ROLLOVER SIMULATION OF SPORTS UTILITY VEHICLES

M. RAM PRABHU(M. RAM PRABHU),N.S. ANDRES(N.S. ANDRES),엄용균(Y.G. Eom),장봉춘(B.C. JANG) 한국자동차공학회 2005 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2005 No.5_2

The simulations on dynamic stability of Sports Utility Vehicles using Carsim/Vehsim software are presented on this paper with the aim of studying the rollover process occurring in such vehicles. Carsim/Vehsim is an integrated simulation package that has been developed for chassis dynamics controls and integration. The simulation procedure makes use of dynamic testing maneuvers (Fishhook tests, J-Turn test and Double Lane Change test) recommended by NHTSA to evaluate the antirollover propensities of SUVs on road. The simulation results emphasize the need for better understanding of SUV rollover performance and characteristics that are very essential in enhancing vehicle design. Furthermore, the simulation dramatically shows less development time and cost reduction compared to field testing. This paper, in general, investigates the dynamic rollover characteristics of 4 SUVs in 2 different road conditions.

A Comparative Study of Operating Angle Optimization of Switched Reluctance Motor with Robust Speed Controller using PSO and GA

Prabhu, V. Vasan,Rajini, V.,Balaji, M.,Prabhu, V. The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.2

This paper's focus is in reducing the torque ripple and increasing the average torque by optimizing switching angles of 8/6 switched reluctance motor while implementing a robust speed controller in the outer loop. The mathematical model of the machine is developed and it is simulated using MATLAB/Simulink. An objective function and constraints are formulated and Optimum turn-on and turn-off angles are determined using Particle swarm optimization and Genetic Algorithm techniques. The novelty of this paper lies in implementing sliding mode speed controller with optimized angles. The results from both the optimization techniques are then compared with initial angles with one of them clearly being the better option. Speed response is compared with PID controller.

A Comparative Study of Operating Angle Optimization of Switched Reluctance Motor with Robust Speed Controller using PSO and GA

V. Vasan Prabhu,V. Rajini,M. Balaji,V. Prabhu 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.2

This paper’s focus is in reducing the torque ripple and increasing the average torque by optimizing switching angles of 8/6 switched reluctance motor while implementing a robust speed controller in the outer loop. The mathematical model of the machine is developed and it is simulated using MATLAB/Simulink. An objective function and constraints are formulated and Optimum turn-on and turn-off angles are determined using Particle swarm optimization and Genetic Algorithm techniques. The novelty of this paper lies in implementing sliding mode speed controller with optimized angles. The results from both the optimization techniques are then compared with initial angles with one of them clearly being the better option. Speed response is compared with PID controller.

Kisspeptins (KiSS-1): Essential Players in Suppressing Tumor Metastasis

Prabhu, Venugopal Vinod,Sakthivel, Kunnathur Murugesan,Guruvayoorappan, Chandrasekharan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Kisspeptins (KPs) encoded by the KiSS-1 gene are C-terminally amidated peptide products, including KP-10, KP-13, KP-14 and KP-54, which are endogenous agonists for the G-protein coupled receptor-54 (GPR54). Functional analyses have demonstrated fundamental roles of KiSS-1 in whole body homeostasis including sexual differentiation of brain, action on sex steroids and metabolic regulation of fertility essential for human puberty and maintenance of adult reproduction. In addition, intensive recent investigations have provided substantial evidence suggesting roles of Kisspeptin signalling via its receptor GPR54 in the suppression of metastasis with a variety of cancers. The present review highlights the latest studies regarding the role of Kisspeptins and the KiSS-1 gene in tumor progression and also suggests targeting the KiSS-1/GPR54 system may represent a novel therapeutic approach for cancers. Further investigations are essential to elucidate the complex pathways regulated by the Kisspeptins and how these pathways might be involved in the suppression of metastasis across a range of cancers.

Metabolite signature associated with stress susceptibility in socially defeated mice

Prabhu, Vishwanath Vasudev,Nguyen, Thong Ba,Cui, Yin,Oh, Young-Eun,Piao, Yan-Hong,Baek, Hyeon-Man,Kim, Joo-Yeon,Shin, Kwang-Hee,Kim, Ji-hyun,Lee, Keon-Hak,Chung, Young-Chul Elsevier 2019 Brain Research Vol.1708 No.-

<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Social defeat represents a naturalistic form of conditioned fear and is often used as an animal model of depression. The present study aimed to identify the neurochemicals in select brain regions of mice exposed to social defeat stress.</P> <P><B>Methods</B></P> <P>Adult <I>C57BL/6N</I> mice were subjected social defeat stress for 10 days. Using high-resolution magic angle spinning <SUP>1</SUP>H nuclear magnetic resonance (HR-MAS <SUP>1</SUP>H NMR), untargeted metabolomes were measured in the amygdala (AMY), dorsal hippocampus (dHIP), dorsal striatum (dST), and prefrontal cortex (PFC).</P> <P><B>Results</B></P> <P>We observed perturbations of glutamine in the AMY; glutamate in the dHIP; glycine and myo-inositol in the dST; and aspartate, choline, and phosphoethanolamine in the PFC of susceptible and/or unsusceptible groups compared to the control group. The susceptible and unsusceptible groups significantly differed with regard to three metabolites: glutamine, glycine, and choline.</P> <P><B>Conclusion</B></P> <P>These findings suggest that social defeat stress induces disturbances in the metabolism of amino acids, lipids, and neurotransmitters in several brain areas. The resulting susceptibility-related metabolites may provide new insights into the pathophysiology underlying stress-related mental illness.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Defeated mice were classified as unsusceptible and susceptible groups. </LI> <LI> HR-MAS <SUP>1</SUP>H NMR revealed disturbances in the metabolites of defeated mice brain. </LI> <LI> Results may elucidate pathophysiological mechanisms related to stress susceptibility. </LI> </UL> </P>

A mechanistic investigation of highly stable nano ZrO₂ decorated nitrogen-rich azacytosine tethered graphene oxide-based dendrimer for the removal of arsenite from water

Prabhu, Subbaiah Muthu,Pawar, Radheshyam Rama,Sasaki, Keiko,Park, Chang Min Elsevier 2019 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.370 No.-

<P><B>Abstract</B></P> <P>We focused to synthesize graphene oxide-polyamidoamine dendrimer, up to 2nd generation, (GO-gen2) <I>via</I> a grafting method and the tethered groups were further covalently functionalized with a nitrogen-rich of an aromatic triazine ring of 5-azacytosine (Aza). Zirconia nanoparticles (ZrO<SUB>2</SUB>) has been identified as promising material for removal of AsO<SUB>3</SUB> <SUP>3−</SUP> from water, however, its practical applicability is hindered due to its nanosize. Hence, ZrO<SUB>2</SUB> was successfully decorated through biomolecule assist on GO-gen2-Aza dendrimer. Various amounts of GO-gen2-Aza were used as stable supports to develop the nanocomposites with ZrO<SUB>2</SUB>. Then, the adsorption efficiency of highly toxic AsO<SUB>3</SUB> <SUP>3−</SUP> on developed composites was investigated for water treatment. The synthesized GO-dendrimer composites were characterized well before and after adsorption of AsO<SUB>3</SUB> <SUP>3−</SUP> using FTIR, PXRD, SEM, XPS, TGA, TEM and BET analysis. Particle size distribution of ZrO<SUB>2</SUB> revealed the peak top at 28 nm by zeta potential measurement. During synthesis, the GO sheets of composite were laminated by incorporation of ZrO<SUB>2</SUB> nanoparticles. The results of the batch experiments showed that ZrO<SUB>2</SUB>@2%GO-gen2-Aza dendrimer had higher adsorption density of AsO<SUB>3</SUB> <SUP>3−</SUP> than that of other developed forms of dendrimer composites. Langmuir equation well described the adsorption isotherm with the maximum adsorption capacity of 1.075 mmol/g. In addition, the enhanced AsO<SUB>3</SUB> <SUP>3−</SUP> adsorption density on ZrO<SUB>2</SUB> surface of ZrO<SUB>2</SUB>@x%GO-gen2-Aza, in which the GO-sheets were delaminated, resulting more ZrO<SUB>2</SUB> was dispersed homogeneously in the GO-sheets for maximum uptake of AsO<SUB>3</SUB> <SUP>3−</SUP> from water, confirmed by PXRD patterns. These results suggested that the developed GO-based dendrimer materials can be utilised for the practical remediation of toxic AsO<SUB>3</SUB> <SUP>3−</SUP> and other similar types of toxic ions, selenite, phosphate and fluoride from the contaminated water.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ZrO<SUB>2</SUB> entrapped GO-based Aza-tethered PAMAM dendrimer composite is prepared. </LI> <LI> Ligand exchange is likely responsible for the adsorption of AsO<SUB>3</SUB> <SUP>3−</SUP>. </LI> <LI> The lamination/delamination chemistry of GO-dendrimer composite are expressed. </LI> <LI> Maximum adsorption capacity of 1.075 mmol/g was achieved for AsO<SUB>3</SUB> <SUP>3−</SUP>. </LI> <LI> Selectivity and reusability test (4 cycles) did not affect the efficiency of AsO<SUB>3</SUB> <SUP>3−</SUP>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Synthesis and characterization of graphene oxide-doped nano-hydroxyapatite and its adsorption performance of toxic diazo dyes from aqueous solution

Prabhu, Subbaiah Muthu,Khan, Abuzar,Hasmath Farzana, M.,Hwang, Gil Chan,Lee, Woojin,Lee, Giehyeon Elsevier 2018 Journal of molecular liquids Vol.269 No.-

<P>In this study, graphene oxide-doped nano-hydroxyapatite (nHAp@GO) composite was synthesized via a simple in-situ one-pot method and was used as an adsorbent for the removal of toxic diazo dyes, Congo Red (CR) and Trypan Blue (TB), in water. A remarkable adsorption capacity for CR (48.5 mg/g) and TB (41.0 mg/g) were shown on the surface of nHAp@GO (2 g/L), respectively, and was much higher than those of bare nHAp or GO. After doping of GO on nHAp, the specific surface area of nHAp was increased by 2.5 times. The presence of sulphur peak in EDX spectrum and S-O stretching vibration peak in FTIR confirmed the adsorption of dyes on the surface of nHAp@GO composite. After the adsorption process, the shifting of d((100)) spacing of nHAp confirmed the loading of bulky organic moieties on nHAp@GO composite. Maximum CR and TB dyes adsorption occurred in a wide range of initial pH between 3.0 and 10.0. The adsorption of both CR and TB dyes are due mainly to the electrostatic interaction, pi - pi stacking interaction, hydrophobic interaction, and hydrogen bonds between dyes and nHAp@GO composite. The nHAp@GO nanocomposite was recycled up to three times at the sustained efficiency after washing with ethanol solution. We believe that such multifunctional material developed in this study will be effectively used for the depollution of toxic diazo dyes in practical applications. (C) 2018 Elsevier B.V. All rights reserved.</P>

Comparative analysis of polyspecificity of the endogenous tRNA synthetase of different expression host towards photocrosslinking amino acids using an in silico approach

Prabhu, N.S.,Yun, H. Elsevier Science, Inc 2017 Journal of molecular graphics & modelling Vol.75 No.-

Photo-induced covalent crosslinking has emerged as the powerful strategy for analyzing and characterizing the protein-protein interaction and mapping protein 3D conformations. In the last decades, a number of photocrosslinking amino acids have been reported but only a few have been efficiently utilized for photocrosslinking purposes. Recently, incorporation of diazirine containing photoactivatable analogs such as photo-methionine, photo-leucine, photo-isoleucine and photo-lysine into target proteins were accomplished in live cells (Human A549cells, HEK 293) by depleting corresponding natural amino acid and supplementing these analogs in the medium. Likewise, incorporation of photo-methionine and photo-leucine is also reported in E. coli. Incorporation of these unnatural amino acids were demonstrated only in a limited number species, thereby conventional methods have been utilized for the protein-protein interaction study in other species. With this in mind, we studied in silico analysis of polyspecificity of four endogenous tRNA synthetases (LeuRS, IleRS, MetRS, and LysRS) from six different species such as Escherichia coli, Pseudomonas fluorescens, Corynebacterium glutamicum, Saccharomyces cerevisiae, Aspergillus oryzae and Homo sapiens towards its photocrosslinking amino acids. In addition, here we describe the active site similarity of different protein bio-factories. Based on the active site similarity and similar binding mode, we predicted that the endogenous tRNA synthetases of all the species are reactive to corresponding photoactivatable analogs. This is the first in silico study to demonstrate that the photocrosslinking unnatural amino acids are recognized by the endogenous tRNA synthetases of different protein expression biofactories.

Defluoridation of Water by Graphene Oxide Supported Needle-Like Complex Adsorbents

Prabhu, S. M.,Elanchezhiyan, S. S.,Lee, G.,Meenakshi, S. Springer Science + Business Media 2016 Journal of inorganic and organometallic polymers a Vol.26 No.4

<P>The dicarboxylic acids like oxalic acid, malonic acid and succinic acid mediated graphene oxide-zirconium needle like complexes were synthesized and used to remove fluoride from simulated fluoride contaminated water. The adsorption of fluoride by dicarboxylic acids mediated graphene oxide-zirconium complexes were by both electrostatic interaction at acidic pH and ion-exchange mechanism at neutral pH. The maximum defluoridation capacity observed was 9.70 mg/g at the minimum contact time of 18 min at room temperature. Various batch equilibrium parameters like pH studies, contact time, common ion interference and temperature studies were optimized. The synthesized graphene oxide and graphene oxide supported complexes were characterized using UV-vis, FTIR, XRD and SEM with EDAX analysis to establish the mechanism of fluoride adsorption. The removal of fluoride was described by the pseudo-second-order reaction kinetics, Freundlich isotherm model and thermodynamic studies which indicates the nature of adsorption was endothermic and spontaneous. Regeneration studies depict that the dicarboxylic acid mediated graphene oxide-zirconium complex can be used as an effective adsorbent for the removal of fluoride ions from wastewater. Also, the field applicability of the material has been verified with field samples collected from nearby fluoride endemic villages.</P>

Compressive residual stress generation at crack tip in bulk metal using acoustic cavitation

Prabhu Murugesan,Sunghwan Jung,Hyungyil Lee 한국생산제조학회 2024 한국생산제조시스템학회 학술발표대회 논문집 Vol.2024 No.4