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- 저자 : Yanguang Wu (검색결과 3 건)
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Xingyuan Miao,Hong Zhao,Boxuan Gao,Tingting Wu,Yanguang Hou 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.6
Compared with traditional plugging methods, the in-pipe intelligent isolation plugging tool (IPT) is advantageous in safety and work efficiency. However, during the plugging process, the flow field around the IPT changes drastically, resulting in vortex-induced vibration and potential failure of the plugging operation. In this study, three foldable spoilers were designed at the tail of the IPT to optimize the flow field. The vibration of the IPT can be alleviated by adjusting the angles of the spoilers. A vibration reduction control system of the IPT was designed based on deep reinforcement learning. First, we conducted an experiment for vibration reduction system. Second, a nonlinear model of the pressure difference based on experimental data was established. Then, a multi-agent self-learning system based on the deep Q-network (DQN) was designed, and the optimal actions were selected in each agent to adjust the spoiler angles during the plugging process. Finally, a controller based on fuzzy reinforcement learning was proposed to flip the spoilers to the optimized angles. The results show that the vibration reduction control system of the IPT reduced the pressure difference by an average of 28.32%, which indicates the stability of the plugging process and a successful reduction of the IPT vibration.
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Shen Xuefang,Chen Xiangyuan,Wang Jing,Liu Jing,Wang Zhiyao,Hua Qing,Wu Qichao,Su Yanguang,He Huanzhong,Hu Yuqin,Meng Zhipeng,Xiong Wanxia,Zhu Minmin 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Hyperglycemia-mediated endothelial inflammation participates in the pathogenesis of cardiovascular complications in subjects with diabetes. Previous studies reported that phosphatase and tensin homolog deleted on chromosome ten (PTEN) and SET8 participate in high glucose-mediated endothelial inflammation. In this study, we hypothesize that SET8 regulates PTEN expression, thus contributing to high glucose-mediated vascular endothelial inflammation. Our data indicated that plasma soluble intercellular adhesion molecule-1 (sICAM-1) and endothelial selectin (e-selectin) were increased in patients with diabetes and diabetic rats. PTEN expression was augmented in the peripheral blood mononuclear cells of patients with diabetes and in the aortic tissues of diabetic rats. Our in vitro study indicated that high glucose increased monocyte/endothelial adhesion, endothelial adhesion molecule expression and p65 phosphorylation in human umbilical vein endothelial cells (HUVECs). Moreover, high glucose led to endothelial inflammation via upregulation of PTEN. Furthermore, high glucose inhibited SET8 expression and histone H4 lysine 20 methylation (H4K20me1), a downstream target of SET8. SET8 overexpression reversed the effects of high-glucose treatment. shSET8-mediated endothelial inflammation was counteracted by siPTEN. Furthermore, SET8 was found to interact with FOXO1. siFOXO1 attenuated high glucose-mediated endothelial inflammation. FOXO1 overexpression-mediated endothelial inflammation was counteracted by siPTEN. H4K20me1 and FOXO1 were enriched in the PTEN promoter region. shSET8 increased PTEN promoter activity and augmented the positive effect of FOXO1 overexpression on PTEN promoter activity. Our in vivo study indicated that SET8 was downregulated and FOXO1 was upregulated in the peripheral blood mononuclear cells of patients with diabetes and the aortic tissues of diabetic rats. In conclusion, SET8 interacted with FOXO1 to modulate PTEN expression in vascular endothelial cells, thus contributing to hyperglycemia-mediated endothelial inflammation.
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Yun-fei Zhang,Man-geng Lu,Hui Liu,Yanguang Wu 한국고분자학회 2017 폴리머 Vol.41 No.2
In this study, effects of mixed hardeners (ammonium chloride mixed with ammonium persulfate, oxalate and phosphoric acid) on the properties of 2,4,6-trimethylolphenate modified UF resin (TMPUF) were studied, and the potlife, gel time and curing temperature of TMPUF/hardeners were characterized. The results indicated that the hardeners used have critical influence on the pH value of TMPUF and some proton donor can be used to lower the pH value of TMPUF with low formaldehyde content. Besides, bamboo particleboards were made with TMPUF/hardeners, and tensile properties, water absorption ratio and the swelling ratio of bamboo particleboards were characterized. The study demonstrated that the tensile strength of bamboo particleboards increased when partial ammonium chloride was replaced by ammonium persulfate to cure the TMPUF adhesives in our experiment.
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