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Clinical Significance of Decompressive Craniectomy Surface Area and Side
Jo, KwangWook,Joo, Won Il,Yoo, Do Sung,Park, Hae-Kwan The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.2
Objective : Decompressive craniectomy (DC) can partially remove the unyielding skull vault and make affordable space for the expansion of swelling brain contents. The objective of this study was to compare clinical outcome according to DC surface area (DC area) and side. Methods : A total of 324 patients underwent different surgical methods (unilateral DC, 212 cases and bilateral DC, 112 cases) were included in this retrospective analysis. Their mean age was 53.4±16.6 years (median, 54 years). Neurological outcome (Glasgow outcome scale), ventricular intracranial pressure (ICP), and midline shift change (preoperative minus postoperative) were compared according to surgical methods and total DC area, DC surface removal rate (DC%) and side. Results : DC surgery was effective for ICP decrease (32.3±16.7 mmHg vs. 19.2±13.4 mmHg, p<0.001) and midline shift change (12.5±7.6 mm vs. 7.8±6.9 mm, p<0.001). The bilateral DC group showed larger total DC area (125.1±27.8 ㎠ for unilateral vs. 198.2±43.0 ㎠ for bilateral, p<0.001). Clinical outcomes were nonsignificant according to surgical side (favorable outcome, p=0.173 and mortality, p=0.470), significantly better when total DC area was over 160 ㎠ and DC% was 46% (p=0.020 and p=0.037, respectively). Conclusion : DC surgery is effective in decrease the elevated ICP, decrease the midline shift and improve the clinical outcome in massive brain swelling patient. Total DC area and removal rate was larger in bilateral DC than unilateral DC but clinical outcome was not influenced by DC side. DC area more than 160 ㎠ and DC surface removal rate more than 46% were more important than DC side.
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A STUDY ON THE CONNECTIONS IN SEX, REX, AND MEX
YOO,KI-JO,PARK,SUNG-HEE 木浦大學校 基礎科學硏究所 1993 基礎科學硏究誌 Vol.11 No.-
In this paper, we first introduce three connection, SE-connections, RE-connection, and ME-connection. In the second, we derive a generalized n-dimensional Riemannian manifold, on which the differential geometric structure is imposed by an unified field tenser ?? through an SE-connection, a RE-connection, and an ME-connection is called an n-dimensional SE-manifold, RE-manifold, and ME-manifold and denoted by ??. ??, and ??, respectively. Finally, the relationships between these manifolds will be investigated in the present paper.
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Jo, Wol Soon,Yang, Kwang Mo,Park, Hee Sung,Kim, Gi Yong,Nam, Byung Hyouk,Jeong, Min Ho,Choi, Yoo Jin Korean Society of ToxicologyKorea Environmental Mu 2012 Toxicological Research Vol.28 No.4
Exposure of cells to ultraviolet B (UVB) radiation can induce production of free radicals and reactive oxygen species (ROS), which damage cellular components. In addition, these agents can stimulate the expression of matrix metalloproteinase (MMP) and decrease collagen synthesis in human skin cells. In this study, we examined the anti-photoaging effects of extracts of Tetraselmis suecica (W-TS). W-TS showed the strongest scavenging activity against 2,2-difenyl-1-picrylhydrazyl (DPPH) and peroxyl radicals, followed by superoxide anions from the xanthine/xanthine oxidase system. We observed that the levels of both intracellular ROS and lipid peroxidation significantly increased in UVB-irradiated human skin fibroblast cells. Furthermore, the activities of enzymatic antioxidants (e.g., superoxide dismutase) and the levels of non-enzymatic antioxidants (e.g., glutathione) significantly decreased in cells. However, W-TS pretreatment, at the maximum tested concentration, significantly decreased intracellular ROS and malondialdehyde (MDA) levels, and increased superoxide dismutase and glutathione levels in the cells. At this same concentration, W-TS did not show cytotoxicity. Type 1 procollagen and MMP-1 released were quantified using RT-PCR techniques. The results showed that W-TS protected type 1 procollagen against UVB-induced depletion in fibroblast cells in a dose-dependent manner via inhibition of UVB-induced MMP-1. Taken together, the results of the study suggest that W-TS effectively inhibits UVB-induced photoaging in skin fibroblasts by its strong anti-oxidant ability.
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Yoo Wonbeak,Choi Hyunji,Son Young Hoon,Lee Jaemin,Jo Seongyea,Jung Dana,Kim Yeon Jeong,Koh Sang Seok,Yang Yong Ryoul,Kwon Eun-Soo,Lee Kwang-Pyo,노경희,Kim Kyung Won,Ko Yousun,Jun Eunsung,Kim Song Cheol,K 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Cancer cachexia is a highly debilitating condition characterized by weight loss and muscle wasting that contributes significantly to the morbidity and mortality of pancreatic cancer. The factors that induce cachexia in pancreatic cancer are largely unknown. We previously showed that pancreatic adenocarcinoma upregulated factor (PAUF) secreted by pancreatic cancer cells is responsible for tumor growth and metastasis. Here, we analyzed the relation between pancreatic cancer-derived PAUF and cancer cachexia in mice and its clinical significance. Body weight loss and muscle weight loss were significantly higher in mice with Panc-1/PAUF tumors than in those with Panc-1/Mock tumors. Direct administration of rPAUF to muscle recapitulated tumor-induced atrophy, and a PAUF-neutralizing antibody abrogated tumor-induced muscle wasting in Panc-1/PAUF tumor-bearing mice. C2C12 myotubes treated with rPAUF exhibited rapid inactivation of Akt-Foxo3a signaling, resulting in Atrogin1/MAFbx upregulation, myosin heavy chain loss, and muscle atrophy. The neutrophil-to-lymphocyte ratio and body weight loss were significantly higher in pancreatic cancer patients with high PAUF expression than in those with low PAUF expression. Analysis of different pancreatic cancer datasets showed that PAUF expression was significantly higher in the pancreatic cancer group than in the nontumor group. Analysis of The Cancer Genome Atlas data found associations between high PAUF expression or a high DNA copy number and poor overall survival. Our data identified tumor-secreted circulating PAUF as a key factor of cachexia, causing muscle wasting in mice. Neutralizing PAUF may be a useful therapeutic strategy for the treatment of pancreatic cancer-induced cachexia.
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Design of Internet Phone (VoIP) for Voice Security using the VPN
Sang-Jo Youk,Seung-Sun Yoo,Gil-cheol Park,Tai-hoon Kim 보안공학연구지원센터 2007 International Journal of Multimedia and Ubiquitous Vol.2 No.3
The VoIP(Voice over IP) has been worldwide used and already put to practical use in many fields. However, it is needed to ensure secret of VoIP call in a special situation. It is relatively difficult to eaves-drop the commonly used PSTN in that it is connected with 1:1 circuit. However, it is difficult to ensure the secret of call on Internet because many users can connect to the Internet at the same time. Therefore, this paper suggests a new model of Internet telephone for eavesdrop prevention enabling VoIP(using SIP protocol) to use the VPN protocol and establish the probability of practical use comparing it with Internet telephone.
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( Yoo Mi Yeo ),( Kyung Wook Jo ),( Sang Do Lee ),( Woo Sugn Kim ),( Tae Sun Shim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Backround : The clinical characteristics is not well described for patietns with a treatment outcome of “treatment failure”, by ATS defi nition, due to a failure to convert within 4 months after initiating a 4-drug standard regimen in patients with drug-susceptible pulmonary tuberculosis (TB). Method : The Study group included 52 consecutive patients with rifampicin-susceptible pulmonary TB in whom culture conversion was failed within 4 months of standard4-drug treatment between January 2001 and December 2013. The Control group included 252 patients with culture conversion within 2 months after initiating treatment. We extracted clinical data retrospectively, and the characteristics and treatment outcomes were compared between two groups. Result : The Study group showed more frequent history of previous TB (38.5% vs. 16.3%), more cavity (36.5% vs. 14.7%), more extensive disease (71.1% vs. 27.0%) and more isoniazid resistance (19.2% vs. 0%) compared with the Control group (p<0.05, each). During follow-up, acquired multidrug-resistance was observed in 25.6% of patients in the Study group. The successful treatment completion rate was lower (69.2% vs. 97.2%, p<0.05) in the Study group. In addition, the recurrence rate and mortality rate was signifi cantly higher in the Study group. Of 52 patients in the Study group, 29 patients (55.8%) maintained 1st-line drug treatment whereas the regimen was switched to to 2nd-line drugs in remaining 23 patients (44.2%). Between these two groups, there were no signifi cant differences in the treatment outcomes (treatment success, mortality and recurrence rates) as well as in the baseline clinical characteristics. Conclusions: The fi nal treatment outcome of the Study group was poorer than in the Control group. However, in some patients, successful treatment completion could be achieved by using 1st-line drugs alone with a simple extension of treatment duration.
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Video Quality Adaptation for Extended Playback Time on Mobile Devices With Limited Energy
Jo, Sung-Woong,Yoo, Wonsuk,Chung, Jong-Moon IEEE 2018 IEEE communications letters Vol.22 No.6
<P>In this letter, a HTTP-based adaptive rate control streaming (HARCS) scheme that selects the video quality level of each chunk for extending playback time is proposed. For this purpose, the expected energy consumption for downloading remaining chunks to be received is stochastically modeled by considering the time-varying wireless network conditions and video characteristics. Then, based on the derived energy model as well as the mobile device’s remaining battery energy, the proposed HARCS scheme adaptively selects the video quality level of each chunk. Measurement results show that HARCS can extend the video playback time up to 57.64% when compared with the conventional adaptation scheme that only considers the wireless network status.</P>
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Jo, Junhyeon,Oh, Inseon,Jin, Mi-Jin,Park, Jungmin,Son, Jae Sung,An, Ki-Seok,Yoo, Jung-Woo ELSEVIER 2017 Organic Electronics Vol. No.
<P><B>Abstract</B></P> <P>Wearable electronics, as a new form of ubiquitous technology, require a sustainable self-powering system with an enhanced mechanical durability. In this report, we demonstrate a conducting polymer based stretchable thermoelectric performance with a synergetic effect of an enhanced power factor due to electron delocalization. The fluorosurfactant treatment of poly(3,4-ethylene dioxythiophene):poly(styrenesulphonate) (PEDOT:PSS) films induced a significant dedoping effect with an enhanced Seebeck coefficient and a morphological change into an elongated lamellar structure. Such structural transformation led to a reduced transport dimensionality with strongly extended electron delocalization yielding a simultaneous enhancement of the electron mobility and the Seebeck coefficient, which produced an improved thermoelectric power factor. Most notably, the mechanical durability of the PEDOT:PSS film was greatly improved tolerating up to a 60% static strain and over several hundred cycles of 50% strain. The demonstrated concomitant enhancement of the mechanical stretchability and thermoelectric performance inspires a promising approach for improving shape-adjustable self-powering devices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> First development of highly stretchable thermoelectric performance based on conducting polymer tolerating up to 60% strain. </LI> <LI> Demonstration of concomitant enhancement of thermoelectric power factor and mechanical durability of the PEDOT:PSS film. </LI> <LI> Characterization of hopping transport and their impact on thermoelectric power factor. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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