Intradural Extramedullary Hematoma after Cervical Epidural Injection: A Case Report

Yena Oh,Jin Young Lee,Woo Seog Sim,Inho kim,Ji Won Choi 대한통증연구학회 2022 International Journal of Pain Vol.13 No.2

Intradural extramedullary (IDEM) hematomas are extremely rare, but present with potentially catastrophic consequences. In the present case, a 71-year-old male, who did not take anticoagulation medication or have any coagulopathy, had an IDEM hematoma after an attempted cervical epidural injection. The patient underwent surgical decompression and regained full muscle power except his right finger abductor. As demonstrated in this case, if there are neurologic symptoms after epidural steroid injection, early recognition and treatment is necessary.

Liver transplantation of a patient with extreme thrombocytopenia - A case report -

Oh Yena,Yoo Seung Yeon,Choi Gyu Seong,김갑수 대한마취통증의학회 2021 Anesthesia and pain medicine Vol.16 No.3

Background: Patients with chronic liver disease (CLD) planned for liver transplantation (LT) often show severe thrombocytopenia, but there is a lack of evidence in deciding the threshold for prophylactic platelet transfusion.Case: A 47-year-old women with acute liver failure was referred for LT. Despite daily transfusion of platelets, platelet counts remained under 10,000/µl. During LT, 2 units of single donor platelets (SDP) were transfused. Although platelet counts remained extremely low (3,000–4,000/µl) no diffuse oozing was observed and the blood loss was 860 ml. Postoperatively, there was no sign of active bleeding or oozing, and the patient received only 1 unit SDP transfusion.Conclusions: CLD patients may have severe thrombocytopenia. However, primary hemostasis may not be significantly hindered due to the existence of rebalanced hemostasis. Prophylactic platelet transfusion in these patients should not be decided based on platelet counts only, but also take other coagulation tests and clinical signs into consideration.

Efficacy and safety of parenteral vitamin D therapy in infants and children with vitamin D deficiency caused by intestinal malabsorption

Yu Sae Bit,Lee Yena,Oh Arum,Yoo Han-Wook,최진호 대한소아내분비학회 2020 Annals of Pediatirc Endocrinology & Metabolism Vol.25 No.2

Purpose: Oral supplementation of vitamin D can be inefficient in patients with vitamin D deficiency caused by intestinal malabsorption. This study investigated the efficacy and safety of parenteral vitamin D supplementation in infants and children with vitamin D deficiency caused by intestinal malabsorption. Methods: This study included 11 patients with vitamin D deficiency who were unresponsive to oral vitamin D or were unable to try oral vitamin D therapy due to underlying conditions. All patients were treated with weekly intramuscular injection of cholecalciferol 50,000 IU. Radiological findings and biochemical parameters including serum calcium, phosphorus, alkaline phosphatase, 25-hydroxyvitamin D3 (25(OH)D3), and parathyroid hormone levels were reviewed retrospectively. Results: Underlying diseases included small bowel atresia (n=3), necrotizing enterocolitis (n=3), congenital megacolon (n=2), chronic intestinal pseudo-obstruction (n=1), congenital mesenteric band (n=1), and Crohn disease (n=1). Three patients exhibited rickets on X-ray findings. The mean duration of treatment was 4.8±2.9 weeks. The alkaline phosphatase levels were decreased from 710±650 IU/L to 442±284 IU/L (P=0.143). The 25(OH)D3 level was increased from 6.0±3.4 ng/mL to 50.4±28.8 ng/mL (P=0.008) after 3 months. Two patients with rickets showed improved radiologic findings after parenteral treatment. Conclusion: Parenteral vitamin D therapy was effective and safe in patients with vitamin D deficiency caused by intestinal malabsorption. Long-term follow-up is needed to establish the efficacy of parenteral vitamin D therapy in a large number of patients.

Three pediatric patients with primary hyperparathyroidism caused by parathyroid adenoma

Oh Arum,Lee Yena,Yoo Han-Wook,Choi Jin-Ho 대한소아내분비학회 2022 Apem Vol.27 No.2

Primary hyperparathyroidism (PHPT) is a hypercalcemia disorder with inappropriately normal or increased serum parathyroid hormone (PTH) levels resulting from excessive secretion of PTH from one or more of the parathyroid glands. PHPT is uncommon in infants and children, with an estimated incidence of 2–5 cases per 100,000 persons. Patients with PHPT usually present with bone pain, urolithiasis, or nephrolithiasis, as well as nonspecific symptoms such as fatigue and weakness. Asymptomatic hypercalcemia may also be detected incidentally. Only a few cases of pediatric PHPT have been reported in Korea. We present three patients (a 9-year-old girl, a 14-year-old boy, and a 14-year-old girl) with PHPT who manifested variable clinical features of hypercalcemia. The first and second patients each had a parathyroid adenoma and presented with abdominal pain caused by pancreatitis and a ureter stone, respectively. The third patient had an ectopic mediastinal parathyroid adenoma and presented with gait disturbance and weakness of the lower extremities. All of the patients underwent surgical resection of parathyroid adenoma, and their serum calcium levels subsequently normalized without medication.

Three pediatric patients with primary hyperparathyroidism caused by parathyroid adenoma

Oh Arum,Lee Yena,Yoo Han-Wook,최진호 대한소아내분비학회 2022 Annals of Pediatirc Endocrinology & Metabolism Vol.27 No.2

Primary hyperparathyroidism (PHPT) is a hypercalcemia disorder with inappropriately normal or increased serum parathyroid hormone (PTH) levels resulting from excessive secretion of PTH from one or more of the parathyroid glands. PHPT is uncommon in infants and children, with an estimated incidence of 2–5 cases per 100,000 persons. Patients with PHPT usually present with bone pain, urolithiasis, or nephrolithiasis, as well as nonspecific symptoms such as fatigue and weakness. Asymptomatic hypercalcemia may also be detected incidentally. Only a few cases of pediatric PHPT have been reported in Korea. We present three patients (a 9-year-old girl, a 14-year-old boy, and a 14-year-old girl) with PHPT who manifested variable clinical features of hypercalcemia. The first and second patients each had a parathyroid adenoma and presented with abdominal pain caused by pancreatitis and a ureter stone, respectively. The third patient had an ectopic mediastinal parathyroid adenoma and presented with gait disturbance and weakness of the lower extremities. All of the patients underwent surgical resection of parathyroid adenoma, and their serum calcium levels subsequently normalized without medication.

Clinical, endocrinological, and molecular features of four Korean cases of cytochrome P450 oxidoreductase deficiency

Lee Yena,최진호,Oh Arum,Kim Gu-Hwan,Park Sook-Hyun,Moon Jung Eun,Ko Cheol Woo,Cheon Chong-Kun,Yoo Han-Wook 대한소아내분비학회 2020 Annals of Pediatirc Endocrinology & Metabolism Vol.25 No.2

Purpose: Cytochrome P450 oxidoreductase (POR) deficiency is a rare autosomal recessive disorder caused by mutations in the POR gene encoding an electron donor for all microsomal P450 enzymes. It is characterized by adrenal insufficiency, ambiguous genitalia, maternal virilization during pregnancy, and skeletal dysplasia. In this study, we investigated the clinical, hormonal, and molecular characteristics of patients with POR deficiency in Korea. Methods: This study included four patients with POR deficiency confirmed by biochemical and molecular analysis of POR. Clinical and biochemical findings were reviewed retrospectively. Mutation analysis of POR was performed by Sanger sequencing after polymerase chain reaction amplification of all coding exons and the exon-intron boundaries. Results: All patients presented with adrenal insufficiency and ambiguous genitalia regardless of their genetic sex. Two patients harbored homozygous p.R457H mutations in POR and presented with adrenal insufficiency and genital ambiguity without skeletal phenotypes. The other two patients with compound heterozygous mutations of c.[1329_1330insC];[1370G>A] (p.[I444Hfs*6];[R457H]) manifested skeletal abnormalities, such as craniosynostosis and radiohumeral synostosis, suggesting Antley-Bixler syndrome. They also had multiple congenital anomalies involving heart, kidney, and hearing ability. All patients were treated with physiologic doses of oral hydrocortisone. Conclusion: We report the cases of 4 patients with POR deficiency identified by mutation analysis of POR. Although the study involved a small number of patients, the POR p.R457H mutation was the most common, suggesting founder effect in Korea. POR deficiency is rare and can be misdiagnosed as 21-hydroxylase or 17α-hydroxylase/17,20-lyase deficiency. Therefore, molecular analysis is critical for confirmatory diagnosis.

AR 기술을 활용한 미술관 관람 모바일 콘텐츠 개발

한예나(Yena Han),오범석(Beom-Seok Oh),유선진(Sunjin Yu) 한국정보기술학회 2023 Proceedings of KIIT Conference Vol.2023 No.6

Methyllucidone inhibits STAT3 activity by regulating the expression of the protein tyrosine phosphatase MEG2 in DU145 prostate carcinoma cells

Jin, Yena,Kim, Young Hwan,Park, Jin Yong,Lee, Yu-Jin,Oh, Hyun-Mi,Choi, Sung-Kyu,Han, Dong Cho,Kwon, Byoung-Mog Elsevier 2018 Bioorganic & medicinal chemistry letters Vol.28 No.5

<P><B>Abstract</B></P> <P>During the search for signal transducer and activator of transcription 3 (STAT3) inhibitors from natural products, methyllucidone, isolated from <I>Lindera</I> species (<I>Lauraceae</I>), was identified as a STAT3 inhibitor. Methyllucidone inhibited STAT3 phosphorylation at tyrosine 705 in a dose- and time dependent manner in DU145 prostate cancer cells and suppressed IL-6-induced STAT3 phosphorylation at Tyr-705 in LNCaP cells. Methyllucidone decreased the expression levels of STAT3 target genes, such as cyclin D1, cyclin A, Bcl-2, Mcl-1, and survivin. Methyllucidone inhibited DU145 cell growth and induced apoptosis by arresting the cell cycle at G1 phase. Notably, knockdown of the MEG2 gene by small interfering RNA suppressed the ability of methyllucidone to inhibit STAT3 activation. Methyllucidone regulates STAT3 activity by modulating MEG2 expression, and our results suggest that this compound is a novel inhibitor of the STAT3 pathway and may be a useful lead molecule for the development of a therapeutic STAT3 inhibitor.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Identification of Potocki–Lupski syndrome in patients with developmental delay and growth failure

Sujin Jun,Yena Lee,Arum Oh,Gu-Hwan Kim,Eulju Seo,Beom Hee Lee,Jin-Ho Choi,Han-Wook Yoo 대한의학유전학회 2019 대한의학유전학회지 Vol.16 No.2

Purpose: Potocki–Lupski syndrome (PTLS), is a recently identiἀed, rare genomic disorder. The patients are affected by in-fantile hypotonia, poor growth and developmental delay. Facial dysmorphism may not be obvious in some patients. PTLS is associated with microduplication at chromosome 17p11.2. In the current study, three Korean patients are reported with their clinical and genetic features. Materials and Methods: The clinical ἀndings of each patient were reviewed. Karyotyping and multiplex ligation-dependent probe ampliἀcation (MLPA) analyses were done for genetic diagnoses.Results: All the patients did not have the characteristic dysmorphic features, such as broad forehead, triangular face, asym-metric smile and palpebral ἀssures. On the other hand, all three patients were affected by variable degree of developmental delay, poor oral intake, failure to thrive, and language development disorders. Chromosome 17p11.2 duplication was identi-ἀed by conventional karyotyping analysis only in one patient, whereas the other conἀrmed by MLPA analyses.Conclusion: Delayed development was mostly commonly observed in our patients without distinct dysmorphic facial fea-tures. In this respect, genomic screening in patients with developmental delay would identify more cases with PTLS to under-stand their long-term clinical courses with the development of adequate psychological and rehabilitation education program.

Interfacial Reactions in Ni/6H-SiC at Low Temperatures

Lim, Suhee,Oh, Jin-Soo,Kwon, Yena,An, Byeong-Seon,Bae, Jee-Hwan,Kim, Tae-Hoon,Park, Min-Ho,Kim, Hyoung-Sub,Yang, Cheol-Woong American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.10

<P>We report the reaction between thin Ni films and 6H-SiC substrates at relatively low temperatures (<550 degrees C) and the diffusion behavior of carbon during silicide formation. The phase transformation and distribution of chemical constituents were investigated using transmission electron microscopy. About 60 nm of Ni was deposited on 6H-SiC using an e-beam evaporator, and samples were then annealed using a rapid thermal annealing process. In a Ni/SiC sample annealed at 450 degrees C, while there are no Ni-silicides present, a graphite inter layer is formed between the SiC substrate and Ni. In addition, Si is released by SiC decomposition diffusing to the Ni layer to form a Ni(Si) solid solution. As the annealing temperature increases to 550 degrees C, a phase transformation begins, with the Ni-silicides going from Ni3Si to Ni31Si12 and N2Si over time. At the very beginning of the Ni/SiC reaction, carbon atoms liberated from SiC diffuse through un-reacted polycrystalline Ni towards the external surface and form a graphite layer. During the silicidation reaction, carbon atoms (a decomposition product formed after the Ni/SiC reaction) are distributed inside the silicide layer and precipitate in the form of graphite.</P>