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Weng, Ling-Ling,Xiang, Jian-Feng,Lin, Jin-Bo,Yi, Shang-Hui,Yang, Li-Tao,Li, Yi-Sheng,Zeng, Hao-Tao,Lin, Sheng-Ming,Xin, Dong-Wei,Zhao, Hai-Liang,Qiu, Shu-Qi,Chen, Tao,Zhang, Min-Guang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.
Weng Ruey-Chee 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.7
Objective: A study was made investigate factors affecting body surface temperature changes after weaning in sows, whether these can be used to aid detection of natural estrus and how they relate to subsequent reproductive performance. Methods: A total of 132 sows were selected during summer from a breeding farm, with mean parity of 3.6±2.3 and 28.5±0.9 days lactation length. Four daily measurements (6:00, 8:00, 16:00, and 18:00) of vulva (VST), udder (UST), ear base and central back skin temperatures for individual sows were taken by an infrared thermometer, continuing up to 8 days post weaning. Results: The VST obtained from sows showing estrus at 4 days post-weaning (4DPW), 5DPW, and 6DPW showed a peak at the fourth day post-weaning, but then started to decrease. The VST of sows not detected in standing heat (NDPW) remained at a lower level during the experiment, but UST was increased soon after weaning. The VST-UST temperature differences during daytime of sows that were showing behavioural standing heat on 4DPW, 5DPW, 6DPW, and 7DPW were 0.46°C±0.123°C, 0.71°C±0.124°C, 0.66°C ±0.171°C, and 0.58°C±0.223°C, respectively. The NDPW sows had the highest UST observed, but also the lowest VST so that a more negative value of temperature difference (–0.31°C) was seen during first few days post-weaning. A total of 119 sows were observed to show standing heat and were bred. The later the estrus, the smaller the litter size (p = 0.005). Conclusion: Sows which did not show behavior indicative of stable standing heat after weaning had a VST which remained at a lower level, but the UST increased soon after weaning. Therefore, for sow heat detection under field conditions, the changes of VST and UST and difference between the two should be considered together to increase the accuracy of detection.
THE CHARACTERISTICS OF ZINC DIFFUSED NORMALLY ON GaAs AND InP JUNCTION FETs
Weng, Tung H. 대한전자공학회 1989 ICVC : International Conference on VLSI and CAD Vol.1 No.1
In this paper, a new technique using semi-sealed quartz bottle for zinc diffusion in GaAs and InP was employed. The basic requirement for zinc diffusion in these materials is to provide an overpressure ambient 50 that decomposition at the diffusion temperature can be avoided. This was done for the case of InP by placing InP wafer with diffusion charge which contained pure zinc and a small amount of InP powder in a semi-sealed bottle. This small amount of InP powder seemed to have provided the needed overpressure ambient to avoid decomposition. TA e surface showed no degradation after diffusion and maintained its original smooth surface. However, the surface was decomposed if no InP powder was added in the diffusion charge. For the case of GaAs, no GaAs powder was needed in the diffusion charge. Only pure zinc was required for producing heavily doped P-layer. The vapor produced by GaAs in the semi-sealed bottle during diffusion seemed to be sufficient to avoid decomposition. This is in sharp contrast to the behavior of zinc diffusion in InP using the same technique The detailed characteristics of the diffused layer of InP are presented. Similar characteristics for GaAs were also obtained. Junction field effect transistors were fabricated using the P layer formed by semi-sealed diffusion for both InP and GaAs. For InP junction FETs the measured transconductance varies from 80 to 100 ms/mm gate length. GaAs junction FETs show similar results with well behaved I-V characteristics.
Weng-Sheng Kuo 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.7
An approximate method for calculating the cadmium ratio of a cyclotron-based thermal neutron radiography system was developed. In this method, the Monte-Carlo code, MCNP6.2, was employed to calculate the neutron capture rates of Au-197, and the cadmium ratio was obtained by computing the ratio of neutron capture rates. From the simulation results, the computed cadmium ratio is reasonably acceptable, and the assumption of ignoring the fast neutron contribution to the cadmium ratio is valid.
Biosafety Risk Control Strategies in Laboratory Animal Research
Weng Shun-tai,Li Qu-wen,Gao Ya-dong,Qiu Yu-feng 한국산업안전보건공단 산업안전보건연구원 2024 Safety and health at work Vol.15 No.1
To understand biosafety's current situation in laboratory animal research and risk factors affecting occupational health. Compliance surveys were conducted by questionnaire via Questionnaire Star (an application app on the Internet) in Chinese. Thirty-nine anonymous questionnaires were collected. The surveyed institution has established 24 types of ABSL (Animal Biosafety Laboratory) and biosafety management organizations and systems equipped with safety equipment. Our study also suggests that the principal of the laboratory establishment fails to perform supervision and inspection responsibilities, the inappropriate design of the animal biosafety laboratory, non-standardized personnel training and health management, non-strict waste management, and insufficient emergency management. The administrative department and work units should address certain safety and occupational health risks in laboratory animal research. The author proposes control strategies based on organizational guarantee, personnel management, emergency management, etc., to help prevent risks and ensure occupational health. Due to regional limitations and small sample size, the results may not be generalisable to all parts of the world. However, some of the key common issues may also be present in other regions, so we believe that this research still has some relevance.
Weng, R.C.,Edwards, S.A.,Hsia, L.C. Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.9
To evaluate different housing systems, 80 gilts were randomly allocated at puberty to four treatments: i) sow stall in gestation followed by farrowing crate (SC), ii) group housing with individual feeding in gestation followed by farrowing crate (GC), iii) ESF (Electronic Sow Feeding) system in gestation followed by farrowing crate (EC), and iv) ESF system followed by group farrowing pen (EG). The results showed that stalled sows had a longer interval between puberty and second estrus (p<0.001). The sows kept in the ESF system gained more body weight (p<0.01) and backfat (p<0.05) prior to service, and more backfat during gestation (p<0.05), but also had greater backfat losses in the subsequent lactation (p<0.01). Sows changing from loose housing to confinement at farrowing had longer gestation length (p<0.001). Total litter size did not differ significantly between gestation treatments, but the number of stillborn piglets was significantly higher in the SC treatment (p<0.01). After weaning, SC sows had the longest interval for rebreeding (p<0.001). Some EG sows came into heat before weaning, giving this treatment the shortest interval. These results indicate that gestation confinement in sow stalls had several detrimental effects on sow performance relative to group housing.
Weng Wenya,Ge Tingwen,Wang Yi,He Lulu,Liu Tinghao,Wang Wanning,Zheng Zongyu,Yu Lechu,Zhang Chi,Lu Xuemian 대한당뇨병학회 2020 Diabetes and Metabolism Journal Vol.44 No.4
Background: Fibroblast growth factor 21 (FGF21) has been only reported to prevent type 1 diabetic nephropathy (DN) in the streptozotocin-induced type 1 diabetes mellitus (T1DM) mouse model. However, the FVB (Cg)-Tg (Cryaa-Tag, Ins2-CALM1) 26OVE/PneJ (OVE26) transgenic mouse is a widely recommended mouse model to recapture the most important features of T1DM nephropathy that often occurs in diabetic patients. In addition, most previous studies focused on exploring the preventive effect of FGF21 on the development of DN. However, in clinic, development of therapeutic strategy has much more realistic value compared with preventive strategy since the onset time of DN is difficult to be accurately predicted. Therefore, in the present study OVE26 mice were used to investigate the potential therapeutic effects of FGF21 on DN. Methods: Four-month-old female OVE26 mice were intraperitoneally treated with recombinant FGF21 at a dose of 100 μg/kg/day for 3 months. The diabetic and non-diabetic control mice were treated with phosphate-buffered saline at the same volume. Renal functions, pathological changes, inflammation, apoptosis, oxidative stress and fibrosis were examined in mice of all groups. Results: The results showed that severe renal dysfunction, morphological changes, inflammation, apoptosis, and fibrosis were observed in OVE26 mice. However, all the renal abnormalities above in OVE26 mice were significantly attenuated by 3-month FGF21 treatment associated with improvement of renal adenosine 5´-monophosphate (AMP)-activated protein kinase (AMPK) activity and sirtuin 1 (SIRT1) expression. Conclusion: Therefore, this study demonstrated that FGF21 might exert therapeutic effects on DN through AMPK-SIRT1 pathway.