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Preoperative Diagnosis and Medical Treatment of Pelvic Actinomycosis
Lee, Hong-Jue,Lee, Su-Jin,Kim, Young-Jae,Kim, Sung-Hee,Lee, Jung-Han,Kim, Seung-Ryoung,Cho, Sam-Hyun 대한미생물학회 2008 Journal of Bacteriology and Virology Vol.38 No.2
The diagnosis of the pelvic actinomycosis is seldom made preoperatively because of no reliable or specific clinical manifestation which has tendency to mimic advanced gynecological malignancy and the relative infrequency of the disease. To explore the method for improvement of preoperative diagnosis and possibility of avoiding the surgical management of pelvic actinomycosis, we collected and summarized the data of age, parity, state of menopause, history of intrauterine device (IUD) use, symptoms, laboratory findings, radiologic findings, provisional diagnosis and treatment from 14 cases diagnosed pathologically and treated in Hanyang University Hospital from 2000 to 2007. Eleven (78.6%) of 14 cases were IUD users. Most common complaints were lower abdominal pain (71.4%) and vaginal discharge (57.1%) which were followed by fever (28.6%) and back pain (28.6%). Four cases (28.6%) were identified as pelvic actinomycosis before operation and in 3 cases (21.4%) malignancy was provisional preoperative diagnosis. Pelvic actinomycosis was suspected via abdominal computed tomography (CT) or cervicovaginal cytology and confirmed via endometrial biopsy or fine needle aspiration biopsy. Two cases that were diagnosed before operation and received only antibiotics therapy had no recurrence. It was suggested that pelvic actinomycosis could be suspected via abdominal CT and cervicovaginal cytology in IUD users, and endometrial biopsy and fine needle aspiration biopsy may help establish the diagnosis before the operation. Adequate preoperative antibiotics therapy could make extensive exploratory surgery avoided or conservative surgery feasible.
급성 골수성 백혈병에서 Aclacinomycin , 6 - Thioguanine , ARA - C 복합 화학 요법의 치료 효과
이문호(Mun Ho Lee),이재훈(Jae Hoon Lee),김병국(Byoung Kook Kim),김노경(Noe Kyeong Kim),최강원(Kang Won Choe),이홍복(Hong Bock Lee),김승택(Seung Taik Kim),서철원(Cheol Won Suh),김시영(Si Young Kim),방영주(Yung Jue Bang) 대한내과학회 1988 대한내과학회지 Vol.34 No.2
N/A Thirty-three patients with AML (untreated 22 and relapsing 11) were treated with induction chemotherapy with Aclacinomycin, 6-Thioguanine and Ara-C, followed by 2 courses of consolidation chemotherapy only, The results were as following: 1) Complete remission rate was 64% in previously untreated patients, and 55% in relapsing patients, respectively. 2) Median duration of response was 47+ weeks in previously untreated, and 26 weeks in relapsing patients, respectively. 3) 1n previously untreated patients, median survival was 58+ weeks. 4) In patients with relapsing AML, median survival of overall patients was 27 weeks. 5) Median period of granulocytopenia (<500/mm3) was 17 days and median time to complete remission was 27 days. Infection was suspected in most cases during hypoplastic phase and caustive organisms were gram negative bacteria, staphylococcus and fungi in most cases. 6) Among the potential prognostic variables including age, inital WBC count, performacne status and peripheral blast count, none was statistically significantly related to complete remission rate. 7) Toxicities including anorexia, nausea, vomiting, headache, alopecia and stomatitis were of mild degree and no demonstable acute cardiotoxicities were observed.
Jue Seong Lee,JungHyeok Seo,Sokho Kim,Md. Mahbubur Rahman,Hong Ju Shin 대한심장학회 2024 Korean Circulation Journal Vol.54 No.1
Background and Objectives: The therapeutic strategy for inflammation and degenerative calcification is of utmost importance for bioprosthetic heart valve (BHV) implanted patients. The purpose of this study was to compare the anti-inflammatory and anti-calcification effects of Entelon150® (grape seed extract), losartan, and rosuvastatin, in a rabbit model of intravascular BHV leaflet implantation in bovine pericardium. Methods: A total of 28 rabbits were implanted with BHV leaflet in the external jugular veins. The Entelon150® group was administered 7.7 mg/kg Entelon150® twice daily for 6 weeks after surgery. The losartan and rosuvastatin groups received 5.14 mg/kg and 1 mg/kg, respectively, once per day. The control group received 1 ml of saline once daily. And then, calcium concentration was measured in the implanted BHV, and histological and molecular analyses were performed on the surrounding tissues. Results: The calcium content of the implanted tissue in the Entelon150® group (0.013±0.004 mg/g) was lower than that in the control group (0.066±0.039 mg/g) (p=0.008). The losartan (0.024±0.016 mg/g, p=0.032) and rosuvastatin (0.022±0.011 mg/g, p=0.032) groups had lower calcium content than the control group, and higher tendency than the Entelon150® group. Immunohistochemistry revealed that the expressions of bone morphogenic protein 2 (BMP2), S-100, and angiotensin II type 1 receptor in the Entelon150® group showed lower tendency than those in the control group. The protein expression levels of BMP2 were reduced in the Entelon150® group compared with those in the control group. Conclusions: Entelon150® exhibited a significant effect, similar to other drugs, in reducing calcification and inflammation in the intravascular bovine pericardium.
Phase I Pharmacokinetic Study of Nivolumab in Korean Patients with Advanced Solid Tumors
Lee, Keun‐,Wook,Lee, Dae Ho,Kang, Jin Hyoung,Park, Joon Oh,Kim, Se Hyun,Hong, Yong Sang,Kim, Seung Tae,Oh, Do‐,Youn,Bang, Yung‐,Jue AlphaMed Press 2018 The oncologist Vol.23 No.2
<P>Conclusion. The pharmacokinetic parameters of nivolumab were similar among patients from Korea, Japan, and the U.S. The safety profile was consistent with findings from previous studies.</P>
구순열·구개열 환자 및 부모의 혈액형에 관한 임상적 고찰
이세일,주철근,홍인표,김종환 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.3
Among the congenital anomalies, the incidence of cleft lip & palate is higher in orientals, is higher and more severe on the left than right side, more cleft lip in men, and more cleft palate in women, the blood type A is relatively more frequent than other blood type in cleft patients, but the interrelationship between the incidence and blood type in cleft patients and their parents, we are studied on interrelationship. Of the 183 patients who received the operation due to cleft lip & palate from March 1986 to July 1992, we have obtained the results as follows by the analysis of the interrelationship between the incidence and the blood type of the patients & their parents. The number of patients of each blood type was as follows ; A (81/183.44.3%), B(36/183,19.7%), AB(21/168,12.5%), O(39/168,22.6%), and of paternal blood type was A(24/135,17.8%), B(30/135,22.2%), AB(39/135,28.8%), O(42/135,42%). The incidence of cleft lip & palate was higher in blood type A patients(81/183,44%), blood type A mothers (84/168,50.0%) aud blood type O fathers(42/135,42%) but there was no correlation between the patient's blood type and parents' blood type.