Self-mixing gas leakage detection of tank based on Er3þ eYb3þ codoped Distributed Bragg Reflector fiber laser

Wenhua Zhang,Rong Xiang,Shuang Wu,Bo Yang,Yu Liu,Jun Zhu,Huaqiao Gui,Jianguo Liu,Liang Lu,Benli Yu 한국물리학회 2014 Current Applied Physics Vol.14 No.5

In this paper we present a novel method of gas leakage detection based on self-mixing interference with an extremely compact Er3þ eYb3þ codoped Distributed Bragg Reflector (EYDBR) fiber laser. According to the simulation and theoretical analysis of gas leakage of tank, we infer that the vibration frequency peak of tank caused by gas leakage increases with the internal pressure. In the experiment, the results agree with the theoretical prediction and the relevance of polynomial fitting about the spectrum peak of tank vibration and internal pressure is 0.99725. Thus, we can get the internal pressure of tank by measuring the vibration frequency peak of tank. Moreover, it has important significance in the prevention of the accident of flammable or explosive gas leakage.

A Novel Dataset Generating Method for Fine-Grained Vehicle Classification with CNN

Shaoyong Yu,Zhijun Song,Songzhi Su,Wei Li,Yun Wu,Wenhua Zeng 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.6

We focus on the issue of dataset generation for fine-grained vehicle classification with CNN. Traditionally, to build a large dataset, images must be first collected manually, and then be annotated with a lot of effort. All these work are time-consuming and cost-prohibitive. In this work we propose a novel method that can generate massive images automatically, and these generated images need no annotation. An AutoCAD 3D model of a car of specified make and model is imported into our system, and then images of different views of the car are generated, these images can describe all the details of a car. By taking these images as training dataset, we use a Convolutional Neural Network to train a model for fine-grained vehicle classification. Experimental results show that these images generated virtually by 3D model indeed work as effective as real images.

Novel reduced-order modeling method combined with three-particle nonlinear transform unscented Kalman filtering for the battery state-of-charge estimation

Xu, Wenhua,Wang, Shunli,Fernandez, Carlos,Yu, Chunmei,Fan, Yongcun,Cao, Wen The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.6

Accurate estimation of the lithium-ion battery state of charge plays an important role in the real-time monitoring and safety control of batteries. In order to solve the problems that the real-time estimation of the lithium-ion battery is difficult and the estimation accuracy is not high under various working conditions, a lithium-ion battery is taken as a research object, and the working characteristics of the lithium-ion battery are studied under various working conditions. In order to reduce the computational complexity of the traditional unscented Kalman algorithm, an improved unscented Kalman algorithm is proposed. Considering the importance of accurately estimating the initial state of charge for later estimation, the initial estimation value is calibrated by using the open-circuit voltage method. Then, the improved unscented Kalman filter algorithm based on a reduced-order model is used for assessing and tracking to realize real-time high-precision estimation of the state of charge of the lithium-ion battery. A simulation model is built and combined with a variety of working conditions data for performance analysis. The experimental results show that the convergence speed and tracking effect are good and that the estimation error control is within 0.8%. It is verified that the reduced order of the three-particle nonlinear transform unscented Kalman results in higher accuracy in the state-of-charge estimation of lithium-ion batteries.

Curcumin Alleviates the Side Effects of Cisplatin on Gastric Emptying of Mice by Inhibiting the Signal Changes of Acetylcholine and Interstitial Cells of Cajal

Hui Li,Wenhua Xu,Xuying Liu,Junli Ye,Peijie Li,Fangfang Shang,Xiaoling Yu 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.9

Cisplatin is a widely used anticancer drug that has adverse effects on gastrointestinal function. Curcumin is a natural polyphenol extracted from the rhizome of turmeric that has a wide range of biological activities. The present study investigated the effects of cisplatin on gastric emptying in mice and examined whether these can be inhibited by curcumin. We found that pretreatment with curcumin (200 mg/kg/day) for 10–30 days partly inhibited the decreases in gastric emptying rate and body weight induced by cisplatin. Furthermore, cisplatin reduced acetylcholine (ACh) concentration and the messenger RNA (mRNA) level of ACh receptor (AChR) as well as acetylcholinesterase activity in the stomach of mice; caused ultrastructural damage to interstitial cells of Cajal (ICC); and altered the expression of c-kit/stem cell factor and the gap junction protein connexin 43 in ICC. Curcumin pretreatment inhibited the effects of cisplatin on ACh indicators and ICC. These results demonstrate that curcumin can protect against cisplatin-induced gastric emptying disorder and thus has therapeutic potential for alleviating this condition in cancer patients receiving cisplatin chemotherapy.

A Novel Tunable Dual-band Left-Handed Metamaterial

Si Li,Atef Z. Elsherbeni,Wenhua Yu,Wenxing Li,Yunlong Mao 한국자기학회 2017 Journal of Magnetics Vol.22 No.4

In this paper, we propose a novel tunable left-handed metamaterial (LHM), the capacitor-loaded short wire pairs (CL-SWPs). It is composed of a pair of short wires connected through a variable capacitor. This LHM is single-sided, and it exhibits not only tunable negative permeability, but also a wide band negative permittivity. It is pointed out with theoretical analysis that its left-handed performance is related to the mutual coupling coefficient. A tunable dual-band LHM is also proposed by simply adding a double slits split ring resonator to this LHM. The simulated results indicate that the closer the two LH bands are, the better performance the CLSWP related left-handed band is, hence identifying our theoretical analysis. The proposed structure is geometrically simple, low-cost and easy for fabrication, and it can be used as a basic particle in the design of tunable multi-band LHMs.

Omi inhibition ameliorates neuron apoptosis and neurological deficit after subarachnoid hemorrhage in rats

Du Yuanfeng,Yang Dingbo,Dong Xiaoqiao,Du Quan,Wang Ding,Shen Yongfeng,Yu Wenhua 한국유전학회 2021 Genes & Genomics Vol.43 No.12

Background Subarachnoid hemorrhage (SAH) is a severe neurological emergency, resulting in cognitive impairments and threatening human's health. Currently, SAH has no efective treatment. It is urgent to search for an efective therapy for SAH. Objective To explore the expression of Omi protein after subarachnoid hemorrhage in rats. Methods SAH rat model was established by injecting blood into the prechiasmatic cistern. Neurological defcit was assessed by detecting neurological defcit scores and brain tissue water contents. Apoptotic cells were evaluated by TUNEL staining and IHC staining. Omi and Cleaved caspase 3 expressions in nerve cells were determined by double staining using IF. Apoptosis-related proteins were measured by Western blotting assay. Results SAH rat model was successfully established, showing more apoptotic cells and high neurological defcit scores in SAH rat. In SAH rat model, Omi expression in nerve cells was elevated and the upregulation of Omi mainly occurred in cytoplasm, accompanied by the degradation of XIAP and the increased cleaved caspase 3/9 and cleaved PARP. Once treated with UCF-101, a specifc inhibitor of Omi, the increased cell apoptosis, left/right brain moisture contents and neurological defcits were notably reversed in SAH rat brain. Of note, SAH-induced the increases of apoptosis-related protein in nerve cells were also rescued by the administration of UCF-101. Conclusions UCF-101-mediated Omi inhibition decreased the degradation of XIAP and subsequently inhibited the activation of apoptosis-related proteins, decreased nerve cell apoptosis, leading to the improvement on early brain injury in SAH rat. UCF-101-based Omi inhibition may be used to treat SAH with great potential application.

Cardiac-targeted delivery of nuclear receptor RORα via ultrasound targeted microbubble destruction optimizes the benefits of regular dose of melatonin on sepsis-induced cardiomyopathy

Shanjie Wang,Kegong Chen,Ye Wang,Zeng Wang,Zhaoying Li,JunChen Guo,Jianfeng Chen,Wenhua Liu,Xiaohui Guo,Guangcan Yan,Chenchen Liang,Huai Yu,Shaohong Fang,Bo Yu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Large-dose melatonin treatment in animal experiments was hardly translated into humans, which may explain the dilemma that the protective effects against myocardial injury in animal have been challenged by clinical trials. Ultrasound-targeted microbubble destruction (UTMD) has been considered a promising drug and gene delivery system to the target tissue. We aim to investigate whether cardiac gene delivery of melatonin receptor mediated by UTMD technology optimizes the efficacy of clinically equivalent dose of melatonin in sepsis-induced cardiomyopathy. Methods Melatonin and cardiac melatonin receptors in patients and rat models with lipopolysaccharide (LPS)- or cecal ligation and puncture (CLP)-induced sepsis were assessed. Rats received UTMD-mediated cardiac delivery of RORα/cationic microbubbles (CMBs) at 1, 3 and 5 days before CLP surgery. Echocardiography, histopathology and oxylipin metabolomics were assessed at 16–20 h after inducing fatal sepsis. Results We observed that patients with sepsis have lower serum melatonin than healthy controls, which was observed in the blood and hearts of Sprague–Dawley rat models with LPS- or CLP-induced sepsis. Notably, a mild dose (2.5 mg/kg) of intravenous melatonin did not substantially improve septic cardiomyopathy. We found decreased nuclear receptors RORα, not melatonin receptors MT1/2, under lethal sepsis that may weaken the potential benefits of a mild dose of melatonin treatment. In vivo, repeated UTMD-mediated cardiac delivery of RORα/CMBs exhibited favorable biosafety, efficiency and specificity, significantly strengthening the effects of a safe dose of melatonin on heart dysfunction and myocardial injury in septic rats. The cardiac delivery of RORα by UTMD technology and melatonin treatment improved mitochondrial dysfunction and oxylipin profiles, although there was no significant influence on systemic inflammation. Conclusions These findings provide new insights to explain the suboptimal effect of melatonin use in clinic and potential solutions to overcome the challenges. UTMD technology may be a promisingly interdisciplinary pattern against sepsis-induced cardiomyopathy.