Assessment of Cellular Proliferation in Oral Verrucous Carcinoma and Well-Differentiated Oral Squamous Cell Carcinoma Using Ki67: A Non-Reliable Factor for Differential Diagnosis?

Zargaran, Massoumeh,Eshghyar, Nosratollah,Baghaei, Fahimeh,Moghimbeigi, Abbas Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Background: Non-invasive oral verrucous carcinoma (OVC) and invasive well-differentiated oral squamous cell carcinoma (OSCC) have similar histopathologic findings but different biological behavior. These two malignancies must be correctly differentiated by pathologists. The aim of this study was to determine immunohistochemical (IHC) expression of Ki67 in OVC and well-differentiated OSCC. Methods: Expression of Ki67 was evaluated by IHC in 15 cases of epithelial hyperplasia with no dysplasia (A group), 15 cases of OVC (B group), 12 cases of microinvasive OSCC(C group) and 15 cases of well-differentiated OSCC (D group). Results: There was a significant difference in Ki67 expression based on pattern distribution of immunostaining positive cells, with quantitative and semi-quantitative analyses, among the four groups ; also, between A group and each of the other three groups (P=0.0001). But there was no significant difference between B and C, C and D, and B and D groups (P>0.05). Conclusions: The three evaluation methods of Ki67 expression showed Ki67 (Mib-1) is not a good immunohistochemical marker to assess invasion status and differentiate OVC from well-differentiated OSCC; also, it cannot be used as a diagnostic tool to distinguish between variants of OSCC with similar grade.

Suitability/Unsuitability of Cell Proliferation as an Indicator of Malignant Potential in Oral Lichen Planus: an Immunohistochemical Study

Zargaran, Massoumeh,Jamshidi, Shokoofeh,Eshghyar, Nosratollah,Moghimbeigi, Abbas Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Background: Oral lichen planus (OLP) is categorized as premalignant lesion although its malignant potential is a matter of controversy. The objective of this study was to investigate Ki67 expression in OLP, oral epithelial dysplasia and oral squamous cell carcinoma (OSCC). Materials and Methods: Expression of Ki67 was evaluated through immunohistochemistry (IHC) in groups of A (17 cases of epithelial hyperplasia), B (16 cases of OLP), C1 (10 cases of mild epithelial dysplasia), C2 (10 cases of severe epithelial dysplasia), D1 (10 cases of well-differentiated OSCC), and D2 (10 cases of poorly-differentiated OSCC). Results: There was a significant difference in Ki67 expression based on quantitative analysis among the six studied groups as well as group B compared bilaterally with groups C2, D1 and D2 (p< 0.0001). However, there was no significant difference between groups B and C1 or between groups D1 and D2 (p> 0.05). Conclusions: Based on the results of the present study it may not be possible to definitely consider malignant transformation potential for OLP. However, expression of Ki67 was significantly higher in OLP than that of epithelial hyperplasia with no significant difference from that of mild epithelial dysplasia. This should be considered by clinicians to carefully and regularly follow up OLP lesions to detect potential subtle changes at an early stage.

Effect of C Content on the Microstructure and Tensile Properties of Lightweight Ferritic Fe-8Al-5Mn-0.1Nb Alloy

A. Zargaran,김한수,곽재현,김낙준 대한금속·재료학회 2015 METALS AND MATERIALS International Vol.21 No.1

Microstructure and tensile properties of ferritic Fe-8Al-5Mn-0.1Nb lightweight steels with different C contents(0.005, 0.02, and 0.05 wt%) have been investigated in the present study. It shows that the microstructurebecomes more elongated along the rolling direction, i.e., increasing propensity towards unrecrystallizationwith an increase in C content. This is mainly due to the effect of NbC on retarding the dynamic recrystallizationof ferrite during hot rolling, which is active for higher C (0.02C and 0.05C) containing alloys. Inthe case of the 0.05C alloy, there is an additional precipitation of κ-carbide particles, which also retard thedynamic recrystallization of ferrite during hot rolling, resulting in a much more elongated structure in the 0.05Ccontaining alloy than in the 0.02C alloy in as-hot rolled condition. Although κ-carbide particles retard thedynamic recrystallization of ferrite during hot rolling, they play an opposite role during final annealing,i.e., promoting static recrystallization by the operation of particle-stimulated nucleation mechanism, resulting inthe development of homogeneously distributed fine grains in the 0.05C alloy. As a result, the 0.05C alloy showshigher strength and larger elongation than the lower C containing alloys.

New candidates for treatment and management of carpal tunnel syndrome based on the Persian Canon of Medicine

Mohammad Setayesh,Arman Zargaran,Amir Reza Sadeghifar,Mehdi Salehi,Hossein Rezaeizadeh 한국한의학연구원 2018 Integrative Medicine Research Vol.7 No.2

Carpal tunnel syndrome (CTS) is defined as a compressing median mononeuropathy. CTS is one of the major costly debilitating diseases of the hand. Although CTS is a relatively recent concept in current medicine, some evidences show that medieval physicians in Persian medicine (PM) such as Avicenna were familiar with it. The PM textbook written by Avicenna, the Canon of Medicine, defines the anatomy of carpal tunnel and median nerve, as well as mononeuropathy; it also offers suggestions for the prevention and treatment of carpal tunnel syndrome (called as Vaja al-asab and Khadar) in the chapter of nerve diseases. The book describes not only symptoms including pain, paresthesia, hypoesthesia, tingling, and numbness, but also its etiology such as nerve compression (entrapment neuropathy); nonphysical reasons such as disturbed balance among the four body humors; alteration in the nerve's temperament (Mizaj) that prevents the transmission of nerve impulses; and the others such as nutrition, mental condition, sleep, weather condition, body movements, and proper disposal of body waste. Furthermore, the book suggests a lifestyle modification method based on six factors and 10 prescriptions composed with 85 natural products that are not actively used for CTS treatment in modern times. The medicinal suggestions for CTS in the Canon of Medicine will be good candidates for discovering new treatments besides providing historical significance to the various insights considered 1000 years ago.

Improvement of Impact Toughness of 5Mn-1Al-0.5Ti Steel by Intercritical Annealing

이일철,하유미,이학철,A. Zargaran,Nack J. Kim 대한금속·재료학회 2017 METALS AND MATERIALS International Vol.23 No.2

The present study is aimed at improving the impact toughness of 5Mn-1Al-0.5Ti steel by incorporating ferrite-martensite dual phase microstructure by intercritical annealing. Although (8-12)Mn martensitic steels usuallyshow very low impact toughness due to the occurrence of intergranular fracture, the martensitic structure ofthe present 5Mn-1Al-0.5Ti steel fails by transgranular cleavage fracture due to higher grain boundary strengththan matrix strength incurred by reduced Mn content and segregation of Ti along grain boundaries. Nevertheless, itstill shows very poor impact toughness at room temperature due to its coarse grain size. The application of intercriticalannealing, i.e., formation of dual phase microstructure, is shown to significantly decrease ductile-to-brittletransition temperature (DBTT), with only a small degradation of tensile properties; however, microstructuralexaminations show that most of ferrite/martensite interfaces have a character of low angle boundaries andtherefore such decrease in DBTT is not necessarily due to the formation of ferrite-martensite dual phase structure,but rather to the refinement of grain size by low temperature annealing.

부분 재결정된 탄소 첨가 CoCrFeNiMo 중엔트로피합금의 인장 거동

권현석(Hyeonseok Kwon),Alireza Zargaran,Peyman Asghari-Rad,김은성(Eun Seong Kim),구강희(Gang Hee Gu),이정완(Jungwan Lee),문종언(Jongun Moon),배재웅(Jae Wung Bae),김형섭(Hyoung Seop Kim) 한국소성가공학회 2022 한국소성가공학회 학술대회 논문집 Vol.2022 No.5

Efficacy of a Persian herbal medicine compound on coronavirus disease 2019 (COVID-19): A randomized controlled trial

Setayesh Mohammad,Karimi Mehrdad,Zargaran Arman,Abousaidi Hamid,Shahesmaeili Armita,Amiri Fatemeh,Sadat Hasheminasab Fatemeh 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.3

Background: The global attention to the capacities of traditional medicine for alleviating the clinical man-ifestations of COVID-19 has been growing. The present trial aimed to evaluate the efficacy and safety of a Persian herbal medicine formula among patients with COVID-19. Methods: The present trial was conducted in Afzalipour hospital, Kerman, Iran, from June to September 2020. Hospitalized COVID-19 patients were randomly divided into intervention (Persian herbal medicine formula + routine treatment) or control (only routine treatment) groups. The intervention group received both capsule number 1 and 2 every 8 hours for 7 days. Capsule number 1 contained extract of the Gly-cyrrhiza glabra, Punica granatum, and Rheum palmatum, and the second capsule was filled by Nigella sativa powder. Participants were followed up to 7 days. The primary outcome was the number of hospitaliza-tion days, while cough, fever, and respiratory rate, days on oxygen (O2) therapy, and mortality rate were considered as the secondary outcomes. Results: Eighty-two patients were enrolled to the study, while 79 cases completed the trial and their data were analyzed (mean age: 59.1 ± 17.1 years). Based on the results, the Persian medicine formula decreased the mean hospitalization days, so that the mean difference of length of hospitalization as pri-mary outcome was 2.95 ± 0.43 days. A significant clinical improvement was observed regarding dyspnea, need for O2) therapy, and respiratory rate in the intervention group. No adverse effects were reported. Conclusion: The present study supported the use of the Persian medicine formula as an adjuvant therapy for hospitalized COVID-19 patients. Background: The global attention to the capacities of traditional medicine for alleviating the clinical man-ifestations of COVID-19 has been growing. The present trial aimed to evaluate the efficacy and safety of a Persian herbal medicine formula among patients with COVID-19. Methods: The present trial was conducted in Afzalipour hospital, Kerman, Iran, from June to September 2020. Hospitalized COVID-19 patients were randomly divided into intervention (Persian herbal medicine formula + routine treatment) or control (only routine treatment) groups. The intervention group received both capsule number 1 and 2 every 8 hours for 7 days. Capsule number 1 contained extract of the Gly-cyrrhiza glabra, Punica granatum, and Rheum palmatum, and the second capsule was filled by Nigella sativa powder. Participants were followed up to 7 days. The primary outcome was the number of hospitaliza-tion days, while cough, fever, and respiratory rate, days on oxygen (O2) therapy, and mortality rate were considered as the secondary outcomes. Results: Eighty-two patients were enrolled to the study, while 79 cases completed the trial and their data were analyzed (mean age: 59.1 ± 17.1 years). Based on the results, the Persian medicine formula decreased the mean hospitalization days, so that the mean difference of length of hospitalization as pri-mary outcome was 2.95 ± 0.43 days. A significant clinical improvement was observed regarding dyspnea, need for O2) therapy, and respiratory rate in the intervention group. No adverse effects were reported. Conclusion: The present study supported the use of the Persian medicine formula as an adjuvant therapy for hospitalized COVID-19 patients.

Effect of Reduction of Area on Microstructure and Mechanical Properties of Twinning-Induced Plasticity Steel During Wire Drawing

황중기,K. Wierzbanowski,유장영,A. Zargaran,김낙준 대한금속·재료학회 2015 METALS AND MATERIALS International Vol.21 No.5

The effect of reduction of area (RA), 10%, 20%, and 30%, during wire drawing on the inhomogeneities in microstructure and mechanical properties along the radial direction of Fe-Mn-Al-C twinning-induced plasticity steel has been investigated. After wire drawing, the deformation texture developed into the major <111> and minor <100> duplex fiber texture. However, the <111> texture became more pronounced in both center and surface areas as the RA per pass increased. It also shows that a larger RA per pass resulted in a higher yield strength and smaller elongation than a smaller RA per pass at all strain levels. Although inhomogeneities in microstructure and mechanical properties along the radial direction decreased with increasing RA per pass, there existed an optimum RA per pass for maximum drawing limit. Insufficient penetration of strain from surface to center at small RA per pass (e.g., 10%) and high friction and unsound metal flow at large RA per pass (e.g., 30%) all resulted in heterogeneous microstructure and mechanical properties along the radial direction of drawn wire. On the other hand, 20% RA per pass improved the drawing limit by about 30% as compared to the 10% and 30% RAs per pass.

Room and cryogenic mechanical properties in CoCrFeNi medium-entropy alloy fabricated by cold-consolidation process

S. Son(손수정),Peyman Asghari-Rad,Alireza Zargaran,H.S. Kim(김형섭) 한국소성가공학회 2022 한국소성가공학회 학술대회 논문집 Vol.2022 No.5

Exceptional combination of ultra-high strength and excellent ductility by inevitably generated Mn-segregation in austenitic steel

Jo, Min Chul,Lee, Hyungsoo,Zargaran, A.,Ryu, Joo Hyun,Sohn, Seok Su,Kim, Nack J.,Lee, Sunghak Elsevier 2018 Materials science & engineering. properties, micro Vol.737 No.-

<P><B>Abstract</B></P> <P>Austenitic high-Mn steels have been nominated as potential alloys for ultra-high strength and excellent ductility, but the high-Mn content inevitably generates band-shaped Mn-segregation due to dendritic solidification from the steel melt. This segregation band often causes unintended deformation mechanisms and anisotropic mechanical properties, and deteriorates formability. Here, we effectively utilize the Mn-segregated bands for the improvement of tensile properties by actively producing TWinning- and TRansformation-induced plasticity (TWIP and TRIP) mechanisms in high- and low-Mn-segregated bands. We also adopt a mixed microstructure of non-recrystallized and recrystallized austenite mainly formed in high- and low-Mn-segregated bands, respectively. The TWIP+TRIP mechanisms generating highly-sustained strain hardening and high strain hardening, coupled with partial recrystallization and precipitation hardening, are working successfully for overcoming low-yield-strength characteristics of austenite to reach 1 GPa and for achieving the excellent tensile strength of 1.5 GPa and ductility of 44%. Our results demonstrate how the Mn-segregation-induced TWIP+TRIP mechanisms can be a novel idea in ultra-high-strength steel design.</P>