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Kim, Jung Woo,Lim, Sung Chul,Lee, Moo Yeol,Lee, Jeong Woon,Oh, Won Keun,Kim, Sang Kyum,Kang, Keon Wook WILEY-VCH Verlag 2010 Molecular Nutrition & Food Research (Print) Vol.54 No.10
<P>Neointima, defined as abnormal growth of the intimal layer of blood vessels, is believed to be a critical event in the development of vascular occlusive disease. Although resveratrol's inhibitory effects on proliferation and migration of vascular smooth muscle cells has been reported, its activity on neointimal formation is still unclear. Oral administration of trans-resveratrol significantly suppressed intimal hyperplasia in a wire-injured femoral artery mouse model. In cultured vascular smooth muscle cells, trans-resveratrol inhibited platelet-derived growth factor-stimulated DNA synthesis and cell proliferation with down-regulation of cyclin D and pRB. Moreover, platelet-derived growth factor-induced production of reactive oxygen species was inhibited by trans-resveratrol and the compound induced heme oxygenase-1 (HO-1). The anti-proliferative activity of trans-resveratrol was reversed by an HO-1 inhibitor, ZnPPIX. Subcellular fractionation and reporter gene analyses revealed that trans-resveratrol increased the level of nuclear Nrf2 and antioxidant response element reporter activity, and that these were essential for the induction of HO-1. Trans-resveratrol also enhanced the activities of phosphatidyl inositol 3-kinase and extracellular signal regulated kinase, and phosphatidyl inositol 3-kinase was required for Nrf2/antioxidant response element-dependent HO-1 induction. These data have significant implications for the elucidation of the pharmacological mechanism by which trans-resveratrol prevents vascular occlusive diseases.</P>
Description of unrecorded bacterial species belonging to the phylum Actinobacteria in Korea
Kim, Mi-Sun,Kim, Seung-Bum,Cha, Chang-Jun,Im, Wan-Taek,Kim, Won-Yong,Kim, Myung-Kyum,Jeon, Che-Ok,Yi, Hana,Yoon, Jung-Hoon,Kim, Hyung-Rak,Seong, Chi-Nam The National Institute of Biological Resources 2021 Journal of species research Vol.10 No.1
For the collection of indigenous prokaryotic species in Korea, 77 strains within the phylum Actinobacteria were isolated from various environmental samples, fermented foods, animals and clinical specimens in 2019. Each strain showed high 16S rRNA gene sequence similarity (>98.8%) and formed a robust phylogenetic clade with actinobacterial species that were already defined and validated with nomenclature. There is no official description of these 77 bacterial species in Korea. The isolates were assigned to 77 species, 31 genera, 18 families, 14 orders and 2 classes of the phylum Actinobacteria. All the strains except one Coriobacteriia strain were affiliated within the class Actinomycetia. Among them, the orders Streptomycetales and Microbacteriales were predominant. A number of strains were isolated from forest soils, riverside soils, and ginseng cultivated soils. Twenty-nine strains were isolated from 'Protected Ecosystem and Scenery Areas'. Morphological properties, basic biochemical characteristics, isolation source and strain IDs are described in the species descriptions.
Unrecorded prokaryotic species belonging to the class Actinobacteria in Korea
Kim, Mi-Sun,Jeong, Seong-Hwa,Kang, Joo-Won,Kim, Seung-Bum,Cho, Jang-Cheon,Cha, Chang-Jun,Im, Wan-Taek,Bae, Jin-Woo,Lee, Soon-Dong,Kim, Won-Yong,Kim, Myung-Kyum,Seong, Chi-Nam The National Institute of Biological Resources 2019 Journal of species research Vol.8 No.1
For the collection of indigenous prokaryotic species in Korea, 35 strains within the class Actinobacteria were isolated from various environmental samples (animals and clinical specimens) in 2017. Each strain showed high 16S rRNA gene sequence similarity (>98.8%) and formed a robust clade with recognized actinobacterial species. The isolates were assigned to 35 species, 22 genera, 15 families, and 8 orders of the class Actinobacteria. There are no official descriptions of these 35 bacterial species in Korea. Morphological properties, basic biochemical characteristics, isolation source, and strain IDs are included in the species descriptions.
A Study on Physical Environment and Consumers' Repatronage Intention
Kim Won Kyum,He He 한국콘텐츠학회 2007 International Journal of Contents Vol.3 No.4
Chinese hotel industry needs to continue consummation. Especially the physical environment direct or the indirect influence to the consumers has not caused the hotel managers enough attention. Chinese hotel industry also lacks to the physical environment whole perception and the understanding. This paper research purposes are: how through that improve the hotel physical hotels. And what's disparities between the Chinese hotel industry in the physical environment and the Western developed country, how needs to improve and so on. Therefore, this paper has mainly studied and analysis the hotel atmosphere, the hotel facility. the hotel cleanliness, the hotel position, customers' overall satisfaction, the repatronage which independent effect, relations and the importance of them in Chinese hotel industry. This paper have made 5 hypotheses to relations of the hotel atmosphere, the hotel facility. the hotel cleanliness, the hotel position and customer's overall satisfaction, the repatronage. We have carried on the questionnaire survey to four hotels, altogether send out to the 250 questionnaires, and have received 202 questionnaires. Through after these analyses, the 1 hypothesis cannot have the data support. Therefore, the conclusions are: the first, the good hotel atmosphere has the positive influence to the consumer overall perception; the second. the higher hotel cleanliness has the positive influence to the consumer overall perception; the third. the convenience hotel position has the positive influence to consumer's perception; the fourth, the consumers' higher overall satisfaction has the positive influence to consumer's repatronage. But the influence of the higher hotel facility to consumers' perception cannot have the enough support from the data.
IRF7 promotes glioma cell invasion by inhibiting AGO2 expression.
Kim, Jun-Kyum,Jin, Xiong,Ham, Seok Won,Lee, Seon Yong,Seo, Sunyoung,Kim, Sung-Chan,Kim, Sung-Hak,Kim, Hyunggee Saikon Pub. Co 2015 TUMOR BIOLOGY Vol.36 No.7
<P>Interferon regulatory factor 7 (IRF7) is the master transcription factor that plays a pivotal role in the transcriptional activation of type I interferon genes in the inflammatory response. Our previous study revealed that IRF7 is an important regulator of tumor progression via the expression of inflammatory cytokines in glioma. Here, we report that IRF7 promotes glioma invasion and confers resistance to both chemotherapy and radiotherapy by inhibiting expression of argonaute 2 (AGO2), a regulator of microRNA biogenesis. We found that IRF7 and AGO2 expression levels were negatively correlated in patients with glioblastoma multiforme. Ectopic IRF7 expression led to a reduction in AGO2 expression, while depletion of IRF7 resulted in increased AGO2 expression in the LN-229 glioma cell line. In an in vitro invasion assay, IRF7 overexpression enhanced glioma cell invasion. Furthermore, reconstitution of AGO2 expression in IRF7-overexpressing cells led to decreased cell invasion, whereas the reduced invasion due to IRF7 depletion was rescued by AGO2 depletion. In addition, IRF7 induced chemoresistance and radioresistance of glioma cells by diminishing AGO2 expression. Finally, AGO2 depletion alone was sufficient to accelerate glioma cell invasion in vitro and in vivo, indicating that AGO2 regulates cancer cell invasion. Taken together, our results indicate that IRF7 promotes glioma cell invasion and both chemoresistance and radioresistance through AGO2 inhibition.</P>
Kim, Won-Geun,Kim, Chang-Kyum,Lee, Jong-Tae,Kim, Jeong-Soo,Yun, Chang-Wan,Yook, Se-Jin Pergamon 2017 Transportation Research Part D. Transport & Enviro Vol.53 No.-
<P><B>Abstract</B></P> <P>The characteristics of fine particle emission from a light-duty diesel vehicle operated on a chassis dynamometer were investigated according to vehicle acceleration and road grade. Particle number (PN) concentration and particle mass (PM) concentration were measured using a Solid Particle Counting System (SPCS), an Engine Exhaust Particle Sizer (EEPS), and a Dekati Low Pressure Impactor (DLPI). In this study, actual mass distribution of particles emitted from the tested diesel vehicle was determined by sampling the particles on 25-mm Teflon-coated filters installed at 13 impactor stages of the DLPI and then compared with the particle mass distribution converted from the particle number distribution measured by the EEPS. In order to evaluate the characteristics of fine particle emission under various conditions of vehicle acceleration and road grade, testing was conducted with or without installing a Diesel Particulate Filter (DPF). In general, PN and PM concentrations increased with both increasing vehicle acceleration and increasing road grade.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fine particle emission characteristics of a light-duty diesel vehicle were examined. </LI> <LI> A diesel vehicle was operated at various vehicle accelerations and road grades. </LI> <LI> Actual mass distribution of particles emitted from test diesel vehicle was obtained. </LI> <LI> Mass concentration increased as both vehicle acceleration and road grade increased. </LI> </UL> </P>
Kim, Won Kyum 한국균학회 1987 韓國菌學會誌 Vol.15 No.2
Two dimensional electrophoretograms of detergent-soluble polypeptides extracted from dormant urediospores were used to compare inter-and intraspecific relationships among nine races of rye stem rust (Puccinia graminis f. sp. secalis) , a hybrid between rye stem rust and wheat stem rust (P. graminis f. sp. tritici), and its parents. More than 280 polypeptides were detected in each race of rye stem rust. The nine races differed by one to five genes for virulence and by five to seven polypeptides, but these differences were not correlated. The rye/wheat stem rust hybrid, rye stem rust parent and wheat stem rust parent differed by 12 polypeptides. The polypeptide patterns of the rye stem rust races were similar to those previously found for wheat and oat stem rusts. Rye stem rust and wheat stem rust had 270 polypeptides in common, and differed by 17 polypeptides. In contrast, ninety-two polypeptides separated rye and oat stem rusts. The considerable homology in polypeptide patterns is consistent with the view that these three cereal stem rusts are related, and that rye stem rust and wheat stem rust have the closest genetic relationship.