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Nonlocal Formulation for Numerical Analysis of Post-Blast Behavior of RC Columns
Li, Zhong-Xian,Zhong, Bo,Shi, Yanchao,Yan, Jia-Bao Korea Concrete Institute 2017 International Journal of Concrete Structures and M Vol.11 No.2
Residual axial capacity from numerical analysis was widely used as a critical indicator for damage assessment of reinforced concrete (RC) columns subjected to blast loads. However, the convergence of the numerical result was generally based on the displacement response, which might not necessarily generate the correct post-blast results in case that the strain softening behavior of concrete was considered. In this paper, two widely used concrete models are adopted for post-blast analysis of a RC column under blast loading, while the calculated results show a pathological mesh size dependence even though the displacement response is converged. As a consequence, a nonlocal integral formulation is implemented in a concrete damage model to ensure mesh size independent objectivity of the local and global responses. Two numerical examples, one to a RC column with strain softening response and the other one to a RC column with post-blast response, are conducted by the nonlocal damage model, and the results indicate that both the two cases obtain objective response in the post-peak stage.
Flexural Behavior of Circular Hollow RC Piers with Reduced Amounts of Inner Hoops
Zhong-Xian Li,Chun-yu Du,Xiao Liang,Bo Zhao 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.2
Reversed cyclic loading tests of two circular hollow RC piers were conducted in this study to investigate the effect of different amounts of inner and outer circular hoops on their flexural behavior. The test results showed that the column with a smaller amount of inner circular hoops presented better flexural response than the as-built column with an equal amount of inner and outer circular hoops. Also, the demand developed on the inner circular hoops was smaller than the outer one within the plastic hinge regions, which verified that using a smaller amount of inner circular hoops was reasonable and effective. By examining the confining stress experienced by the concrete in the radial and circumferential directions based on a detailed theoretical analysis, a modeling approach was proposed to take the confinement effect in circular hollow RC piers into consideration. The proposed modeling approach was validated through comparisons with the experimental study and satisfactory agreement was found.
Analysis of a mode-I crack perpendicular to an imperfect interface
Zhong, Xian-Ci,Li, Xian-Fang,Lee, Kang Yong Elsevier 2009 International journal of solids and structures Vol.46 No.6
<P><B>Abstract</B></P><P>The elastostatic problem of a mode-I crack embedded in a bimaterial with an imperfect interface is investigated. The crack is in proximity to and perpendicular to the imperfect interface, which is governed by linear spring-like relations. The Fourier transform is applied to reduce the associated mixed-boundary value problem to a singular integral equation with Cauchy kernel. By numerically solving the resulting equation, stress intensity factors near both crack tips are evaluated. Obtained results reveal that the stress intensity factors in the presence of the imperfect interface vary between that with a perfect interface and that with a completely debonding interface. Moreover, an increase in the interface parameters decreases the stress intensity factors. In particular, when crack approaches to the weakened interface closer, the stress intensity factors become larger for a sliding interface, and become larger or smaller for a Winkler interface, depending on the crack lying in a stiffer or softer material. The influences of the imperfection of the interface on the stress intensity factors for a bimaterial composed of aluminum and steel are presented graphically.</P>
Li, Qing Zhong,Huang, Qing Xian,Li, Shu Cui,Yang, Mei Zi,Rao, Bin The Korean Society of Pharmacology 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.5
A simple, sensitive and reproducible high-performance liquid chromatography (HPLC) method has been validated for determining concentrations of glutamate, glycine, and alanine in human plasma. Proteins in plasma were precipitated with perchloric acid, followed by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC). Simultaneous analysis of glutamate, glycine, and alanine is achieved using reversed-phase HPLC conditions and ultraviolet detection. Excellent linearity was observed for these three amino acids over their concentration ranges with correlation coefficients (r)>0.999. The intra- and inter-day precision were below 10%. This method utilizes quality control samples and demonstrates excellent plasma recovery and accuracy. The developed method has been successfully applied to measure plasma glutamate, glycine, and alanine in twenty volunteers.
Nonlocal Formulation for Numerical Analysis of Post-Blast Behavior of RC Columns
Zhong-Xian Li,Bo Zhong,Yanchao Shi,Jia-Bao Yan 한국콘크리트학회 2017 International Journal of Concrete Structures and M Vol.11 No.2
Residual axial capacity from numerical analysis was widely used as a critical indicator for damage assessment of reinforced concrete (RC) columns subjected to blast loads. However, the convergence of the numerical result was generally based on the displacement response, which might not necessarily generate the correct post-blast results in case that the strain softening behavior of concrete was considered. In this paper, two widely used concrete models are adopted for post-blast analysis of a RC column under blast loading, while the calculated results show a pathological mesh size dependence even though the displacement response is converged. As a consequence, a nonlocal integral formulation is implemented in a concrete damage model to ensure mesh size independent objectivity of the local and global responses. Two numerical examples, one to a RC column with strain softening response and the other one to a RC column with post-blast response, are conducted by the nonlocal damage model, and the results indicate that both the two cases obtain objective response in the post-peak stage.
Qing Zhong Li,Qing Xian Huang,Shu Cui Li,Mei Zi Yang,Bin Rao 대한생리학회-대한약리학회 2012 The Korean Journal of Physiology & Pharmacology Vol.15 No.5
A simple, sensitive and reproducible high-performance liquid chromatography (HPLC) method has been validated for determining concentrations of glutamate, glycine, and alanine in human plasma. Proteins in plasma were precipitated with perchloric acid, followed by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC). Simultaneous analysis of glutamate, glycine, and alanine is achieved using reversed-phase HPLC conditions and ultraviolet detection. Excellent linearity was observed for these three amino acids over their concentration ranges with correlation coefficients (r)>0.999. The intra- and inter-day precision were below 10%. This method utilizes quality control samples and demonstrates excellent plasma recovery and accuracy. The developed method has been successfully applied to measure plasma glutamate, glycine, and alanine in twenty volunteers.
Qing Zhong Li,Qing Xian Huang,Shu Cui Li,Mei Zi Yang,Bin Rao 대한약리학회 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.5
A simple, sensitive and reproducible high-performance liquid chromatography (HPLC) method has been validated for determining concentrations of glutamate, glycine, and alanine in human plasma. Proteins in plasma were precipitated with perchloric acid, followed by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC). Simultaneous analysis of glutamate, glycine, and alanine is achieved using reversed-phase HPLC conditions and ultraviolet detection. Excellent linearity was observed for these three amino acids over their concentration ranges with correlation coefficients (r)>0.999. The intra- and inter-day precision were below 10%. This method utilizes quality control samples and demonstrates excellent plasma recovery and accuracy. The developed method has been successfully applied to measure plasma glutamate, glycine, and alanine in twenty volunteers.
Ya-Jun Li,Ji-Wei Li,Kai-Lin Chen,Jin Li,Mei-Zuo Zhong,Xian-Ling Liu,Ping-Yong Yi,Hui Zhou 대한혈액학회 2020 Blood Research Vol.55 No.1
BackgroundHuman immunodeficiency virus (HIV)-negative plasmablastic lymphoma (PBL) is a rare entity of diffuse large B-cell lymphoma (DLBCL). The clinicopathological features of and optimal treatment for HIV-negative PBL remain largely unknown.MethodsTo gain insight into this distinct lymphoma, we summarized the clinicopathologic charac-teristics of 8 unpublished HIV-negative PBLs and performed a comprehensive review of 394 published cases.ResultsOf the 8 unpublished PBLs, the median patient age was 53.0 years. Four patients pre-sented with stage IV disease. All 8 patients showed a plasma cell-like immunophenotype. Of the six patients who received anthracycline-based chemotherapy, including two who received bortezomib, three patients achieved a continuous complete response, two pa-tients died due to disease progression, and one patient was lost to follow-up. The other two patients achieved continuous complete response after receiving chemotherapy com-bined with radiotherapy and surgery. Of the 402 patients, the majority were male, with a mean age of 58.0 years. EBV infection was detected in 55.7% of the patients. The median survival times of the patients who received CHOP or CHOP-like regimens and intensive regimens were not reached and 23.0 months, respectively, and the intensive regimen did not improve the survival outcome (P=0.981). Multivariate analysis showed that EBER remained the only independent factor affecting overall survival (OS).ConclusionHIV-negative PBL is a distinct entity with a predilection for elderly and immunosup-pressed individuals. Intensive chemotherapy had no apparent survival benefits over the CHOP regimen in terms of OS; the prognosis of this disease is poor with current chemo-therapy methods, and treatment remains a challenge.