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Yun, Kwi-Dug,Yang, Yunzhi,Lim, Hyun-Pil,Oh, Gye-Jeong,Koh, Jeong-Tae,Bae, In-Ho,Kim, Jaehyung,Lee, Kwang-Min,Park, Sang-Won Elsevier 2010 Materials science & engineering. C, Materials for Vol.30 No.1
<P><B>Abstract</B></P><P>This study was to evaluate wettability, cell response, and osseointegration of nanotubular titanium (Ti) surface by anodic oxidation. Commercially pure Ti discs were treated by polishing, sandblasting, and anodizing. These surfaces were characterized by scanning electron microscopy and contact angle measurement. MC3T3-E1 osteoblast cell was used to evaluate cell response <I>in vitro</I>. The cell morphology, cell viability, and alkaline phosphatase (ALP) specific activity were assessed. The Ti implants of 2.0mm diameter and 5.0mm long treated by anodizing and sandblasting/anodizing were inserted into the tibia of rats. After 3weeks, the histology of the Ti–bone interface was examined. SEM observations showed that the anodizing and sandblasting/anodizing created the nanotubular surface and graded nanotubular-micro-roughened surfaces, respectively. The anodizing and sandblasting/anodizing significantly improved the hydrophilicity of Ti. The significant greatest cell spreading and ALP specific activity were observed on the graded nanotubular-micro-roughened surfaces treated by sandblasting/anodizing. The <I>in vivo</I> study shows that newly formed bone was intimately in contact with the nanotubular surfaces without adverse immune response. This study has suggested that the graded nanotubular-micro-roughened surface of Ti treated with sandblasting/anodizing is very promising in implantology due to improved hydrophilicity, favorable cell response, and excellent osseointegration.</P>
New organic 4‐(4‐methoxystyryl)‐1‐methylpyridinium crystals for nonlinear optical applications
Yun-Sang Lee,O-Pil Kwon,Woojin Yoon,Hoseop Yun,Mojca Jazbinsek4,In Cheol Yu,Fabian Rotermund,Dongwook Kim 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.11
In this study, an organic nonlinear optical salt crystal, 4-(4-methoxystyryl)-1-methylpyridinium 4-bromobenzenesulfonate (MOS-BBS), is newly reported. MOS-BBS crystals exhibit perfectly parallel molecular ordering of 4-(4-methoxystyryl)-1-methylpyridinium (MOS) cationic chromophores with noncentrosymmetric P1space group symmetry, which provides an optimal configuration for maximizing themacroscopic second-order optical nonlinearity. The macroscopic optical nonlinearityof the MOS-BBS crystals is very large, with the diagonal effective first hyperpolarizabilityof 160 1030 esu. Furthermore, the MOS-BBS crystals exhibit a high thermalcrystal-phase stability. The lowest phase transition temperature of the MOS-BBS crystalsis 265C, which is ~90C higher than that of previously reported MOS-basedcrystals.
Complication analysis of distal pancreatectomy based on early personal experience
Sung-Jin Park,Hyung-Il Seo,Soo-Hee Go,Sung-Pil Yun,Ji-Yeon Lee 한국간담췌외과학회 2011 한국간담췌외과학회지 Vol.15 No.4
Backgrounds/Aims: The objective of this study was to evaluate the relationship between initial personal experiences with distal pancreatectomy and perioperative risk factors, outcomes, and management of pancreatic fistulas. Methods: Between May, 2007 and May, 2010, a total of 28 patients who had undergone elective distal pancreatectomy were evaluated for this study. Perioperative factors and the occurrence of pancreatic fistula were analyzed on the basis of International Study Group of Pancreatic Fistula (ISGPF) criteria. Results: There were sixteen cases of benign neoplasms and twelve cases of malignant tumors. The remnant pancreas was manually sutured with ligation of the pancreatic duct (n=14), auto-suture stapling along with manual sutures (n=12), or stapling alone (n=2). According to the ISGPF classification, morbidity and mortality associated with pancreatic fistulas was 42.9% (n=12) and 0%, respectively. These pancreatic fistulae were classified as grade A in 8 cases (28.6%), grade B in 3 cases (10.7%), and grade C in one case (3.6%). All patients with pancreatic fistula were treated conservatively. Conclusions: Perioperative factors do not affect the risk of pancreatic fistula. Adequate drainage is the most effective method for management of a pancreatic fistula after distal pancreatectomy. (Korean J Hepatobiliary Pancreat Surg 2011;15:243-247)
( Yun Nah Lee ),( Young Seok Kim ),( Sang Gyune Kim ),( Jae Pil Han ),( Sae Hwan Lee ),( Soung Won Jeong ),( Jae Young Jang ),( Hong Soo Kim ),( Boo Sung Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Clinical usefulness of noninvasive diagnostic methods for the evaluation of liver fibrosis was not fully documented. We evaluated the accuracy of the FibroScan®, acoustic radiation force impulse (ARFI) and real time elastography (RTE) and the efficacy of the addition of the platelet and P2MS to the elastography for predicting liver fibrosis in nonalcoholic liver disease (NALD). Methods: FibroScan®, ARFI and RTE were performed simultaneously at the same day of liver biopsy in 70 patients with various NALD from October 2010 to March 2011. ARFI was performed with SIEMENS ACUSON S2000 ultrasound system and RTE with HITACHI HI VISION-Preirus and EUP-L52 linear probe (3-7MHz). The median values of 10 measurements in ARFI and RTE were calculated, respectively. We used platelet count and P2/MS [platelet count (109/L)]2/ [monocyte fraction(%)×segmented neutrophil fraction (%)] for predicting more accurately liver fibrosis. We defined Vs as velocity of sheer wave (m/s) in ARFI and Es as elasticity score in RTE. Results: From 70 patients, 10 had METAVIR scoring system F0, 4 had F1, 22 had F2, 12 had F3 and 22 had F4. Positive correlations between each methods and fibrosis were found in FibroScan®, ARFI, RTE, P2MS, Vs/PLT, Vs/P2MS, Es/PLT, and Es/P2MS. In the diagnosis of significanct fibrosis (≥F2), the area under the receiver-operating characteristic curve (AUROC)s by FibroScan, ARFI and RTE are 0.689, 0.687 and 0.554. The AUROCs by Vs/PLT and Es/PLT are 0.860 and 0.769. In addition, the AUROCs by P2MS, Vs/P2MS and Es/P2MS are 0.781, 0.778 and 0.746. Comparing with AUROC of each methods for predicting fibrosis (≥F2), Vs/PLT is superior to ARFI (p=0.0018) and Es/PLT is also superior to RTE (p=0.015). Es/P2MS is superior to RTE (p=0.0316), but Vs/P2MS is not significantly different to ARFI (p=0.1491). Moreover, Vs/ P2MS is not superior to Vs/PLT (p=0.0084) and not significantly different to Es/PLT (p=0.5481). Conclusion: Both FibroScan® and ARFI are useful noninvasive modalities for the assessment of liver fibrosis. Vs/P2MS and Es/P2MS can be more helpful for predicting liver fibrosis in NALD than elastography alone, but are not superior to Vs/PLT and Es/PLT.
( Sung Eun Kim ),( Young Pil Yun ),( Suk Won Lee ),( Il Keun Kwon ),( Su Jin Ahn ),( Richard Leesungbok ) 한국조직공학과 재생의학회 2010 조직공학과 재생의학 Vol.7 No.2
The purpose of this study was to determine the influential factors on the early osteoblastic differentiation of MG63 osteoblast-like cells cultured on micro-grooved Ti substrata. Commercially pure Ti discs with surface microgrooves of various dimensions were fabricated using photolithography. Both ground and acid-etched Ti were used as controls. Surface widths of the Ti substrata were calculated and used as the surface area parameters. These surfaces were characterized by X-ray photoelectron spectroscopy (XPS) and water contact angle (WCA). Early osteoblastic differentiation of MG63 human osteoblast-like cells were analyzed using an alkaline phosphatase (ALP) activity test. Pearson`s correlation analysis and multiple regression analysis were used to analyze the correlations between experimental results and to determine the influential factors on osteoblastic differentiation, respectively. The results of experiments showed significant correlations between surface properties and osteoblastic differentiation. Surface width was determined to be the greatest influential factor on the ALP activity after 1 day of osteogenic culture. The water contact angles measured in perpendicular directions to the microgrooves showed greatest influence on the ALP activity on day 7. This study indicates that the factors influencing the early osteoblastic differentiation on micro-grooved Ti substrata show respective time-dependence.
Subacute Thyroiditis with Coexisting Papillary Carcinoma
Pil-Soo Sung,Min-Hee Kim,Dong-Jun Lim,Yoon-Hee Choi,Moo-Il Kang,Bong-Yun Cha,Ja Seong Bae 대한갑상선학회 2011 International Journal of Thyroidology Vol.4 No.1
Subacute thyroiditis with coexisting papillary carcinoma is very rare. Here, we report a case of 36-year-old Korean female with both thyroid diseases. She presented with acute onset of anterior neck pain and swelling for 2 weeks. Physical examination, laboratory and image findings suggested subacute thyroiditis. Ultrasonographic examination found a 0.8 cm-sized marked hypoechoic nodule surrounded by multiple irregular hypoechoic lesions and central lymph node metastasis was suspected. Subsequent fine needle aspiration cytology for this nodule showed papillary carcinoma. Two months of oral prednisolone therapy relieved clinical symptoms and normalized her thyroid function. Total thyroidectomy was performed along with central neck dissection and the nodule was confirmed to be papillary carcinoma with one metastatic lymph node among ten dissected nodes, otherwise unremarkable. The other portion of the thyroid showed the typical pathologic features of subacute thyroiditis. Thyroid ultrasonography as an ancillary diagnostic tool in subacute thyroiditis may have clinical implications of finding out hidden malignancy, although the association between two diseases is unclear.
Impact of hs-CRP on outcomes in acute myocardial infarction according to LDL cholesterol level (초)
( Sang Woong Choi ),( Yun Kyeong Cho ),( Jae Pil Lee ),( Ji Hyun Sohn ),( Hyun Ok Cho ),( Hyoung Seob Park ),( Hyuck Jun Yoon ),( Hyung Seop Kim ),( Chang Wook Nam ),( Seung Ho Hur ),( Yoon Nyun Kim ) 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1
( Yun Nah Lee ),( Young Seok Kim ),( Sang Gyune Kim ),( Jae Pil Han ),( Sae Hwan Lee ),( Soung Won Jeong ),( Jae Young Jang ),( Hong Soo Kim ),( Boo Sung Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Clinical usefulness of noninvasive diagnostic methods for the evaluation of liver fibrosis was not fully documented. We evaluated the accuracy of the FibroScan®, acoustic radiation force impulse (ARFI) and real time elastography (RTE) and the efficacy of the addition of the platelet and P2MS to the elastography for predicting liver fibrosis in nonalcoholic liver disease (NALD). Methods: FibroScan®, ARFI and RTE were performed simultaneously at the same day of liver biopsy in 70 patients with various NALD from October 2010 to March 2011. ARFI was performed with SIEMENS ACUSON S2000 ultrasound system and RTE with HITACHI HI VISION-Preirus and EUP-L52 linear probe (3-7MHz). The median values of 10 measurements in ARFI and RTE were calculated, respectively. We used platelet count and P2/MS [platelet count (109/L)]2/ [monocyte fraction(%)×segmented neutrophil fraction (%)] for predicting more accurately liver fibrosis. We defined Vs as velocity of sheer wave (m/s) in ARFI and Es as elasticity score in RTE. Results: From 70 patients, 10 had METAVIR scoring system F0, 4 had F1, 22 had F2, 12 had F3 and 22 had F4. Positive correlations between each methods and fibrosis were found in FibroScan®, ARFI, RTE, P2MS, Vs/PLT, Vs/P2MS, Es/PLT, and Es/P2MS. In the diagnosis of significanct fibrosis (≥F2), the area under the receiver-operating characteristic curve (AUROC)s by FibroScan, ARFI and RTE are 0.689, 0.687 and 0.554. The AUROCs by Vs/PLT and Es/PLT are 0.860 and 0.769. In addition, the AUROCs by P2MS, Vs/P2MS and Es/P2MS are 0.781, 0.778 and 0.746. Comparing with AUROC of each methods for predicting fibrosis (≥F2), Vs/PLT is superior to ARFI (p=0.0018) and Es/PLT is also superior to RTE (p=0.015). Es/P2MS is superior to RTE (p=0.0316), but Vs/P2MS is not significantly different to ARFI (p=0.1491). Moreover, Vs/P2MS is not superior to Vs/PLT (p=0.0084) and not significantly different to Es/PLT (p=0.5481). Conclusion: Both FibroScan® and ARFI are useful noninvasive modalities for the assessment of liver fibrosis. Vs/P2MS and Es/P2MS can be more helpful for predicting liver fibrosis in NALD than elastography alone, but are not superior to Vs/PLT and Es/PLT.
Comparison of Outcomes between STEMI and NSTEMI patients with Totally Occluded IRA (초)
( Sang Woong Choi ),( Yun Kyeong Cho ),( Jae Pil Lee ),( Ji Hyun Sohn ),( Hyun Ok Cho ),( Hyoung Seob Park ),( Hyuck Jun Yoon ),( Hyung Seop Kim ),( Chang Wook Nam ),( Seung Ho Hur ),( Yoon Nyun Kim ) 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1