Fast-convergence trilinear decomposition algorithm for angle and range estimation in FDA-MIMO radar

Wang, Cheng,Zheng, Wang,Li, Jianfeng,Gong, Pan,Li, Zheng Electronics and Telecommunications Research Instit 2021 ETRI Journal Vol.43 No.1

A frequency diverse array (FDA) multiple-input multiple-output (MIMO) radar employs a small frequency increment across transmit elements to produce an angle-range-dependent beampattern for target angle and range detection. The joint angle and range estimation problem is a trilinear model. The traditional trilinear alternating least square (TALS) algorithm involves high computational load due to excessive iterations. We propose a fast-convergence trilinear decomposition (FC-TD) algorithm to jointly estimate FDA-MIMO radar target angle and range. We first use a propagator method to obtain coarse angle and range estimates in the data domain. Next, the coarse estimates are used as initialized parameters instead of the traditional TALS algorithm random initialization to reduce iterations and accelerate convergence. Finally, fine angle and range estimates are derived and automatically paired. Compared to the traditional TALS algorithm, the proposed FC-TD algorithm has lower computational complexity with no estimation performance degradation. Moreover, Cramer-Rao bounds are presented and simulation results are provided to validate the proposed FC-TD algorithm effectiveness.

Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle

Gong, Yingyun,Cao, Rui,Ding, Guolian,Hong, Sungguan,Zhou, Wenjun,Lu, Wenyun,Damle, Manashree,Fang, Bin,Wang, Chuhan C.,Qian, Justin,Lie, Natasha,Lanzillotta, Cristina,Rabinowitz, Joshua D.,Sun, Zheng Elsevier 2018 Molecular and cellular endocrinology Vol.471 No.-

<P><B>Abstract</B></P> <P>Nuclear receptors regulate gene expression by differentially binding to coactivators or corepressors in a ligand-dependent manner, which further recruits a set of epigenome-modifying enzymes that remodel chromatin conformation. Histone acetylation is a major epigenomic change controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). HDAC3 is the only HDAC that confers the enzymatic activity to the complexes nucleated by nuclear receptor corepressors NCoR and SMRT. To address the metabolic function of HDAC3, we have deleted it specifically in mouse skeletal muscles. We have performed the following omics profiling in skeletal muscles of these mice: (1) RNA-seq profiling of total RNA; (2) Global nuclear run-on (GRO-seq) analysis of nascent RNAs; (3) Chromatin immuno-precipitation (ChIP-seq) of HDAC3 at both early evening and early morning; (4) proteomics profiling with mass spectrometry; (5) snap-shot metabolomics profiling of water-soluble metabolites at the basal condition; (6) snap-shot metabolomics profiling of lipid species at the basal condition; (7) kinetic fluxomics analysis of glucose utilization using <SUP>13</SUP>C<SUB>6</SUB>-glucose <I>In vivo</I> during treadmill running exercise. These approaches have provided several novel insights into how nuclear receptors regulate circadian rhythm of skeletal muscle fuel metabolism, which has been published elsewhere. Here we present the original datasets and technical details during the execution, analysis, and interpretation of these omics studies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A mouse model with skeletal muscle-specific KO of HDAC3. </LI> <LI> <I>in vivo</I> RNA-seq, GRO-seq, and ChIP-seq identified relevance to circadian clock. </LI> <LI> Total proteome profiling in muscle samples. </LI> <LI> Metabolomics profiling identified disruption of BCAAs metabolism. </LI> <LI> Fluxomics with <SUP>13</SUP>C-glucose <I>in vivo</I> during treadmill running. </LI> </UL> </P>

Research of high response control technology of a moving coil electromechanical converter

Gong Zhang,Zheng Xu,Weijun Wang,Zhichen Hou,Xing Gu,Ning Lin,Liangwei Luo,Jing Huang 제어로봇시스템학회 2016 제어로봇시스템학회 국제학술대회 논문집 Vol.2016 No.10

Electromechanical converters (EMCs) are regarded as the most widely employed linear motion mechanism in various industry driving fields. This study tries to improve the characteristics deficiency of a moving coil electro-mechanical converter (MC-EMC), such as the output electromagnetic force, response time and response speed, and based on the time constant and currents are effected by inductance and resistance of the transformation coils, the carrying current coils of MC-EMC are adopted a transformation of segmentation and combination. The mathematical model and simulation for the response time, displacement, output electromagnetic force, acceleration of MC-EMC are proposed respectively. Results show that compared coils in parallel divided into three sections with coils in single group, the displacement step response time is reduced from 14.6㎳ to 9.94㎳ the response speed is over doubled, and electromagnetic force is raised about 8 times, the acceleration is increased by 8.7 times, the peak response time is reduced about 0.5 times, which means the design MC-EMC could realize the performance of short response time and high electromagnetic force, and display good prospects.

Outcomes Based on Risk Assessment of Anastomotic Leakage after Rectal Cancer Surgery

Gong, Jian-Ping,Yang, Liu,Huang, Xin-En,Sun, Bei-Cheng,Zhou, Jian-Nong,Yu, Dong-Sheng,Zhou, Xin,Li, Dong-Zheng,Guan, Xin,Wang, Dong-Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Purpose: Anastomotic leakage (AL) is associated with high morbidity and mortality, high reoperation rates, and increased hospital length of stay. Here we investigated the risk factors for AL after anterior resection for rectal cancer with a double stapling technique. Patients and Methods: Data for 460 patients who underwent primary anterior resection with a double stapling technique for rectal carcinoma at a single institution from 2003 to 2007 were prospectively collected. All patients experienced a total mesorectal excision (TME) operation. Clinical AL was defined as the presence of leakage signs and confirmed by diagnostic work-up according to ICD-9 codes 997.4, 567.22 (abdominopelvic abscess), and 569.81 (fistula of the intestine). Univariate and logistic regression analyses of 20 variables were undertaken to determine risk factors for AL. Survival was analysed using the Cox regression method. Results: AL was noted in 35 (7.6%) of 460 patients with rectal cancer. :Median age of the patients was 65 (50-74) and 161 (35%) were male. The diagnosis of AL was made between the 6th and 12th postoperative day (POD; mean 8th POD). After univariate and multivariate analysis, age (p=0.004), gender (p=0.007), tumor site (p<0.001), preoperative body mass index (EMI) (p<0.001), the reduction of TSGF on 5th POD less than 10U/ml (p=0.044) and the pH value of pelvic dranage less than or equal to 6.978 on 3rd POD (p<0.001) were selected as 6 independent risk factors for AL. It was shown that significant differences in survival of the patients were AL-related (p<0.001), high ASA score related (p=0.036), high-level EMI related (p=0.007) and advanced TNM stage related <p<0.001). Conclusions: AL after anterior resection for rectal carcinoma is related to advanced age, low tumor site, male sex, high preoperative EMI, low pH value of pelvic drainage on POD 3 and a significant reduction of TSGF on POD 5. In addition to their high risk of immediate postoperative morbidity and mortality, AL, worse physical status, severe obesity and advanced TNM stage have similarly negative impact on survival.

Peroxisome Proliferator-Activated Receptor α Facilitates Osteogenic Differentiation in MC3T3-E1 Cells via the Sirtuin 1-Dependent Signaling Pathway

Gong, Kai,Qu, Bo,Wang, Cairu,Zhou, Jingsong,Liao, Dongfa,Zheng, Wei,Pan, Xianming Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.6

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by lack of insulin and high glucose levels. T2DM can cause bone loss and fracture, thus leading to diabetic osteoporosis. Promoting osteogenic differentiation of osteoblasts may effectively treat diabetic osteoporosis. We previously reported that Sirtuin 1 (Sirt1), a $NAD^+$-dependent deacetylase, promotes osteogenic differentiation through downregulation of peroxisome proliferator-activated receptor (PPAR) ${\gamma}$. We also found that miR-132 regulates osteogenic differentiation by downregulating Sirt1 in a $PPAR{\beta}/{\delta}$-dependent manner. The ligand-activated transcription factor, $PPAR{\alpha}$, is another isotype of the peroxisome proliferator-activated receptor family that helps maintain bone homeostasis and promot bone formation. Whether the regulatory role of $PPAR{\alpha}$ in osteogenic differentiation is mediated via Sirt1 remains unclear. In the present study, we aimed to determine this role and the underlying mechanism by using high glucose (HG) and free fatty acids (FFA) to mimic T2DM in MC3T3-E1 cells. The results showed that HG-FFA significantly inhibited expression of $PPAR{\alpha}$, Sirt1 and osteogenic differentiation, but these effects were markedly reversed by $PPAR{\alpha}$ overexpression. Moreover, siSirt1 attenuated the positive effects of $PPAR{\alpha}$ on osteogenic differentiation, suggesting that $PPAR{\alpha}$ promotes osteogenic differentiation in a Sirt1-dependent manner. Luciferase activity assay confirmed interactions between $PPAR{\alpha}$ and Sirt1. These findings indicate that $PPAR{\alpha}$ promotes osteogenic differentiation via the Sirt1-dependent signaling pathway.

Improved Four-channel PBTDPA Control Strategy Using Force Feedback Bilateral Teleoperation System

Xin Gong,Lixiao Wang,Yuanyuan Mou,Haili Wang,Xiaoqian Wei,Wenfeng Zheng,Lirong Yin 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.3

Bilateral teleoperation robots with force feedback enable humans to accomplish these tasks without exposing them to these hazardous environments. Its stability and transparency describe the performance of bilateral teleoperation systems with force feedback. Bilateral teleoperation with force feedback enables humans to combine tactics with optesthesia. However, the force feedback may lead to bilateral teleoperation instability if the communication channels’ time delay exists. The instability of bilateral teleoperation with force feedback, which is brought in by the time delay, has become one of the complicated problems researchers need to solve. Transparency is one of the leading design objectives of the teleoperation system. There are two evaluation criteria for transparency: the accuracy of the position followed by the master mechanical arm and the accuracy of the feedback received by the slave arm from the master arm. The main content of this paper is as follows: 1) This paper researches and summarizes the control structures and control algorithms of several well-developed force-feedback bilateral teleoperation systems and decides to improve the PBTDPA algorithm, which aligns with practical application requirements. 2) The fourchannel structure makes the transparency of force-feedback bilateral teleoperation systems perfect in theory. This paper uses the four-channel structure combined with the PBTDPA algorithm to improve the transparency of the approach. 3) Moreover, the delay predictor is used to improve the four-channel power-based time domain passivity approach (PBTDPA) control strategy. The delay differential predictor is added to the communication channel. The delay change rate differential predictor can estimate the communication channel’s delay change rate instead of the maximum delay change rate to improve transparency. The simulation experiment of the improved control strategy was carried out. The results show the excellent performance of our design.

EFFECT OF ASYMMETRICAL STAND STIFFNESS ON HOT ROLLED STRIP SHAPE

DIANYAO GONG,JIANZHONG XU,ZHENG JIANG,XIAOMING ZHANG,XUZNGHUA LIU,GUODONG WANG 한국소성가공학회 2008 한국소성가공학회 컨퍼런스 Vol.2008 No.10

Peroxisome Proliferator-Activated Receptor α Facilitates Osteogenic Differentiation in MC3T3-E1 Cells via the Sirtuin 1-Dependent Signaling Pathway

Kai Gong,Bo Qu,Cairu Wang,Jingsong Zhou,Dongfa Liao,Wei Zheng,Xianming Pan 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.6

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by lack of insulin and high glucose levels. T2DM can cause bone loss and fracture, thus leading to diabetic osteoporosis. Promoting osteogenic differentiation of osteoblasts may effectively treat diabetic osteoporosis. We previously reported that Sirtuin 1 (Sirt1), a NAD+-dependent deacetylase, promotes osteogenic differentiation through downregulation of peroxisome proliferator-activated receptor (PPAR) γ. We also found that miR-132 regulates osteogenic differentiation by downregulating Sirt1 in a PPAR /δ-dependent manner. The ligand-activated transcription factor, PPAR , is another isotype of the peroxisome proliferator-activated receptor family that helps maintain bone homeostasis and promot bone formation. Whether the regulatory role of PPAR in osteogenic differentiation is mediated via Sirt1 remains unclear. In the present study, we aimed to de-termine this role and the underlying mechanism by using high glucose (HG) and free fatty acids (FFA) to mimic T2DM in MC3T3-E1 cells. The results showed that HG-FFA significantly inhibited expression of PPAR , Sirt1 and osteogenic differentiation, but these effects were markedly reversed by PPAR overexpression. Moreover, siSirt1 attenuated the positive effects of PPAR on osteogenic differentiation, suggesting that PPAR promotes osteogenic differentiation in a Sirt1-dependent manner. Luciferase activity assay confirmed interactions between PPAR and Sirt1. These findings indicate that PPAR promotes osteogenic differentiation via the Sirt1-dependent signaling pathway.

A Novel Recombinant BCG Vaccine Encoding Eimeria tenella Rhomboid and Chicken IL-2 Induces Protective Immunity Against Coccidiosis

Qiuyue Wang,Lifeng Chen,Jianhua Li,Jun Zheng,Ning Cai,Pengtao Gong,Shuhong Li,He Li,Xichen Zhang 대한기생충학열대의학회 2014 The Korean Journal of Parasitology Vol.52 No.3

Protective potential of Chinese herbal extracts against microsporidian Nosema ceranae, an emergent pathogen of western honey bees, Apis mellifera L.

Chen Xiuxian,Wang Shuai,Xu Yingying,Gong Hongri,Wu Yuqi,Chen Yanping,Hu Fuliang,Zheng Huoqing 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.1

Nosema ceranae, a newly emergent parasite invading western honey bees (Apis mellifera L.), is indicated to threaten honey bee health at both individual and colony levels. However, the efficient and environmentallyfriendly treatments are quite limited at present. To find alternative medicine to control Nosema diseases, the effect of 8 types of herbal extracts against N. ceranae infection were screened under laboratory condition. Of which, 1% Andrographis paniculata (A. paniculata) decoction was found to significantly decrease N. ceranae spore numbers on 7 days post infection (dpi) and 13 dpi. Then, our results further revealed that A. paniculata decoction at doses ranging from 1% to 7% displayed significant efficient inhibition of Nosema spore proliferation and improved the infected bees’ survival rates in a dose-dependent manner. A. paniculata decoction was found to protect the gut tissues of infected workers from damage cause by N. ceranae, which might be due to the regu lation of the expression of certain genes in Wnt and JNK pathways, including armadillo, basket, frizzled2 and groucho. Additionally, our study suggested that A. paniculata decoction performed this Nosema spore-reducing potential over its two monomers, andrographolide and dehydrographolide. Taken together, this work enables us to better understand A. paniculata decoction’s potential to inhibit N. ceranae infection, thus providing a new guidance for developing applicable drugs to control Nosema diseases.