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Yaotang Ji,Hongli Suo,ZiLi Zhang,Lin Ma,Jiazhi Li,Chengxi Zhang,Xingyu Wu,Shaheen Kausar,Jin Cui,Min Liu,Yi Wang,Qiuliang Wang 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.5
Three types of Ni8W/Ni12W/Ni8W composite substrates with strong cube texture, high yield strength, and low magnetizationwere produced by heavy cold rolling and annealing processes. The three types of composite substrates have the same thickness,but the ratios of thickness between Ni–8 at%W and Ni–12 at%W layer are different. The contents of tungsten exceed9.3 at%, 10 at%, and 10.3 at% in the three types of obtained substrates. The presence of Ni alloys with higher W content inthe Ni–12 at%W of the three composite substrates strongly enhanced the mechanical properties with about 290, 300 and315 MPa respectively, and decreased the ferromagnetic behavior of the whole substrates. Additionally, it was found that anarea that enhances cubic nucleation and growth in the Ni8W layer of composite substrates.
Zhongyuan Tian,Lu Yang,Penghui Li,Yuncai Xiao,Jian Peng,Xiliang Wang,Zili Li,Mei Liu,Dingren Bi,Deshi Shi 한국통합생물학회 2016 Animal cells and systems Vol.20 No.2
Enterococcus faecium HDRsEf1 strain used as a probiotic to inhibit intestine inflammation and improve animal growth performance has been proved by our research team; however, it remains unclear how HDRsEf1 was recognized by intestine cells and how it activates the downstream pathway which benefit intestine health. In this study, HDRsEf1 was used to stimulate HT-29 cell line to partially uncover the intestine benefit mechanism of HDRsEf1. The results of cell viability assays showed that HDRsEf1 had no toxicity on HT-29 at concentrations up to 1 × 108 CFU/mL, HDRsEf1 could upregulate the TLR1, TLR2, and TLR6 mRNA level, especially TLR2, and significantly downregulate the mRNA level of TLR4, TLR5, TLR7, TLR8, but did not significantly affect the mRNA or protein level of MyD88, which suggests that HDRsEf1 activates the TLR2 pathway in an MyD88-independent pattern. HDRsEf1 could significantly downregulate the mRNA level of pro-inflammatory factors IL-1β, IL-6, IL-8, IL-12p35, IL-17, and TNF-α and did not affect the anti-inflammatory factors IL-10, PPAR-γ, and TSLP; besides HDRsEf1 did not upregulate the degradation of IκB in HT-29 cells. By contrast, enterohemorrhagic E. coli (EHEC) O157:H7 strongly up-regulated the mRNA level of pro-inflammatory factors IL-1β, IL-6, IL-8, IL-23, and TNF-α, downregulated obviously anti-inflammatory factor PPAR-ɣ, and obviously upregulated the degradation of IκB, which suggested that HDRsEf1 may act as an antagonist to regulate intestine inflammation response to intestine pathogen. These findings shed a light on the intestine benefit mechanism of HDRsEf1.
Junli Lyu,Encong Zhu,Rukai Li,Bai Sun,Zili Wang 국제구조공학회 2023 Steel and Composite Structures, An International J Vol.46 No.4
In order to study the fire resistance of castellated composite beams with ortho-hexagonal holes and different beamend restraints, temperature rise tests with constant load were conducted on full-scale castellated composite beams with orthohexagonal holes and hinge or rigid joint constraints to investigate the temperature distribution, displacement changes and failure patterns of castellated composite beams with two different beam-end constraints during the whole course of fire. The results show that (1) During the fire, the axial pressure and horizontal expansion deformation generated in the rigid joint constrained composite beam were larger than those in the hinge joint constrained castellated composite beam, and their maximum horizontal expansion displacements were 30.2 mm and 17.8 mm, respectively. (2) After the fire, the cracks on the slab surface of the castellated composite beam with rigid joint constraint were more complicated than hinge restraint, and the failure more serious; the lower flange and web at the ends of the castellated steal beams with hinge and rigid joint constraint produced serious local buckling, and the angles of the ortho-hexagonal holes at the support cracked; the welds at both ends of the castellated composite beam with rigid joint constraint cracked. (3) Based on the simplified calculation method of solid-web composite beam, considering the effect of holes on the web, this paper calculated the axial force and displacement of the beam-end constrained castellated composite beams under fire. The calculation results agreed well with the test results.