http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Dynamic Expression of Specific miRNAs during Erythroid Differentiation of Human Embryonic Stem Cells
Hong Lian Jin,김계성,김종수,Young June Kim,Su Jin Kim,Hal E. Broxmeyer 한국분자세포생물학회 2012 Molecules and cells Vol.34 No.2
MicroRNAs (miRNAs) are small non-coding RNAs that re-gulate gene expression at post-transcriptional levels through mRNA degradation or translation inhibition. Little is known regarding miRNA participation in regulating he-matopoietic, or more specifically erythroid differentiation. This study was aimed at identifying erythroid lineage-specific miRNAs expressed during in vitro erythropoiesis using human embryonic stem cells (hESCs) and human umbilical cord blood (CB) CD34+ cells. CD34+ hematopoietic cells were produced from hESCs in vitro and subsequently induced to differentiate into erythroid cells by culture in sequence on OP9 feeder cells and then with mesenchymal stromal cells (MSC) in the presence of cytokines. Expression profiles of erythroid lineage-specific miRNAs were analyzed by quantitative PCR during in vitro differentiation. Expression levels of miR-142-3p, miR-142-5p, miR-146a and miR-451 were dynamically changed during differentiation of hESCs to CD34+ hematopoietic cells, and in subsequent differentiation of the CD34+ cells into the erythroid lineage. This suggests that these four miRNAs might be involved in regulating erythropoiesis.
Lian Jin, Hong,Pennant, William A.,Hyung Lee, Min,Su, Sung,Ah Kim, Hyun,Lu Liu, Meng,Soo Oh, Jin,Cho, Joon,Nyun Kim, Keung,Heum Yoon, Do,Ha, Yoon Lippincott Williams Wilkins, Inc. 2011 1528-1159) Vol.36 No.11
STUDY DESIGN.: An in vitro neural hypoxia model and rat spinal cord injury (SCI) model were used to assess the regulation of therapeutic vascular endothelial growth factor (VEGF) gene expression in mouse neural stem cells (mNSCs) by the EPO (erythropoietin) enhancer or RTP801 promoter. OBJECTIVE.: To increase VEGF gene expression in mNSCs under hypoxic conditions in SCI lesions but avoid unwanted overexpression of VEGF in normal sites, we developed a hypoxia-inducible gene expression system consisting of the EPO enhancer and RTP801 promoter fused to VEGF or the luciferase gene, then transfected into mNSCs. SUMMARY OF BACKGROUND DATA.: On the basis of the ischemic response in the injured area, poor cell survival at the transplantation site is a consistent problem with NSC transplantation after SCI. Although VEGF directly protects neurons and enhances neurite outgrowth, uncontrolled overexpression of VEGF in uninjured tissue may cause serious adverse effects. To effectively improve NSC survival in ischemic sites after transplantation, we evaluated mNSCs modified by a hypoxia-inducible VEGF gene expression system in an SCI model. METHODS.: Hypoxia-inducible luciferase or VEGF plasmids were constructed using the EPO enhancer or RTP801 promoter. The effect of these systems on targeted gene expression and cell viability was evaluated in mNSCs in both hypoxic in vitro injury and a rat SCI model in vivo. RESULTS.: The gene expression system containing the EPO enhancer or RTP801 promoter significantly increased the expression of the luciferase reporter gene and therapeutic VEGF gene under hypoxic conditions. The Epo-SV-VEGF plasmid transfection group had significantly fewer apoptotic cells in vitro. This system also augmented cell viability in the in vivo SCI model. CONCLUSION.: These results strongly suggest the potential utility of mNSCs modified by a hypoxia-inducible VEGF gene expression system in the development of effective stem cell transplantation protocols in SCI.
Liu, Lian Jin,Yoo, Jin Cheol,Hong, Joon Hee Informa UK (TaylorFrancis) 2008 Nucleosides, nucleotides & nucleic acids Vol.27 No.10
<P>The first synthetic route of novel 4'-cyclopropylated carbovir analgues is described. The construction of cyclopropylated quaternary carbon at 4'-position of carbocyclic nucleosides was successfully made via sequential Johnson's orthoester rearrangement and ring-closing metathesis (RCM) starting from ethyl glycolate. Synthesized compounds 15 and 16 showed moderate antiviral activity without any cytotoxicity up to 100 micromol.</P>
Short synthesis and antiviral activity of acyclic phosphonic acid nucleoside analogues.
Liu, Lian Jin,Yoo, Jin Cheol,Hong, Joon Hee Marcel Dekker 2009 NUCLEOSIDES NUCLEOTIDES AND NUCLEIC ACIDS Vol.28 No.2
<P>An efficient route for synthesizing novel allylic and cyclopropanoid phosphonic acid nucleoside analogues is described. The condensation of the bromine derivatives 6 and 18 with nucleoside bases (A, U, T, C, G) under standard nucleophilic substitution and deprotection conditions, afforded the target phosphonic acid nucleoside analogues. These compounds were evaluated for their antiviral properties against various viruses. Cyclopropanoid phosphonic adenine nucleoside analogue 23 showed significant anti-HIV activity.</P>
Synthesis and Anti-HCV Activity of 3',5'-cyclic SATE Phosphonodiester Nucleoside as a Novel Prodrug
Liu, Lian Jin,Seo, Rac-Seok,Yoo, Seung-Won,Choi, Jin,Hong, Joon-Hee Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.4
A novel 2',4'-dimethyl carbocyclic adenosine 5'-phosphonic acid analogue (20) was prepared using acyclic stereoselective route from commercially available 4-hydroxybutan-2-one (4). To improve cellular permeability and enhance the anti-HCV activity of this phosphonic acid, a 3',5'-cyclic SATE phosphonodiester nucleoside prodrug (22) was prepared. The synthesized phosphonic nucleoside analogues, (20) and (22), were assayed for their ability to inhibit HCV RNA replication in a subgenomic replicon Huh7 cell line.
일반 논문 : 중국조선어에서의 한어기원 한자어 수용의 전래와 발전 방향
김홍련 ( Hong Lian Jin ) 한민족문화학회 2006 한민족문화연구 Vol.19 No.-
이 논문은 중국 연변사회과학원 언어연구소에서 편찬한 『조선말사전』에 수록된 한반도 남북에서 쓰이지 않는 한어기원 한자어를 연구대상으로, 한어기원 한자어가 어떤 과정을 통해 조선어에 수용되었으며 그 도중에 어떤 문제점들이 존재하는가를 밝힘과 동시에 앞으로의 발전 방향에 대해 고찰하였다. 한어기원 한자어는 수용 과정에서 여러 가지 문제점들이 있었다. 한어기원 한자어는 조선어가 중국에서의 발전과정 중에 나타난 특수 변이현상으로서 한국이나 조선과 불일치성을 초래하게 되었고, 실재 언어생활에서의 사용은 수용된 표준어와 일치성을 이루지 못하고 있다. 또한, 중국에서의 조선어는 자체의 규범원칙에 따르고 남북 언어통일의 유리한 방향을 위해 규범을 해오고 있다. 한어기원 한자어의 전래와 발전 방향을 통하여 다음과 같은 사실을 얻을 수 있다. 첫째, 한어기원 한자어의 수용 고조기는 중국사회의 변혁사건과 일정한 연관성을 띠고 있으며, 어휘규범화와 어휘의 수용은 불가분리적인 관계임을 알 수 있다. 어휘규범을 정확히 제정함으로써 수용과 사용의 거리를 좁힐 수 있을 것이다. 둘째, 한어기원 한자어의 수용의 발전 추세에 대해 예측한다는 자체가 많은 미비점이 존재하므로 일부 문제들은 정확하지 않거나 훗날 적합하지 않다고 증명될 수도 있다. 그렇지만, 한어기원 한자어의 어휘의미와 어휘형식을 기초로 예측했기에 어느 정도 정확성이 부여될 것이다. In the given Chinese language environment, Chinese Korean assimilates quite a number of Chinese-originated vocabulary, which is a result of the combination of many factors, such as the society and the language, the language and the culture, and the bilinguals etc. However, problems emerge during the assimilation process due to the vague norms and standards, which shows that Chinese-originated vocabulary and Korean vocabulary norms have influence over each other, and that the practical use of Chinese-originated vocabulary often goes against the standardization. The norms of Chinese-originated vocabulary should go along with the language norms in Korean peninsula, and take into consideration the conditions in China as well. Based on the status-quo of Chinese-originated vocabulary in Chinese Korean, it could be predicted that new words representing new features and concepts of China will greatly enrich the vocabulary system.
Diameter-Selective Synthesis of Single-Walled Carbon Nanotubes on Supported Cobalt Catalysts
Hong Wang,Lian Yang,Pingting Chen,Xiaodong Tang,Jin Yang,Sha Zhu,Yuanyi Liao 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.8
Supported Co catalysts were prepared by impregnating the support (MgO, SiO2 and Al2O3) with Co(acac)2 solution, and diameter-selective growth of single-walled carbon nanotubes (SWCNTs) by ethanol chemical vapor deposition has been assessed on these Co catalysts. In contrast to Co/SiO2 and Co/Al2O3 catalysts with relatively high surface areas, Co/MgO catalyst with a low surface area demonstrates the best performances in the diameter-selective growth of SWCNTs under an optimal growth condition. Multiple characterizations on catalysts and SWCNTs revealed that Co(acac)2 was absorbed on MgO by ligand exchange and anhydrous solvent CH2Cl2 strengthened the anchoring of Co(acac)2 on the MgO surface, which resulted in well-dispersed Co species upon calcination in air. Under a modest reduction temperature, the reduction of Co oxides provided Co clusters, which were anchored by the unreacted Co ions in the interior of MgO support, leading to the synthesis of SWCNTs with a narrow diameter distribution.