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이미희,Hye Ryeon Lim,Tek Hyung Lee,박종철 한국생체재료학회 2009 생체재료학회지 Vol.13 No.1
In this study, we fabricated porous PLGA microparticles loaded with EGCG by a modified water-in-oil-in-water (W/ O/W) double emulsion solvent evaporation method. The physicochemical properties of the EGCG-loaded PLGA microparticles were studied using scanning electron microscopy (SEM), Fourier transformed-infrared (FT-IR) spectroscopy and in vitro release measurements. A remarkable burst effect was observed on first stage however the released amount was reduced largely with time. This result showed that the release of EGCG increased by its loading amount. Also, EGCG - loaded PLGA particles inhibited the growth of rat aortic smooth muslce cells (RASMC). This study demonstrates that PLGA microparticle system is potential as an efficient EGCG carrier in medical therapy.
이미희,한재숙,소궤신행,남출륭구,Lee Mi-Hee,Han Jae-Sook,Kozukue Nobuyuki,Minamide Takahisa 동아시아식생활학회 2005 동아시아식생활학회지 Vol.15 No.3
This study was carried out to examine physicochemical characteristics of three kinds of commercial spinach produced from three areas(Gyeongbuk Yeongdeok Younghea, Gyeongnam Tongyeong Yongnam, Gyeongnam Tongyeong Gwangdo) in autumn of 2004. The length, weight, moisture, minerals, oxalic acid, chlorophyll, vitamin C, and Hunter's color values of spinach leaves and stem; were determined. Mg, Ca, Na, K, chlorophyll, and vitamin C contents of leaves were higher than those of stems. On the other hand, stem; showed higher contents in Fe, P and oxalic acid Moisture, Mg, Na, Fe, chlorophyll, and vitamin C contents in the spinach leaves from Gwangdo were higher than those from Yongnam and Younghea, but oxalic acid lower a little.
감각 조절 장애 아동에 대한 감각통합치료 캠프의 효과 - 사례보고
이미희,Lee, Mi-Hee 대한감각통합치료학회 2003 대한감각통합치료학회지 Vol.1 No.1
Objective : To explore the effect of intensive sensory integration therapy through daily camp programs for children with sensory modulation disorder. Methods : A comparison of quantitative data and qualitative description between before and after sensory integration therapy camp and main outcome measure was used, including MAP behavior checklist, JSI-2, COPM, sensory history, STEP-SI. Results : The adaptive response was increased and sensory modulation problems were observed less than before the camp. Conclusion : For this study a more diverse, extended and intensive SI program is considered necessary. Further study is needed to develop these findings.
추출 용매에 따른 산딸기 추출물의 항산화 및 항균 활성
이미희,이정은,Lee, Mi-Hee,Lee, Jeong-Eun 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.5
The objective of the present study was to determine the total phenol and flavonoid contents and to evaluate the antioxidant potential, of different solvent extracts (ethyl acetate, n-butanol, chloroform, and water) from Robus idaeus in various radical scavenging models (DPPH activity, superoxide dismutase (SOD) activity, reducing power, and nitrite scavenging activity), along with their antimicrobial potential. Measurement of total phenol and flavonoid content of the ethyl acetate extract of R. idaeus was found to be significantly higher than those of the other extracts. The ethyl acetate extract (at a concentration of $1,000{\mu}g/mL$) showed significantly higher reducing power and DPPH radical scavenging activity as compared to the other extracts. Results were dose-dependent. Moreover, the ethyl acetate extract of R. idaeus ($1,000{\mu}g/mL$) showed potent antioxidant efficacy ($85.5{\pm}1.18%$) as evidenced by nitrite scavenging ability at pH 1.2. All solvent extracts of R. idaeus showed lower SOD-like activity (13.72~20.54%). In addition, the antimicrobial activity of all solvent extracts except water extract showed strong inhibition (inhibitory zones in mm) of Staphylococcus aureus ($19.40{\pm}1.00mm$) and Bacillus cereus ($20.50{\pm}0.21mm$) growth. In particular, ethyl acetate extracts (100 mg/mL) showed antimicrobial activity comparable to that of tetracycline (0.01 mg/mL), which was used as a positive control. The results of this study indicate that the ethyl acetate extract of R. idaeus is a natural antioxidant and antimicrobial, with enriched phenols and flavonoids concentration, that has potential in the development of health-enhancing food products.
이동훈 ( Dong Hun Lee ),도은진 ( Eun Jin Doh ),이진영 ( Jin Young Lee ),박양 ( Yang Park ),오재원 ( Jae Won Oh ),이미희 ( Mi Hee Lee ),홍수종 ( Soo Jong Hong ),이소연 ( So-yeon Lee ),박준수 ( Joon Soo Park ),남동호 ( Dong-ho Nahm 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.4
Purpose: The effective management of atopic dermatitis (AD) adjusted to individual clinical courses and demands can be challenging to both patients and physicians. Understanding of actual situations, experienced and perceived by patients with AD and their caregivers, is essential to improve clinical outcomes and satisfaction in real practice.Methods: This multicenter survey was conducted in patients with AD or their caregivers from 9 centers with questionnaires on diagnosis and management of AD.Results: A total of 324 patients and caregivers participated in the study. Most of the AD cases were initially diagnosed by physicians (80.6%), followed by self-diagnosis. Patients and caregivers thought that allergic substances, such as house dust mites, food, and pollutants, are responsible for AD development; moisturization, environmental control, and improvement of the body constitution are important for AD management. Allergy tests were performed in 194 patients (59.9%), but allergen avoidance strategy was instructed in only 81 subjects (41.8%). Major topical medications were steroids (81.8%) and topical immunomodulators (34.3%), while systemic medications were steroids (42.6%), antihistamines (36.4%), and cyclosporins (2.8%). One hundred eighty-one subjects (55.9%) had received complementary alternative medicine, including Oriental medicine. Many subjects desired to receive individualized management, use of specialized institutions for AD as well as evidence-based, effective, sustainable treatment.Conclusion: Our findings suggest that there may still be an unmet need for patients with AD in real practice. Personalized, evidence-based, and multidisciplinary approaches, including patient education, should be implemented for good outcomes. (Allergy Asthma Respir Dis 2016:4:271-275)
어린이집 적응과정에서 영아기 자녀의 어머니가 경험한 어린이집 지원의 의미
이미희(Lee Mi Hee),김언경(Kim Eon Kyung) 학습자중심교과교육학회 2021 학습자중심교과교육연구 Vol.21 No.16
목적 본 연구는 어린이집 적응과정에서 영아기 자녀의 어머니가 경험한 어린이집의 지원이 무엇인지 알아보고, 이것이 어떤 의미를 갖는지 탐색함으로써 영아기 적응프로그램과 부모교육의 내용과 방향에 대한 기초자료를 제공하고자 하였다. 방법 이를 위하여 영아기 자녀를 어린이집에 보낸 경험이 있는 어머니 5명을 대상으로 반구조화된 형태의 심층면담을 실시하였다. 총 5주 동안 각 3회씩 면담을 실시하였으며, 면담은 회당 30분~1시간 30분 정도가 소요되었다. 면담의 내용은 모두 녹음하여 전사하였다. 전사된 면담의 내용은 개방코딩 방법을 사용하여 이를 범주화하고, 질적으로 분석하였다. 결과 연구 결과 첫째, 어린이집 적응과정에서 영아기 자녀의 어머니가 경험한 어린이집의 지원은 ‘처음인 부모와 아이에게 정서적 지원하기’, ‘부모 역할과 자녀 양육에 대한 정보 지원하기’였다. 둘째, 어린이집 적응과정에서 영아기 자녀의 어머니가 경험한 어린이집 지원의 의미는 ‘부모와 아이 모두에게 처음이었던 과정의 문턱 넘어서기’, ‘함께 키우는 우리 아이’로 나타났다. 결론 어린이집 적응 과정은 영아뿐만 아니라 부모도 함께 적응해나가는 과정으로 어린이집에서는 부모와 자녀 모두에게 개별적인 요구를 수용하는 정서적 지원을 통해 신뢰감을 형성하여 안정적으로 적응해나갈 수 있도록 해야 하며, 각 가정의 상황에 맞는 자녀 양육과 부모역할에 대한 정보를 제공함으로써 부모와 함께 협력하여 영아의 안정적인 적응을 위해 노력해야 한다. Objectives The purposes of this study were to examines the child care center support experienced by mothers of infant children in the adaptation process, and by analyzing what it means, we wanted to provide basic data on the contents and direction of infant child adaptation programs and parent education. Methods For this study, a semi-structured in-depth interview was conducted with five mothers who had sent their infant children to child care centers. The interview was held three times each for a total of five weeks, and it took 0.5 to 1.5 hours per meeting. All the contents of the interview were recorded and transcribed. The content of the transcribed interviews was categorized and qualitatively analyzed using the open coding method. Results First, the study found that the support of child care centers experienced by mothers who send infant children to child care centers in the adaptation process is ‘Emotional support for the first-time parents and children.’, ‘Supporting information about parental roles and child-rearing.’ Second, the meanings of that support are ‘Crossing the threshold of a process that was first for both parents and children.’, ‘Our children that we raise together.’. Conclusions The adaptation process of child care centers is that not only children but also parents adapt together, and child care centers should build trust through emotional support that accommodates individual needs for both parents and children so that they can adapt stably. In addition, by providing information on child-rearing and parental roles suitable for each family s circumstances, it is necessary to work together with the parents to ensure stable adjustment of the infant.