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Development of autoimmune hepatitis in a psoriasis patient without immunosuppressive therapy
( Wonyong Jo ),( Young-sun Suh ),( Sang-il Lee ),( Yun-hong Cheon ),( Jeongmin Hong ),( Sang Su Lee ),( Ji Eun Kim ),( Gyung Hyuck Ko ),( Hyun-ok Kim ) 대한간학회 2017 Clinical and Molecular Hepatology(대한간학회지) Vol.23 No.2
We present a case of a 65-year-old man with psoriasis who developed autoimmune hepatitis (AIH) without receiving immunosuppressive therapy with either anti-tumor necrosis factor-α or methotrexate. The AIH had completely resolved at 2 months after prednisolone and azathioprine therapy. This case confirms the need to consider AIH in psoriasis patients who experience new elevations in liver enzymes. To our knowledge, this is first description of the development of AIH in an immunosuppressant-naive patient with psoriasis. (Clin Mol Hepatol 2017;23:184-187)
Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury
Cho, Wonyong,Song, Jie-Young,Oh, Se Won,Kim, Myung Gyu,Ko, Yoon Sook,Lee, Hee Yong,Jo, Sang Kyung The Korean Academy of Medical Sciences 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.10
<P>Effective clearance of inflammatory cells is required for resolution of inflammation. Here, we show in vivo evidence that apoptosis and reverse transendothelial migration (rTEM) are important mechanisms in eliminating neutrophils and facilitating recovery following ischemia/reperfusion injury (IRI) of the kidney. The clearance of neutrophils was delayed in the Bax knockout (KO)<SUP>BM</SUP> → wild-type (WT) chimera in which bone marrow derived cells are partially resistant to apoptosis, compared to WT<SUP>BM</SUP> → WT mice. These mice also showed delayed functional, histological recovery, increased tissue cytokines, and accelerated fibrosis. The circulating intercellular adhesion molecule-1 (ICAM-1)<SUP>+</SUP> Gr-1<SUP>+</SUP> neutrophils displaying rTEM phenotype increased during the recovery phase and blockade of junctional adhesion molecule-C (JAM-C), a negative regulator of rTEM, resulted in an increase in circulating ICAM-1<SUP>+</SUP> neutrophils, faster resolution of inflammation and recovery. The presence of Tamm-Horsfall protein (THP) in circulating ICAM-1<SUP>+</SUP> neutrophils could suggest that they are derived from injured kidneys. In conclusion, we suggest that apoptosis and rTEM are critically involved in the clearance mechanisms of neutrophils during the recovery phase of IRI.</P>