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- 저자 : Wenfeng Zhao (검색결과 6 건)
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A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases
Zhao, Jian,Ma, Jianyang,Deng, Yun,Kelly, Jennifer A,Kim, Kwangwoo,Bang, So-Young,Lee, Hye-Soon,Li, Quan-Zhen,Wakeland, Edward K,Qiu, Rong,Liu, Mengru,Guo, Jianping,Li, Zhanguo,Tan, Wenfeng,Rasmussen, Nature Pub. Co 2017 Nature genetics Vol.49 No.3
<P>Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a strong genetic component characterized by autoantibody production and a type 1 interferon signatures. Here we report a missense variant (g.74779296G>A; p.Arg90His) in NCF1, encoding the p47phox subunit of the phagocyte NADPH oxidase (NOX2), as the putative underlying causal variant that drives a strong SLE-associated signal detected by the lmmunochip in the GTF2IRD1-GTF2I region at 7q11.23 with a complex genomic structure. We show that the p.Arg90His substitution, which is reported to cause reduced reactive oxygen species (ROS) production(2), predisposes to SLE (odds ratio (OR) = 3.47 in Asians (P-meta = 3.1 x 10(-104)), OR = 2.61 in European Americans, OR = 2.02 in African Americans) and other autoimmune diseases, including primary Sjogren's syndrome (OR = 2.45 in Chinese, OR = 2.35 in European Americans) and rheumatoid arthritis (OR = 1.65 in Koreans). Additionally, decreased and increased copy numbers of NCF1 predispose to and protect against SLE, respectively. Our data highlight the pathogenic role of reduced NOX2-derived ROS levels in autoimmune diseases.</P>
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Failure Mode of Orthotropic Two-way Composite Slab under Concentrated Load
Yulin Zhan,Wenfeng Huang,Yu Qiao,Zhouyuan Xu,Renda Zhao 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.12
Ordinary reinforced concrete two-way slabs generally suffer from punching failure under concentrated loads, which is a brittle failure and unfavorable to the structures. The composite slabs with steel sheets and PBL (perfobond rib) shear connectors have been applied for reducing the damage to bridge decks from vehicles. Although it is widely used on bridges, the failure mode of the orthotropic two-way composite slabs has rarely been studied when subject to concentrated loads. Accordingly, static loading tests with concentrated forward central load was carried out on 4 two-way composite slabs, in which the effects of the thickness of steel bottom sheets and concrete plates and spacing of PBL shear connectors on mechanical properties were investigated. The test results show that about 12% of the ultimate bearing capacity decreases when the perfobond ribs are spaced farther apart from 180 mm to 240 mm or the thickness of steel bottom sheets is reduced from 10 mm to 8 mm. And the bearing capacity drops by 38.2% when the thickness of concrete plates decreases by 30 mm. The steel-concrete composite slabs exhibit clear bidirectional force characteristics during the loading process, with the main forced direction being along the perfobond ribs, which is related to the stiffness ratio of the two directions. The two-way composite slabs have high bearing capacity and ductility, with obvious signs before failure. The specimens continue to bear the load after local punching failure of concrete near the loading point, which shows the features of both bending and punching failure. Based on the test results, a bending punching failure mode is proposed, which provides a new approach for the calculation of ultimate bearing capacity. An analytical calculation method for ultimate bearing capacity of orthotropic two-way composite slabs based on the failure mode above is derived with yield line theory and plastic theory, which is in excellent agreement with the tested results.
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A mode transition strategy from air to oxyfuel combustion in a 35MW coal-fired power plant boiler
Zixue Luo,Wenfeng Cheng,Bo Wu,Yongchun Zhao,Junying Zhang 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.5
The atmosphere under the conditions of a coal combustion reaction in the furnace is the factor that makes the most significant difference during mode transition from traditional air to oxy-fuel combustion. The flue gas is adopted as the primary air and secondary air for pulverized-coal conveying and the support of combustion; it has a high carbon dioxide concentration during the oxy-fuel combustion. The air-leakage reduces CO2 enrichment and leads to thermal NOx production. A control strategy of this shift operation is conducted in a 35MW oxy-fuel combustion power plant boiler by adjusting the furnace pressure, regulating the recirculation rate of the flue gas and amending the oxygen concentration in the inlet stream. The furnace pressure can be changed smoothly and stabilized at a micro-positive level as the pressurized air flow is monitored at a suitable range. The combustion-supporting flue gas is modified by the oxygen content in the furnace outlet, and the circulation rate of the flue gas verifies the regulation process. Results show that the CO2 concentration in the flue gas can be rapidly increased along with the increment of furnace pressure and oxygen in the inlet stream; then, this procedure gradually becomes flattened. The CO2 content in the flue gas correlates with the recirculation rate of the flue gas and oxygen concentration in the inlet stream. The two operation parameters should be maintained at a high CO2 concentration in a range from 0.6-0.7 and 29.5%-30.5%, respectively. Sampling analysis shows that SO2 and NOx emissions were 26 (±1.5) mg/MJ and 90 (±11.7) mg/MJ in air condition, 14 (±0.4) mg/MJ and 34 (±1.6) mg/MJ in oxy-fuel combustion; the burnout rate, mechanical losses of incomplete combustion and the unburned carbon rate remained similar at these two stable combustion modes. This mode transition scheme should provide a reference for monitoring and diagnostics, design and operation control of an oxygen-enriched pulverized-coal combustion power plant boiler.
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Zhongwei Wang,Hu Li,Wenfeng Zhao,Song Yang 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.66 No.-
A novel carbon-increasing catalytic route via one-pot cascade acylation–alkylation of biomass-derived 2-methylfuran and acetic anhydride over Sn4+-exchanged K-10 montmorillonite (Sn4+-K-10) was demonstrated to be highly efficient for the production of C17 oxygenate 1,1,1-tris(5-methyl-2-furyl)ethane with a high yield of 87% and 90% selectivity at 60 °C in 8 h under solvent-free conditions. Characterization techniques manifested Sn4+-K-10 to have layered and mesoporous (5.7 nm) texture structure, Lewis–Brønsted acid paired sites and uniformly dispersed Sn species, which greatly contributed to the predominant reactivity and recyclability of Sn4+-K-10. Systematic studies based on GC–MS and NMR were also conducted to elucidate the catalytic mechanism.
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Jian He,Hu Li,Yanxiu Liu,Wenfeng Zhao,Tingting Yang,Wei Xue,Song Yang 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.43 No.-
A series of mesoporous acid–base bifunctional Zr/B mixed oxides with different molar ratios wereprepared by a sol–gel method, and developed for conversion of ethyl levulinate (EL) to g-valerolactone(GVL) by using alcohol as hydrogen source. The morphological structures and physico-chemicalcharacteristics of the synthesized materials were identified by various techniques. A high GVL yield of88.5% was achieved from EL in 2-propanol when Zr1B1 was used. And acid–base sites played a synergicrole in synthesizing GVL from EL as evident by poisoning experiments. Furthermore, the catalyst could bereused several times without significant loss of its catalytic activity.
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