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Baojiao Gao,Jian Meng,Yang Xu,Yongqi Zhang 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.24 No.-
For the purification of lanthanide, Fe3+ ion surface-imprinted material was prepared with sodium pstyrenesulfonate (SSS) as functional monomer and using a novel ion surface-imprinting technique of ‘‘synchronously graft polymerizing and imprinting’’. In solution, the anionic monomers SSS are distributed around template Fe3+ ion by right of ion exchange action. The graft/cross-linking copolymerization of SSS and crosslinker N,N0-methylenebisacrylamide (MBA) on SiO2 particles was initiated by a surface initiating system, obtaining Fe3+ ion surface-imprinted material IIP-PSSS/SiO2. It possesses special recognition selectivity for Fe3+ ion, and its selectivity coefficients for Fe3+ ion are 5.77 relative to La3+ ion and 5.69 relative to Pr3+ ion, respectively.
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Xiaoyu Li,Chuhao Li,Yang Hu,Yongqi Yu,Wenjie Zeng,Haibiao Wu 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.6
The coolant temperature feedback coefficient is an important parameter of reactor core power controlsystem. To study the coolant temperature feedback coefficient influence on the core power controlsystem of small PWR, the core power control system is built with the nonlinear model and fuzzy controltheory. Then, the uncertainty quantification method of reactor core parameters is established based onthe Latin hypercube sampling method and the Bootstrap method. Finally, under the conditions ofreactivity step perturbation and coolant inlet temperature step perturbation, uncertainty analysis for twocases is carried out. The result shows that with fuzzy controller and fuzzy PID controller, the uncertaintyof the coolant temperature feedback coefficient affects the core power control system, and the maximumuncertainties of core relative power, coolant temperature deviation, fuel temperature deviation and totalreactivity are acceptable
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Hongliang Li,Yue Zhou,Yongqi Yang,Yiwen Zha,Bingqian Ye,Seo-Yeong Mun,Wenwen Zhuang,Jingyan Liang,Won Sun Park The Korean Society of Pharmacology 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.4
Voltage-dependent K<sup>+</sup> (Kv) channels are widely expressed on vascular smooth muscle cells and regulate vascular tone. Here, we explored the inhibitory effect of encainide, a class Ic anti-arrhythmic agent, on Kv channels of vascular smooth muscle from rabbit coronary arteries. Encainide inhibited Kv channels in a concentration-dependent manner with an IC<sub>50</sub> value of 8.91 ± 1.75 μM and Hill coefficient of 0.72 ± 0.06. The application of encainide shifted the activation curve toward a more positive potential without modifying the inactivation curve, suggesting that encainide inhibited Kv channels by altering the gating property of channel activation. The inhibition by encainide was not significantly affected by train pulses (1 and 2 Hz), indicating that the inhibition is not use (state)-dependent. The inhibitory effect of encainide was reduced by pretreatment with the Kv1.5 subtype inhibitor. However, pretreatment with the Kv2.1 subtype inhibitor did not alter the inhibitory effects of encainide on Kv currents. Based on these results, encainide inhibits vascular Kv channels in a concentration-dependent and use (state)-independent manner by altering the voltage sensor of the channels. Furthermore, Kv1.5 is the main Kv subtype involved in the effect of encainide.
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Changming Liu,Xiaoling Li,Ruiping Yang,Yanling Mo,Yongqi Wang,Feng Xian,Xian Zhang,Fei Wang 한국원예학회 2014 Horticulture, Environment, and Biotechnology Vol.55 No.6
Powdery mildew caused by Podosphaera xanthii (P. xanthii) is one of important diseases in melon. Wehave previously investigated the differential gene expression in the incompatible P. xanthii-melon interactions andidentified one EST containing homologous sequences to S-adenosylmethionine decarboxylase (SAMDC) cDNA. Giventhis, SAMDC gene of Cucumis melo was cloned and designated as CmSAMDC in this study. It was 1,095 bp longand encoded a 364-amino acid peptide with a molecular mass of 40 kD. By sequence analyzing, the deducedCmSAMDC protein was shown to have two conserved regions of a putative proenzyme cleavage site and a PESTdomain. In addition, the expressions of CmSAMDC in the resistant melon materials increased more sharply than inthe susceptible the melon materials, and the higher polyamines (PAs) and hydrogen peroxide (H2O2) contents inresistant melon materials were found as well, which were accompanied by up-regulation of the stress-responsive defenseenzyme activities. Over-expression of CmSAMDC in Arabidopsis resulted in greatly reduced pathogen infection in theinoculated leaves of transgenic lines, enhanced resistance to powdery mildew, and the enhanced resistance appearedto be associated with pathogen-induced cell death. Taken together, our results suggested that CmSAMDC and perhapsits orthologous genes might be involved in responses of plants to biotrophic pathogens.
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Rapid Screen of IL-5/IL-5Rα Blocking Antibodies in the HEK293-IL-5Rα-CSF2RB Transfected Cell Line
Shijie Li,Fei Han,Chang Liu,Weiyan Dai,Wenfeng Ke,Yongqi Chen,Eric Fordjour,Yankun Yang,Zhonghu Bai 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.4
Interleukin-5 (IL-5) binding to interleukin-5 receptor subunit alpha (IL-5Rα) increases the number of eosinophils and enhances eosinophil activity. This leads to eosinophil tissue infiltration and damage to the lungs, ultimately resulting in exacerbation of asthma. Antibodies that block IL-5 binding to IL-5Rα are thought to play an important role in advanced asthma. Currently, key methods used to screen for targeted drugs are Surface Plasmon Resonance which is costly and anti-proliferation assays which are tedious and have a low signal-to-noise ratio. Here we describe a Fluorescence Activated Cell Sorting (FACS) assay, based on human embryonic kidney (HEK)- 293 cells with stable expression of IL-5Rα and the cytokine receptor common subunit beta (CSF2RB). Cells co-expressing IL-5Rα and CSF2RB had a 16% increase in the ability to bind IL-5 compared to cells expressing only IL-5Rα. The optimal concentration of IL-5 for the FACS assay was 0.1 μg/mL. The established FACS was used to screen anti IL-5 nanobodies and hybridoma supernatants for candidate antibodies that block the IL-5/IL-5α interaction. When compared to anti-proliferation assays, this method saved up to 90% of the assay time, offering the advantage of rapidity and accuracy in vitro. The assay described here provides a novel approach for rapid screening of IL-5/IL- 5Rα blocking antibodies in vitro to accelerate the development of drugs for asthma.
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