Pharmacognostic Profile of Trigonella Seed and Its Hypoglycaemic Activity

Zhari Ismail,Norhayati Ismail,Mariam Ahmad 한국생약학회 1995 Natural Product Sciences Vol.1 No.1

Pharmacognostic study was carried out on the seeds of Trigonella foenumgraecum L. (fenugreek) in order to establish its pharmacognostic characteristics. In view of its renewed interest as a dietary supplement among the local inhabitants afflicted with diabetes, its hypoglycaemic activity in normal as well as diabetic rats was also investigated. Oral glucose tolerance test showed that a suspension of the powdered trigonella seed inhibited the increase in blood glucose levels in normal rats that had been treated with an oral glucose load prior to the test. A reduction in the blood glucose levels was also observed when a suspension of the powdered seed was given by gastric intubation to the streptozotocin-induced diabetic rats. These findings suggested that trigonella seeds possessed some hypoglycaemic activities that might be useful to the diabetics.

Efficacy and Safety of Labisia pumila var alata Water Extract Among Pre- and Postmenopausal Women

Mohd Noor Norhayati,Annie George,Nik Hussain Nik Hazlina,Abdul Kadir Azidah,Hassan Intan Idiana,Kim Sooi Law,Ismail Shaiful Bahari,Wan Mohamed Wan Zahiruddin,Eckehard Liske,Abas Azreena 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.8

This study evaluated the effectiveness and safety of Labisia pumila var alata (L. pumila) water extract for improving quality of life, cardiovascular and hormonal balance. A randomized, double-blind, placebo-controlled, parallel group, 16-week study in healthy pre- and postmenopausal women aged 40–60 years was conducted in Kelantan, Malaysia. The subjects were randomized to 400mg propriety extract of L. pumila or placebo. A Women’s Health Questionnaire was used to assess quality of life. Repeated-measures analysis of variance was used to evaluate the data. A total of 197 subjects (L. pumila: n = 102 and placebo: n = 95) were analyzed. Subjects in the herbal group showed improved memory/concentration, vasomotor symptoms, menstrual symptoms, and sleep problems by 8.3%, 15.9%, 11.8%, and 31.0%, respectively. The greatest improvement was observed for the question: ‘‘I get frightened or panic feelings for apparently no reason at all’’ with a 53% decrease as compared with placebo. Improvements were also seen in the cardiovascular parameters, and the safety profiles were normal. Postmenopausal women supplemented with L. pumila showed no changes in gynecological relevant hormones luteinizing hormone (LH), folliclestimulating hormone (FSH), and 17b-Estradiol.Water extract of L. pumila was shown to be safe and effective for improving several parameters of quality of life and cardiovascular risks factors (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C]).

Maternal Vitamin D Supplementation for the Prevention of Respiratory Tract Infections in Offspring: A Meta-Analysis

Zaharah Sulaiman,Norhayati Mohd Noor,Shaiful Bahari Ismail,Anis Syahirah Far’ain Mohd Lukman,Muhammad Irfan,Nik Hazlina Nik Hussain 대한가정의학회 2022 Korean Journal of Family Medicine Vol.43 No.3

Background: Vitamin D may enhance immune system function and provide a protective effect against infections. Feto-maternal circulation plays an important role in supplying the developing fetus with nutrients and antibodies for its development and health during pregnancy and for its early years of life after birth. This meta-analysis aimed to determine the effectiveness of maternal vitamin D supplementation in preventing respiratory tract infections (RTIs) in children.Methods: We searched the Central and MEDLINE databases and went through all the reference lists in the related articles. We also searched for ongoing trials at http://www.who.int/ictrp/en/ and www.clinicaltrials.gov. Random-ized controlled trials comparing vitamin D supplementation with a placebo or no treatment in pregnant women published in the English language up to March 2019 were included. Two reviewers extracted data independently using a predefined protocol and assessed the risk of bias using the Cochrane risk of bias tool, with differences agreed upon by consensus. The predefined primary outcome was the number of offspring who had RTIs. The sec-ondary outcome was the presence of measurable serum immunoglobulin E levels.Results: Three trials involving 3,224 participants (mother–child pairs) met the inclusion criteria and were included in this review. The present analysis reported that maternal supplementation with vitamin D had no effect on RTIs among children (n=1,486 offspring; risk ratio, 0.95; 95% confidence interval, 0.82–1.11; random effects; I2 statistics, 0%).Conclusion: Maternal vitamin D supplementation had no effect on RTIs in children. Therefore, consideration of other prevention methods in this regard is recommended.

Metoclopramide for Milk Production in Lactating Women: A Systematic Review and Meta-Analysis

Nik Hazlina Nik Hussain,Norhayati Mohd. Noor,Shaiful Bahari Ismail,Nur Amirah Zainuddin,Zaharah Sulaiman 대한가정의학회 2021 Korean Journal of Family Medicine Vol.42 No.6

Background: Breastfeeding is recognized as the optimal form of nutrition for the physical and neurological devel-opment of infants and is considered the most significant way to prevent child mortality. This study aimed to assess the effectiveness of metoclopramide for enhancing milk production in lactating women.Methods: We searched the Cochrane Central Register of Controlled Trials and MEDLINE for randomized con-trolled trials comparing metoclopramide with a placebo, no treatment, or other galactagogue drugs. We included breastfeeding women with term or preterm infants.Results: We retrieved 164 records from our search of the electronic databases and 20 records from other sources. Eight trials involving 342 lactating women that used metoclopramide were included in this review after assessing the eligibility criteria. The meta-analysis of these trials revealed that metoclopramide did not increase the milk vol-ume of the intervention groups compared to that of the control groups. There was a significant increase in the se-rum concentrations of prolactin when the mothers were administered metoclopramide. No significant adverse events were reported.Conclusion: Metoclopramide did not improve milk production in lactating women. Therefore, we do not recom-mend using metoclopramide to increase milk production in lactating women.

The Impact of Intellectual Capital Efficiency on Jordanian Companies Performance: The Moderating Roles of CEO Duality

ABDELGHAFOUR JOS, Rawan,MAT HUSIN, Norhayati,ISMAIL HYARAT, Hamza Korea Distribution Science Association 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.10

CEO duality and its impact on firm performance represent one of the most contentious issues in both academia and business. This study, therefore, aims to examine the moderating role of CEO duality in the relationship between intellectual capital Efficiency (human, structural, relational, Capital Employed, and Innovation) and firm performance (earnings per share and Tobin's Q) among Jordanian companies. The study sample consists of services listed companies on Amman Stock Exchange. The study used panel data for the period 2014-2018 with a sample size of 230 observations. SPSS software was used to analyze the collected data. The regression results indicate a significant relationship between, IC and firm performance. When CEO Duality is incorporated into the model as a moderator, there is an increase in the R² by 7.9%. The findings from this study expand the theoretical underpinning of corporate governance research by identifying the performance implications of CEO duality within the Jordanian context. It also contributes significantly to the literature review about the current status of the practices taken in the intellectual capital components efficiency among companies listed on the Amman Stock Exchange. Findings from this study also provide contributions to the concerned policymakers such as the Ministry of Finance, Securities Commission, and Amman Stock Exchange in Jordan, to improve the current policies related to intellectual capital efficiency.