융모성 질환의 임상적 고찰

공지원,정두수,이승철,정은신,이형열,이영혜 예수병원 1992 예수병원학술지 Vol.13 No.-

Ofloxacin에 대한 약물사용검토

심은희,김주휘,유영인,공경희,윤덕심 한국병원약사회 1996 병원약사회지 Vol.13 No.1

Drug use evaluation(DUE) is a system for assuring the quality of drug use in patient care. It was performed on ofloxacin for the purpose of presenting the more reasonable drug therapy. Fifty eight cased of patients, who had been treated with ofloxacin in Korea University Kuro Hospital form September 1. 1994 to April 30. 1995, were reviewed retrospectively. The applicated criteria for ofloxacin was "Criteria for Drug Use Evaluation" established by ASHP report 1993. The results of the analysis show that 34 cases (59%) were met with the criteria for the justification of use, while 24 cases (41%) were not. In critical indicators, several criteria including culture & sensitivity test, vital sing, WBC monitoring and urinalysis were relatively well performed showing the accepted level above 70%, while serum creatinine monitoring and administration time were infrequently performed with low accepted level. Accepted level of ofloxacin was relatively high, while notice about drug interaction and complications were low, which indicate that medication were being performed under the insufficient information about each drug in clinic. The cased met with all criteria were 13 cases (22%), all included of which were in internal medicine. From the results, it could be concluded that medical staff should get the more information on general area of antimicrobial agents include complication, duration of therapy and characteristics of each drugs.

Remote quantitative analysis of cerium through a shielding window by stand-off laser-induced breakdown spectroscopy

Gong, Y.,Choi, D.,Han, B.Y.,Yoo, J.,Han, S.H.,Lee, Y. North Holland Pub. Co 2014 JOURNAL OF NUCLEAR MATERIALS Vol.453 No.1

Laser-Induced Breakdown Spectroscopy (LIBS) has been considered in many applications in nuclear industry. LIBS can be an ideal technique for analyzing the inaccessible nuclear materials typically located behind a shielding window. We report the effect of optical transmittance of the shielding window on the analytical performances of stand-off LIBS for the preliminary surrogate sample of demonstration pyrochemical process, a mixture of cerium oxide (CeO<SUB>2</SUB>) and potassium chloride (KCl). A pulsed laser beam was focused on the surface of the sample located 1.45m away from the stand-off LIBS device. The laser-induced plasma emission was collected through a Schmidt-Cassegrain telescope. LIBS spectra were obtained in an open path and through the shielding window. Univariate calibration curves were obtained using the integrated area of partially resolved Ce I and II lines. The limits of detection (LOD) for Ce were estimated to be 0.046 and 0.061wt.% for the open-path and through-window analysis, respectively. We found that the through-window LOD is mainly influenced by the optical transmittance of the shielding window and therefore, the through-window LOD can be predicted from the open-path LOD and the optical transmittance of the shielding window. Also, multivariate calibration using partial least squares regression was successfully applied. The quality of calibration could be improved by the multivariate analysis.

Boreal winter Arctic Oscillation as an indicator of summer SST anomalies over the western tropical Indian Ocean

Gong, D. Y.,Guo, D.,Gao, Y.,Yang, J.,Mao, R.,Qu, J.,Gao, M.,Li, S.,Kim, S. J. Springer Science + Business Media 2017 Climate dynamics Vol.48 No.7

<P>The inter-annual relationship between the boreal winter Arctic Oscillation (AO) and summer sea surface temperature (SST) over the western tropical Indian Ocean (TIO) for the period from 1979 to 2015 is investigated. The results show that the January-February-March AO is significantly correlated with the June-July-August SST and SST tendency. When both El Nio/Southern Oscillation (ENSO) and the Indian Ocean Dipole (IOD) variance are excluded, the winter AO is significantly correlated with the regional mean SST of the western TIO (40-E and S-N), . The multi-month SST tendency, i.e., the SST difference of June-July-August minus April-May, is correlated with the winter AO at . Composite analysis indicates similar warming over the western TIO. Two statistical models are established to predict the subsequent summer's SST and SST tendency. The models use the winter AO, the winter ENSO and the autumn-winter IOD indexes as predictors and explain 65 and 62 % of the variance of the subsequent summer's SST and SST tendency, respectively. Investigation of the regional air-sea fluxes and oceanic dynamics reveals that the net surface heat flux cannot account for the warming, whereas the oceanic Rossby wave plays a predominant role. During positive AO winters, the enhanced Arabian High causes stronger northern winds in the northern Indian Ocean and leads to anomalous cross-equatorial air-flow. The Ekman pumping in association with the anomalous wind stress curl in the central TIO generates a significantly deeper thermocline and above-normal sea surface height at 60-75E and 5-S. The winter AO-forced Rossby wave propagates westward and arrives at the western coast in summer, resulting in the significant SST increase. Forced by the observed winter AO-related wind stress anomalies over the Indian Ocean, the ocean model reasonably reproduces the Rossby wave as well as the resulting surface ocean warming over the western TIO in the subsequent summer. Observational analysis and numerical experiments suggest the importance of the oceanic dynamics in connecting the winter AO and summer SST anomalies.</P>

Magnetic and Magnetocaloric Properties of Ca0.97La0.03MnO3 Manganites

Gong, G. D.,Hu, P. F.,Li, Y.,Kim, D. H.,Liu, C. L.,Phan, T. L.,Ho, T. A.,Yu, S. C.,Telegin, A.,Naumov, S. V. Springer Science + Business Media 2016 Journal of electronic materials Vol.45 No.7

<P>In spite of many previous studies on electron-doped CaMnO3 perovskite manganites, detailed investigations into the influence of low-doping concentrations on their magnetic and magnetocaloric (MC) properties have not been carried out yet. Additionally, there is still the lack of the comparison between single-crystal (SC) and polycrystalline (PC) materials. Dealing with these problems, we prepared orthorhombic Ca0.97La0.03MnO3 SC and PC samples. Magnetization measurements versus the temperature and magnetic field revealed remarkable differences in the magnetic property, particularly around the antiferromagnetic/ferromagnetic-paramagnetic phase-transition region. The analyses of the magnetization versus magnetic field, M(H), data indicated a weak MC effect with magnetic-entropy changes less than 0.1 J kg(-1) K-1 for an applied field interval H = 10 kOe because ferromagnetic interactions between Mn3+ and Mn4+ ions are insignificant. The differences in the magnetic and MC properties of the SC and PC samples are ascribed to the effects of grain boundary, magnetic anisotropy, and nonstoichiometry in oxygen.</P>

Research on simulation and experiment for surface topography machined by a novel point grinding wheel

Y. D. Gong,G. Q. Yin,X. L. Wen,M. Han,J. B. Yan,J. Cheng 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.10

Grains motion path will be changed in the point grinding process due to the existence of variable angle α. To verify the difference betweenpoint grinding and traditional grinding, the moving relationship and coordinate transformation between grinding wheel and workpieceare used to put the grain movement function equivalent to parabola, then point grinding cutting path is concluded. Based on grainsdistribution on the grinding wheel surface, the 3D geometry simulation topography of workpiece is obtained by extending the effectiveinterference trails along the axial direction. Furthermore, a vitrified bond CBN wheel with a coarse grinding area angle θ is proposed andthe principle of design and preparation of these novel grinding wheels are studied. The typical processing parameters are chosen to grindQT700 ladder shaft; the simulation results are verified by using the VHX-1000E microscope and the non-contact 3D surface profilometerto observe the workpiece surface topography and measure the surface roughness. The results indicated that the simulation microstructurescoincide well with the experimental measurements and the values of simulation roughness are 0.5 times of experiments. So, the geometricsimulation model provided an auxiliary and prediction method for the actual processing topography analysis. In addition, grindingwheels with different θ are used to grind ladder shafts with a series of grinding parameters. The influence trend of inclining angle α, cuttingdepth ap, axial feeding speed vf and grinding wheel speed vs on surface roughness is obtained. It is concluded that the values ofworkpiece surface roughness using novel grinding wheel are less than using the traditional grinding wheel under the condition of thesame processing parameters.

Strain induced hardening and softening behaviors of deformed Cu and Cu-Ge alloys

Gong, Y.L.,Kim, H.S.,Ren, S.Y.,Zeng, S.D.,Zhu, X.K. Published for the Materials Research Society by th 2016 Journal of materials research Vol.31 No.5

<▼1><B>Abstract</B><P/></▼1><▼2><P>Herein, Cu and Cu-Ge alloys with different stacking fault energies (SFEs) are prepared via rolling at room temperature (RTR) and via a combination of high-pressure torsion (HPT) and RTR (HPT + RTR). The x-ray diffraction measurements reveal that the grain size, dislocation density, and twin density vary with the strain and SFEs. The tensile tests indicate that the strength of materials with medium SFEs increases initially and then slightly declines, while the ductility is enhanced by increasing the strain via HPT. In contrast, for low-SFE materials, enhanced strength and improved ductility may be achieved simultaneously through increasing the strain to a high level. The variation of strength with respect to strain is primarily dependent on the solute concentration and SFE. The underlying mechanisms governing the effect of strain and SFE on the microstructures and mechanical properties of the metals are also discussed.</P></▼2>

Saccharomyces cerevisiae Live Cells Decreased In vitro Methane Production in Intestinal Content of Pigs

Gong, Y.L.,Liao, X.D.,Liang, J.B.,Jahromi, M.F.,Wang, H.,Cao, Z.,Wu, Y.B. Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.6

An in vitro gas production technique was used in this study to elucidate the effect of two strains of active live yeast on methane ($CH_4$) production in the large intestinal content of pigs to provide an insight to whether active live yeast could suppress $CH_4$ production in the hindgut of pigs. Treatments used in this study include blank (no substrate and no live yeast cells), control (no live yeast cells) and yeast (YST) supplementation groups (supplemented with live yeast cells, YST1 or YST2). The yeast cultures contained $1.8{\times}10^{10}$ cells per g, which were added at the rates of 0.2 mg and 0.4 mg per ml of the fermented inoculum. Large intestinal contents were collected from 2 Duroc${\times}$Landrace${\times}$Yorkshire pigs, mixed with a phosphate buffer (1:2), and incubated anaerobically at $39^{\circ}C$ for 24 h using 500 mg substrate (dry matter (DM) basis). Total gas and $CH_4$ production decreased (p<0.05) with supplementation of yeast. The methane production reduction potential (MRP) was calculated by assuming net methane concentration for the control as 100%. The MRP of yeast 2 was more than 25%. Compared with the control group, in vitro DM digestibility (IVDMD) and total volatile fatty acids (VFA) concentration increased (p<0.05) in 0.4 mg/ml YST1 and 0.2 mg/ml YST2 supplementation groups. Proportion of propionate, butyrate and valerate increased (p<0.05), but that of acetate decreased (p<0.05), which led to a decreased (p<0.05) acetate: propionate (A: P) ratio in the both YST2 treatments and the 0.4 mg/ml YST 1 supplementation groups. Hydrogen recovery decreased (p<0.05) with yeast supplementation. Quantity of methanogenic archaea per milliliter of inoculum decreased (p<0.05) with yeast supplementation after 24 h of incubation. Our results suggest that live yeast cells suppressed in vitro $CH_4$ production when inoculated into the large intestinal contents of pigs and shifted the fermentation pattern to favor propionate production together with an increased population of acetogenic bacteria, both of which serve as a competitive pathway for the available H2 resulting in the reduction of methanogenic archaea.

Combined treatment with vitamin C and sulindac synergistically induces p53- and ROS-dependent apoptosis in human colon cancer cells

Gong, E.Y.,Shin, Y.J.,Hwang, I.Y.,Kim, J.H.,Kim, S.M.,Moon, J.H.,Shin, J.S.,Lee, D.H.,Hur, D.Y.,Jin, D.H.,Hong, S.W.,Lee, W.K.,Lee, W.J. Elsevier/North-Holland 2016 Toxicology letters Vol.258 No.-

Sulindac has anti-neoplastic properties against colorectal cancers; however, its use as a chemopreventive agent has been limited due to toxicity and efficacy concerns. Combinatorial treatment of colorectal cancers has been attempted to maximize anti-cancer efficacy with minimal side effects by administrating NSAIDs in combination with other inhibitory compounds or drugs such as l-ascorbic acid (vitamin C), which is known to exhibit cytotoxicity towards various cancer cells at high concentrations. In this study, we evaluated a combinatorial strategy utilizing sulindac and vitamin C. The death of HCT116 cells upon combination therapy occurred via a p53-mediated mechanism. The combination therapeutic resistance developed in isogenic p53 null HCT116 cells and siRNA-mediated p53 knockdown HCT116 cells, but the exogenous expression of p53 in p53 null isogenic cells resulted in the induction of cell death. In addition, we investigated an increased level of intracellular ROS (reactive oxygen species), which was preceded by p53 activation. The expression level of PUMA (p53-upregulated modulator of apoptosis), but not Bim, was significantly increased in HCT116 cells in response to the combination treatment. Taken together, our results demonstrate that combination therapy with sulindac and vitamin C could be a novel anti-cancer therapeutic strategy for p53 wild type colon cancers.

Experimental study on fabrication and evaluation of a micro-scale shaft grinding tool

Y. D. Gong,X. L. Wen,J. Cheng,G. Q. Yin,C. Wang 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.3

This paper presents a micro-grinding experiment on AISI 1020 steel and Ti-6Al-4V to study micro-grinding principle and the changerule of the force and surface with different grinding parameters. A novel micro shaft grinding tool is fabricated by cold sprayed withCBN grains, the manufacturing is carried out on a desktop micro machine developed by NEU. Influences caused by particle size on surfacequality has been discussed, it has been tested that low surface roughness could be achieved on 3000 particle size of micro shaftgrinding tool, the roughness of AISI 1020 steel accomplished in the experiment is about 0.086 μm. Measured micro-grinding force of Ti-6Al-4V decreases with the increasing spindle speed and the decreasing cutting depth. The surface roughness decreases with the increasingspindle speed and the decreasing feed rate. The minimum surface roughness is 325 nm with the spindle speed of 48000 r/min and thefeed rate of 20 μm/s.