What Can Caenorhabditis elegans Tell Us About Nematiocides and Parasites\ulcorner

Dent, Joseph A. The Korean Society for Biotechnology and Bioengine 2001 Biotechnology and Bioprocess Engineering Vol.6 No.4

Nematode infections compromise human health and reduce agricultural productivtiy. Experiments that exploit the powerful molecular genetics of the free-living nematode Caenorhabdl - elegans have contributed to our understanding of how the major classes of anthelmintic nema-tocides kill worms and how worms might evolve resistance to these drugs In C. elegans, as in parasites, benzimidixoles interfere with microtubule polyumerization the imidazothiazoles/tetra-hydropyrimidines activate nicotinic acetylcholine receptors, and the macrocyclic la ctones activate qlutamate-gate chloride chanels. Mutant alleles of genes that encode drug targes often confer resistance in C. elegans. Preliminary evidence suggests that alleles of homologous genes in parasites will, in many cases, also play a role in resistance. Thus information acquired from C. elegans can be usefully applied to understand the mechanisms of drug sensitivity and the genetics of resis-tance in parasites.

Hiatus Hernia and Reflux

Dent, John Medical Publications Korea 1976 Medical Progress Vol.3 No.9

Economic exchange and Diplomacy in Korea-EU relations

Dent, Christopher, M 韓國外國語大學校 經濟經營硏究所 1998 經濟經營硏究 Vol.17 No.1

SOUTH KOREA'S FOREIGN ECONOMIC POLICY: NEW PARAMETERS AND PRESSURES EXAMINED

Dent. Christopher M The Institute of East and West Studies 1998 Global economic review Vol.27 No.2

This paper considers the various challenges and pressures that confront Korea in developing its future foreign economic policy (FEP). It is set against the context of the country's recent financial problems but also examines previous economic developments in the Korean economy, how the parameters of FEP can be defined, the impact of globalisation and systemic change in the world economy, the tension between domestic and international forces in the crucible of FEP-making and offers a theoretical perspective to this latter discussion. Finally, the future direction of Korea's FEP is considered with particular reference to issues of economic diplomacy, diversification and the 'advocacy' principle.

Using the SPICES model to develop innovative teaching opportunities in ambulatory care venues

John Dent 한국의학교육학회 2014 Korean journal of medical education Vol.26 No.1

It is possible to begin new teaching opportunities in a variety of ambulatory care venues and design these teaching and learningprogrammes using the SPICES approach to curriculum reform. In an ambulatory care teaching programme it is possible to stimulatemore student-centred learning and to move away from clinician-focused teaching. Opportunities for integrated learning and problemsolving can be provided and an inter-professional approach fostered. Learning in the clinical context can be structured to meet bothstudents’ needs and curriculum requirements. Finally, opportunities for elective studies can be taken by students with a particularinterest in a topic encountered. Developing a new teaching programme in an ambulatory care venue provides an opportunity tointroduce elements of the SPICES approach to learning. The new programme created can be a model of innovative teaching ina medical school wishing to develop a revised undergraduate curriculum.

[特輯]The ASEM Process: A British Perspective

Christopher M. DENT 신아시아연구소(구 신아세아질서연구회) 2000 신아세아 Vol.7 No.3

싱가포르가 1994년에 제기한 파리선언을 계기로 국제체제의 경제화, APEC의 발전 등 국제환경의 제 변화가 ASEM의 수립으로 이어졌다. 특히 유럽은 태평양시대에서 주변부로 뒤떨어질 위기에 직면했고, 유럽연합은 1994년 "신아시아 전략"을 수립하였다. ASEM체제는 바로 이를 추진하기 위한 하나의 장이 되었다. ASEM은 서로 상충될 수 있는 여러 성격을 지닌다. 첫째, ASEM은 세계의 자본주의 발전을 강화시키는 지역간 프로젝트이다. 둘째, ASEM은 북미·유럽·아시아라는 삼각정치경제체제를 조정하는 역할을 담당한다. 셋째, ASEM은 다자주의를 강화시키는 도구이다. 넷째, ASEM은 동시에 다자주의의 발전을 저해하는 요소가 될 수 있다. 다섯째, ASEM은 미래에 형성될 수 있든 유라시아 시민사회의 기초가 될 수 있다. 다른 유럽 국가들과 마찬가지로 영국은 ASEM에 깊은 관심을 갖고 있다. 1997-8년 동아시아 경제위기의 와중에 1998년 런던에서 제2차 ASEM이 개최되었다. ASEM에 대한 영국의 입장은 여러 복합적 변수들의 영향을 받는다. 무엇보다 영국은 국내적으로 보호주의의 유혹을 거부하고 자유주의를 확산해야 한다는 입장이 강하다는 점이다. 대처 집권기의 영국은 미국보다 먼저 신자유주의의 시험장이었다. 영국뿐만 아니라 유럽연합은 ASEM과 WTO체제 간의 조화를 지속적으로 희망해 왔다. 국제관계적 측면에서 영국의 ASEM에 대한 태도는 영국·유럽관계, 영국 ·구(舊)대영제국 식민지관계, 경제 및 투자 강대국으로서의 영국의 이익 등에 의해 영향을 받는다. 예를 들어 영국은 남아시아 국가들과 역사적·문화적 유대관계가 깊다. 따라서 ASEM이 남아시아 지역으로 확대될 경우 영국의 ASEM에 대한 이해는 한층 더 깊어질 것이다. 1997년 외무장관 로빈 쿡은 영국의 새로운 외교정책 원칙으로 안보, 번영, 삶의 질, 상호존중을 지적하였다. 영국의 ASEM에 대한 입장도 기본적으로 이 연장선상에 있다. ASEM에 대한 영국의 관심은 이념적·정치경제적 측면도 포함된다. 영국은 동아시아 국가에 유럽형 신자유주의가 미국형보다 더 적합할 것으로 본다. 영국은 유럽 내 신자유주의에 대한 이념적 논의에 적극 가담해 왔다. 블레어 수상과 A. 기든스의 제3의 길은 그 가능성의 한 표현이다. 제3의 길의 원칙은 다음과 같다: (1)사회민주주의의 갱신, (2)시장과 세계화의 도전에 대한 적극적인 대처, (3)국가와 시민 모두의 공민적 책임 부담, (4)교육·수송·보건 분야의 사회적 투자, (5)개인에 기초한 것이 아니라 공동체에 기초한 정치 등이다. ASEM은 영국이나 유럽연합에게 자신들의 이념과 정치경제모델을 알릴 수 있는 유용한 장이다.

Using the SPICES model to develop innovative teaching opportunities in ambulatory care venues

John A. Dent 한국의학교육학회 2014 Korean journal of medical education Vol.26 No.1

It is possible to begin new teaching opportunities in a variety of ambulatory care venues and design these teaching and learning programmes using the SPICES approach to curriculum reform. In an ambulatory care teaching programme it is possible to stimulate more student-centred learning and to move away from clinician-focused teaching. Opportunities for integrated learning and problem solving can be provided and an inter-professional approach fostered. Learning in the clinical context can be structured to meet both students’ needs and curriculum requirements. Finally, opportunities for elective studies can be taken by students with a particular interest in a topic encountered. Developing a new teaching programme in an ambulatory care venue provides an opportunity to introduce elements of the SPICES approach to learning. The new programme created can be a model of innovative teaching in a medical school wishing to develop a revised undergraduate curriculum.

Unusual magnetic order in the pseudogap region of the superconductor HgBa₂CuO_4+δ

Li, Y.,Balé,dent, V.,Bariš,ić,, N.,Cho, Y.,Fauqué,, B.,Sidis, Y.,Yu, G.,Zhao, X.,Bourges, P.,Greven, M. Macmillan Publishers Limited. All rights reserved 2008 Nature Vol.455 No.7211

The pseudogap region of the phase diagram is an important unsolved puzzle in the field of high-transition-temperature (high-T<SUB>c</SUB>) superconductivity, characterized by anomalous physical properties. There are open questions about the number of distinct phases and the possible presence of a quantum-critical point underneath the superconducting dome. The picture has remained unclear because there has not been conclusive evidence for a new type of order. Neutron scattering measurements for YBa<SUB>2</SUB>Cu<SUB>3</SUB>O<SUB>6+δ</SUB> (YBCO) resulted in contradictory claims of no and weak magnetic order, and the interpretation of muon spin relaxation measurements on YBCO and of circularly polarized photoemission experiments on Bi<SUB>2</SUB>Sr<SUB>2</SUB>CaCu<SUB>2</SUB>O<SUB>8+δ</SUB>(refs 12, 13) has been controversial. Here we use polarized neutron diffraction to demonstrate for the model superconductor HgBa<SUB>2</SUB>CuO<SUB>4+δ</SUB> (Hg1201) that the characteristic temperature T* marks the onset of an unusual magnetic order. Together with recent results for YBCO, this observation constitutes a demonstration of the universal existence of such a state. The findings appear to rule out theories that regard T* as a crossover temperature rather than a phase transition temperature. Instead, they are consistent with a variant of previously proposed charge-current-loop order that involves apical oxygen orbitals, and with the notion that many of the unusual properties arise from the presence of a quantum-critical point.

Trajectories, Transitions, and Trends in Frailty among Older Adults: A Review

Emiel O. Hoogendijk,Elsa Dent 대한노인병학회 2022 Annals of geriatric medicine and research Vol.26 No.4

Frailty is an age-related clinical state associated with deterioration across multiple physiological systems and a leading cause of morbidity and mortality later in life. To understand how frailty develops and what causes its progression, longitudinal data with repeated frailty measurements are required. This review summarizes evidence from longitudinal studies on frailty trajectories, transitions, and trends. We identified several consistent findings: frailty increases with aging and is a dynamic condition, and more recent generations of older adults have higher frailty levels. These findings have both clinical and public health relevance, including the provision of healthcare and aged care services in the coming years. Further studies are required, particularly those conducted in low- and middle-income countries and those investigating factors associated with changes in frailty. The latter may help develop better-targeted interventions to reverse or slow the progression of frailty.

Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24)

Bhutia, Sujit K.,Das, Swadesh K.,Azab, Belal,Dash, Rupesh,Su, Zhao-Zhong,Lee, Seok-Geun,Dent, Paul,Curiel, David T.,Sarkar, Devanand,Fisher, Paul B. Taylor and Francis 2011 Autophagy Vol.7 No.9