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( Anna Chang ),( Chi-Feng Hung ),( Pei-Wen Hsieh ),( Horng-Huey Ko ),( Su-Jane Wang ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.6
Eupafolin, a constituent of the aerial parts of Phyla nodiflora, has neuroprotective property. Because reducing the synaptic release of glutamate is crucial to achieving pharmacotherapeutic effects of neuroprotectants, we investigated the effect of eupafolin on glutamate release in rat cerebrocortical synaptosomes and explored the possible mechanism. We discovered that eupafolin depressed 4-aminopyridine (4-AP)-induced glutamate release, and this phenomenon was prevented in the absence of extracellular calcium. Eupafolin inhibition of glutamate release from synaptic vesicles was confirmed through measurement of the release of the fluorescent dye FM 1-43. Eupafolin decreased 4-AP-induced [Ca<sup>2+</sup>]<sub>i</sub> elevation and had no effect on synaptosomal membrane potential. The inhibition of P/Q-type Ca<sup>2+</sup> channels reduced the decrease in glutamate release that was caused by eupafolin, and docking data revealed that eupafolin interacted with P/Q-type Ca<sup>2+</sup> channels. Additionally, the inhibition of calcium/calmodulindependent protein kinase II (CaMKII) prevented the effect of eupafolin on evoked glutamate release. Eupafolin also reduced the 4-AP-induced activation of CaMK II and the subsequent phosphorylation of synapsin I, which is the main presynaptic target of CaMKII. Therefore, eupafolin suppresses P/Q-type Ca<sup>2+</sup> channels and thereby inhibits CaMKII/synapsin I pathways and the release of glutamate from rat cerebrocortical synaptosomes.
Chang, Hye Jung,Kalinin, Sergei V.,Morozovska, Anna N.,Huijben, Mark,Chu, Ying‐,Hao,Yu, Pu,Ramesh, Ramamoorthy,Eliseev, Evgeny A.,Svechnikov, George S.,Pennycook, Stephen J.,Borisevich, Albina Y WILEY‐VCH Verlag 2011 Advanced Materials Vol.23 No.21
<P><B>Direct atomic displacement mapping at ferroelectric interfaces</B> by aberration corrected scanning transmission electron microscopy(STEM) (a‐STEM image, b‐corresponding displacement profile) is combined with Landau‐Ginsburg‐Devonshire theory to obtain the complete interface electrostatics in real space, including separate estimates for the polarization and intrinsic interface charge contributions. </P>
최저주거기준 미달가구의 특성 및 지역적 차이에 관한 연구
서안나(Anna Seo),여창환(Change Hwan Yeo),김재익(Jae Ik Kim) 한국주택학회 2016 주택연구 Vol.24 No.3
본 연구에서는 최저주거기준 미달가구를 면적기준과 시설기준으로 구분하여 그들의 특성을 분석하였다. 분석을 위해 2010년 주거실태조사 자료를 사용하였으며 이항로짓모형으로 최저주거기준 미달가구의 사회경제적 특성뿐만 아니라 지역적 특성도 아울러 파악하였다. 분석결과 면적기준 최저주거기준 미달가구는 도시지역-청년층-공동주택의 문제로 요약되는 반면, 시설기준 미달가구는 농어촌지역-비청년층-단독주택의 문제로 요약되었다. 그리고 주택이외의 거처 즉, 기타거처의 거주자가 두 기준 모두 최저주거기준 미달가구가 될 확률이 가장 높게 나타났다. 본 연구는 이러한 분석결과를 바탕으로 최저주거기준 미달유형에 알맞은 정책적 대응방안이 요구되며 또한, 지역특성을 고려한 정책적 접근이 중요함을 강조하였다. In spite of the policy efforts to reduoe housing poverty, national housing poverty ratio measured by the ratio of households under sub-standard housing conditions was still high (10.6%) in 2010. This research is designed to analyze the current status of households in sub-standard national housing conditions both in terms of living area and facility standard based on the 2010 Korea Housing Survey data, and to suggest some useful housing policy implications. The characteristics of households under substandard housing condition in living area standard reveal that it is a problem of young households, renters, and non-house shelters. Consequently, it is a problem of urban area, rather than rural area. Meanwhile, the characteristics of households under substandard housing condition in facility standard demonstrate that it is a problem of old people and non-house shelters. In contrast with living area standard, it is a problem of rural area, rather than urban area. This research also proves that there exists a severe difference in type of substandard housing conditions among regions. Housing policy priority should be given differently between rural and urban areas, as well as among regions. Therefore, housing policy implementation should be led by local governments who better know local situations and conditions.
Morphological Study of the Subdeltoid Bursa and its Innerrvation
서창민 ( Chang Min Seo ),전안나 ( Anna Jeon ),정윤희 ( Yoon Hee Jeong ),김경용 ( Kyung Yong Kim ),한승호 ( Seung Ho Han ),이원복 ( Won Bok Lee ) 중앙대학교 의학연구소 2017 中央醫大誌 Vol.42 No.1
The subdeltoid bursa is one of the main structures that cause shoulder pain. Previous studies have discussed the locations and innervation of sensory nerve of the subacromial bursa at large, and there was no detailed study focusing on the subdeltoid bursa. The aim of this study was to accurately identify the distribution of sensory nerve branches running to subdeltoid bursa with mesoscopic dissection and the boundaries after injecting gelatin into the bursa. Fifteen shoulders of 11 Korean soft cadavers were dissected (average age 65, age ranged 43~88 years). The most prominent point of greater tubercle of the humerus (GT) were used reference point. The horizontal line passing through GT was used as x-axis and the vertical line passing through the GT was used as y-axis. The average anterior, posterior, superior, and inferior were 1.9±0.6, 2.4±1.3, 2.1±0.7, and 3.2±1.5 cm from the GT, respectively. The most common shape of subdeltoid bursa was oval shape. In 15 shoulders, the anterior branch of the axillary nerve distributed to subdeltoid bursa with running posteriorly. The muscular branch of anterior and middle parts of the deltoid distributed to the branch of nerve that into the subdeltoid bursa. Most branches of axillary nerve were distributed in the posterolateral area. Chung-Ang J Med 2017; 42(1): 25-30