHC, we observed that the mRNA and protein expression of CDC42EP2 were upregulated compared to normal tissues. Upregulated CDC42EP2 expression was associated with a worse prognosis based on the clinicopathological characteristics of patients with LIHC. Furthermore, CDC42EP2 was positively associated with TIICs. In the co-expression and functional enrichment analyses of CDC42EP2, 11,416 genes showed positive associations with CDC42EP2 while 8,008 genes showed negative associations. CDC42EP2-related co-expression genes were involved in protein localization to the endoplasmic reticulum, translational initiation, and RNA catabolic processes in gene set enrichment analysis-Gene Ontology (GSEA-GO), and regulated the ribosome, spliceosome, and primary immune deficiency in the GSEA-Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. In a survival map, 23 and 17 genes that exhibited positive associations with CDC42EP2 showed a significant hazard ratio (HR) for overall survival and disease-free survival, respectively. Conclusion: Our findings demonstrated that CDC42EP2 is a novel prognostic biomarker and a potential tumor immune therapeutic target in patients with LIHC.
Seo, Jin-Won,Kim, Hee-Sung,Yi, Hye-Suk,Jeong, Sun-A The Korean Society of Limnology 2009 생태와 환경 Vol.38 No.1
The study was conducted in 2007~2008 in order to understand preference of physical microhabitat on the $1^{st}$-class endangered species, Gobiobotia naktongensis inhabiting the Gam Stream, tributary of Nakdong River. The total number of fish caught from the study sites was 3,671 representing 7 families 24 species. There were 8 Korean endemic species including Odontobutis platycephala, and 2 introduced species (Carassius cuvieri, Micropterus salmoides) were found. According to investigation and analysis of physical microhabitat on Gobiobotia naktongensis caught in the Gam Stream, a total of 57 individuals were found at shallow depth (0.14~0.46 m) and run (0.239~0.585m $sec^{-1}$). As a result of sieve analysis, stream beds consisted of about 1% gravel and 99% sand (83.4% coarse sand, 15.6% find sand). Therefore, Gobiobotia naktongensis seemed to inhabit shallow-run with coarse sand bed than deep-pool microhabitat. The findings indicate preference of physical microhabitat on Gobiobotia naktongensis, and it is important to enhance efficiency of fish conservation and ecological restoration with understanding species-specific characteristics in microhabitat including protected species.
A Case of Painful Hashimoto Thyroiditis that Mimicked Subacute Thyroiditis
Hye Mi Seo,Miyeon Kim,Jaeseok Bae,Jo-Heon Kim,Jeong Won Lee,이상아,Gwanpyo Koh,Dae Ho Lee 전남대학교 의과학연구소 2012 전남의대학술지 Vol.48 No.1
Hashimoto thyroiditis (HT) is an autoimmune thyroid disorder that usually presents as a diffuse, nontender goiter, whereas subacute thyroiditis (SAT) is an uncommon disease that is characterized by tender thyroid enlargement, transient thyrotoxicosis, and an elevated erythrocyte sedimentation rate (ESR). Very rarely, patients with HT can present with painful, tender goiter or fever, a mimic of SAT. We report a case of painful HT in a 68-year-old woman who presented with pain and tenderness in a chronic goiter. Her ESR was definitely elevated and her thyroid laboratory tests suggested subclinical hypothyroidism of autoimmune origin. 99mTc pertechnetate uptake was markedly decreased. Fine needle aspiration biopsy revealed reactive and polymorphous lymphoid cells and occasional epithelial cells with Hürthle cell changes. Her clinical symptoms showed a dramatic response to glucocorticoid treatment. She became hypothyroid finally and is now on levothyroxine therapy.
Seo, Hyo-Jung,Choi, Yun-Jung,Kim, Hyun-Jeong,Jeong, Yong-Hyu,Cho, Arthur,Lee, Jae-Hoon,Yun, Mi-Jin,Choi, Hye-Jin,Lee, Jong-Doo,Kang, Won-Jun The Korea Society of Nuclear Medicine 2011 핵의학 분자영상 Vol.45 No.3
Purpose Bone metastasis from hepatocellular carcinoma (HCC) can present with soft tissue formation, resulting in oncologic emergency. Contrast-enhanced FDG PET/CT and bone scintigraphy were compared to evaluate characteristics of bone metastases with or without soft tissue formation from HCC. Methods Of 4,151 patients with HCC, 263 patients had bone metastases. Eighty-five patients with bone metastasis from HCC underwent contrast-enhanced FDG PET/CT. Fifty-four of the enrolled subjects had recent $^{99m}Tc$-HDP bone scintigraphy available for comparison. Metastatic bone lesions were identified with visual inspection on FDG PET/CT, and maximum standardized uptake value ($SUV_{max}$) was used for the quantitative analysis. Confirmation of bone metastasis was based on histopathology, combined imaging modalities, or serial follow-up studies. Results Forty-seven patients (55%) presented with soft tissue formation, while the remaining 38 patients presented without soft tissue formation. Frequent sites of bone metastases from HCC were the spine (39%), pelvis (19%), and rib cage (14%). The soft-tissue-formation group had more frequent bone pain (77 vs. 37%, p<0.0001), higher $SUV_{max}$ (6.02 vs. 3.52, p<0.007), and higher incidence of photon defect in bone scintigraphy (75 vs. 0%) compared to the non-soft-tissue-formation group. FDG PET/CT had higher detection rate for bone metastasis than bone scintigraphy both in lesion-based analysis (98 vs. 53%, p=0.0015) and in patient-based analysis (100 vs. 80%, p<0.001). Conclusions Bone metastasis from HCC showed a high incidence of soft tissue formation requiring emergency treatment. Although the characteristic findings for soft tissue formation such as photon defect in bone scintigraphy are helpful in detection, overall detectability of bone metastasis is higher in FDG PET/CT. Contrast-enhanced PET/CT will be useful in finding and delineating softtissue- forming bone metastasis from HCC.
18F-FDG PET/CT in hepatocellular carcinoma: detection of bone metastasis and prediction of prognosis
Seo, Hyo Jung,Kim, Gun Min,Kim, Joo Hoon,Kang, Won Jun,Choi, Hye Jin Chapman and Hall in association with the British N 2015 Nuclear medicine communications Vol.36 No.3
<P>Objective The purpose of this study was to assess the diagnostic accuracy and prognostic value of F-18-fluorodeoxyglucose PET/computed tomography (CT) in bone metastases from hepatocellular carcinoma (HCC). Patients and methods Of 3912 consecutive HCC patients, 67 patients who had undergone both PET/CT and bone scintigraphy (BS) within a 3-month interval were evaluated. Results Bone metastases were most frequently found in the pelvis (20%), followed by the lumbar spine (14%) and long bones (13%). PET/CT was significantly more sensitive than BS in region-based analyses, with 273 confirmed bone metastases (96.7 vs. 52.7%, respectively; P< 0.001), and in patient-based analyses (99 vs. 85%; P= 0.042). The median survival period was 5 (range, 0.4-18) months. On univariate analysis, poor prognostic factors included age (< 60 years), multiple bone metastases, lymph node metastasis, high serum a-fetoprotein (>= 400 IU/ml), Child-Pugh class B, and high maximum standardized uptake value (SUVmax) of bone metastasis (> 5.0). Large metabolic volume (>= 200 cm(3)) of bone metastasis was another poor prognostic factor. On Cox regression analysis, high a-fetoprotein was the only poor prognostic factor with statistical significance. Conclusion PET/CT was more sensitive than BS in bone metastasis from HCC by both patient-based and region-based analyses, and offered additional information on survival. PET/CT can be helpful in early diagnosis and opportune treatment of bone metastasis from HCC. Copyright (c) 2015 Wolters Kluwer Health, Inc. All rights reserved.</P>
Seo, Jeongkuk,Kim, Won Seog,Kim, Jin Seok,Kim, Seok Jin,Lee, Jae Hoon,Hong, Jun Shik,Lee, Gyeong-Won,Oh, Sung Yong,Lee, Ji-Hyun,Yoon, Dok Hyun,Lee, Won-Sik,Kim, Hyo Jung,Kwak, Jae-Yong,Kang, Hye Jin,J Korean Society of Hematology; Korean Society of Bl 2017 Blood Research Vol.52 No.3
<P><B>Background</B></P><P>Rituximab plus cyclophosphamide, vincristine, and prednisone (R-CVP) is one of the effective chemotherapeutic regimens for patients with advanced stage marginal zone lymphoma (MZL). However, prognostic factors that affect the outcome of treatment for MZL are not well understood.</P><P><B>Methods</B></P><P>Between August 2006 and June 2013, patients with newly diagnosed stage III and IV MZL treated with R-CVP as a first-line therapy from 15 institutions were retrospectively analyzed. Patients' clinical and laboratory data at diagnosis were collected by review of medical records.</P><P><B>Results</B></P><P>A total of 80 patients were analyzed. Bone marrow involvement was observed in 30% cases. Twelve patients (15%) had nodal MZL, and 41.3% patients exhibited multiple mucosa-associated lymphoma tissue sites. Overall response rate was 91.3%, including 73.8% achieving complete response. Advanced MZL patients treated with R-CVP showed a 3-year progression-free survival (PFS) rate of 69.6%. Prognostic markers significantly affecting PFS in univariate analysis were platelet to lymphocyte ratio (PLR, <95 vs. ≥95, <I>P</I>=0.014), serum albumin (≤3.9 vs. >3.9 g/dL, <I>P</I>=0.008), and the International Prognostic Index (IPI) score (1 vs. 2–4, <I>P</I>=0.032). In multivariate analysis, only PLR (<95 vs. ≥95, HR 0.367, 95% CI, 0.139–0.971, <I>P</I>=0.043) was an independent risk factor for PFS.</P><P><B>Conclusion</B></P><P>PLR ≥95 at diagnosis is an independent prognostic marker for PFS in advanced stage MZL patients treated with R-CVP. This marker may aid clinicians in predicting the response to R-CVP chemotherapy in stage III and IV MZL patients.</P>
P-8 : Evaluation of the Effectiveness of a Nutrition Support Team in Surgical Patients
( Hye Young Chun ),( Hye Jin Kang ),( Su Jin Park ),( Hyo Jung Park ),( Myung Sook Min ),( Yong Won In ),( Young Mi Lee ),( Jeong Meen Seo ) 한국정맥경장영양학회 2012 한국정맥경장영양학회 학술대회집 Vol.2012 No.-
Background: In surgical patients, nutritional status affects on postoperative morbidity and mortality, so adequate nutrition support is needed. The purpose of this study was to evaluate the effectiveness of intervention by a nutrition support team (NST) in the Samsung Medical Center. Method: We reviewed retrospectively surgical inpatients who were administered commercial parenteral nutrition (PN) via central vein more than 5 days from January 1 to June 30, 2011. Patients with and without NST intervention were compared in demographics, duration of receiving PN, total calories, macronutrients, micronutrients and complications. Results: Of total 99 patients, 52 patients were supported with NST intervention (study group) and 47 patients were not (control group). Between two groups, there was no significant difference in gender, ages, baseline nutritional status and duration of receiving PN. Control group was supplied excessive calories in comparison with study group (% of calories supplied to targeted, 126±30.3% vs 106±24.4%, p<0.01). However, difference of amino acid supplement was not significant (1.2±0.3 g/kg vs 1.3±0.2 g/kg, p=0.51). In supplying micronutrients, study group was received more proper amount of trace elements than control group (p<0.01). In complications, the incidences of hyperglycemia (9.6% vs 42.6%, p<0.01) and abnormality in Ca and P (Ca 38.5% vs 66%, p=0.02; P 40.4% vs 72.3%, p<0.01) were significantly low in study group. Significantly lower incidence of hyperglycemia in study group suggested that adequate calories could be provided by NST intervention.