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Zhou, Yongqin,Hu, Bo,Wang, Hang,Jin, Ningzhi,Zhou, Meilan The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.2
In this paper, a flux linkage model based on four magnetization curves fitting is proposed for three-phase 12/8 switched reluctance motor (SRM), with the analysis of the basic principle of flux detection method and function analysis method. In the model, the single value function mapping relationship between position angle and flux is established, which can achieve a direct estimation of rotor position. The realization scheme of SRM indirect position detection system is presented. It is proved by simulation and experiment that the proposed scheme is suitable for rotor position detection of SRM, and has high accuracy of position estimation.
Zhou Yongqin,Huang Ce,Chen Junjie,Shi Guijun,Zhou Meilan 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.6
Due to synchronous rectification based on Phase-shift full bridge converter is difficult to work in a state of soft switch, to solve this problem, this paper sets out an control approach of synchronous rectification based on the ZVZCS phase-shifted full-bridge, and the drive signal of synchronous rectification side uses leading-leg drive waveform after a certain time delay and applies the resonant principle in the switching process,not only keeping full bridge ZVZCS soft switching but also realizing MOSFET of the synchronous rectification ZVS. The simulation of saber and experimental research show that the converter has a good performance.
Yongqin Zhou,Bo Hu,Hang Wang,Ningzhi Jin,Meilan Zhou 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.2
In this paper, a flux linkage model based on four magnetization curves fitting is proposed for three-phase 12/8 switched reluctance motor (SRM), with the analysis of the basic principle of flux detection method and function analysis method. In the model, the single value function mapping relationship between position angle and flux is established, which can achieve a direct estimation of rotor position. The realization scheme of SRM indirect position detection system is presented. It is proved by simulation and experiment that the proposed scheme is suitable for rotor position detection of SRM, and has high accuracy of position estimation.
Fan Yang,Hairong Xiong,Li Duan,Qian Li,Xin Li,Yongqin Zhou 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4
Purpose MicroRNAs (miRNAs) are a group of small non-coding RNAs involved in different cancers, including lung cancer. Here, we aim to investigate the expression profiles of circulating miRNAs and their roles contributed to the progress of lung cancer. Materials and Methods The levels of circulating miRNA in lung cancer patients were investigated by miRNAs assay. Then we predicted the target genes of aberrantly expressing miRNAs by searching genetic databases. Based on the A549 cells transfected with miR-1246 mimics or miR-1246 inhibitor, we further measured the roles of miR-1246 involving in the epithelial-mesenchymal transition (EMT), migration and invasion capacities of lung cancer cells in vitro. Finally, we detected the effects of miR-1246 on glycogen synthase kinase-3β (GSK-3β)/β-catenin pathway by immunofluorescence and Western blot, respectively. Results We identified that 14 miRNAs were aberrantly expressed in the serum of lung cancer patients. Among them, miR-1246 was the most up-regulated. The cell assays indicated that miR-1246 significantly increased the migration and invasion capabilities of A549 lung cancer cells. Meanwhile, immunofluorescence analysis revealed that miR-1246 promoted EMT process of A549 cells accompanying with decreasing E-cadherin expression, while increasing vimentin and transforming growth factor β expression. Furthermore, an online tool predicated that miR-1246 might bind to 3'-untranslated region of GSK-3β, which was confirmed by overexpression and knockdown of miR-1246 assays. Conclusion Taken together, the study illustrates that miR-1246 regulates Wnt/β-catenin pathway through targeting GSK-3β/β-catenin, which partly contributing to tumor metastasis. MiR- 1246 may play an essential role in the diagnosis and therapeutic of lung cancer.
Therapeutic inhibition of SGK1 suppresses colorectal cancer
Xuchun Liang,Chunling Lan,Guanming Jiao,Wencheng Fu,Xuesha Long,Yu An,Kejin Wang,Jinzhe Zhou,Ting Chen,Yongqin Li,Jiahong Xu,Qi Huang,Bin Xu,Junjie Xiao 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Colorectal cancer (CRC) is one of the leading causes of death worldwide. Thus, the development of new therapeutic targets for CRC treatment is urgently needed. SGK1 is involved in various cellular activities, and its dysregulation can result in multiple cancers. However, little is known about its roles and associated molecular mechanisms in CRC. In present study, we found that SGK1 was highly expressed in tumor tissues compared with peri-tumor samples from CRC patients. In vitro experiments revealed that SGK1 overexpression promoted colonic tumor cell proliferation and migration and inhibited cell apoptosis induced by 5-fluorouracil (5-FU), while SGK1 shRNA and inhibitors showed the inverse effects. Using CRC xenograft mice models, we demonstrated that knockdown or therapeutic inhibition of SGK1 repressed tumor cell proliferation and tumor growth. Moreover, SGK1 inhibitors increased p27 expression and promoted p27 nuclear accumulation in colorectal cancer cells, and p27 siRNAs could attenuate the repression of CRC cell proliferation induced by SGK1 inhibitors. Collectively, SGK1 promotes colorectal cancer development via regulation