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Establishing a Nomogram for Stage IA-IIB Cervical Cancer Patients after Complete Resection
Zhou, Hang,Li, Xiong,Zhang, Yuan,Jia, Yao,Hu, Ting,Yang, Ru,Huang, Ke-Cheng,Chen, Zhi-Lan,Wang, Shao-Shuai,Tang, Fang-Xu,Zhou, Jin,Chen, Yi-Le,Wu, Li,Han, Xiao-Bing,Lin, Zhong-Qiu,Lu, Xiao-Mei,Xing, H Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: This study aimed to establish a nomogram by combining clinicopathologic factors with overall survival of stage IA-IIB cervical cancer patients after complete resection with pelvic lymphadenectomy. Materials and Methods: This nomogram was based on a retrospective study on 1,563 stage IA-IIB cervical cancer patients who underwent complete resection and lymphadenectomy from 2002 to 2008. The nomogram was constructed based on multivariate analysis using Cox proportional hazard regression. The accuracy and discriminative ability of the nomogram were measured by concordance index (C-index) and calibration curve. Results: Multivariate analysis identified lymph node metastasis (LNM), lymph-vascular space invasion (LVSI), stromal invasion, parametrial invasion, tumor diameter and histology as independent prognostic factors associated with cervical cancer survival. These factors were selected for construction of the nomogram. The C-index of the nomogram was 0.71 (95% CI, 0.65 to 0.77), and calibration of the nomogram showed good agreement between the 5-year predicted survival and the actual observation. Conclusions: We developed a nomogram predicting 5-year overall survival of surgically treated stage IA-IIB cervical cancer patients. More comprehensive information that is provided by this nomogram could provide further insight into personalized therapy selection.
Zhou, Lei,Yu, Lan,Feng, Zhen-Zhong,Gong, Xiao-Meng,Cheng, Ze-Nong,Yao, Nan,Wang, Dan-Na,Wu, Shi-Wu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10
Background: Gastric cancer is the second leading cause of cancer-related death in Asia, and the majority type is gastric adenocarcinoma (GAC). Most GAC patients die of recurrence and metastasis. Cancer stem cells (CSCs) have been thought to be responsible for the initiation, development, metastasis, and ultimately recurrence of cancer. In this study, we aimed to investigate expression and clinical significance of CSCs markers, CD133 and Lgr5, and vasculogenic mimicry (VM) in primary GAC. Materials and Methods: Specimens from 261 Chinese patients with follow-up were analyzed for CD133, Lgr5 protein expression and VM by immunohistochemical and histochemical staining. The Pearson Chi's square test was used to assess the associations among the positive staining of these markers and clinicopathological characteristics. Postoperative overall survival time was were studied by univariate and multivariate analyses. Results: In GAC tissues, positive rates of 49.0%, 38.7%, and 26.8% were obtained for CD133, Lgr5, and VM, respectively. The mean score of microvessel density (MVD) was $21.7{\pm}11.1$ in GAC tissues. There was a significantly difference between the positive and negative groups. There was a positive relationship between the VM, the expression of CD133 and Lgr5, and the score of MVD and the grades of tumor, lymph node metastasis, TNM stages (all p<0.05). The overall mean survival time of the patients with CD133, Lgr5, VM, and MVD (${\geq}22$) positive expression was lower than that of patients with negative expression. The score of MVD, positive expression of CD133 and VM were independent prognostic factors of GAC (p<0.05). Conclusions: VM, and expression of CD133, Lgr5, and the score of MVD are related to grades of tumor, lymph node metastasis, TNM stages, and overall mean survival time. It is suggested that CSCs and VM could play an important role in the evolution of GAC.
Wu, Yao,Tong, Xiang,Tang, Ling-Li,Zhou, Kai,Zhong, Chuan-Hong,Jiang, Shu Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Background: Associations between the rs6010620 polymorphism in the regulator of telomere elongation helicase1 (RTEL1) gene and glioma have been widely reported but the results were not inconclusive. The aim of the current study was to investigate the association between the rs6010620 polymorphism in RTEL1 gene and risk of glioma by meta-analysis. Materials and Methods: We searched PubMed, Embase, Wanfang Weipu and CNKI (China National Knowledge Infrastructure) databases, which included all research published 05 May 2014. A total of 8,292 cases and 12,419 controls from 14 case-control studies involving the rs6010620 polymorphism in the RTEL1 gene were included. Statistical analysis was performed using STATA 12.0 software. Results: The results indicated that the rs6010620 polymorphism in RTEL1 gene was indeed associated with risk of glioma (OR=1.474, 95%CI=1.282-1.694, p<0.001). On subgroup analysis by ethnicity, we found associations between the rs6010620 polymorphism in the RTEL1 gene and risk of glioma in both Caucasians and Asians. Conclusions: The current meta-analysis suggested that the rs6010620 polymorphism in the RTEL1 gene might increase risk of glioma. In future, larger case-control studies are needed to confirm our results.
Wie Zhou,Xiaoxia Zhong,Luqi Yaun,Qiwei Shu,Xiaochen Wu,Yuxing Xia 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.5I
Titanium-oxide (TiO2) thin films were deposited on unheated (111)-Si substrates by reactive dc magnetron sputtering with a substrate bias voltage of .100 V. A pure metallic titanium target was sputtered in a mixture of argon and oxygen. The structure and the optical properties of the deposited films were studied by changing the value of the total sputtering pressure. X-ray diffraction patterns show the following features: (a) only one wide rutile (110) diffraction peak was observed at a total sputtering pressure of 0.3 Pa; (b) no diffraction peak was observed at 1.2 Pa, implying an amorphous phase; (c) a TiO2 film with a pure anatase phase was obtained at 3.6 Pa, and the dominant diffraction was from the anatase (101) planes. The surface morphology was characterized with atomic force microscopy, and the roughness of the surface was found to increase with the crystal size derived from the XRD data. The optical constants were determined by using spectroscopic ellipsometry. The film deposited at 0.3 Pa, a rutile phase, possessed both a high refractive index and a low extinction coefficient. The value of the optical bandgap for the deposited on films in this experiment was much higher than the reported experimental and theoretical values.D
An Optimization Model on Virtual Machines Allocation Based on Radial Basis Function Neural Networks
Wei Wu,Wencai Du,Hui Zhou,Jiezhuo Zhong,Zhen Guo 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.6
Properly allocation of virtual machines is important for computing infrastructures scheduling. This paper presents systemic method on virtual machine array optimization control based on artificial intelligence and matrix control theory. According to request service data from users to provide proper VMs roughly via intelligent pattern recognition based on RBFNN, the data is sent to a multiple-targets optimization process to produce VMs allocation matrix precisely, thus enable to minimize the cast and enhance efficiency of the whole array to achieve low consumption optimization and ensure the stability of the system. Simulation experiments confirmed the effectiveness of this model and adaption ability in online dynamics.
12-year LIDAR Observations of Tropospheric Aerosol over Hefei (31.9°N, 117.2°E), China
Decheng Wu,Jun Zhou,Dong Liu,Zhenzhu Wang,Zhiqing Zhong,Chen-Bo Xie,Fudi Qi,Aiyuan Fan,Yingjian Wang 한국광학회 2011 Current Optics and Photonics Vol.15 No.1
12-year LIDAR observations of tropospheric aerosol vertical distribution using a Mie scattering LIDAR in Hefei (31.9°N, 117.2°E) from 1998 to 2009 are presented and analyzed in this paper. Characters of temporal variation and vertical distribution of tropospheric aerosol over Hefei are summarized from the LIDAR measurements. The impacts of natural source and human activities on the aerosol vertical distribution over Hefei could be seen clearly. Dust particles from the north in spring could affect the aerosol distributions below about 12 km over Hefei, and aerosol scale height in April reaches 2.29±0.68 km. Both LIDAR measurements and surface visibility imply that aerosols in the lower troposphere have been increasing since about 2005.
Varistor and dielectric properties of Cr2O3 doped SnO2eZn2SnO4 composite ceramics
Guo-Zhong Zang,Feng-Zi Zhou,Jing-Xiao Cao,Xiao-Fei Wang,Zhao-Wu Wang,Li-Ben Li,Guo-Rong Li 한국물리학회 2014 Current Applied Physics Vol.14 No.12
Cr2O3 doped SnO2eZn2SnO4 composite ceramics were prepared by traditional ceramic processing and the varistor, dielectric properties were investigated. With increasing Cr2O3 content, the breakdown electrical field EB increases from 11 to 92 V/mm and the relative dielectric constant εr measured at 1 kHz, 50 C decreases from 11,028 to 3412, respectively. The barrier height fB about 0.8e0.84 eV and the decreasing of SnO2 grain size suggest that the varistor behavior with high εr is originated from SnO2 eSnO2 or SnO2eZn2SnO4 grain boundary. In the dielectric spectra lower than 1 kHz, a dielectric peak is presented and depressed with increasing bias voltage. Similarly, at high temperature, the dielectric constant also presents a dielectric peak in the temperature spectra and the peak becomes faint with increasing frequency. The exhibition of the dielectric peak is thought to be attributed to the conduction of grain boundary since it is accompanied by the sharp increase of dielectric loss. In addition, a dielectric relaxation with the activation energy about 0.4e0.5 eV was observed in the temperature range of 20 e100 C. Based on the results, the formation mechanism of Schottky barriers at grain boundaries and the varistor behavior with high dielectric constant are well understood.
Yaqi Wu,Chaojie Chong,Zhewen Dong,Zixian Wang,Haokun Chen,Shumei Zhong,Qi Qi Pang,Jia-Le Song,Yanyuan Zhou 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To explore the ameliorative effect of Phellinus linteus polysaccharide(PLP) on letrozole-induced PCOS rats. A total of 32 female SD rats were randomly divided into normal group, PCOS group, metformin group and PLP group, and weighed every three days. The estrous cycle of rats was observed by vaginal smear ten days before sacrifice. The estrous cycle of PCOS rats was disordered, the ovaries showed polycystic changes and the body weight and the relative weight of the ovaries increased (P<0.05). The estrous cycle, polycystic ovary, body weight and relative weight of the ovaries in PLP group and Metformin group recovered significantly (P<0.05). The serum levels of TC, TG, LDL-C, HDL-C, FINS, T, LH, E2 and FSH were detected by ELISA kits. After treatment, the serum levels of TC, TG, LDL-C, FINS, T, LH and LH/FSH in the PLP group and Metformin group were lower than PCOS group (P<0.05). In addition, the serum levels of E2, FSH and HDL-C were increased (P<0.05) in the PLP group and Metformin group. The results showed that Phellinus linteus polysaccharides can ameliorate glucose and lipid metabolism, polycystic ovary and regulate the levels of sex hormones in PCOS rats.