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Xu, Xiao-Hua,Peng, Xue-Hong,Yu, Ping,Xu, Xiao-Yuan,Cai, Er-Hui,Guo, Pi,Li, Ke Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
Neoadjuvant chemotherapy for resectable esophageal carcinoma has been a focus of study, but no agreement has been reached on clinical randomized controlled trials and relevant systematic evaluation. The purpose of this study was to perform a meta-analysis on published randomized controlled trials (RCTs) that compared neoadjuvant chemotherapy and surgery with surgery alone for resectable esophageal carcinoma. Medline and manual searches was conducted in PubMed, ASCO (American Society of Clinical Oncology) meeting summary, Embase, the Cochrane Library (up to October 2010), Chinese Biomedical Literature Database, China National Knowledge Infrastructure, VIP Database, Wanfang Database. The selection contents were to identify all published and unpublished RCTs that compared neoadjuvant chemotherapy and surgery with surgery alone for resectable esophageal carcinoma. Sixteen RCTs which included 2,594 patients were selected. The risk ratio (RR) (95% confidence interval [CI]; P value), expressed as neoadjuvant chemotherapy and surgery versus surgery alone (treatment versus control), was 1.02 (0.95, 1.10; P=0.54) for 1-year survival, 1.29 (1.13, 1.47; P=0.0001) for 3-year survival, 1.31 (1.13, 1.51; P=0.0003) for 5-year survival, 1.00 (0.95, 1.04; P= 0.85) for rate of resection and 0.89 (0.64, 1.23; P=0.48) for operative mortality. The results showed that neoadjuvant chemotherapy for resectable esophageal carcinoma can raise the overall survival rate of patients with esophageal carcinoma, but it does not affect treatment-related mortality.
Hui-Ru Xu,Ping-Yuan Lee,Ya-Wei Tsai,Ying-Chieh Lee 한양대학교 세라믹연구소 2021 Journal of Ceramic Processing Research Vol.22 No.2
Titanium dioxide thin films with silver dopant (Ag-TiO2) were successfully prepared on glass substrates using the thermaloxidation method. Ag-doped titanium films were prepared using direct current (DC) and radio frequency (RF) magnetron cosputteringsystems. The thermal oxidation temperature and Ag content effects on the phase evolution, microstructure, andphoto catalytic activity of TiO2 film were studied. The crystalline structures and photo catalytic activity of the annealed AgdopedTiO2 films were methodically investigated using transmission electron microscopy (TEM), field emission scanningelectron microscopy (FESEM), X-ray diffraction (XRD), and ultraviolet spectrophotometry. The results exhibited that thethermal oxidation process at 550 oC clearly caused rutile phase formation in the 2.7% Ag-doped TiO2 films directly affectingthe photo catalytic activity. The Ag-doped TiO2 films showed good photo catalytic activity under UV-light radiation, with 59%methylene blue dye degradation rate.
Hui Lan Xu,Woo Yang Chung 한국목재공학회 2012 목재공학 Vol.40 No.5
Mass transfer behavior in wood was estimated through its microscopic structure. The diffusion coefficients which were decided by theoretical equations are influenced by different anatomical properties of wood. From the experiment, the moisture flux was linear to the square root of time. The diffusion coefficients had a regular tendency during the time elapse. During the modeling, it is necessary to understand the limitation of parameters and consider the particular situation to be simulated. In hardwood, because the apertures were not considered, tangential mass transfer simulation was totally different from experiment. As a result, a hardwood model design should consider the apertures which are even on the fiber walls.
Xu, Wei,Ma, Wei-Wei,Zeng, Hui-Hui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Background: In this study, we aimed to evaluate the growth inhibitory effect of the combination of ethaselen (BBSKE) and low fixed dose of selenite against A549 human non-small cell lung cancer cells in vitro. Materials and Methods: Growth inhibitory effects against A549 cells were determined by SRB assay. Combination index (CI) values were calculated based on Chou-Talalay median-effect analyses. Dose reduction index (DRI) values were applied to calculate dose reduction of selenite. Contents of free thiols and GSH were determined by DTNB assay and intracellular ROS levels by DCFH-DA fluorescence labeling. Results: Compared with BBSKE or selenite single treatment, the combined application of ethaselen and a low fixed dose of selenite shortened the onset time of sodium selenite, reduced $IC_{50}$ values, and increased the maximum inhibition rates, suggesting a possible molecular mechanism of the synergism. Obvious synergistic effects were observed after different times of combination treatment, especially after 24 h. Compared with selenite single treatment, dosage of selenite could be remarkably reduced in combination therapy to gain the same inhibitory effect on cell proliferation. Compared with BBSKE single treatment, the content of free thiols and GSH were significantly reduced and ROS levels greatly elevated in the combination group. For the combination treatment, cell viability increased as greater concentrations of GSH were added. Conclusions: All these results indicate that the combination treatment of BBSKE and selenite showed synergism to inhibit A549 cell proliferation in vitro, and also reduced the selenite dosage to mitigate its toxicity which is very meaningful for combination chemotherapy of lung cancer. The synergism was probably caused by the accelerated exhaustion of intracellular reductive substances, such as free thiols and GSH, which ultimately leads to enhanced oxidative stress and apoptosis.
Xu, Han-Feng,Chen, Lei,Liu, Xian-Dong,Zhan, Yun-Hong,Zhang, Hui-Hui,Li, Qing,Wu, Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Renal cell carcinoma (RCC) is the most lethal of all urological cancers and tumor angiogenesis is closely related with its growth, invasion, and metastasis. Recent studies have suggested that epidermal growth factor-like domain multiple 7 (EGFL7) is overexpressed by many tumors, such as colorectal cancer and hepatocellular carcinoma; it is also correlated with progression, metastasis, and a poor prognosis. However, the role of EGFL7 in RCC is not clear. In this study, we examined how EGFL7 contributes to the growth of RCC using a co-culture system in vitro and a xenograft model in vivo. Downregulated EGFL7 expression in RCC cells affected the migration and tubule formation of HMEC-1 cells, but not their growth and apoptosis in vitro. The level of focal adhesion kinase (FAK) phosphorylation in HMEC-1 cells decreased significantly when co-cultured with 786-0/iEGFL7 cells compared with 786-0 cells. After adding rhEGFL7, the level of FAK phosphorylation in HMEC-1 cells was significantly elevated compared with phosphate-buffered saline (PBS) control. However, FAK phosphorylation was abrogated by EGFR inhibition. The average size of RCC local tumors in the 786-0/iEGFL7 group was noticeably smaller than those in the 786-0 cell group and their vascular density was also significantly decreased. These data suggest that EGFL7 has an important function in the growth of RCC by facilitating angiogenesis.
Hui Xu,Chunzhi Wang,Hongwei Chen 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.11
When considering the coexistence of Software-Defined Networking (SDN) and non-SDN, unified management of SDN calls for study on both the information representation and the communication pattern. This paper first proposes the use of the extension theory in order to formally define management information of SDN in a unified manner. And this paper then introduces the concept of unified manager to the communication pattern for unified management of SDN, and considers application of the queuing theory from the perspective of the basic queue and the queue spaces. Finally, simulation results validate that, proposed approach based on the queuing theory is feasible for unified management of SDN from the viewpoint of the communication pattern.
Xu, Hui,Zhang, Xiaopeng,Wu, Zhijun,Feng, Ying,Zhang, Cheng,Xie, Minmin,Yang, Yahui,Zhang, Yi,Feng, Chong,Ma, Tai The Korean Gastric Cancer Association 2021 Journal of gastric cancer Vol.21 No.3
Purpose: While several prognostic models for the stratification of death risk have been developed for patients with advanced gastric cancer receiving first-line chemotherapy, they have seldom been tested in the Chinese population. This study investigated the performance of these models and identified the optimal tools for Chinese patients. Materials and Methods: Patients diagnosed with metastatic or recurrent gastric adenocarcinoma who received first-line chemotherapy were eligible for inclusion in the validation cohort. Their clinical data and survival outcomes were retrieved and documented. Time-dependent receiver operating characteristic (ROC) and calibration curves were used to evaluate the predictive ability of the models. Kaplan-Meier curves were plotted for patients in different risk groups divided by 7 published stratification tools. Log-rank tests with pairwise comparisons were used to compare survival differences. Results: The analysis included a total of 346 patients with metastatic or recurrent disease. The median overall survival time was 11.9 months. The patients were different into different risk groups according to the prognostic stratification models, which showed variability in distinguishing mortality risk in these patients. The model proposed by Kim et al. showed relative higher predicting abilities compared to the other models, with the highest χ<sup>2</sup> (25.8) value in log-rank tests across subgroups, and areas under the curve values at 6, 12, and 24 months of 0.65 (95% confidence interval [CI]: 0.59-0.72), 0.60 (0.54-0.65), and 0.63 (0.56-0.69), respectively. Conclusions: Among existing prognostic tools, the models constructed by Kim et al., which incorporated performance status score, neutrophil-to-lymphocyte ratio, alkaline phosphatase, albumin, and tumor differentiation, were more effective in stratifying Chinese patients with gastric cancer receiving first-line chemotherapy.
An Integrated Approach for Monitoring Service Level Parameters of Software-Defined Networking
Hui Xu,Hongwei Chen 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.6
Software-Defined Networking (SDN) is a new-generation network that decouples the control plane and the data plane, and an additional management plane still lacks a mature implementation solution. In this case, monitoring service level parameters is of great significance to study issues related to service management for SDN. This paper then aims to apply the queuing theory and the extension theory to monitor service level parameters of SDN and propose an integrated approach based on both two theories from the formalization point of view. Simulation result and scenario analysis validate that, the proposed integrated approach prospects a feasible way of formalizing the solution to monitor service level parameters of SDN.