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Concurrent chemoradiotherapy for squamous cell carcinoma of the rectum.
Jeong, Bae Gwon,Kim, Dae Yong,Kim, Sun Young G. Thieme 2013 Hepato-gastroenterology Vol.60 No.123
<P>Primary squamous cell carcinoma of the rectum is a rare malignancy. Early reports suggest that the standard treatment is surgery, but clinical outcomes of chemoradiotherapy are more satisfying than those of surgery in recent experience. Our aim was to ascertain the effectiveness of chemoradiotherapy for squamous cell carcinoma of the rectum.</P>
권옥배(Gwon, Ok-Bae),신창훈(Sin, Chang-Hun),박승수(Park, Seung-Su),한정민(Han, Jeong-Min),이정환(Lee, Jeong-Hwan) 한국신재생에너지학회 2006 한국신재생에너지학회 학술대회논문집 Vol.2006 No.06
In Japan, research and development were undertaken on gas hydrate-side industrial processes associated with power generation system connections that may particularly be necessary to develop gas hydrated technology-based industrial systems. In so doing, data and engineering technologies useful n formulating guidelines on design of practical process were accumulated. In addition, basic research into theoretical evidence were carried out to promote and support the development of technological elements for those processes. In basic research designed to promote and support the research and development of elemental technologies microanalyses were conducted to understand the decomposition mechanism of mixed gas hydrate. Moreover, measurement technologies that can be applied in industrial processes, such as numerical analyses and concentration ion measurement, were examined. Japan has developed a highly efficient gas hydrate formation process using micro-bubbles with a tubular reactor. Higher formation rate over conventional systems has been obtained by the process. As mentioned above, the technical problems were clarified and the economics were studied from a view point of the NGH technology in this study. The results can be applied for utilization and must contribute to popularization of gas hydrate production.
방사선을 이용한 느릅나무 추출 다당류가 함유된 하이드로젤의 제조 및 항염증성 평가
권희정(Hui Jeong Gwon),박은지(Eun Ji Park),최종배(Jong Bae Choi),임종영(Jong Young Lim),정진오(Jin Oh Jeong),신영민(Young Min Shin),정성린(Sung In Jeong),박종석(Jong Seok Park),임윤묵(Youn Mook Lim),최영훈(Young Hun Choi),김상숙(Sang 한국고분자학회 2014 폴리머 Vol.38 No.1
본 연구에서는 방사선 기술을 이용하여 항염증 특성을 가지는 천연 추출물을 함유하는 고분자 하이드로젤을 제조하여 항염증 패치로서의 유용성을 확인하였다. 천연 추출물로는 오래 전부터 전통 민간요법으로 항염제나 궤양 및 종양 치료 등에 사용되고 있는 느릅나무를 사용하였고, 생체 적합성 고분자인 poly(vinyl alcohol)(PVA)와 보습률 향상을 위해 글리세린을 첨가하여 감마선 가교에 의해 다당류 함유 고분자 하이드로젤을 제조하였다. 제조된 하이드로젤은 항염증 패치로 사용하기에 우수한 기계적 물성을 나타내었고, 사이토카인 분비를 효과적으로 억제함은 물론 세포독성도 나타나지 않는 것을 확인하였다. 결론적으로 느릅나무 추출 다당류가 함유된 하이드로젤은 항염증패치로써 유용하게 사용될 수 있음을 확인하였다. In this study, polysaccharide-poly(vinyl alcohol) (PVA) hydrogels were prepared by using γ-ray and evaluatedfor potential application as an anti-inflammation patch. Ulmus davidiana var. japonica (UD), one of polysaccharides hasbeen particularly used as an oriental remedy for the treatment of inflammation and ulcers. PVA as a biocompatible polymerand glycerin as a moisturizer were blended with the UD, and its hydrogels were prepared by radiation crosslinking. Characterizations for UD hydrogels were performed by using cytotoxicity assay, antioxidant activity test, and physicochemicaltest such as gel fraction ratio, and swelling behavior. The results showed that these UD hydrogels had excellentphysical properties, anti-inflammation activity, and non-cytotoxicity on the cells. Therefore, these polysaccharidebased-UD hydrogels can be effectively used as an inflammation patch.
방사선 이용 미생물 발효 셀룰로오스 다공성 폼 제조 및 특성
권희정 ( Hui Jeong Gwon ),신영민 ( Young Min Shin ),최종배 ( Jong Bae Choi ),임종영 ( Jong Young Lim ),정진오 ( Jin Oh Jeong ),정성린 ( Sung In Jeong ),박종석 ( Jong Seok Park ),김진규 ( Jin Kyu Kim ),임윤묵 ( Youn Mook Lim ),최 한국환경생물학회 2013 환경생물 : 환경생물학회지 Vol.31 No.4
Microbial fermented cellulose gel, citrus gel (CG), was successfully fabricated to porous foam by radiation treatment and freeze drying. The chemically induced radiation was used to create highly porous foam and further freeze drying of the CG produced tough foams with interconnected open pores for use in tissue engineering. The microstructure of the CG foam was controlled by varying the irradiation dose and quenching temperature with pore size ranging from several microns to a few hundred microns. Tensile strength and Gurley value of the CG foam were influenced by irradiation dose. These radiation induced CG foams are promising scaffolds for tissue engineering.
감마선 조사에 의한 헤파린이 도입된 박테리아 셀룰로오스의 골조 직공학용 지지체로서의 개발 및 특성분석
정성린 ( Sung In Jeong ),정진오 ( Jin Oh Jeong ),최종배 ( Jong Bae Choi ),신영민 ( Young Min Shin ),박종석 ( Jong Seok Park ),권희정 ( Hui Jeong Gwon ),노영창 ( Young Chang Nho ),안성준 ( Sung Jun An ),박만용 ( Man Young Park ) 한국조직공학과 재생의학회 2014 조직공학과 재생의학 Vol.11 No.2s
Bacterial cellulose(BC) scaffolds are generated from gel by gluconacetobacter hansenii TL-2C. BC has good properties such as high-burst pressure and the ultrafine highly nanofibrous structure of mimic natural extra celluar matrix(ECM) for tissue engineering. In this study, 2-aminoethyl methacrylate(AEMA) was grafted onto BC surface using gamma-irradiation and then heparin immobilized it using EDC/NHS reaction. The surface morphology of scaffolds were confirmed BC membranes by SEM for heparin and AEMA grafted it, so that it was not changed surface morphology. The result of TBO, fluorescamine staining, ATR-FTIR confirmed that heparin and AEMA immobilized it. Also result of in vitro test, heparin immobilized AEMA-BC proliferation of hMSC to higher than unmodified BC by CCK-8 and ALP activity then heparin immobilized AEMA-BC cumulative of BMP-2 was confirmed decrease by release test. Therefore, heparin and AEMA grafted BC scaffolds have been possible to tissue scaffold in bone tissue engineering.
권순길 ( Gwon Sun Gil ),김상현 ( Kim Sang Hyeon ),이정익 ( Lee Jeong Ig ),서장원 ( Seo Jang Won ),장재원 ( Jang Jae Won ),김순배 ( Kim Sun Bae ),박정식 ( Park Jeong Sig ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.3
배 경 : 만성신부전에서 관상동맥 질환의 유병률은 정상인에 비해 증가되어 있으며 죽상경화증이 신기능을 저하시킬 수도 있다고 생각되나 아직까지 이에 대한 정확한 보고는 되어있지 않다. 맥압은 죽상경화의 정도를 반영하며 신부전 환자에서 증가되어 있어, 이에 저자들은 죽상동맥경화에 따른 관상동맥 질환과 맥압의 변화가 신부전을 진행시키는지에 대한 관련성을 비교 검토하고자한다. 방 법 : 서울아산병원에서 3년 이상 추적 관찰이 가능하였던 경증의 만성신부전 환자들을 대상으로 심혈관조영술로 관상동맥질환 여부를 검사하였고 혈청 크레아티닌 농도 및 여러 변수들을 추적 관찰하여 관상동맥질환의 유무에 따른 신부전의 진행 여부를 비교하였으며, 다변량회귀분석을 통해 신부전을 진행시킬 수 있는 여러 변수들의 관련성 여부를 검토하였다. 또한 맥압의 증가가 신부전에 주는 영향 및 이와 관련된 여러 변수들을 비교 분석하였다. 결 과 : 전체 87명 (남자 54 여자 33명)의 환자들 중 45명이 관상동맥질환이 있었으며 42명은 없었다. 관상동맥질환이 있던 45명 중 34명 (76%)에서 신부전이 진행되었으며, 관상동맥질환이 없는 42명 가운데는 22명 (52%)이 신부전의 진행을 보였다. 여러 요인들 중 신부전의 진행과 유의하게 관련된 요인으로는 평균 동맥압, 맥압, 당뇨병성 신증, 24시간 요단백, 혈청 총 콜레스테롤 농도가 있었으며 들 중 특히 맥압이 관상동맥질환과 관련이 있었다. 결 론 : 죽상경화에 의한 관상동맥질환 및 맥압의 증가는 경도의 만성신부전 환자에서 신부전의 진행과 유의한 관련이 있는 것으로 사료된다. Background : Patients with end-stage renal disease have farther excess rate of coronary artery disease (CAD) than nonuremic population. There is a possibility that artherocslerosis may aggravate renal insufficiency, but it is not certain. Pulse pressure was also significantly increased in patients with chronic renal disese (CRD), and had been implicated in the development of atherocclerosis. The purpose fo this study is to identify the association of atherosclerotic CAD and pulse pressure with renal disease progression in patients with mild CRD Method : The patients with mild CRD who had been followed up more than 3 years in Asan medical center, Seoul, Korea, were included. We evaluated their CAD via coronary angiography, and followed up their serum creatinine levels and other parameters assumed to be associated with progression of CRD. All clinical and laboratory parameters were analyzed by multivariate logictic method. And we examined the association between pulse pressure and progression of CRD with related factors via multivariate logistic analysis. Results: Total 87 patients (54 were men and 33 were women) were included in this study. 45 patients had coronary heart disease and 42 had not. Comparison of CRD progression between the patients who had CAD (n=45) and those who not (n=42) showed a significant difference (76% vs 52%, p<0.05). Mean arterial pressure, pulse pressure, presence of diabetic nephrophthy, 24hour urine protein, total cholesterol were the parameters associated with the progression of CRD. Among of them, proteinuria and mean arterial pressure were independent risk factors for renal disease progression. Therer was a significant association between CAD and pulse pressure. Conclusion: Atherosclerotic CAD and increased pulse pressure were associated with renal disease progression in the patients with mild renal insufficiency. (Korean J Nephrol 2003;22(3):313-320)