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RISS 인기검색어
- 검색키워드
- 저자 : Zhari Ismail (검색결과 3 건)
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Pharmacognostic Profile of Trigonella Seed and Its Hypoglycaemic Activity
Zhari Ismail,Norhayati Ismail,Mariam Ahmad 한국생약학회 1995 Natural Product Sciences Vol.1 No.1
Pharmacognostic study was carried out on the seeds of Trigonella foenumgraecum L. (fenugreek) in order to establish its pharmacognostic characteristics. In view of its renewed interest as a dietary supplement among the local inhabitants afflicted with diabetes, its hypoglycaemic activity in normal as well as diabetic rats was also investigated. Oral glucose tolerance test showed that a suspension of the powdered trigonella seed inhibited the increase in blood glucose levels in normal rats that had been treated with an oral glucose load prior to the test. A reduction in the blood glucose levels was also observed when a suspension of the powdered seed was given by gastric intubation to the streptozotocin-induced diabetic rats. These findings suggested that trigonella seeds possessed some hypoglycaemic activities that might be useful to the diabetics.
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In Vitro Cholinomimetic Effect of Loranthus Ferrugineus in Isolated Guinea Pig Ileum
Omar Ziad Ameer,Ibrahim M. Salman,Mohammad Jamshed Ahmad Siddiqui,Mun Fei Yam,Raghava Naidu Sriramaneni,Amirin Sadikun,Zhari Ismail,Amin Malik Shah,Mohd. Zaini Asmawi 사단법인약침학회 2009 Journal of Acupuncture & Meridian Studies Vol.2 No.4
This study aimed to elucidate the mechanism(s) of the spasmogenic action of Loranthus ferrugineus in isolated guinea pig ileum. Thus the contractile responses of guinea pig ileum to graded additions of either L. ferrugineus methanol extract or its n-butanol fraction were tested in the presence and absence of various pharmacological interventions. The data showed that L. ferrugineus methanol extract and the n-butanol fraction produced a concentration-dependent spasmogenic effect in isolated guinea pig ileum segments. These effects were significantly inhibited in the presence of 1 μM atropine. In contrast, the response to the lowest concentrations of L. ferrugineus methanol extract (0.25, 0.5 and 1 mg/mL) and n-butanol fraction of L. ferrugineus (0.125, 0.25 and 0.5 mg/mL) were considerably enhanced in the presence of 0.05 μM neostigmine. Neither L. ferrugineus methanol extract nor n-butanol fraction contractile responses were affected upon the incubation of the ileal segments with 100 μM hexamethonium. The results of this study show that the spasmogenic effect of L. ferrugineus is possibly mediated through a direct action on intestinal muscarinic receptors. It is suggested that the bioactive constituents of L. ferrugineus serve as a substrate for acetylcholinesterase. This study aimed to elucidate the mechanism(s) of the spasmogenic action of Loranthus ferrugineus in isolated guinea pig ileum. Thus the contractile responses of guinea pig ileum to graded additions of either L. ferrugineus methanol extract or its n-butanol fraction were tested in the presence and absence of various pharmacological interventions. The data showed that L. ferrugineus methanol extract and the n-butanol fraction produced a concentration-dependent spasmogenic effect in isolated guinea pig ileum segments. These effects were significantly inhibited in the presence of 1 μM atropine. In contrast, the response to the lowest concentrations of L. ferrugineus methanol extract (0.25, 0.5 and 1 mg/mL) and n-butanol fraction of L. ferrugineus (0.125, 0.25 and 0.5 mg/mL) were considerably enhanced in the presence of 0.05 μM neostigmine. Neither L. ferrugineus methanol extract nor n-butanol fraction contractile responses were affected upon the incubation of the ileal segments with 100 μM hexamethonium. The results of this study show that the spasmogenic effect of L. ferrugineus is possibly mediated through a direct action on intestinal muscarinic receptors. It is suggested that the bioactive constituents of L. ferrugineus serve as a substrate for acetylcholinesterase.
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Hussein M. Baharetha,Zeyad D. Nassar,Abdalrahim F. Aisha,Mohamed B. Khadeer Ahamed,Foaud Saleih R. Al-Suede,Mohd Omar Abd Kadir,Zhari Ismail,Amin Malik Shah Abdul Majid 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.12
Nigella sativa, commonly referred as black cumin, is a popular spice that has been used since the ancient Egyptians. It has traditionally been used for treatment of various human ailments ranging from fever to intestinal disturbances to cancer. This study investigated the apoptotic, antimetastatic, and anticancer activities of supercritical carbon dioxide (SCCO2) extracts of the seeds of N. sativa Linn. against estrogen-dependent human breast cancer cells (MCF-7). Twelve extracts were prepared from N. sativa seeds using the SC-CO2 extraction method by varying pressure and temperature. Extracts were analyzed using FTIR and UV-Vis spectrometry. Cytotoxicity of the extracts was evaluated on various human cancer and normal cell lines. Of the 12 extracts, 1 extract (A3) that was prepared at 60C and 2500 psi (*17.24 MPa) showed selective antiproliferative activity against MCF-7 cells with an IC50 of 53.34 – 2.15 lg/mL. Induction of apoptosis was confirmed by evaluating caspases activities and observing the cells under a scanning electron microscope. In vitro antimetastatic properties of A3 were investigated by colony formation, cell migration, and cell invasion assays. The elevated levels of caspases in A3 treated MCF-7 cells suggest that A3 is proapoptotic. Further nuclear condensation and fragmentation studies confirmed that A3 induces cytotoxicity through the apoptosis pathway. A3 also demonstrated remarkable inhibition in migration and invasion assays of MCF-7 cells at subcytotoxic concentrations. Thus, this study highlights the therapeutic potentials of SC-CO2 extract of N. sativa in targeting breast cancer.
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